SrasV1, Ncbi, Merge, bibRecord, 001C39

The nucleocapsid protein of severe acute respiratory syndrome coronavirus inhibits cell cytokinesis and proliferation by interacting with translation elongation factor 1alpha.

Identifieur interne : 001C39 ( Ncbi/Merge ); précédent : 001C38; suivant : 001C40

The nucleocapsid protein of severe acute respiratory syndrome coronavirus inhibits cell cytokinesis and proliferation by interacting with translation elongation factor 1alpha.

Auteurs : Bing Zhou [République populaire de Chine] ; Junli Liu ; Qiuna Wang ; Xuan Liu ; Xiaorong Li ; Ping Li ; Qingjun Ma ; Cheng Cao

Source :

Journal of virology [ 1098-5514 ] ; 2008.

RBID : pubmed:18448518

Descripteurs français

English descriptors

KwdEn :
- Actins (metabolism), Blotting, Far-Western, Cell Line, Cell Proliferation, Cytokinesis (physiology), Humans, Immunoprecipitation, Lymphocytes (virology), Nucleocapsid Proteins (metabolism), Peptide Elongation Factor 1 (metabolism), Protein Binding, Protein Biosynthesis (physiology), Protein Interaction Mapping, SARS Virus (physiology), Surface Plasmon Resonance, Two-Hybrid System Techniques.
MESH :
- chemical , metabolism : Actins, Nucleocapsid Proteins, Peptide Elongation Factor 1.
- physiology : Cytokinesis, Protein Biosynthesis, SARS Virus.
- virology : Lymphocytes.
- Blotting, Far-Western, Cell Line, Cell Proliferation, Humans, Immunoprecipitation, Protein Binding, Protein Interaction Mapping, Surface Plasmon Resonance, Two-Hybrid System Techniques.

Abstract

Severe acute respiratory syndrome coronavirus (SARS-CoV) is the etiological agent of SARS, an emerging disease characterized by atypical pneumonia. Using a yeast two-hybrid screen with the nucleocapsid (N) protein of SARS-CoV as a bait, the C terminus (amino acids 251 to 422) of the N protein was found to interact with human elongation factor 1-alpha (EF1alpha), an essential component of the translational machinery with an important role in cytokinesis, promoting the bundling of filamentous actin (F-actin). In vitro and in vivo interaction was then confirmed by immuno-coprecipitation, far-Western blotting, and surface plasmon resonance. It was demonstrated that the N protein of SARS-CoV induces aggregation of EF1alpha, inhibiting protein translation and cytokinesis by blocking F-actin bundling. Proliferation of human peripheral blood lymphocytes and other human cell lines was significantly inhibited by the infection of recombinant retrovirus expressing SARS-CoV N protein.

DOI: 10.1128/JVI.00133-08
PubMed: 18448518

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 001B57
to stream PubMed, to step Curation: 001B57
to stream PubMed, to step Checkpoint: 001988

Links to Exploration step

pubmed:18448518

Le document en format XML

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<term>Biosynthèse des protéines (physiologie)</term>
<term>Cartographie d'interactions entre protéines</term>
<term>Cytocinèse (physiologie)</term>
<term>Facteur-1 d'élongation de la chaîne peptidique (métabolisme)</term>
<term>Humains</term>
<term>Immunoprécipitation</term>
<term>Liaison aux protéines</term>
<term>Lignée cellulaire</term>
<term>Lymphocytes (virologie)</term>
<term>Prolifération cellulaire</term>
<term>Protéines nucléocapside (métabolisme)</term>
<term>Résonance plasmonique de surface</term>
<term>Technique de Far-Western</term>
<term>Techniques de double hybride</term>
<term>Virus du SRAS (physiologie)</term>
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<term>Protéines nucléocapside</term>
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<term>Virus du SRAS</term>
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<term>Immunoprécipitation</term>
<term>Liaison aux protéines</term>
<term>Lignée cellulaire</term>
<term>Prolifération cellulaire</term>
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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome coronavirus (SARS-CoV) is the etiological agent of SARS, an emerging disease characterized by atypical pneumonia. Using a yeast two-hybrid screen with the nucleocapsid (N) protein of SARS-CoV as a bait, the C terminus (amino acids 251 to 422) of the N protein was found to interact with human elongation factor 1-alpha (EF1alpha), an essential component of the translational machinery with an important role in cytokinesis, promoting the bundling of filamentous actin (F-actin). In vitro and in vivo interaction was then confirmed by immuno-coprecipitation, far-Western blotting, and surface plasmon resonance. It was demonstrated that the N protein of SARS-CoV induces aggregation of EF1alpha, inhibiting protein translation and cytokinesis by blocking F-actin bundling. Proliferation of human peripheral blood lymphocytes and other human cell lines was significantly inhibited by the infection of recombinant retrovirus expressing SARS-CoV N protein.</div>
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<affiliations><list><country><li>République populaire de Chine</li>
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<settlement><li>Pékin</li>
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<name sortKey="Li, Ping" sort="Li, Ping" uniqKey="Li P" first="Ping" last="Li">Ping Li</name>
<name sortKey="Li, Xiaorong" sort="Li, Xiaorong" uniqKey="Li X" first="Xiaorong" last="Li">Xiaorong Li</name>
<name sortKey="Liu, Junli" sort="Liu, Junli" uniqKey="Liu J" first="Junli" last="Liu">Junli Liu</name>
<name sortKey="Liu, Xuan" sort="Liu, Xuan" uniqKey="Liu X" first="Xuan" last="Liu">Xuan Liu</name>
<name sortKey="Ma, Qingjun" sort="Ma, Qingjun" uniqKey="Ma Q" first="Qingjun" last="Ma">Qingjun Ma</name>
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The nucleocapsid protein of severe acute respiratory syndrome coronavirus inhibits cell cytokinesis and proliferation by interacting with translation elongation factor 1alpha.

The nucleocapsid protein of severe acute respiratory syndrome coronavirus inhibits cell cytokinesis and proliferation by interacting with translation elongation factor 1alpha.

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