The solution structure of coronaviral stem-loop 2 (SL2) reveals a canonical CUYG tetraloop fold.
Identifieur interne : 002305 ( Ncbi/Merge ); précédent : 002304; suivant : 002306The solution structure of coronaviral stem-loop 2 (SL2) reveals a canonical CUYG tetraloop fold.
Auteurs : Chul Won Lee [États-Unis] ; Lichun Li ; David P. GiedrocSource :
- FEBS letters [ 1873-3468 ] ; 2011.
Descripteurs français
- KwdFr :
- ARN viral (), ARN viral (génétique), Appariement de bases, Données de séquences moléculaires, Modèles moléculaires, Relation structure-activité, Régions 5' non traduites (génétique), Solutions, Spectroscopie par résonance magnétique, Séquence conservée, Séquence nucléotidique, Séquences répétées inversées (génétique), Virus du SRAS (génétique).
- MESH :
- génétique : ARN viral, Régions 5' non traduites, Séquences répétées inversées, Virus du SRAS.
- ARN viral, Appariement de bases, Données de séquences moléculaires, Modèles moléculaires, Relation structure-activité, Solutions, Spectroscopie par résonance magnétique, Séquence conservée, Séquence nucléotidique.
English descriptors
- KwdEn :
- 5' Untranslated Regions (genetics), Base Pairing, Base Sequence, Conserved Sequence, Inverted Repeat Sequences (genetics), Magnetic Resonance Spectroscopy, Models, Molecular, Molecular Sequence Data, RNA, Viral (chemistry), RNA, Viral (genetics), SARS Virus (genetics), Solutions, Structure-Activity Relationship.
- MESH :
- chemical , chemistry : RNA, Viral.
- chemical , genetics : 5' Untranslated Regions, RNA, Viral.
- genetics : Inverted Repeat Sequences, SARS Virus.
- Base Pairing, Base Sequence, Conserved Sequence, Magnetic Resonance Spectroscopy, Models, Molecular, Molecular Sequence Data, Solutions, Structure-Activity Relationship.
Abstract
The transcription and replication of the severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) is regulated by specific viral genome sequences within 5'- and 3'-untranslated regions (5'-UTR and 3'-UTR). Here we report the solution structure of 5'-UTR derived stem-loop 2 (SL2) of SARS-CoV determined by NMR spectroscopy. The highly conserved pentaloop of SL2 is stacked on 5-bp stem and adopts a canonical CUYG tetraloop fold with the 3' nucleotide (U51) flipped out of the stack. The significance of this structure in the context of a previous mutagenesis analysis of SL2 function in replication of the related group 2 coronavirus, mouse hepatitis virus, is discussed.
DOI: 10.1016/j.febslet.2011.03.002
PubMed: 21382373
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pubmed:21382373Le document en format XML
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Giedroc</name></author></analytic><series><title level="j">FEBS letters</title><idno type="eISSN">1873-3468</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>5' Untranslated Regions (genetics)</term><term>Base Pairing</term><term>Base Sequence</term><term>Conserved Sequence</term><term>Inverted Repeat Sequences (genetics)</term><term>Magnetic Resonance Spectroscopy</term><term>Models, Molecular</term><term>Molecular Sequence Data</term><term>RNA, Viral (chemistry)</term><term>RNA, Viral (genetics)</term><term>SARS Virus (genetics)</term><term>Solutions</term><term>Structure-Activity Relationship</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral ()</term><term>ARN viral (génétique)</term><term>Appariement de bases</term><term>Données de séquences moléculaires</term><term>Modèles moléculaires</term><term>Relation structure-activité</term><term>Régions 5' non traduites (génétique)</term><term>Solutions</term><term>Spectroscopie par résonance magnétique</term><term>Séquence conservée</term><term>Séquence nucléotidique</term><term>Séquences répétées inversées (génétique)</term><term>Virus du SRAS (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>5' Untranslated Regions</term><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Inverted Repeat Sequences</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term><term>Régions 5' non traduites</term><term>Séquences répétées inversées</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Base Pairing</term><term>Base Sequence</term><term>Conserved Sequence</term><term>Magnetic Resonance Spectroscopy</term><term>Models, Molecular</term><term>Molecular Sequence Data</term><term>Solutions</term><term>Structure-Activity Relationship</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ARN viral</term><term>Appariement de bases</term><term>Données de séquences moléculaires</term><term>Modèles moléculaires</term><term>Relation structure-activité</term><term>Solutions</term><term>Spectroscopie par résonance magnétique</term><term>Séquence conservée</term><term>Séquence nucléotidique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The transcription and replication of the severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) is regulated by specific viral genome sequences within 5'- and 3'-untranslated regions (5'-UTR and 3'-UTR). Here we report the solution structure of 5'-UTR derived stem-loop 2 (SL2) of SARS-CoV determined by NMR spectroscopy. The highly conserved pentaloop of SL2 is stacked on 5-bp stem and adopts a canonical CUYG tetraloop fold with the 3' nucleotide (U51) flipped out of the stack. The significance of this structure in the context of a previous mutagenesis analysis of SL2 function in replication of the related group 2 coronavirus, mouse hepatitis virus, is discussed.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21382373</PMID><DateCompleted><Year>2011</Year><Month>05</Month><Day>26</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-3468</ISSN><JournalIssue CitedMedium="Internet"><Volume>585</Volume><Issue>7</Issue><PubDate><Year>2011</Year><Month>Apr</Month><Day>06</Day></PubDate></JournalIssue><Title>FEBS letters</Title><ISOAbbreviation>FEBS Lett.</ISOAbbreviation></Journal><ArticleTitle>The solution structure of coronaviral stem-loop 2 (SL2) reveals a canonical CUYG tetraloop fold.</ArticleTitle><Pagination><MedlinePgn>1049-53</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.febslet.2011.03.002</ELocationID><Abstract><AbstractText>The transcription and replication of the severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) is regulated by specific viral genome sequences within 5'- and 3'-untranslated regions (5'-UTR and 3'-UTR). Here we report the solution structure of 5'-UTR derived stem-loop 2 (SL2) of SARS-CoV determined by NMR spectroscopy. The highly conserved pentaloop of SL2 is stacked on 5-bp stem and adopts a canonical CUYG tetraloop fold with the 3' nucleotide (U51) flipped out of the stack. The significance of this structure in the context of a previous mutagenesis analysis of SL2 function in replication of the related group 2 coronavirus, mouse hepatitis virus, is discussed.</AbstractText><CopyrightInformation>Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. 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Giedroc</name><name sortKey="Li, Lichun" sort="Li, Lichun" uniqKey="Li L" first="Lichun" last="Li">Lichun Li</name></noCountry><country name="États-Unis"><region name="Indiana"><name sortKey="Lee, Chul Won" sort="Lee, Chul Won" uniqKey="Lee C" first="Chul Won" last="Lee">Chul Won Lee</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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