Current discovery progress of some emerging anti-infective chalcones: Highlights from 2016 to 2017.
Identifieur interne : 002F49 ( Ncbi/Merge ); précédent : 002F48; suivant : 002F50Current discovery progress of some emerging anti-infective chalcones: Highlights from 2016 to 2017.
Auteurs : Debarshi Kar Mahapatra ; Soumajit Ghorai ; Sanjay Kumar Bharti ; Asmita Gajbhiye Patil ; Shovanlal GayenSource :
- Current drug discovery technologies [ 1875-6220 ] ; 2018.
Abstract
The anti-infective potentials of the natural products are very well known for centuries and are a part of traditional healing. The foremost therapeutic classes include flavones, isoflavones, flavonols, flavanones, flavanols, proanthocyanidins, anthocyanidins, chalcones, and aurones. The chalcone or 1,3-diphenyl-2E-propene-1-one represents the class of natural product which comprise of benzylideneacetophenone function; i.e. two aromatic moieties linked together by a α, β-unsaturated carbonyl bridge comprising of three-carbons. At present, chalcone is one of the privileged scaffolds that can be synthesized in the laboratory to derive different pharmacologically active compounds. This article is the continued form of the previously published work on anti-infective perspectives of chalcones (highlighted till 2015). The current work emphasizes on the discovery process of the chalcone in the period of 2016 to 2017 on malaria, trypanosomiasis, leishmaniasis, filaria, tuberculosis, netamodes, Human Immunodeficiency Virus (HIV), Tobacco Mosaic Virus (TMV), Severe Acute Respiratory Syndrome (SARS), and miscellaneous conditions. This review comprehensively focuses on the latest progress related with the anti-infective chalcones. The content includes the crucial structural features of chalcone scaffold including structure activity relationship(s) along with their plausible mechanism of action(s) from the duration Jan 2016 to Dec 2017. This literature will be of prime interest to medicinal chemists in getting ideas and concepts for better rational development of potential anti-infective inhibitors.
DOI: 10.2174/1570163815666180720170030
PubMed: 30033873
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India.</nlm:affiliation><wicri:noCountry code="subField">Madhya Pradesh</wicri:noCountry></affiliation></author></analytic><series><title level="j">Current drug discovery technologies</title><idno type="eISSN">1875-6220</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The anti-infective potentials of the natural products are very well known for centuries and are a part of traditional healing. The foremost therapeutic classes include flavones, isoflavones, flavonols, flavanones, flavanols, proanthocyanidins, anthocyanidins, chalcones, and aurones. The chalcone or 1,3-diphenyl-2E-propene-1-one represents the class of natural product which comprise of benzylideneacetophenone function; i.e. two aromatic moieties linked together by a α, β-unsaturated carbonyl bridge comprising of three-carbons. At present, chalcone is one of the privileged scaffolds that can be synthesized in the laboratory to derive different pharmacologically active compounds. This article is the continued form of the previously published work on anti-infective perspectives of chalcones (highlighted till 2015). The current work emphasizes on the discovery process of the chalcone in the period of 2016 to 2017 on malaria, trypanosomiasis, leishmaniasis, filaria, tuberculosis, netamodes, Human Immunodeficiency Virus (HIV), Tobacco Mosaic Virus (TMV), Severe Acute Respiratory Syndrome (SARS), and miscellaneous conditions. This review comprehensively focuses on the latest progress related with the anti-infective chalcones. The content includes the crucial structural features of chalcone scaffold including structure activity relationship(s) along with their plausible mechanism of action(s) from the duration Jan 2016 to Dec 2017. This literature will be of prime interest to medicinal chemists in getting ideas and concepts for better rational development of potential anti-infective inhibitors.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">30033873</PMID><DateRevised><Year>2019</Year><Month>11</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1875-6220</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2018</Year><Month>Jul</Month><Day>20</Day></PubDate></JournalIssue><Title>Current drug discovery technologies</Title><ISOAbbreviation>Curr Drug Discov Technol</ISOAbbreviation></Journal><ArticleTitle>Current discovery progress of some emerging anti-infective chalcones: Highlights from 2016 to 2017.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.2174/1570163815666180720170030</ELocationID><Abstract><AbstractText>The anti-infective potentials of the natural products are very well known for centuries and are a part of traditional healing. The foremost therapeutic classes include flavones, isoflavones, flavonols, flavanones, flavanols, proanthocyanidins, anthocyanidins, chalcones, and aurones. The chalcone or 1,3-diphenyl-2E-propene-1-one represents the class of natural product which comprise of benzylideneacetophenone function; i.e. two aromatic moieties linked together by a α, β-unsaturated carbonyl bridge comprising of three-carbons. At present, chalcone is one of the privileged scaffolds that can be synthesized in the laboratory to derive different pharmacologically active compounds. This article is the continued form of the previously published work on anti-infective perspectives of chalcones (highlighted till 2015). The current work emphasizes on the discovery process of the chalcone in the period of 2016 to 2017 on malaria, trypanosomiasis, leishmaniasis, filaria, tuberculosis, netamodes, Human Immunodeficiency Virus (HIV), Tobacco Mosaic Virus (TMV), Severe Acute Respiratory Syndrome (SARS), and miscellaneous conditions. This review comprehensively focuses on the latest progress related with the anti-infective chalcones. The content includes the crucial structural features of chalcone scaffold including structure activity relationship(s) along with their plausible mechanism of action(s) from the duration Jan 2016 to Dec 2017. This literature will be of prime interest to medicinal chemists in getting ideas and concepts for better rational development of potential anti-infective inhibitors.</AbstractText><CopyrightInformation>Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mahapatra</LastName><ForeName>Debarshi Kar</ForeName><Initials>DK</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Vishwavidyalaya (A Central University), Sagar 470003, Madhya Pradesh. India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ghorai</LastName><ForeName>Soumajit</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Vishwavidyalaya (A Central University), Sagar 470003, Madhya Pradesh. India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bharti</LastName><ForeName>Sanjay Kumar</ForeName><Initials>SK</Initials><AffiliationInfo><Affiliation>Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur 495009, Chhattisgarh. India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Patil</LastName><ForeName>Asmita Gajbhiye</ForeName><Initials>AG</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Vishwavidyalaya (A Central University), Sagar 470003, Madhya Pradesh. India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gayen</LastName><ForeName>Shovanlal</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Vishwavidyalaya (A Central University), Sagar 470003, Madhya Pradesh. India.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>07</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>United Arab Emirates</Country><MedlineTA>Curr Drug Discov Technol</MedlineTA><NlmUniqueID>101157212</NlmUniqueID><ISSNLinking>1570-1638</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Chalcone</Keyword><Keyword MajorTopicYN="N">Infective</Keyword><Keyword MajorTopicYN="N">Malaria</Keyword><Keyword MajorTopicYN="N">Parasite</Keyword><Keyword MajorTopicYN="N">SAR</Keyword><Keyword MajorTopicYN="N">Viral.</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>04</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>07</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>07</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>7</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>7</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>7</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30033873</ArticleId><ArticleId IdType="pii">CDDT-EPUB-91869</ArticleId><ArticleId IdType="doi">10.2174/1570163815666180720170030</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Bharti, Sanjay Kumar" sort="Bharti, Sanjay Kumar" uniqKey="Bharti S" first="Sanjay Kumar" last="Bharti">Sanjay Kumar Bharti</name><name sortKey="Gayen, Shovanlal" sort="Gayen, Shovanlal" uniqKey="Gayen S" first="Shovanlal" last="Gayen">Shovanlal Gayen</name><name sortKey="Ghorai, Soumajit" sort="Ghorai, Soumajit" uniqKey="Ghorai S" first="Soumajit" last="Ghorai">Soumajit Ghorai</name><name sortKey="Mahapatra, Debarshi Kar" sort="Mahapatra, Debarshi Kar" uniqKey="Mahapatra D" first="Debarshi Kar" last="Mahapatra">Debarshi Kar Mahapatra</name><name sortKey="Patil, Asmita Gajbhiye" sort="Patil, Asmita Gajbhiye" uniqKey="Patil A" first="Asmita Gajbhiye" last="Patil">Asmita Gajbhiye Patil</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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