Early cytokine mRNA expression profiles predict Morbillivirus disease outcome in ferrets.
Identifieur interne : 001868 ( Ncbi/Merge ); précédent : 001867; suivant : 001869Early cytokine mRNA expression profiles predict Morbillivirus disease outcome in ferrets.
Auteurs : Nicholas Svitek [Canada] ; Veronika Von MesslingSource :
- Virology [ 0042-6822 ] ; 2007.
Descripteurs français
- KwdFr :
- ARN messager (biosynthèse), ARN messager (génétique), Analyse de survie, Analyse de séquence d'ADN, Animaux, Cellules sanguines (immunologie), Charge virale, Clonage moléculaire, Cytokines (biosynthèse), Cytokines (génétique), Cytokines (immunologie), Données de séquences moléculaires, Expression des gènes, Furets, Infections à virus morbilleux (immunologie), Infections à virus morbilleux (physiopathologie), Infections à virus morbilleux (virologie), Modèles animaux de maladie humaine, Mâle, RT-PCR (), Virus de la maladie de Carré (immunologie), Virus de la maladie de Carré (physiologie).
- MESH :
- biosynthèse : ARN messager, Cytokines.
- génétique : ARN messager, Cytokines.
- immunologie : Cellules sanguines, Cytokines, Infections à virus morbilleux, Virus de la maladie de Carré.
- physiologie : Virus de la maladie de Carré.
- physiopathologie : Infections à virus morbilleux.
- virologie : Infections à virus morbilleux.
- Analyse de survie, Analyse de séquence d'ADN, Animaux, Charge virale, Clonage moléculaire, Données de séquences moléculaires, Expression des gènes, Furets, Modèles animaux de maladie humaine, Mâle, RT-PCR.
English descriptors
- KwdEn :
- Animals, Blood Cells (immunology), Cloning, Molecular, Cytokines (biosynthesis), Cytokines (genetics), Cytokines (immunology), Disease Models, Animal, Distemper Virus, Canine (immunology), Distemper Virus, Canine (physiology), Ferrets, Gene Expression, Male, Molecular Sequence Data, Morbillivirus Infections (immunology), Morbillivirus Infections (physiopathology), Morbillivirus Infections (virology), RNA, Messenger (biosynthesis), RNA, Messenger (genetics), Reverse Transcriptase Polymerase Chain Reaction (methods), Sequence Analysis, DNA, Survival Analysis, Viral Load.
- MESH :
- chemical , biosynthesis : Cytokines, RNA, Messenger.
- chemical , genetics : Cytokines, RNA, Messenger.
- immunology : Blood Cells, Cytokines, Distemper Virus, Canine, Morbillivirus Infections.
- methods : Reverse Transcriptase Polymerase Chain Reaction.
- physiology : Distemper Virus, Canine.
- physiopathology : Morbillivirus Infections.
- virology : Morbillivirus Infections.
- Animals, Cloning, Molecular, Disease Models, Animal, Ferrets, Gene Expression, Male, Molecular Sequence Data, Sequence Analysis, DNA, Survival Analysis, Viral Load.
Abstract
Severe immunosuppression is a hallmark of Morbillivirus infections. To study the underlying mechanisms, we have developed a ferret model of canine distemper virus infection. The model reproduces all clinical signs of measles, but the lack of ferret-specific reagents has limited the characterization of the cellular immune response. Towards this, we cloned ferret cytokines and established semi-quantitative real-time PCR assays. To demonstrate the utility of these assays we compared the cytokine profiles elicited by lethal and non-lethal strains during the prodromal phase. We observed a general lack of cytokine induction in animals that later succumbed to the disease, whereas survivors mounted a robust and sustained response. The newly developed cytokine assays strengthen and expand the ferret model not only for Morbillivirus pathogenesis studies but also for several other human respiratory viruses including influenza and SARS.
DOI: 10.1016/j.virol.2007.01.002
PubMed: 17289104
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is a hallmark of Morbillivirus infections. To study the underlying mechanisms, we have developed a ferret model of canine distemper virus infection. The model reproduces all clinical signs of measles, but the lack of ferret-specific reagents has limited the characterization of the cellular immune response. Towards this, we cloned ferret cytokines and established semi-quantitative real-time PCR assays. To demonstrate the utility of these assays we compared the cytokine profiles elicited by lethal and non-lethal strains during the prodromal phase. We observed a general lack of cytokine induction in animals that later succumbed to the disease, whereas survivors mounted a robust and sustained response. The newly developed cytokine assays strengthen and expand the ferret model not only for Morbillivirus pathogenesis studies but also for several other human respiratory viruses including influenza and SARS.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17289104</PMID><DateCompleted><Year>2007</Year><Month>07</Month><Day>12</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0042-6822</ISSN><JournalIssue CitedMedium="Print"><Volume>362</Volume><Issue>2</Issue><PubDate><Year>2007</Year><Month>Jun</Month><Day>05</Day></PubDate></JournalIssue><Title>Virology</Title><ISOAbbreviation>Virology</ISOAbbreviation></Journal><ArticleTitle>Early cytokine mRNA expression profiles predict Morbillivirus disease outcome in ferrets.</ArticleTitle><Pagination><MedlinePgn>404-10</MedlinePgn></Pagination><Abstract><AbstractText>Severe immunosuppression is a hallmark of Morbillivirus infections. To study the underlying mechanisms, we have developed a ferret model of canine distemper virus infection. The model reproduces all clinical signs of measles, but the lack of ferret-specific reagents has limited the characterization of the cellular immune response. Towards this, we cloned ferret cytokines and established semi-quantitative real-time PCR assays. To demonstrate the utility of these assays we compared the cytokine profiles elicited by lethal and non-lethal strains during the prodromal phase. We observed a general lack of cytokine induction in animals that later succumbed to the disease, whereas survivors mounted a robust and sustained response. 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