SrasV1, Ncbi, Merge, bibRecord, 002913

Coronavirus NSP6 restricts autophagosome expansion.

Identifieur interne : 002913 ( Ncbi/Merge ); précédent : 002912; suivant : 002914

Coronavirus NSP6 restricts autophagosome expansion.

Auteurs : Eleanor M. Cottam ; Matthew C. Whelband ; Thomas Wileman

Source :

Autophagy [ 1554-8635 ] ; 2014.

RBID : pubmed:24991833

Descripteurs français

KwdFr :
- Animaux, Autophagie, Cellules Vero, Coronavirus (métabolisme), Facteurs temps, Lysosomes (métabolisme), Phagosomes (métabolisme), Protéines adaptatrices de la transduction du signal (métabolisme), Protéines virales (métabolisme), Sérine-thréonine kinases TOR (métabolisme), Virus de la bronchite infectieuse (physiologie).
MESH :
- métabolisme : Coronavirus, Lysosomes, Phagosomes, Protéines adaptatrices de la transduction du signal, Protéines virales, Sérine-thréonine kinases TOR.
- physiologie : Virus de la bronchite infectieuse.
- Animaux, Autophagie, Cellules Vero, Facteurs temps.

English descriptors

KwdEn :
- Adaptor Proteins, Signal Transducing (metabolism), Animals, Autophagy, Chlorocebus aethiops, Coronavirus (metabolism), Infectious bronchitis virus (physiology), Lysosomes (metabolism), Phagosomes (metabolism), TOR Serine-Threonine Kinases (metabolism), Time Factors, Vero Cells, Viral Proteins (metabolism).
MESH :
- chemical , metabolism : Adaptor Proteins, Signal Transducing, TOR Serine-Threonine Kinases, Viral Proteins.
- metabolism : Coronavirus, Lysosomes, Phagosomes.
- physiology : Infectious bronchitis virus.
- Animals, Autophagy, Chlorocebus aethiops, Time Factors, Vero Cells.

Abstract

Autophagy is a cellular response to starvation that generates autophagosomes to carry long-lived proteins and cellular organelles to lysosomes for degradation. Activation of autophagy by viruses can provide an innate defense against infection, and for (+) strand RNA viruses autophagosomes can facilitate assembly of replicase proteins. We demonstrated that nonstructural protein (NSP) 6 of the avian coronavirus, infectious bronchitis virus (IBV), generates autophagosomes from the ER. A statistical analysis of MAP1LC3B puncta showed that NSP6 induced greater numbers of autophagosomes per cell compared with starvation, but the autophagosomes induced by NSP6 had smaller diameters compared with starvation controls. Small diameter autophagosomes were also induced by infection of cells with IBV, and by NSP6 proteins of MHV and SARS and NSP5, NSP6, and NSP7 of arterivirus PRRSV. Analysis of WIPI2 puncta induced by NSP6 suggests that NSP6 limits autophagosome diameter at the point of omegasome formation. IBV NSP6 also limited autophagosome and omegasome expansion in response to starvation and Torin1 and could therefore limit the size of autophagosomes induced following inhibition of MTOR signaling, as well as those induced independently by the NSP6 protein itself. MAP1LC3B-puncta induced by NSP6 contained SQSTM1, which suggests they can incorporate autophagy cargos. However, NSP6 inhibited the autophagosome/lysosome expansion normally seen following starvation. Taken together the results show that coronavirus NSP6 proteins limit autophagosome expansion, whether they are induced directly by the NSP6 protein, or indirectly by starvation or chemical inhibition of MTOR signaling. This may favor coronavirus infection by compromising the ability of autophagosomes to deliver viral components to lysosomes for degradation.

DOI: 10.4161/auto.29309
PubMed: 24991833

Links toward previous steps (curation, corpus...)

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Links to Exploration step

pubmed:24991833

Le document en format XML

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<ReferenceList><Reference><Citation>J Virol. 2000 Oct;74(19):8953-65</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10982339</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Autophagy. 2013 Apr;9(4):496-509</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23328491</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2004 Mar 12;279(11):10136-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14699140</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncogene. 2004 Dec 16;23(58):9314-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15602573</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2005 Jan 28;120(2):159-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15680321</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Biol. 2005 May;3(5):e156</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15884975</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Traffic. 2006 Feb;7(2):129-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16420522</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2006 May 12;312(5775):875-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16690857</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vet Res. 2007 Mar-Apr;38(2):281-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17296157</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2007 Aug 17;282(33):24131-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17580304</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Cell Biol. 2007 Oct;9(10):1102-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17909521</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Autophagy. 2007 Nov-Dec;3(6):581-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17700057</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2007 Nov;81(22):12543-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17804493</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Host Microbe. 2007 Mar 15;1(1):23-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18005679</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cell Biol. 2008 Aug 25;182(4):685-701</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18725538</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Biol. 2008 Sep 16;6(9):e226</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18798692</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Cell Biol. 2009 Apr;11(4):468-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19270693</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2009 Apr 17;30(4):588-98</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19362021</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Immunol. 2009 May;10(5):480-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19305394</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2009 Sep;83(17):8565-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19515765</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Top Microbiol Immunol. 2009;335:323-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19802573</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Autophagy. 2009 Oct;5(7):1062-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19713743</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Host Microbe. 2010 Feb 18;7(2):115-27</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20159618</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEBS Lett. 2010 Apr 2;584(7):1302-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20074568</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEBS Lett. 2010 Apr 2;584(7):1280-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20138172</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Host Microbe. 2010 Jun 25;7(6):500-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20542253</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2010 Jun 17;465(7300):942-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20526321</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cell Biol. 2010 Aug 23;190(4):511-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20713597</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2011 Oct;85(20):10561-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21835792</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Autophagy. 2011 Nov;7(11):1335-47</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21799305</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2012 Mar;86(5):2474-87</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22190716</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Autophagy. 2012 Oct;8(10):1434-47</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22739997</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Autophagy. 2013 Feb 1;9(2):164-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23182945</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2013 Feb 1;288(5):3571-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23233667</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Autophagy. 2010 May;6(4):506-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20505359</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2013 Mar 21;495(7441):389-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23455425</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Med. 2003 Mar-Apr;9(3-4):65-76</Citation>
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</Reference>
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<tree><noCountry><name sortKey="Cottam, Eleanor M" sort="Cottam, Eleanor M" uniqKey="Cottam E" first="Eleanor M" last="Cottam">Eleanor M. Cottam</name>
<name sortKey="Whelband, Matthew C" sort="Whelband, Matthew C" uniqKey="Whelband M" first="Matthew C" last="Whelband">Matthew C. Whelband</name>
<name sortKey="Wileman, Thomas" sort="Wileman, Thomas" uniqKey="Wileman T" first="Thomas" last="Wileman">Thomas Wileman</name>
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   |texte=   Coronavirus NSP6 restricts autophagosome expansion.
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Coronavirus NSP6 restricts autophagosome expansion.

Coronavirus NSP6 restricts autophagosome expansion.

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