Prevention and treatment of respiratory viral infections: Presentations on antivirals, traditional therapies and host-directed interventions at the 5th ISIRV Antiviral Group conference
Identifieur interne : 002E73 ( Ncbi/Merge ); précédent : 002E72; suivant : 002E74Prevention and treatment of respiratory viral infections: Presentations on antivirals, traditional therapies and host-directed interventions at the 5th ISIRV Antiviral Group conference
Auteurs : Jennifer L. Mckimm-BreschkinSource :
- Antiviral Research [ 0166-3542 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- prevention & control : Respiratory Tract Infections.
- therapy : Respiratory Tract Infections.
- virology : Respiratory Tract Infections.
- Humans.
Abstract
The International Society for Influenza and other Respiratory Virus Diseases held its 5th Antiviral Group (isirv-AVG) Conference in Shanghai, China, in conjunction with the Shanghai Public Health Center and Fudan University from 14-16 June 2017. The three-day programme encompassed presentations on some of the clinical features, management, immune responses and virology of respiratory infections, including influenza A(H1N1)pdm09 and A(H7N9) viruses, MERS-CoV, SARS-CoV, adenovirus Type 80, enterovirus D68, metapneumovirus and respiratory syncytial virus (RSV). Updates were presented on several therapeutics currently in clinical trials, including influenza polymerase inhibitors pimodivir/JNJ6362387, S033188, favipiravir, monoclonal antibodies MHAA45449A and VIS410, and host directed strategies for influenza including nitazoxanide, and polymerase ALS-008112 and fusion inhibitors AK0529, GS-5806 for RSV. Updates were also given on the use of the currently licensed neuraminidase inhibitors. Given the location in China, there were also presentations on the use of Traditional Chinese Medicines. Following on from the previous conference, there were ongoing discussions on appropriate endpoints for severe influenza in clinical trials from regulators and clinicians, an issue which remains unresolved. The aim of this conference summary is to provide information for not only conference participants, but a detailed referenced review of the current status of clinical trials, and pre-clinical development of therapeutics and vaccines for influenza and other respiratory diseases for a broader audience.
Url:
DOI: 10.1016/j.antiviral.2017.11.013
PubMed: 29162476
PubMed Central: 7133686
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Mckimm-Breschkin</name></author></analytic><series><title level="j">Antiviral Research</title><idno type="ISSN">0166-3542</idno><idno type="eISSN">1872-9096</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Humans</term><term>Respiratory Tract Infections (prevention & control)</term><term>Respiratory Tract Infections (therapy)</term><term>Respiratory Tract Infections (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Humains</term><term>Infections de l'appareil respiratoire ()</term><term>Infections de l'appareil respiratoire (virologie)</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections de l'appareil respiratoire</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Infections de l'appareil respiratoire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The International Society for Influenza and other Respiratory Virus Diseases held its 5th Antiviral Group (isirv-AVG) Conference in Shanghai, China, in conjunction with the Shanghai Public Health Center and Fudan University from 14-16 June 2017. The three-day programme encompassed presentations on some of the clinical features, management, immune responses and virology of respiratory infections, including influenza A(H1N1)pdm09 and A(H7N9) viruses, MERS-CoV, SARS-CoV, adenovirus Type 80, enterovirus D68, metapneumovirus and respiratory syncytial virus (RSV). Updates were presented on several therapeutics currently in clinical trials, including influenza polymerase inhibitors pimodivir/JNJ6362387, S033188, favipiravir, monoclonal antibodies MHAA45449A and VIS410, and host directed strategies for influenza including nitazoxanide, and polymerase ALS-008112 and fusion inhibitors AK0529, GS-5806 for RSV. Updates were also given on the use of the currently licensed neuraminidase inhibitors. Given the location in China, there were also presentations on the use of Traditional Chinese Medicines. Following on from the previous conference, there were ongoing discussions on appropriate endpoints for severe influenza in clinical trials from regulators and clinicians, an issue which remains unresolved. The aim of this conference summary is to provide information for not only conference participants, but a detailed referenced review of the current status of clinical trials, and pre-clinical development of therapeutics and vaccines for influenza and other respiratory diseases for a broader audience.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Acosta, P L" uniqKey="Acosta P">P.L. Acosta</name></author><author><name sortKey="Caballero, M T" uniqKey="Caballero M">M.T. Caballero</name></author><author><name sortKey="Polack, F P" uniqKey="Polack F">F.P. Polack</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Agrawal, A S" uniqKey="Agrawal A">A.S. 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Shu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><double pmid="29162476"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Prevention and treatment of respiratory viral infections: Presentations on antivirals, traditional therapies and host-directed interventions at the 5th ISIRV Antiviral Group conference</title><author><name sortKey="Mckimm Breschkin, Jennifer L" sort="Mckimm Breschkin, Jennifer L" uniqKey="Mckimm Breschkin J" first="Jennifer L." last="Mckimm-Breschkin">Jennifer L. Mckimm-Breschkin</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">29162476</idno><idno type="pmc">7133686</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133686</idno><idno type="RBID">PMC:7133686</idno><idno type="doi">10.1016/j.antiviral.2017.11.013</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000B56</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B56</idno><idno type="wicri:Area/Pmc/Curation">000B56</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000B56</idno><idno type="wicri:Area/Pmc/Checkpoint">000594</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000594</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Prevention and treatment of respiratory viral infections: Presentations on antivirals, traditional therapies and host-directed interventions at the 5th ISIRV Antiviral Group conference</title><author><name sortKey="Mckimm Breschkin, Jennifer L" sort="Mckimm Breschkin, Jennifer L" uniqKey="Mckimm Breschkin J" first="Jennifer L." last="Mckimm-Breschkin">Jennifer L. Mckimm-Breschkin</name></author></analytic><series><title level="j">Antiviral Research</title><idno type="ISSN">0166-3542</idno><idno type="eISSN">1872-9096</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The International Society for Influenza and other Respiratory Virus Diseases held its 5th Antiviral Group (isirv-AVG) Conference in Shanghai, China, in conjunction with the Shanghai Public Health Center and Fudan University from 14-16 June 2017. The three-day programme encompassed presentations on some of the clinical features, management, immune responses and virology of respiratory infections, including influenza A(H1N1)pdm09 and A(H7N9) viruses, MERS-CoV, SARS-CoV, adenovirus Type 80, enterovirus D68, metapneumovirus and respiratory syncytial virus (RSV). Updates were presented on several therapeutics currently in clinical trials, including influenza polymerase inhibitors pimodivir/JNJ6362387, S033188, favipiravir, monoclonal antibodies MHAA45449A and VIS410, and host directed strategies for influenza including nitazoxanide, and polymerase ALS-008112 and fusion inhibitors AK0529, GS-5806 for RSV. Updates were also given on the use of the currently licensed neuraminidase inhibitors. Given the location in China, there were also presentations on the use of Traditional Chinese Medicines. Following on from the previous conference, there were ongoing discussions on appropriate endpoints for severe influenza in clinical trials from regulators and clinicians, an issue which remains unresolved. The aim of this conference summary is to provide information for not only conference participants, but a detailed referenced review of the current status of clinical trials, and pre-clinical development of therapeutics and vaccines for influenza and other respiratory diseases for a broader audience.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Acosta, P L" uniqKey="Acosta P">P.L. Acosta</name></author><author><name sortKey="Caballero, M T" uniqKey="Caballero M">M.T. Caballero</name></author><author><name sortKey="Polack, F P" uniqKey="Polack F">F.P. Polack</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Agrawal, A S" uniqKey="Agrawal A">A.S. Agrawal</name></author><author><name sortKey="Ying, T" uniqKey="Ying T">T. Ying</name></author><author><name sortKey="Tao, X" uniqKey="Tao X">X. Tao</name></author><author><name sortKey="Garron, T" uniqKey="Garron T">T. 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Shu</name></author></analytic></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Prevention and treatment of respiratory viral infections: Presentations on antivirals, traditional therapies and host-directed interventions at the 5th ISIRV Antiviral Group conference.</title><author><name sortKey="Mckimm Breschkin, Jennifer L" sort="Mckimm Breschkin, Jennifer L" uniqKey="Mckimm Breschkin J" first="Jennifer L" last="Mckimm-Breschkin">Jennifer L. Mckimm-Breschkin</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne, Australia. Electronic address: jmbvirology@gmail.com.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><affiliation wicri:level="2"><nlm:affiliation>College of Basic Medical Sciences, Fudan University, Shanghai, China; Lindsley F. Kimball Research Institute, New York Blood Center, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Basic Medical Sciences, Fudan University, Shanghai, China; Lindsley F. Kimball Research Institute, New York Blood Center, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Hui, David S" sort="Hui, David S" uniqKey="Hui D" first="David S" last="Hui">David S. Hui</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong Special Administrative Region.</nlm:affiliation><orgName type="university">Université chinoise de Hong Kong</orgName><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Beigel, John H" sort="Beigel, John H" uniqKey="Beigel J" first="John H" last="Beigel">John H. Beigel</name><affiliation wicri:level="2"><nlm:affiliation>Leidos Biomedical Research, Inc., Support to National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Leidos Biomedical Research, Inc., Support to National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Govorkova, Elena A" sort="Govorkova, Elena A" uniqKey="Govorkova E" first="Elena A" last="Govorkova">Elena A. Govorkova</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis</wicri:regionArea><wicri:noRegion>Memphis</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Nelson" sort="Lee, Nelson" uniqKey="Lee N" first="Nelson" last="Lee">Nelson Lee</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine and Dentistry, University of Alberta, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Medicine and Dentistry, University of Alberta</wicri:regionArea><wicri:noRegion>University of Alberta</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:29162476</idno><idno type="pmid">29162476</idno><idno type="doi">10.1016/j.antiviral.2017.11.013</idno><idno type="wicri:Area/PubMed/Corpus">000A58</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A58</idno><idno type="wicri:Area/PubMed/Curation">000A58</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A58</idno><idno type="wicri:Area/PubMed/Checkpoint">000977</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000977</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Prevention and treatment of respiratory viral infections: Presentations on antivirals, traditional therapies and host-directed interventions at the 5th ISIRV Antiviral Group conference.</title><author><name sortKey="Mckimm Breschkin, Jennifer L" sort="Mckimm Breschkin, Jennifer L" uniqKey="Mckimm Breschkin J" first="Jennifer L" last="Mckimm-Breschkin">Jennifer L. Mckimm-Breschkin</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne, Australia. Electronic address: jmbvirology@gmail.com.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><affiliation wicri:level="2"><nlm:affiliation>College of Basic Medical Sciences, Fudan University, Shanghai, China; Lindsley F. Kimball Research Institute, New York Blood Center, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Basic Medical Sciences, Fudan University, Shanghai, China; Lindsley F. Kimball Research Institute, New York Blood Center, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Hui, David S" sort="Hui, David S" uniqKey="Hui D" first="David S" last="Hui">David S. Hui</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong Special Administrative Region.</nlm:affiliation><orgName type="university">Université chinoise de Hong Kong</orgName><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Beigel, John H" sort="Beigel, John H" uniqKey="Beigel J" first="John H" last="Beigel">John H. Beigel</name><affiliation wicri:level="2"><nlm:affiliation>Leidos Biomedical Research, Inc., Support to National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Leidos Biomedical Research, Inc., Support to National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Govorkova, Elena A" sort="Govorkova, Elena A" uniqKey="Govorkova E" first="Elena A" last="Govorkova">Elena A. Govorkova</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis</wicri:regionArea><wicri:noRegion>Memphis</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Nelson" sort="Lee, Nelson" uniqKey="Lee N" first="Nelson" last="Lee">Nelson Lee</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine and Dentistry, University of Alberta, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Medicine and Dentistry, University of Alberta</wicri:regionArea><wicri:noRegion>University of Alberta</wicri:noRegion></affiliation></author></analytic><series><title level="j">Antiviral research</title><idno type="eISSN">1872-9096</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Humans</term><term>Respiratory Tract Infections (prevention & control)</term><term>Respiratory Tract Infections (therapy)</term><term>Respiratory Tract Infections (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Humains</term><term>Infections de l'appareil respiratoire ()</term><term>Infections de l'appareil respiratoire (virologie)</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections de l'appareil respiratoire</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Infections de l'appareil respiratoire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The International Society for Influenza and other Respiratory Virus Diseases held its 5th Antiviral Group (isirv-AVG) Conference in Shanghai, China, in conjunction with the Shanghai Public Health Center and Fudan University from 14-16 June 2017. The three-day programme encompassed presentations on some of the clinical features, management, immune responses and virology of respiratory infections, including influenza A(H1N1)pdm09 and A(H7N9) viruses, MERS-CoV, SARS-CoV, adenovirus Type 80, enterovirus D68, metapneumovirus and respiratory syncytial virus (RSV). Updates were presented on several therapeutics currently in clinical trials, including influenza polymerase inhibitors pimodivir/JNJ6362387, S033188, favipiravir, monoclonal antibodies MHAA45449A and VIS410, and host directed strategies for influenza including nitazoxanide, and polymerase ALS-008112 and fusion inhibitors AK0529, GS-5806 for RSV. Updates were also given on the use of the currently licensed neuraminidase inhibitors. Given the location in China, there were also presentations on the use of Traditional Chinese Medicines. Following on from the previous conference, there were ongoing discussions on appropriate endpoints for severe influenza in clinical trials from regulators and clinicians, an issue which remains unresolved. The aim of this conference summary is to provide information for not only conference participants, but a detailed referenced review of the current status of clinical trials, and pre-clinical development of therapeutics and vaccines for influenza and other respiratory diseases for a broader audience.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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