Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon.
Identifieur interne : 001660 ( Ncbi/Merge ); précédent : 001659; suivant : 001661Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon.
Auteurs : Luisa Cervantes-Barragan [Allemagne] ; Roland Züst ; Friedemann Weber ; Martin Spiegel ; Karl S. Lang ; Shizuo Akira ; Volker Thiel ; Burkhard LudewigSource :
- Blood [ 0006-4971 ] ; 2007.
Descripteurs français
- KwdFr :
- Animaux, Cellules dendritiques (immunologie), Cellules dendritiques (métabolisme), Glycoprotéines membranaires (immunologie), Humains, Infections à coronavirus (immunologie), Infections à coronavirus (virologie), Infections à coronavirus (étiologie), Interféron alpha (biosynthèse), Interféron de type I (biosynthèse), Interféron de type I (immunologie), Récepteur de type Toll-7 (immunologie), Réplication virale, Souris, Virus du SRAS.
- MESH :
- biosynthèse : Interféron alpha, Interféron de type I.
- immunologie : Cellules dendritiques, Glycoprotéines membranaires, Infections à coronavirus, Interféron de type I, Récepteur de type Toll-7.
- métabolisme : Cellules dendritiques.
- virologie : Infections à coronavirus.
- étiologie : Infections à coronavirus.
- Animaux, Humains, Réplication virale, Souris, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Coronavirus Infections (etiology), Coronavirus Infections (immunology), Coronavirus Infections (virology), Dendritic Cells (immunology), Dendritic Cells (metabolism), Humans, Interferon Type I (biosynthesis), Interferon Type I (immunology), Interferon-alpha (biosynthesis), Membrane Glycoproteins (immunology), Mice, SARS Virus, Toll-Like Receptor 7 (immunology), Virus Replication.
- MESH :
- chemical , biosynthesis : Interferon Type I, Interferon-alpha.
- etiology : Coronavirus Infections.
- immunology : Coronavirus Infections, Dendritic Cells, Interferon Type I, Membrane Glycoproteins, Toll-Like Receptor 7.
- metabolism : Dendritic Cells.
- virology : Coronavirus Infections.
- Animals, Humans, Mice, SARS Virus, Virus Replication.
Abstract
This study demonstrates a unique and crucial role of plasmacytoid dendritic cells (pDCs) and pDC-derived type I interferons (IFNs) in the pathogenesis of mouse coronavirus infection. pDCs controlled the fast replicating mouse hepatitis virus (MHV) through the immediate production of type I IFNs. Recognition of MHV by pDCs was mediated via TLR7 ensuring a swift IFN-alpha production following encounter with this cytopathic RNA virus. Furthermore, the particular type I IFN response pattern was not restricted to the murine coronavirus, but was also found in infection with the highly cytopathic human severe acute respiratory syndrome (SARS) coronavirus. Taken together, our results suggest that rapid production of type I IFNs by pDCs is essential for the control of potentially lethal coronavirus infections.
DOI: 10.1182/blood-2006-05-023770
PubMed: 16985170
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002089
- to stream PubMed, to step Curation: 002089
- to stream PubMed, to step Checkpoint: 001E43
Links to Exploration step
pubmed:16985170Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon.</title><author><name sortKey="Cervantes Barragan, Luisa" sort="Cervantes Barragan, Luisa" uniqKey="Cervantes Barragan L" first="Luisa" last="Cervantes-Barragan">Luisa Cervantes-Barragan</name><affiliation wicri:level="1"><nlm:affiliation>Research Department, Kantonal Hospital St Gallen, Switzerland, and Abeteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Research Department, Kantonal Hospital St Gallen, Switzerland, and Abeteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg</wicri:regionArea><wicri:noRegion>Universitat Freiburg</wicri:noRegion><wicri:noRegion>Universitat Freiburg</wicri:noRegion><wicri:noRegion>Universitat Freiburg</wicri:noRegion></affiliation></author><author><name sortKey="Zust, Roland" sort="Zust, Roland" uniqKey="Zust R" first="Roland" last="Züst">Roland Züst</name></author><author><name sortKey="Weber, Friedemann" sort="Weber, Friedemann" uniqKey="Weber F" first="Friedemann" last="Weber">Friedemann Weber</name></author><author><name sortKey="Spiegel, Martin" sort="Spiegel, Martin" uniqKey="Spiegel M" first="Martin" last="Spiegel">Martin Spiegel</name></author><author><name sortKey="Lang, Karl S" sort="Lang, Karl S" uniqKey="Lang K" first="Karl S" last="Lang">Karl S. Lang</name></author><author><name sortKey="Akira, Shizuo" sort="Akira, Shizuo" uniqKey="Akira S" first="Shizuo" last="Akira">Shizuo Akira</name></author><author><name sortKey="Thiel, Volker" sort="Thiel, Volker" uniqKey="Thiel V" first="Volker" last="Thiel">Volker Thiel</name></author><author><name sortKey="Ludewig, Burkhard" sort="Ludewig, Burkhard" uniqKey="Ludewig B" first="Burkhard" last="Ludewig">Burkhard Ludewig</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:16985170</idno><idno type="pmid">16985170</idno><idno type="doi">10.1182/blood-2006-05-023770</idno><idno type="wicri:Area/PubMed/Corpus">002089</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002089</idno><idno type="wicri:Area/PubMed/Curation">002089</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002089</idno><idno type="wicri:Area/PubMed/Checkpoint">001E43</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001E43</idno><idno type="wicri:Area/Ncbi/Merge">001660</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon.</title><author><name sortKey="Cervantes Barragan, Luisa" sort="Cervantes Barragan, Luisa" uniqKey="Cervantes Barragan L" first="Luisa" last="Cervantes-Barragan">Luisa Cervantes-Barragan</name><affiliation wicri:level="1"><nlm:affiliation>Research Department, Kantonal Hospital St Gallen, Switzerland, and Abeteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Research Department, Kantonal Hospital St Gallen, Switzerland, and Abeteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg</wicri:regionArea><wicri:noRegion>Universitat Freiburg</wicri:noRegion><wicri:noRegion>Universitat Freiburg</wicri:noRegion><wicri:noRegion>Universitat Freiburg</wicri:noRegion></affiliation></author><author><name sortKey="Zust, Roland" sort="Zust, Roland" uniqKey="Zust R" first="Roland" last="Züst">Roland Züst</name></author><author><name sortKey="Weber, Friedemann" sort="Weber, Friedemann" uniqKey="Weber F" first="Friedemann" last="Weber">Friedemann Weber</name></author><author><name sortKey="Spiegel, Martin" sort="Spiegel, Martin" uniqKey="Spiegel M" first="Martin" last="Spiegel">Martin Spiegel</name></author><author><name sortKey="Lang, Karl S" sort="Lang, Karl S" uniqKey="Lang K" first="Karl S" last="Lang">Karl S. Lang</name></author><author><name sortKey="Akira, Shizuo" sort="Akira, Shizuo" uniqKey="Akira S" first="Shizuo" last="Akira">Shizuo Akira</name></author><author><name sortKey="Thiel, Volker" sort="Thiel, Volker" uniqKey="Thiel V" first="Volker" last="Thiel">Volker Thiel</name></author><author><name sortKey="Ludewig, Burkhard" sort="Ludewig, Burkhard" uniqKey="Ludewig B" first="Burkhard" last="Ludewig">Burkhard Ludewig</name></author></analytic><series><title level="j">Blood</title><idno type="ISSN">0006-4971</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Coronavirus Infections (etiology)</term><term>Coronavirus Infections (immunology)</term><term>Coronavirus Infections (virology)</term><term>Dendritic Cells (immunology)</term><term>Dendritic Cells (metabolism)</term><term>Humans</term><term>Interferon Type I (biosynthesis)</term><term>Interferon Type I (immunology)</term><term>Interferon-alpha (biosynthesis)</term><term>Membrane Glycoproteins (immunology)</term><term>Mice</term><term>SARS Virus</term><term>Toll-Like Receptor 7 (immunology)</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules dendritiques (immunologie)</term><term>Cellules dendritiques (métabolisme)</term><term>Glycoprotéines membranaires (immunologie)</term><term>Humains</term><term>Infections à coronavirus (immunologie)</term><term>Infections à coronavirus (virologie)</term><term>Infections à coronavirus (étiologie)</term><term>Interféron alpha (biosynthèse)</term><term>Interféron de type I (biosynthèse)</term><term>Interféron de type I (immunologie)</term><term>Récepteur de type Toll-7 (immunologie)</term><term>Réplication virale</term><term>Souris</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Interferon Type I</term><term>Interferon-alpha</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Interféron alpha</term><term>Interféron de type I</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules dendritiques</term><term>Glycoprotéines membranaires</term><term>Infections à coronavirus</term><term>Interféron de type I</term><term>Récepteur de type Toll-7</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus Infections</term><term>Dendritic Cells</term><term>Interferon Type I</term><term>Membrane Glycoproteins</term><term>Toll-Like Receptor 7</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Dendritic Cells</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules dendritiques</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Mice</term><term>SARS Virus</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Réplication virale</term><term>Souris</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study demonstrates a unique and crucial role of plasmacytoid dendritic cells (pDCs) and pDC-derived type I interferons (IFNs) in the pathogenesis of mouse coronavirus infection. pDCs controlled the fast replicating mouse hepatitis virus (MHV) through the immediate production of type I IFNs. Recognition of MHV by pDCs was mediated via TLR7 ensuring a swift IFN-alpha production following encounter with this cytopathic RNA virus. Furthermore, the particular type I IFN response pattern was not restricted to the murine coronavirus, but was also found in infection with the highly cytopathic human severe acute respiratory syndrome (SARS) coronavirus. Taken together, our results suggest that rapid production of type I IFNs by pDCs is essential for the control of potentially lethal coronavirus infections.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16985170</PMID><DateCompleted><Year>2007</Year><Month>03</Month><Day>06</Day></DateCompleted><DateRevised><Year>2007</Year><Month>01</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0006-4971</ISSN><JournalIssue CitedMedium="Print"><Volume>109</Volume><Issue>3</Issue><PubDate><Year>2007</Year><Month>Feb</Month><Day>01</Day></PubDate></JournalIssue><Title>Blood</Title><ISOAbbreviation>Blood</ISOAbbreviation></Journal><ArticleTitle>Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon.</ArticleTitle><Pagination><MedlinePgn>1131-7</MedlinePgn></Pagination><Abstract><AbstractText>This study demonstrates a unique and crucial role of plasmacytoid dendritic cells (pDCs) and pDC-derived type I interferons (IFNs) in the pathogenesis of mouse coronavirus infection. pDCs controlled the fast replicating mouse hepatitis virus (MHV) through the immediate production of type I IFNs. Recognition of MHV by pDCs was mediated via TLR7 ensuring a swift IFN-alpha production following encounter with this cytopathic RNA virus. Furthermore, the particular type I IFN response pattern was not restricted to the murine coronavirus, but was also found in infection with the highly cytopathic human severe acute respiratory syndrome (SARS) coronavirus. Taken together, our results suggest that rapid production of type I IFNs by pDCs is essential for the control of potentially lethal coronavirus infections.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cervantes-Barragan</LastName><ForeName>Luisa</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Research Department, Kantonal Hospital St Gallen, Switzerland, and Abeteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Züst</LastName><ForeName>Roland</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Weber</LastName><ForeName>Friedemann</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Spiegel</LastName><ForeName>Martin</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Lang</LastName><ForeName>Karl S</ForeName><Initials>KS</Initials></Author><Author ValidYN="Y"><LastName>Akira</LastName><ForeName>Shizuo</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Thiel</LastName><ForeName>Volker</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Ludewig</LastName><ForeName>Burkhard</ForeName><Initials>B</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2006</Year><Month>09</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Blood</MedlineTA><NlmUniqueID>7603509</NlmUniqueID><ISSNLinking>0006-4971</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007370">Interferon Type I</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016898">Interferon-alpha</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008562">Membrane Glycoproteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C477038">Tlr7 protein, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051199">Toll-Like Receptor 7</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003713" MajorTopicYN="N">Dendritic Cells</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007370" MajorTopicYN="N">Interferon Type I</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016898" MajorTopicYN="N">Interferon-alpha</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008562" MajorTopicYN="N">Membrane Glycoproteins</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051199" MajorTopicYN="N">Toll-Like Receptor 7</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>9</Month><Day>21</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>3</Month><Day>7</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>9</Month><Day>21</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16985170</ArticleId><ArticleId IdType="pii">blood-2006-05-023770</ArticleId><ArticleId IdType="doi">10.1182/blood-2006-05-023770</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Akira, Shizuo" sort="Akira, Shizuo" uniqKey="Akira S" first="Shizuo" last="Akira">Shizuo Akira</name><name sortKey="Lang, Karl S" sort="Lang, Karl S" uniqKey="Lang K" first="Karl S" last="Lang">Karl S. Lang</name><name sortKey="Ludewig, Burkhard" sort="Ludewig, Burkhard" uniqKey="Ludewig B" first="Burkhard" last="Ludewig">Burkhard Ludewig</name><name sortKey="Spiegel, Martin" sort="Spiegel, Martin" uniqKey="Spiegel M" first="Martin" last="Spiegel">Martin Spiegel</name><name sortKey="Thiel, Volker" sort="Thiel, Volker" uniqKey="Thiel V" first="Volker" last="Thiel">Volker Thiel</name><name sortKey="Weber, Friedemann" sort="Weber, Friedemann" uniqKey="Weber F" first="Friedemann" last="Weber">Friedemann Weber</name><name sortKey="Zust, Roland" sort="Zust, Roland" uniqKey="Zust R" first="Roland" last="Züst">Roland Züst</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Cervantes Barragan, Luisa" sort="Cervantes Barragan, Luisa" uniqKey="Cervantes Barragan L" first="Luisa" last="Cervantes-Barragan">Luisa Cervantes-Barragan</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001660 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 001660 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= pubmed:16985170
|texte= Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:16985170" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |