The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome
Identifieur interne : 001487 ( Ncbi/Merge ); précédent : 001486; suivant : 001488The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome
Auteurs : Wai Po Chong ; Wk Eddie Ip ; Gloria Hoi Wan Tso ; Man Wai Ng ; Wilfred Hing Sang Wong ; Helen Ka Wai Law ; Raymond Wh Yung [République populaire de Chine] ; Eudora Y. Chow [République populaire de Chine] ; Kl Au [République populaire de Chine] ; Eric Yt Chan [République populaire de Chine] ; Wilina Lim [République populaire de Chine] ; Js Malik Peiris [République populaire de Chine] ; Yu Lung LauSource :
- BMC Infectious Diseases [ 1471-2334 ] ; 2006.
Abstract
Cytokines play important roles in antiviral action. We examined whether polymorphisms of
A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of
Url:
DOI: 10.1186/1471-2334-6-82
PubMed: 16672072
PubMed Central: 1468415
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Chow</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.417037.6</institution-id><institution-id institution-id-type="ISNI">0000 0004 1771 3082</institution-id><institution>Department of Pathology,</institution><institution>United Christian Hospital,</institution></institution-wrap>Hong Kong SAR, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hong Kong SAR</wicri:regionArea></affiliation></author><author><name sortKey="Au, Kl" sort="Au, Kl" uniqKey="Au K" first="Kl" last="Au">Kl Au</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.415229.9</institution-id><institution-id institution-id-type="ISNI">0000 0004 1799 7070</institution-id><institution>Princess Margaret Hospital,</institution></institution-wrap>Hong Kong SAR, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hong Kong SAR</wicri:regionArea></affiliation></author><author><name sortKey="Chan, Eric Yt" sort="Chan, Eric Yt" uniqKey="Chan E" first="Eric Yt" last="Chan">Eric Yt Chan</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id><institution-id institution-id-type="ISNI">0000000121742757</institution-id><institution>Queen Mary Hospital,</institution><institution>The University of Hong Kong,</institution></institution-wrap>Hong Kong SAR, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hong Kong SAR</wicri:regionArea></affiliation></author><author><name sortKey="Lim, Wilina" sort="Lim, Wilina" uniqKey="Lim W" first="Wilina" last="Lim">Wilina Lim</name><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="GRID">grid.461944.a</institution-id><institution-id 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SAR</wicri:regionArea></affiliation></author><author><name sortKey="Lau, Yu Lung" sort="Lau, Yu Lung" uniqKey="Lau Y" first="Yu Lung" last="Lau">Yu Lung Lau</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id><institution-id institution-id-type="ISNI">0000000121742757</institution-id><institution>Department of Paediatrics and Adolescent Medicine, The Hong Kong Jockey Club Research Centre,</institution><institution>The University of Hong Kong,</institution></institution-wrap>Pokfulam, Hong Kong SAR China</nlm:aff><wicri:noCountry code="subfield">Hong Kong SAR China</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16672072</idno><idno type="pmc">1468415</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1468415</idno><idno type="RBID">PMC:1468415</idno><idno type="doi">10.1186/1471-2334-6-82</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">000292</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000292</idno><idno type="wicri:Area/Pmc/Curation">000292</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000292</idno><idno type="wicri:Area/Pmc/Checkpoint">001029</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001029</idno><idno type="wicri:Area/Ncbi/Merge">001487</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome</title><author><name sortKey="Chong, Wai Po" sort="Chong, Wai Po" uniqKey="Chong W" first="Wai Po" last="Chong">Wai Po Chong</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id><institution-id institution-id-type="ISNI">0000000121742757</institution-id><institution>Department of Paediatrics and Adolescent Medicine, The Hong Kong Jockey Club Research Centre,</institution><institution>The University of Hong Kong,</institution></institution-wrap>Pokfulam, Hong Kong SAR China</nlm:aff><wicri:noCountry code="subfield">Hong Kong SAR China</wicri:noCountry></affiliation></author><author><name sortKey="Ip, Wk Eddie" sort="Ip, Wk Eddie" uniqKey="Ip W" first="Wk Eddie" last="Ip">Wk Eddie Ip</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id><institution-id institution-id-type="ISNI">0000000121742757</institution-id><institution>Department of Paediatrics and Adolescent Medicine, The Hong Kong Jockey Club Research Centre,</institution><institution>The University of Hong Kong,</institution></institution-wrap>Pokfulam, Hong Kong SAR China</nlm:aff><wicri:noCountry code="subfield">Hong Kong SAR China</wicri:noCountry></affiliation></author><author><name sortKey="Tso, Gloria Hoi Wan" sort="Tso, Gloria Hoi Wan" uniqKey="Tso G" first="Gloria Hoi Wan" last="Tso">Gloria Hoi Wan Tso</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id><institution-id institution-id-type="ISNI">0000000121742757</institution-id><institution>Department of Paediatrics and Adolescent Medicine, The Hong Kong Jockey Club Research Centre,</institution><institution>The University of Hong Kong,</institution></institution-wrap>Pokfulam, Hong Kong SAR China</nlm:aff><wicri:noCountry code="subfield">Hong Kong SAR China</wicri:noCountry></affiliation></author><author><name sortKey="Ng, Man Wai" sort="Ng, Man Wai" uniqKey="Ng M" first="Man Wai" last="Ng">Man Wai Ng</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id><institution-id institution-id-type="ISNI">0000000121742757</institution-id><institution>Department of Paediatrics and Adolescent Medicine, The Hong Kong Jockey Club Research Centre,</institution><institution>The University of Hong Kong,</institution></institution-wrap>Pokfulam, Hong Kong SAR China</nlm:aff><wicri:noCountry code="subfield">Hong Kong SAR China</wicri:noCountry></affiliation></author><author><name sortKey="Wong, Wilfred Hing Sang" sort="Wong, Wilfred Hing Sang" uniqKey="Wong W" first="Wilfred Hing Sang" last="Wong">Wilfred Hing Sang Wong</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id><institution-id institution-id-type="ISNI">0000000121742757</institution-id><institution>Department of Paediatrics and Adolescent Medicine, The Hong Kong Jockey Club Research Centre,</institution><institution>The University of Hong Kong,</institution></institution-wrap>Pokfulam, Hong Kong SAR China</nlm:aff><wicri:noCountry code="subfield">Hong Kong SAR China</wicri:noCountry></affiliation></author><author><name sortKey="Law, Helen Ka Wai" sort="Law, Helen Ka Wai" uniqKey="Law H" first="Helen Ka Wai" last="Law">Helen Ka Wai Law</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id><institution-id institution-id-type="ISNI">0000000121742757</institution-id><institution>Department of Paediatrics and Adolescent Medicine, The Hong Kong Jockey Club Research Centre,</institution><institution>The University of Hong Kong,</institution></institution-wrap>Pokfulam, Hong Kong SAR China</nlm:aff><wicri:noCountry code="subfield">Hong Kong SAR China</wicri:noCountry></affiliation></author><author><name sortKey="Yung, Raymond Wh" sort="Yung, Raymond Wh" uniqKey="Yung R" first="Raymond Wh" last="Yung">Raymond Wh Yung</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Pathology, Pamela Nethersole Youde Hospital, Hong Kong SAR, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathology, Pamela Nethersole Youde Hospital, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Chow, Eudora Y" sort="Chow, Eudora Y" uniqKey="Chow E" first="Eudora Y" last="Chow">Eudora Y. Chow</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.417037.6</institution-id><institution-id institution-id-type="ISNI">0000 0004 1771 3082</institution-id><institution>Department of Pathology,</institution><institution>United Christian Hospital,</institution></institution-wrap>Hong Kong SAR, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hong Kong SAR</wicri:regionArea></affiliation></author><author><name sortKey="Au, Kl" sort="Au, Kl" uniqKey="Au K" first="Kl" last="Au">Kl Au</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.415229.9</institution-id><institution-id institution-id-type="ISNI">0000 0004 1799 7070</institution-id><institution>Princess Margaret Hospital,</institution></institution-wrap>Hong Kong SAR, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hong Kong SAR</wicri:regionArea></affiliation></author><author><name sortKey="Chan, Eric Yt" sort="Chan, Eric Yt" uniqKey="Chan E" first="Eric Yt" last="Chan">Eric Yt Chan</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id><institution-id institution-id-type="ISNI">0000000121742757</institution-id><institution>Queen Mary Hospital,</institution><institution>The University of Hong Kong,</institution></institution-wrap>Hong Kong SAR, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hong Kong SAR</wicri:regionArea></affiliation></author><author><name sortKey="Lim, Wilina" sort="Lim, Wilina" uniqKey="Lim W" first="Wilina" last="Lim">Wilina Lim</name><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="GRID">grid.461944.a</institution-id><institution-id institution-id-type="ISNI">000000041790898X</institution-id><institution>Government Virus Unit, Department of Health,</institution></institution-wrap>Hong Kong SAR, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hong Kong SAR</wicri:regionArea></affiliation></author><author><name sortKey="Peiris, Js Malik" sort="Peiris, Js Malik" uniqKey="Peiris J" first="Js Malik" last="Peiris">Js Malik Peiris</name><affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id><institution-id institution-id-type="ISNI">0000000121742757</institution-id><institution>Department of Microbiology,</institution><institution>The Hong Kong Jockey Club Research Centre, Pokfulam, The University of Hong Kong,</institution></institution-wrap>Hong Kong SAR, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hong Kong SAR</wicri:regionArea></affiliation></author><author><name sortKey="Lau, Yu Lung" sort="Lau, Yu Lung" uniqKey="Lau Y" first="Yu Lung" last="Lau">Yu Lung Lau</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id><institution-id institution-id-type="ISNI">0000000121742757</institution-id><institution>Department of Paediatrics and Adolescent Medicine, The Hong Kong Jockey Club Research Centre,</institution><institution>The University of Hong Kong,</institution></institution-wrap>Pokfulam, Hong Kong SAR China</nlm:aff><wicri:noCountry code="subfield">Hong Kong SAR China</wicri:noCountry></affiliation></author></analytic><series><title level="j">BMC Infectious Diseases</title><idno type="eISSN">1471-2334</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Cytokines play important roles in antiviral action. We examined whether polymorphisms of <italic>IFN-γ</italic>,<italic>TNF-α</italic> and <italic>IL-10</italic> affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS).</p></sec><sec><title>Methods</title><p>A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of <italic>IFN-γ</italic>,<italic>TNF-α</italic> and <italic>IL-10</italic> for their associations with SARS.</p></sec><sec><title>Results</title><p><italic>IFN-γ</italic> +874A allele was associated with susceptibility to SARS in a dose-dependent manner (<italic>P</italic> < 0.001). Individuals with <italic>IFN-γ</italic> +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of <italic>IL-10</italic> and <italic>TNF-α</italic> were not associated with SARS susceptibility.</p></sec><sec><title>Conclusion</title><p><italic>IFN-γ</italic> +874A allele was shown to be a risk factor in SARS susceptibility.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author><author><name sortKey="Lai, St" uniqKey="Lai S">ST Lai</name></author><author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Yam, Ly" uniqKey="Yam L">LY Yam</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name></author><author><name sortKey="Nicholls, J" uniqKey="Nicholls J">J Nicholls</name></author><author><name sortKey="Yee, Wk" uniqKey="Yee W">WK Yee</name></author><author><name sortKey="Yan, Ww" uniqKey="Yan W">WW Yan</name></author><author><name sortKey="Cheung, Mt" uniqKey="Cheung M">MT Cheung</name></author><author><name sortKey="Cheng, Vc" uniqKey="Cheng V">VC Cheng</name></author><author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name></author><author><name sortKey="Tsang, Dn" uniqKey="Tsang D">DN Tsang</name></author><author><name sortKey="Yung, Rw" uniqKey="Yung R">RW Yung</name></author><author><name sortKey="Ng, Tk" uniqKey="Ng T">TK Ng</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, Yl" uniqKey="Lau Y">YL Lau</name></author><author><name sortKey="Peiris, Jm" uniqKey="Peiris J">JM Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Booth, Cm" uniqKey="Booth C">CM Booth</name></author><author><name sortKey="Matukas, Lm" uniqKey="Matukas L">LM Matukas</name></author><author><name sortKey="Tomlinson, Ga" uniqKey="Tomlinson G">GA Tomlinson</name></author><author><name sortKey="Rachlis, Ar" uniqKey="Rachlis A">AR Rachlis</name></author><author><name sortKey="Rose, Db" uniqKey="Rose D">DB Rose</name></author><author><name sortKey="Dwosh, Ha" uniqKey="Dwosh H">HA Dwosh</name></author><author><name sortKey="Walmsley, Sl" uniqKey="Walmsley S">SL Walmsley</name></author><author><name sortKey="Mazzulli, T" uniqKey="Mazzulli T">T Mazzulli</name></author><author><name sortKey="Avendano, M" uniqKey="Avendano M">M Avendano</name></author><author><name sortKey="Derkach, P" uniqKey="Derkach P">P Derkach</name></author><author><name sortKey="Ephtimios, Ie" uniqKey="Ephtimios I">IE Ephtimios</name></author><author><name sortKey="Kitai, I" uniqKey="Kitai I">I Kitai</name></author><author><name sortKey="Mederski, Bd" uniqKey="Mederski B">BD Mederski</name></author><author><name sortKey="Shadowitz, Sb" uniqKey="Shadowitz S">SB Shadowitz</name></author><author><name sortKey="Gold, Wl" uniqKey="Gold W">WL Gold</name></author><author><name sortKey="Hawryluck, La" uniqKey="Hawryluck L">LA Hawryluck</name></author><author><name sortKey="Rea, E" uniqKey="Rea E">E Rea</name></author><author><name sortKey="Chenkin, Js" uniqKey="Chenkin J">JS Chenkin</name></author><author><name sortKey="Cescon, Dw" uniqKey="Cescon D">DW Cescon</name></author><author><name sortKey="Poutanen, Sm" uniqKey="Poutanen S">SM Poutanen</name></author><author><name sortKey="Detsky, As" uniqKey="Detsky A">AS Detsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Jw" uniqKey="Chan J">JW Chan</name></author><author><name sortKey="Ng, Ck" uniqKey="Ng C">CK Ng</name></author><author><name sortKey="Chan, Yh" uniqKey="Chan Y">YH Chan</name></author><author><name sortKey="Mok, Ty" uniqKey="Mok T">TY Mok</name></author><author><name sortKey="Lee, S" uniqKey="Lee S">S Lee</name></author><author><name sortKey="Chu, Sy" uniqKey="Chu S">SY Chu</name></author><author><name sortKey="Law, Wl" uniqKey="Law W">WL Law</name></author><author><name sortKey="Lee, Mp" uniqKey="Lee M">MP Lee</name></author><author><name sortKey="Li, Pc" uniqKey="Li P">PC Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leung, Gm" uniqKey="Leung G">GM Leung</name></author><author><name sortKey="Hedley, Aj" uniqKey="Hedley A">AJ Hedley</name></author><author><name sortKey="Ho, Lm" uniqKey="Ho L">LM Ho</name></author><author><name sortKey="Chau, P" uniqKey="Chau P">P Chau</name></author><author><name sortKey="Wong, Io" uniqKey="Wong I">IO Wong</name></author><author><name sortKey="Thach, Tq" uniqKey="Thach T">TQ Thach</name></author><author><name sortKey="Ghani, Ac" uniqKey="Ghani A">AC Ghani</name></author><author><name sortKey="Donnelly, Ca" uniqKey="Donnelly C">CA Donnelly</name></author><author><name sortKey="Fraser, C" uniqKey="Fraser C">C Fraser</name></author><author><name sortKey="Riley, S" uniqKey="Riley S">S Riley</name></author><author><name sortKey="Ferguson, Nm" uniqKey="Ferguson N">NM Ferguson</name></author><author><name sortKey="Anderson, Rm" uniqKey="Anderson R">RM Anderson</name></author><author><name sortKey="Tsang, T" uniqKey="Tsang T">T Tsang</name></author><author><name sortKey="Leung, Py" uniqKey="Leung P">PY Leung</name></author><author><name sortKey="Wong, V" uniqKey="Wong V">V Wong</name></author><author><name sortKey="Chan, Jc" uniqKey="Chan J">JC Chan</name></author><author><name sortKey="Tsui, E" uniqKey="Tsui E">E Tsui</name></author><author><name sortKey="Lo, Sv" uniqKey="Lo S">SV Lo</name></author><author><name sortKey="Lam, Th" uniqKey="Lam T">TH Lam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ip, Wk" uniqKey="Ip W">WK Ip</name></author><author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name></author><author><name sortKey="Law, Hk" uniqKey="Law H">HK Law</name></author><author><name sortKey="Tso, Gh" uniqKey="Tso G">GH Tso</name></author><author><name sortKey="Kong, Ek" uniqKey="Kong E">EK Kong</name></author><author><name sortKey="Wong, Wh" uniqKey="Wong W">WH Wong</name></author><author><name sortKey="To, Yf" uniqKey="To Y">YF To</name></author><author><name sortKey="Yung, Rw" uniqKey="Yung R">RW Yung</name></author><author><name sortKey="Chow, Ey" uniqKey="Chow E">EY Chow</name></author><author><name sortKey="Au, Kl" uniqKey="Au K">KL Au</name></author><author><name sortKey="Chan, Ey" uniqKey="Chan E">EY Chan</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name></author><author><name sortKey="Jensenius, Jc" uniqKey="Jensenius J">JC Jensenius</name></author><author><name sortKey="Turner, Mw" uniqKey="Turner M">MW Turner</name></author><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author><author><name sortKey="Lau, Yl" uniqKey="Lau Y">YL Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name></author><author><name sortKey="Zhou, G" uniqKey="Zhou G">G Zhou</name></author><author><name sortKey="Zhi, L" uniqKey="Zhi L">L Zhi</name></author><author><name sortKey="Yang, H" uniqKey="Yang H">H Yang</name></author><author><name sortKey="Zhai, Y" uniqKey="Zhai Y">Y Zhai</name></author><author><name sortKey="Dong, X" uniqKey="Dong X">X Dong</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Gao, X" uniqKey="Gao X">X Gao</name></author><author><name sortKey="Zhu, Y" uniqKey="Zhu Y">Y Zhu</name></author><author><name sortKey="He, F" uniqKey="He F">F He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Vs" uniqKey="Chan V">VS Chan</name></author><author><name sortKey="Chan, Ky" uniqKey="Chan K">KY Chan</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name></author><author><name sortKey="Cheung, An" uniqKey="Cheung A">AN Cheung</name></author><author><name sortKey="Zheng, B" uniqKey="Zheng B">B Zheng</name></author><author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name></author><author><name sortKey="Mak, W" uniqKey="Mak W">W Mak</name></author><author><name sortKey="Ngan, Hy" uniqKey="Ngan H">HY Ngan</name></author><author><name sortKey="Xu, X" uniqKey="Xu X">X Xu</name></author><author><name sortKey="Screaton, G" uniqKey="Screaton G">G Screaton</name></author><author><name sortKey="Tam, Pk" uniqKey="Tam P">PK Tam</name></author><author><name sortKey="Austyn, Jm" uniqKey="Austyn J">JM Austyn</name></author><author><name sortKey="Chan, Lc" uniqKey="Chan L">LC Chan</name></author><author><name sortKey="Yip, Sp" uniqKey="Yip S">SP Yip</name></author><author><name sortKey="Peiris, M" uniqKey="Peiris M">M Peiris</name></author><author><name sortKey="Khoo, Us" uniqKey="Khoo U">US Khoo</name></author><author><name sortKey="Lin, Cl" uniqKey="Lin C">CL Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biron, Ca" uniqKey="Biron C">CA Biron</name></author><author><name sortKey="Nguyen, Kb" uniqKey="Nguyen K">KB Nguyen</name></author><author><name sortKey="Pien, Gc" uniqKey="Pien G">GC Pien</name></author><author><name sortKey="Cousens, Lp" uniqKey="Cousens L">LP Cousens</name></author><author><name sortKey="Salazar Mather, Tp" uniqKey="Salazar Mather T">TP Salazar-Mather</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Makhatadze, Nj" uniqKey="Makhatadze N">NJ Makhatadze</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mulligan, Ms" uniqKey="Mulligan M">MS Mulligan</name></author><author><name sortKey="Varani, J" uniqKey="Varani J">J Varani</name></author><author><name sortKey="Dame, Mk" uniqKey="Dame M">MK Dame</name></author><author><name sortKey="Lane, Cl" uniqKey="Lane C">CL Lane</name></author><author><name sortKey="Smith, Cw" uniqKey="Smith C">CW Smith</name></author><author><name sortKey="Anderson, Dc" uniqKey="Anderson D">DC Anderson</name></author><author><name sortKey="Ward, Pa" uniqKey="Ward P">PA Ward</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mulligan, Ms" uniqKey="Mulligan M">MS Mulligan</name></author><author><name sortKey="Vaporciyan, Aa" uniqKey="Vaporciyan A">AA Vaporciyan</name></author><author><name sortKey="Miyasaka, M" uniqKey="Miyasaka M">M Miyasaka</name></author><author><name sortKey="Tamatani, T" uniqKey="Tamatani T">T Tamatani</name></author><author><name sortKey="Ward, Pa" uniqKey="Ward P">PA Ward</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fiorentino, Df" uniqKey="Fiorentino D">DF Fiorentino</name></author><author><name sortKey="Bond, Mw" uniqKey="Bond M">MW Bond</name></author><author><name sortKey="Mosmann, Tr" uniqKey="Mosmann T">TR Mosmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moore, Kw" uniqKey="Moore K">KW Moore</name></author><author><name sortKey="De Waal Malefyt, R" uniqKey="De Waal Malefyt R">R de Waal Malefyt</name></author><author><name sortKey="Coffman, Rl" uniqKey="Coffman R">RL Coffman</name></author><author><name sortKey="O Garra, A" uniqKey="O Garra A">A O'Garra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Inoue, G" uniqKey="Inoue G">G Inoue</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Panuska, Jr" uniqKey="Panuska J">JR Panuska</name></author><author><name sortKey="Merolla, R" uniqKey="Merolla R">R Merolla</name></author><author><name sortKey="Rebert, Na" uniqKey="Rebert N">NA Rebert</name></author><author><name sortKey="Hoffmann, Sp" uniqKey="Hoffmann S">SP Hoffmann</name></author><author><name sortKey="Tsivitse, P" uniqKey="Tsivitse P">P Tsivitse</name></author><author><name sortKey="Cirino, Nm" uniqKey="Cirino N">NM Cirino</name></author><author><name sortKey="Silverman, Rh" uniqKey="Silverman R">RH Silverman</name></author><author><name sortKey="Rankin, Ja" uniqKey="Rankin J">JA Rankin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Standiford, Tj" uniqKey="Standiford T">TJ Standiford</name></author><author><name sortKey="Strieter, Rm" uniqKey="Strieter R">RM Strieter</name></author><author><name sortKey="Lukacs, Nw" uniqKey="Lukacs N">Nw Lukacs</name></author><author><name sortKey="Kunkel, Sl" uniqKey="Kunkel S">SL Kunkel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kalechman, Y" uniqKey="Kalechman Y">Y Kalechman</name></author><author><name sortKey="Gafter, U" uniqKey="Gafter U">U Gafter</name></author><author><name sortKey="Gal, R" uniqKey="Gal R">R Gal</name></author><author><name sortKey="Rushkin, G" uniqKey="Rushkin G">G Rushkin</name></author><author><name sortKey="Yan, D" uniqKey="Yan D">D Yan</name></author><author><name sortKey="Albeck, M" uniqKey="Albeck M">M Albeck</name></author><author><name sortKey="Sredni, B" uniqKey="Sredni B">B Sredni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tso, Hw" uniqKey="Tso H">HW Tso</name></author><author><name sortKey="Ip, Wk" uniqKey="Ip W">WK Ip</name></author><author><name sortKey="Chong, Wp" uniqKey="Chong W">WP Chong</name></author><author><name sortKey="Tam, Cm" uniqKey="Tam C">CM Tam</name></author><author><name sortKey="Chiang, Aks" uniqKey="Chiang A">AKS Chiang</name></author><author><name sortKey="Lau, Yl" uniqKey="Lau Y">YL Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ben Ari, Z" uniqKey="Ben Ari Z">Z Ben-Ari</name></author><author><name sortKey="Mor, E" uniqKey="Mor E">E Mor</name></author><author><name sortKey="Papo, O" uniqKey="Papo O">O Papo</name></author><author><name sortKey="Kfir, B" uniqKey="Kfir B">B Kfir</name></author><author><name sortKey="Sulkes, J" uniqKey="Sulkes J">J Sulkes</name></author><author><name sortKey="Tambur, Ar" uniqKey="Tambur A">AR Tambur</name></author><author><name sortKey="Tur Kaspa, R" uniqKey="Tur Kaspa R">R Tur-Kaspa</name></author><author><name sortKey="Klein, T" uniqKey="Klein T">T Klein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kerr, Jr" uniqKey="Kerr J">JR Kerr</name></author><author><name sortKey="Mccoy, M" uniqKey="Mccoy M">M McCoy</name></author><author><name sortKey="Burke, B" uniqKey="Burke B">B Burke</name></author><author><name sortKey="Mattey, Dl" uniqKey="Mattey D">DL Mattey</name></author><author><name sortKey="Pravica, V" uniqKey="Pravica V">V Pravica</name></author><author><name sortKey="Hutchinson, Iv" uniqKey="Hutchinson I">IV Hutchinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pravica, V" uniqKey="Pravica V">V Pravica</name></author><author><name sortKey="Perrey, C" uniqKey="Perrey C">C Perrey</name></author><author><name sortKey="Stevens, A" uniqKey="Stevens A">A Stevens</name></author><author><name sortKey="Lee, Jh" uniqKey="Lee J">JH Lee</name></author><author><name sortKey="Hutchinson, Iv" uniqKey="Hutchinson I">IV Hutchinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scagnolari, C" uniqKey="Scagnolari C">C Scagnolari</name></author><author><name sortKey="Vicenzi, E" uniqKey="Vicenzi E">E Vicenzi</name></author><author><name sortKey="Bellomi, F" uniqKey="Bellomi F">F Bellomi</name></author><author><name sortKey="Stillitano, Mg" uniqKey="Stillitano M">MG Stillitano</name></author><author><name sortKey="Pinna, D" uniqKey="Pinna D">D Pinna</name></author><author><name sortKey="Poli, G" uniqKey="Poli G">G Poli</name></author><author><name sortKey="Clementi, M" uniqKey="Clementi M">M Clementi</name></author><author><name sortKey="Dianzani, F" uniqKey="Dianzani F">F Dianzani</name></author><author><name sortKey="Antonelli, G" uniqKey="Antonelli G">G Antonelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sainz, B" uniqKey="Sainz B">B Sainz</name></author><author><name sortKey="Mossel, Ec" uniqKey="Mossel E">EC Mossel</name></author><author><name sortKey="Peters, Cj" uniqKey="Peters C">CJ Peters</name></author><author><name sortKey="Garry, Rf" uniqKey="Garry R">RF Garry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turner, Dm" uniqKey="Turner D">DM Turner</name></author><author><name sortKey="Williams, Dm" uniqKey="Williams D">DM Williams</name></author><author><name sortKey="Sankaran, D" uniqKey="Sankaran D">D Sankaran</name></author><author><name sortKey="Lazarus, M" uniqKey="Lazarus M">M Lazarus</name></author><author><name sortKey="Sinnott, Pj" uniqKey="Sinnott P">PJ Sinnott</name></author><author><name sortKey="Hutchinson, Iv" uniqKey="Hutchinson I">IV Hutchinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crawley, E" uniqKey="Crawley E">E Crawley</name></author><author><name sortKey="Kay, R" uniqKey="Kay R">R Kay</name></author><author><name sortKey="Sillibourne, J" uniqKey="Sillibourne J">J Sillibourne</name></author><author><name sortKey="Patel, P" uniqKey="Patel P">P Patel</name></author><author><name sortKey="Hutchinson, I" uniqKey="Hutchinson I">I Hutchinson</name></author><author><name sortKey="Woo, P" uniqKey="Woo P">P Woo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilson, Ag" uniqKey="Wilson A">AG Wilson</name></author><author><name sortKey="Symons, Ja" uniqKey="Symons J">JA Symons</name></author><author><name sortKey="Mcdowell, Tl" uniqKey="Mcdowell T">TL McDowell</name></author><author><name sortKey="Mcdevitt, Ho" uniqKey="Mcdevitt H">HO McDevitt</name></author><author><name sortKey="Duff, Gw" uniqKey="Duff G">GW Duff</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">BMC Infect. Dis</journal-id><journal-title-group><journal-title>BMC Infectious Diseases</journal-title></journal-title-group><issn pub-type="epub">1471-2334</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">16672072</article-id><article-id pub-id-type="pmc">1468415</article-id><article-id pub-id-type="publisher-id">346</article-id><article-id pub-id-type="doi">10.1186/1471-2334-6-82</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome</article-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Chong</surname><given-names>Wai Po</given-names></name><address><email>h9820905@graduate.hku.hk</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Ip</surname><given-names>WK Eddie</given-names></name><address><email>WIP@partners.org</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Tso</surname><given-names>Gloria Hoi Wan</given-names></name><address><email>h98083405@hkusua.hku.hk</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ng</surname><given-names>Man Wai</given-names></name><address><email>ivy_natsu@yahoo.com.hk</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Wong</surname><given-names>Wilfred Hing Sang</given-names></name><address><email>whswong@hkucc.hku.hk</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Law</surname><given-names>Helen Ka Wai</given-names></name><address><email>hkwlaw@hkucc.hku.hk</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Yung</surname><given-names>Raymond WH</given-names></name><address><email>rwhyung@ha.org.hk</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Chow</surname><given-names>Eudora Y</given-names></name><address><email>chowe@ha.org.hk</email></address><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Au</surname><given-names>KL</given-names></name><address><email>klau@ha.org.hk</email></address><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Chan</surname><given-names>Eric YT</given-names></name><address><email>eytchan@ha.org.hk</email></address><xref ref-type="aff" rid="Aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Lim</surname><given-names>Wilina</given-names></name><address><email>wllim@pacific.net.hk</email></address><xref ref-type="aff" rid="Aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Peiris</surname><given-names>JS Malik</given-names></name><address><email>malik@hkucc.hku.hk</email></address><xref ref-type="aff" rid="Aff7">7</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Lau</surname><given-names>Yu Lung</given-names></name><address><email>lauylung@hkucc.hku.hk</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id><institution-id institution-id-type="ISNI">0000000121742757</institution-id><institution>Department of Paediatrics and Adolescent Medicine, The Hong Kong Jockey Club Research Centre,</institution><institution>The University of Hong Kong,</institution></institution-wrap>Pokfulam, Hong Kong SAR China</aff><aff id="Aff2"><label>2</label>Department of Pathology, Pamela Nethersole Youde Hospital, Hong Kong SAR, China</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="GRID">grid.417037.6</institution-id><institution-id institution-id-type="ISNI">0000 0004 1771 3082</institution-id><institution>Department of Pathology,</institution><institution>United Christian Hospital,</institution></institution-wrap>Hong Kong SAR, China</aff><aff id="Aff4"><label>4</label><institution-wrap><institution-id institution-id-type="GRID">grid.415229.9</institution-id><institution-id institution-id-type="ISNI">0000 0004 1799 7070</institution-id><institution>Princess Margaret Hospital,</institution></institution-wrap>Hong Kong SAR, China</aff><aff id="Aff5"><label>5</label><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id><institution-id institution-id-type="ISNI">0000000121742757</institution-id><institution>Queen Mary Hospital,</institution><institution>The University of Hong Kong,</institution></institution-wrap>Hong Kong SAR, China</aff><aff id="Aff6"><label>6</label><institution-wrap><institution-id institution-id-type="GRID">grid.461944.a</institution-id><institution-id institution-id-type="ISNI">000000041790898X</institution-id><institution>Government Virus Unit, Department of Health,</institution></institution-wrap>Hong Kong SAR, China</aff><aff id="Aff7"><label>7</label><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id><institution-id institution-id-type="ISNI">0000000121742757</institution-id><institution>Department of Microbiology,</institution><institution>The Hong Kong Jockey Club Research Centre, Pokfulam, The University of Hong Kong,</institution></institution-wrap>Hong Kong SAR, China</aff></contrib-group><pub-date pub-type="epub"><day>04</day><month>5</month><year>2006</year></pub-date><pub-date pub-type="pmc-release"><day>04</day><month>5</month><year>2006</year></pub-date><pub-date pub-type="collection"><year>2006</year></pub-date><volume>6</volume><elocation-id>82</elocation-id><history><date date-type="received"><day>07</day><month>2</month><year>2006</year></date><date date-type="accepted"><day>04</day><month>5</month><year>2006</year></date></history><permissions><copyright-statement>© Po Chong et al; licensee BioMed Central Ltd. 2006</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><sec><title>Background</title><p>Cytokines play important roles in antiviral action. We examined whether polymorphisms of <italic>IFN-γ</italic>,<italic>TNF-α</italic> and <italic>IL-10</italic> affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS).</p></sec><sec><title>Methods</title><p>A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of <italic>IFN-γ</italic>,<italic>TNF-α</italic> and <italic>IL-10</italic> for their associations with SARS.</p></sec><sec><title>Results</title><p><italic>IFN-γ</italic> +874A allele was associated with susceptibility to SARS in a dose-dependent manner (<italic>P</italic> < 0.001). Individuals with <italic>IFN-γ</italic> +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of <italic>IL-10</italic> and <italic>TNF-α</italic> were not associated with SARS susceptibility.</p></sec><sec><title>Conclusion</title><p><italic>IFN-γ</italic> +874A allele was shown to be a risk factor in SARS susceptibility.</p></sec></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Severe Acute Respiratory Syndrome</kwd><kwd>Antiviral Response</kwd><kwd>Severe Acute Respiratory Syndrome</kwd><kwd>Severe Acute Respiratory Syndrome Patient</kwd><kwd>Severe Acute Respiratory Syndrome Coronavirus</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2006</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Chong, Wai Po" sort="Chong, Wai Po" uniqKey="Chong W" first="Wai Po" last="Chong">Wai Po Chong</name><name sortKey="Ip, Wk Eddie" sort="Ip, Wk Eddie" uniqKey="Ip W" first="Wk Eddie" last="Ip">Wk Eddie Ip</name><name sortKey="Lau, Yu Lung" sort="Lau, Yu Lung" uniqKey="Lau Y" first="Yu Lung" last="Lau">Yu Lung Lau</name><name sortKey="Law, Helen Ka Wai" sort="Law, Helen Ka Wai" uniqKey="Law H" first="Helen Ka Wai" last="Law">Helen Ka Wai Law</name><name sortKey="Ng, Man Wai" sort="Ng, Man Wai" uniqKey="Ng M" first="Man Wai" last="Ng">Man Wai Ng</name><name sortKey="Tso, Gloria Hoi Wan" sort="Tso, Gloria Hoi Wan" uniqKey="Tso G" first="Gloria Hoi Wan" last="Tso">Gloria Hoi Wan Tso</name><name sortKey="Wong, Wilfred Hing Sang" sort="Wong, Wilfred Hing Sang" uniqKey="Wong W" first="Wilfred Hing Sang" last="Wong">Wilfred Hing Sang Wong</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Yung, Raymond Wh" sort="Yung, Raymond Wh" uniqKey="Yung R" first="Raymond Wh" last="Yung">Raymond Wh Yung</name></noRegion><name sortKey="Au, Kl" sort="Au, Kl" uniqKey="Au K" first="Kl" last="Au">Kl Au</name><name sortKey="Chan, Eric Yt" sort="Chan, Eric Yt" uniqKey="Chan E" first="Eric Yt" last="Chan">Eric Yt Chan</name><name sortKey="Chow, Eudora Y" sort="Chow, Eudora Y" uniqKey="Chow E" first="Eudora Y" last="Chow">Eudora Y. Chow</name><name sortKey="Lim, Wilina" sort="Lim, Wilina" uniqKey="Lim W" first="Wilina" last="Lim">Wilina Lim</name><name sortKey="Peiris, Js Malik" sort="Peiris, Js Malik" uniqKey="Peiris J" first="Js Malik" last="Peiris">Js Malik Peiris</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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