Japanese encephalitis virus (JEV): potentiation of lethality in mice by microwave radiation.
Identifieur interne : 001968 ( Ncbi/Merge ); précédent : 001967; suivant : 001969Japanese encephalitis virus (JEV): potentiation of lethality in mice by microwave radiation.
Auteurs : D G Lange [États-Unis] ; J. SedmakSource :
- Bioelectromagnetics [ 0197-8462 ] ; 1991.
Descripteurs français
- KwdFr :
- Animaux, Barrière hémato-encéphalique (effets des radiations), Endothélium vasculaire (cytologie), Endothélium vasculaire (microbiologie), Hypercapnie (), Micro-ondes (effets indésirables), Mâle, Perméabilité capillaire (effets des radiations), Souris, Virulence (effets des radiations), Virus de l'encéphalite japonaise (espèce) (pathogénicité).
- MESH :
- cytologie : Endothélium vasculaire.
- effets des radiations : Barrière hémato-encéphalique, Perméabilité capillaire, Virulence.
- effets indésirables : Micro-ondes.
- microbiologie : Endothélium vasculaire.
- pathogénicité : Virus de l'encéphalite japonaise (espèce).
- Animaux, Hypercapnie, Mâle, Souris.
English descriptors
- KwdEn :
- Animals, Blood-Brain Barrier (radiation effects), Capillary Permeability (radiation effects), Encephalitis Virus, Japanese (pathogenicity), Endothelium, Vascular (cytology), Endothelium, Vascular (microbiology), Hypercapnia (complications), Male, Mice, Microwaves (adverse effects), Virulence (radiation effects).
- MESH :
- adverse effects : Microwaves.
- complications : Hypercapnia.
- cytology : Endothelium, Vascular.
- microbiology : Endothelium, Vascular.
- pathogenicity : Encephalitis Virus, Japanese.
- radiation effects : Blood-Brain Barrier, Capillary Permeability, Virulence.
- Animals, Male, Mice.
Abstract
The expression of Japanese Encephalitis Virus (JEV) lethality in mice requires entry of the virus into the central nervous system. This entry is presumably through the capillary endothelial cells (CEC), because entry between CECs is inhibited by bands of circumferential tight-junctions. A viremic stage occurs during the first 4 to 5 days after JEV administration in mice, and both microwave radiation (2.45-GHz, continuous wave, 10-min exposure) and hypercarbia were employed to increase CEC permeability to JEV. Exposure to microwaves at power densities of 10-50 mW/cm2 resulted in a dose-dependent increase in JEV-induced lethality. Mice did not become tolerant or sensitized to microwave potentiation of JEV-induced mortality because 4 daily exposures at 10 or 50 mW/cm2 (SARS, approximately 24-98 W/kg) did not alter the lethality pattern to subsequent microwave radiation of JEV-exposed animals. Similarly, hypercarbia (5, 10, and 20% CO2) was observed to produce a dose-dependent increase in JEV-induced lethality. Both microwave radiation and hypercarbia are thought to promote pinocytosis in CNS capillary endothelial cells. This may be one mechanism by which they enhance JEV-induced lethality in adult Swiss-Cox mice.
DOI: 10.1002/bem.2250120603
PubMed: 1750827
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 003557
- to stream PubMed, to step Curation: 003557
- to stream PubMed, to step Checkpoint: 003444
Links to Exploration step
pubmed:1750827Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Japanese encephalitis virus (JEV): potentiation of lethality in mice by microwave radiation.</title>
<author><name sortKey="Lange, D G" sort="Lange, D G" uniqKey="Lange D" first="D G" last="Lange">D G Lange</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sedmak, J" sort="Sedmak, J" uniqKey="Sedmak J" first="J" last="Sedmak">J. Sedmak</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="1991">1991</date>
<idno type="RBID">pubmed:1750827</idno>
<idno type="pmid">1750827</idno>
<idno type="doi">10.1002/bem.2250120603</idno>
<idno type="wicri:Area/PubMed/Corpus">003557</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003557</idno>
<idno type="wicri:Area/PubMed/Curation">003557</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003557</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003444</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003444</idno>
<idno type="wicri:Area/Ncbi/Merge">001968</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Japanese encephalitis virus (JEV): potentiation of lethality in mice by microwave radiation.</title>
<author><name sortKey="Lange, D G" sort="Lange, D G" uniqKey="Lange D" first="D G" last="Lange">D G Lange</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sedmak, J" sort="Sedmak, J" uniqKey="Sedmak J" first="J" last="Sedmak">J. Sedmak</name>
</author>
</analytic>
<series><title level="j">Bioelectromagnetics</title>
<idno type="ISSN">0197-8462</idno>
<imprint><date when="1991" type="published">1991</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Blood-Brain Barrier (radiation effects)</term>
<term>Capillary Permeability (radiation effects)</term>
<term>Encephalitis Virus, Japanese (pathogenicity)</term>
<term>Endothelium, Vascular (cytology)</term>
<term>Endothelium, Vascular (microbiology)</term>
<term>Hypercapnia (complications)</term>
<term>Male</term>
<term>Mice</term>
<term>Microwaves (adverse effects)</term>
<term>Virulence (radiation effects)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Barrière hémato-encéphalique (effets des radiations)</term>
<term>Endothélium vasculaire (cytologie)</term>
<term>Endothélium vasculaire (microbiologie)</term>
<term>Hypercapnie ()</term>
<term>Micro-ondes (effets indésirables)</term>
<term>Mâle</term>
<term>Perméabilité capillaire (effets des radiations)</term>
<term>Souris</term>
<term>Virulence (effets des radiations)</term>
<term>Virus de l'encéphalite japonaise (espèce) (pathogénicité)</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Microwaves</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Hypercapnia</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Endothélium vasculaire</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Endothelium, Vascular</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des radiations" xml:lang="fr"><term>Barrière hémato-encéphalique</term>
<term>Perméabilité capillaire</term>
<term>Virulence</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Micro-ondes</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Endothélium vasculaire</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Endothelium, Vascular</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Encephalitis Virus, Japanese</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus de l'encéphalite japonaise (espèce)</term>
</keywords>
<keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Blood-Brain Barrier</term>
<term>Capillary Permeability</term>
<term>Virulence</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Male</term>
<term>Mice</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Hypercapnie</term>
<term>Mâle</term>
<term>Souris</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The expression of Japanese Encephalitis Virus (JEV) lethality in mice requires entry of the virus into the central nervous system. This entry is presumably through the capillary endothelial cells (CEC), because entry between CECs is inhibited by bands of circumferential tight-junctions. A viremic stage occurs during the first 4 to 5 days after JEV administration in mice, and both microwave radiation (2.45-GHz, continuous wave, 10-min exposure) and hypercarbia were employed to increase CEC permeability to JEV. Exposure to microwaves at power densities of 10-50 mW/cm2 resulted in a dose-dependent increase in JEV-induced lethality. Mice did not become tolerant or sensitized to microwave potentiation of JEV-induced mortality because 4 daily exposures at 10 or 50 mW/cm2 (SARS, approximately 24-98 W/kg) did not alter the lethality pattern to subsequent microwave radiation of JEV-exposed animals. Similarly, hypercarbia (5, 10, and 20% CO2) was observed to produce a dose-dependent increase in JEV-induced lethality. Both microwave radiation and hypercarbia are thought to promote pinocytosis in CNS capillary endothelial cells. This may be one mechanism by which they enhance JEV-induced lethality in adult Swiss-Cox mice.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">1750827</PMID>
<DateCompleted><Year>1992</Year>
<Month>01</Month>
<Day>23</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>10</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0197-8462</ISSN>
<JournalIssue CitedMedium="Print"><Volume>12</Volume>
<Issue>6</Issue>
<PubDate><Year>1991</Year>
</PubDate>
</JournalIssue>
<Title>Bioelectromagnetics</Title>
<ISOAbbreviation>Bioelectromagnetics</ISOAbbreviation>
</Journal>
<ArticleTitle>Japanese encephalitis virus (JEV): potentiation of lethality in mice by microwave radiation.</ArticleTitle>
<Pagination><MedlinePgn>335-48</MedlinePgn>
</Pagination>
<Abstract><AbstractText>The expression of Japanese Encephalitis Virus (JEV) lethality in mice requires entry of the virus into the central nervous system. This entry is presumably through the capillary endothelial cells (CEC), because entry between CECs is inhibited by bands of circumferential tight-junctions. A viremic stage occurs during the first 4 to 5 days after JEV administration in mice, and both microwave radiation (2.45-GHz, continuous wave, 10-min exposure) and hypercarbia were employed to increase CEC permeability to JEV. Exposure to microwaves at power densities of 10-50 mW/cm2 resulted in a dose-dependent increase in JEV-induced lethality. Mice did not become tolerant or sensitized to microwave potentiation of JEV-induced mortality because 4 daily exposures at 10 or 50 mW/cm2 (SARS, approximately 24-98 W/kg) did not alter the lethality pattern to subsequent microwave radiation of JEV-exposed animals. Similarly, hypercarbia (5, 10, and 20% CO2) was observed to produce a dose-dependent increase in JEV-induced lethality. Both microwave radiation and hypercarbia are thought to promote pinocytosis in CNS capillary endothelial cells. This may be one mechanism by which they enhance JEV-induced lethality in adult Swiss-Cox mice.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lange</LastName>
<ForeName>D G</ForeName>
<Initials>DG</Initials>
<AffiliationInfo><Affiliation>Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sedmak</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>5P-30-CA-06973-23</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>ES 03363</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Bioelectromagnetics</MedlineTA>
<NlmUniqueID>8008281</NlmUniqueID>
<ISSNLinking>0197-8462</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001812" MajorTopicYN="N">Blood-Brain Barrier</DescriptorName>
<QualifierName UI="Q000528" MajorTopicYN="N">radiation effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002199" MajorTopicYN="N">Capillary Permeability</DescriptorName>
<QualifierName UI="Q000528" MajorTopicYN="N">radiation effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004664" MajorTopicYN="N">Encephalitis Virus, Japanese</DescriptorName>
<QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004730" MajorTopicYN="N">Endothelium, Vascular</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006935" MajorTopicYN="N">Hypercapnia</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008872" MajorTopicYN="N">Microwaves</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014774" MajorTopicYN="N">Virulence</DescriptorName>
<QualifierName UI="Q000528" MajorTopicYN="N">radiation effects</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1991</Year>
<Month>1</Month>
<Day>1</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>1991</Year>
<Month>1</Month>
<Day>1</Day>
<Hour>0</Hour>
<Minute>1</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>1991</Year>
<Month>1</Month>
<Day>1</Day>
<Hour>0</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">1750827</ArticleId>
<ArticleId IdType="doi">10.1002/bem.2250120603</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Maryland</li>
</region>
</list>
<tree><noCountry><name sortKey="Sedmak, J" sort="Sedmak, J" uniqKey="Sedmak J" first="J" last="Sedmak">J. Sedmak</name>
</noCountry>
<country name="États-Unis"><region name="Maryland"><name sortKey="Lange, D G" sort="Lange, D G" uniqKey="Lange D" first="D G" last="Lange">D G Lange</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001968 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 001968 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Ncbi |étape= Merge |type= RBID |clé= pubmed:1750827 |texte= Japanese encephalitis virus (JEV): potentiation of lethality in mice by microwave radiation. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:1750827" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |