Anti–Severe Acute Respiratory Syndrome Coronavirus Immune Responses: The Role Played by Vγ9Vδ2 T Cells
Identifieur interne : 001443 ( Ncbi/Merge ); précédent : 001442; suivant : 001444Anti–Severe Acute Respiratory Syndrome Coronavirus Immune Responses: The Role Played by Vγ9Vδ2 T Cells
Auteurs : Fabrizio Poccia ; Chiara Agrati ; Concetta Castilletti ; Licia Bordi ; Cristiana Gioia ; Douglas Horejsh ; Giuseppe Ippolito [Italie] ; Paul K. S. Chan [République populaire de Chine] ; David S. C. Hui [République populaire de Chine] ; Joseph J. Y. Sung [République populaire de Chine] ; Maria Rosaria Capobianchi ; Miroslav MalkovskySource :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2006.
Descripteurs français
- KwdFr :
- MESH :
- analyse : Récepteur lymphocytaire T antigène, gamma-delta.
- immunologie : Sous-populations de lymphocytes T, Syndrome respiratoire aigu sévère, Virus du SRAS.
- sang : Anticorps antiviraux, Immunoglobuline G.
- Adulte, Femelle, Humains, Mâle, Mémoire immunologique.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Receptors, Antigen, T-Cell, gamma-delta.
- chemical , blood : Antibodies, Viral, Immunoglobulin G.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome, T-Lymphocyte Subsets.
- Adult, Female, Humans, Immunologic Memory, Male.
Abstract
Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus (SARS-CoV) strain. Analyses of T cell repertoires in health care workers who survived SARS-CoV infection during the 2003 outbreak revealed that their effector memory Vγ9Vδ2 T cell populations were selectively expanded ∼3 months after the onset of disease. No such expansion of their αβ T cell pools was detected. The expansion of the Vγ9Vδ2 T cell population was associated with higher anti–SARS-CoV immunoglobulin G titers. In addition, in vitro experiments demonstrated that stimulated Vγ9Vδ2 T cells display an interferon-γ–dependent anti–SARS-CoV activity and are able to directly kill SARS-CoV–infected target cells. These findings are compatible with the possibility that Vγ9Vδ2 T cells play a protective role during SARS
Url:
DOI: 10.1086/502975
PubMed: 16586361
PubMed Central: 7110256
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PMC:7110256Le document en format XML
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Poccia</name><affiliation><nlm:aff id="aff1">Unit of Cellular Immunology,</nlm:aff></affiliation></author><author><name sortKey="Agrati, Chiara" sort="Agrati, Chiara" uniqKey="Agrati C" first="Chiara" last="Agrati">Chiara Agrati</name><affiliation><nlm:aff id="aff1">Unit of Cellular Immunology,</nlm:aff></affiliation></author><author><name sortKey="Castilletti, Concetta" sort="Castilletti, Concetta" uniqKey="Castilletti C" first="Concetta" last="Castilletti">Concetta Castilletti</name><affiliation><nlm:aff wicri:cut=", and" id="aff2">Laboratory of Virology</nlm:aff></affiliation></author><author><name sortKey="Bordi, Licia" sort="Bordi, Licia" uniqKey="Bordi L" first="Licia" last="Bordi">Licia Bordi</name><affiliation><nlm:aff wicri:cut=", and" id="aff2">Laboratory of Virology</nlm:aff></affiliation></author><author><name sortKey="Gioia, Cristiana" sort="Gioia, Cristiana" uniqKey="Gioia C" first="Cristiana" last="Gioia">Cristiana Gioia</name><affiliation><nlm:aff id="aff1">Unit of 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nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K. 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Hui</name><affiliation wicri:level="4"><nlm:aff id="aff4">Centre for Emerging Infectious Diseases, School of Public Health, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre for Emerging Infectious Diseases, School of Public Health, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Sung, Joseph J Y" sort="Sung, Joseph J Y" uniqKey="Sung J" first="Joseph J. Y." last="Sung">Joseph J. Y. Sung</name><affiliation wicri:level="4"><nlm:aff id="aff4">Centre for Emerging Infectious Diseases, School of Public Health, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre for Emerging Infectious Diseases, School of Public Health, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Capobianchi, Maria Rosaria" sort="Capobianchi, Maria Rosaria" uniqKey="Capobianchi M" first="Maria Rosaria" last="Capobianchi">Maria Rosaria Capobianchi</name><affiliation><nlm:aff wicri:cut=", and" id="aff2">Laboratory of Virology</nlm:aff></affiliation></author><author><name sortKey="Malkovsky, Miroslav" sort="Malkovsky, Miroslav" uniqKey="Malkovsky M" first="Miroslav" last="Malkovsky">Miroslav Malkovsky</name><affiliation><nlm:aff id="aff5">Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison</nlm:aff><wicri:noCountry code="subfield">Madison</wicri:noCountry></affiliation></author></analytic><series><title level="j">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antibodies, Viral (blood)</term><term>Female</term><term>Humans</term><term>Immunoglobulin G (blood)</term><term>Immunologic Memory</term><term>Male</term><term>Receptors, Antigen, T-Cell, gamma-delta (analysis)</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>T-Lymphocyte Subsets (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Anticorps antiviraux (sang)</term><term>Femelle</term><term>Humains</term><term>Immunoglobuline G (sang)</term><term>Mâle</term><term>Mémoire immunologique</term><term>Récepteur lymphocytaire T antigène, gamma-delta (analyse)</term><term>Sous-populations de lymphocytes T (immunologie)</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Receptors, Antigen, T-Cell, gamma-delta</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Récepteur lymphocytaire T antigène, gamma-delta</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Sous-populations de lymphocytes T</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term><term>T-Lymphocyte Subsets</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Immunologic Memory</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Mémoire immunologique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus (SARS-CoV) strain. Analyses of T cell repertoires in health care workers who survived SARS-CoV infection during the 2003 outbreak revealed that their effector memory Vγ9Vδ2 T cell populations were selectively expanded ∼3 months after the onset of disease. No such expansion of their αβ T cell pools was detected. The expansion of the Vγ9Vδ2 T cell population was associated with higher anti–SARS-CoV immunoglobulin G titers. In addition, in vitro experiments demonstrated that stimulated Vγ9Vδ2 T cells display an interferon-γ–dependent anti–SARS-CoV activity and are able to directly kill SARS-CoV–infected target cells. These findings are compatible with the possibility that Vγ9Vδ2 T cells play a protective role during SARS</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ksiazek, Tg" uniqKey="Ksiazek T">TG Ksiazek</name></author><author><name sortKey="Erdman, D" uniqKey="Erdman D">D Erdman</name></author><author><name sortKey="Goldsmith, Cs" uniqKey="Goldsmith C">CS Goldsmith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name></author><author><name sortKey="Hui, D" uniqKey="Hui D">D Hui</name></author><author><name sortKey="Wu, A" uniqKey="Wu A">A Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dandekar, Aa" uniqKey="Dandekar A">AA Dandekar</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dandekar, Aa" uniqKey="Dandekar A">AA 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Moser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Casetti, R" uniqKey="Casetti R">R Casetti</name></author><author><name sortKey="Perretta, G" uniqKey="Perretta G">G Perretta</name></author><author><name sortKey="Taglioni, A" uniqKey="Taglioni A">A Taglioni</name></author></analytic></biblStruct></listBibl></div1></back></TEI><double pmid="16586361"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Anti–Severe Acute Respiratory Syndrome Coronavirus Immune Responses: The Role Played by Vγ9Vδ2 T Cells<xref ref-type="fn" rid="fn1"></xref></title><author><name sortKey="Poccia, Fabrizio" sort="Poccia, Fabrizio" uniqKey="Poccia F" first="Fabrizio" last="Poccia">Fabrizio Poccia</name><affiliation><nlm:aff id="aff1">Unit of Cellular Immunology,</nlm:aff></affiliation></author><author><name sortKey="Agrati, Chiara" sort="Agrati, Chiara" uniqKey="Agrati C" first="Chiara" last="Agrati">Chiara Agrati</name><affiliation><nlm:aff id="aff1">Unit of Cellular Immunology,</nlm:aff></affiliation></author><author><name sortKey="Castilletti, Concetta" sort="Castilletti, Concetta" uniqKey="Castilletti C" first="Concetta" last="Castilletti">Concetta Castilletti</name><affiliation><nlm:aff wicri:cut=", and" id="aff2">Laboratory of Virology</nlm:aff></affiliation></author><author><name sortKey="Bordi, Licia" sort="Bordi, Licia" uniqKey="Bordi L" first="Licia" last="Bordi">Licia Bordi</name><affiliation><nlm:aff wicri:cut=", and" id="aff2">Laboratory of Virology</nlm:aff></affiliation></author><author><name sortKey="Gioia, Cristiana" sort="Gioia, Cristiana" uniqKey="Gioia C" first="Cristiana" last="Gioia">Cristiana Gioia</name><affiliation><nlm:aff id="aff1">Unit of Cellular Immunology,</nlm:aff></affiliation></author><author><name sortKey="Horejsh, Douglas" sort="Horejsh, Douglas" uniqKey="Horejsh D" first="Douglas" last="Horejsh">Douglas Horejsh</name><affiliation><nlm:aff wicri:cut=", and" id="aff2">Laboratory of Virology</nlm:aff></affiliation></author><author><name sortKey="Ippolito, Giuseppe" sort="Ippolito, Giuseppe" uniqKey="Ippolito G" first="Giuseppe" last="Ippolito">Giuseppe Ippolito</name><affiliation wicri:level="3"><nlm:aff id="aff3">Department of Epidemiology, National Institute for Infectious Diseases “Lazzaro Spallanzani,” Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Epidemiology, National Institute for Infectious Diseases “Lazzaro Spallanzani,” Istituto di Ricovero e Cura a Carattere Scientifico, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K. S." last="Chan">Paul K. S. Chan</name><affiliation wicri:level="4"><nlm:aff id="aff4">Centre for Emerging Infectious Diseases, School of Public Health, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre for Emerging Infectious Diseases, School of Public Health, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Hui, David S C" sort="Hui, David S C" uniqKey="Hui D" first="David S. C." last="Hui">David S. C. Hui</name><affiliation wicri:level="4"><nlm:aff id="aff4">Centre for Emerging Infectious Diseases, School of Public Health, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre for Emerging Infectious Diseases, School of Public Health, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Sung, Joseph J Y" sort="Sung, Joseph J Y" uniqKey="Sung J" first="Joseph J. Y." last="Sung">Joseph J. Y. Sung</name><affiliation wicri:level="4"><nlm:aff id="aff4">Centre for Emerging Infectious Diseases, School of Public Health, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre for Emerging Infectious Diseases, School of Public Health, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Capobianchi, Maria Rosaria" sort="Capobianchi, Maria Rosaria" uniqKey="Capobianchi M" first="Maria Rosaria" last="Capobianchi">Maria Rosaria Capobianchi</name><affiliation><nlm:aff wicri:cut=", and" id="aff2">Laboratory of Virology</nlm:aff></affiliation></author><author><name sortKey="Malkovsky, Miroslav" sort="Malkovsky, Miroslav" uniqKey="Malkovsky M" first="Miroslav" last="Malkovsky">Miroslav Malkovsky</name><affiliation><nlm:aff id="aff5">Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison</nlm:aff><wicri:noCountry code="subfield">Madison</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16586361</idno><idno type="pmc">7110256</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110256</idno><idno type="RBID">PMC:7110256</idno><idno type="doi">10.1086/502975</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">000896</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000896</idno><idno type="wicri:Area/Pmc/Curation">000896</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000896</idno><idno type="wicri:Area/Pmc/Checkpoint">001166</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001166</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Anti–Severe Acute Respiratory Syndrome Coronavirus Immune Responses: The Role Played by Vγ9Vδ2 T Cells<xref ref-type="fn" rid="fn1"></xref></title><author><name sortKey="Poccia, Fabrizio" sort="Poccia, Fabrizio" uniqKey="Poccia F" first="Fabrizio" last="Poccia">Fabrizio Poccia</name><affiliation><nlm:aff id="aff1">Unit of Cellular Immunology,</nlm:aff></affiliation></author><author><name sortKey="Agrati, Chiara" sort="Agrati, Chiara" uniqKey="Agrati C" first="Chiara" last="Agrati">Chiara Agrati</name><affiliation><nlm:aff id="aff1">Unit of Cellular Immunology,</nlm:aff></affiliation></author><author><name sortKey="Castilletti, Concetta" sort="Castilletti, Concetta" uniqKey="Castilletti C" first="Concetta" last="Castilletti">Concetta Castilletti</name><affiliation><nlm:aff wicri:cut=", and" id="aff2">Laboratory of Virology</nlm:aff></affiliation></author><author><name sortKey="Bordi, Licia" sort="Bordi, Licia" uniqKey="Bordi L" first="Licia" last="Bordi">Licia Bordi</name><affiliation><nlm:aff wicri:cut=", and" id="aff2">Laboratory of Virology</nlm:aff></affiliation></author><author><name sortKey="Gioia, Cristiana" sort="Gioia, Cristiana" uniqKey="Gioia C" first="Cristiana" last="Gioia">Cristiana Gioia</name><affiliation><nlm:aff id="aff1">Unit of Cellular Immunology,</nlm:aff></affiliation></author><author><name sortKey="Horejsh, Douglas" sort="Horejsh, Douglas" uniqKey="Horejsh D" first="Douglas" last="Horejsh">Douglas Horejsh</name><affiliation><nlm:aff wicri:cut=", and" id="aff2">Laboratory of Virology</nlm:aff></affiliation></author><author><name sortKey="Ippolito, Giuseppe" sort="Ippolito, Giuseppe" uniqKey="Ippolito G" first="Giuseppe" last="Ippolito">Giuseppe Ippolito</name><affiliation wicri:level="3"><nlm:aff id="aff3">Department of Epidemiology, National Institute for Infectious Diseases “Lazzaro Spallanzani,” Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Epidemiology, National Institute for Infectious Diseases “Lazzaro Spallanzani,” Istituto di Ricovero e Cura a Carattere Scientifico, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K. S." last="Chan">Paul K. S. Chan</name><affiliation wicri:level="4"><nlm:aff id="aff4">Centre for Emerging Infectious Diseases, School of Public Health, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre for Emerging Infectious Diseases, School of Public Health, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Hui, David S C" sort="Hui, David S C" uniqKey="Hui D" first="David S. C." last="Hui">David S. C. Hui</name><affiliation wicri:level="4"><nlm:aff id="aff4">Centre for Emerging Infectious Diseases, School of Public Health, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre for Emerging Infectious Diseases, School of Public Health, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Sung, Joseph J Y" sort="Sung, Joseph J Y" uniqKey="Sung J" first="Joseph J. Y." last="Sung">Joseph J. Y. Sung</name><affiliation wicri:level="4"><nlm:aff id="aff4">Centre for Emerging Infectious Diseases, School of Public Health, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre for Emerging Infectious Diseases, School of Public Health, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Capobianchi, Maria Rosaria" sort="Capobianchi, Maria Rosaria" uniqKey="Capobianchi M" first="Maria Rosaria" last="Capobianchi">Maria Rosaria Capobianchi</name><affiliation><nlm:aff wicri:cut=", and" id="aff2">Laboratory of Virology</nlm:aff></affiliation></author><author><name sortKey="Malkovsky, Miroslav" sort="Malkovsky, Miroslav" uniqKey="Malkovsky M" first="Miroslav" last="Malkovsky">Miroslav Malkovsky</name><affiliation><nlm:aff id="aff5">Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison</nlm:aff><wicri:noCountry code="subfield">Madison</wicri:noCountry></affiliation></author></analytic><series><title level="j">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus (SARS-CoV) strain. Analyses of T cell repertoires in health care workers who survived SARS-CoV infection during the 2003 outbreak revealed that their effector memory Vγ9Vδ2 T cell populations were selectively expanded ∼3 months after the onset of disease. No such expansion of their αβ T cell pools was detected. The expansion of the Vγ9Vδ2 T cell population was associated with higher anti–SARS-CoV immunoglobulin G titers. In addition, in vitro experiments demonstrated that stimulated Vγ9Vδ2 T cells display an interferon-γ–dependent anti–SARS-CoV activity and are able to directly kill SARS-CoV–infected target cells. These findings are compatible with the possibility that Vγ9Vδ2 T cells play a protective role during SARS</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ksiazek, Tg" uniqKey="Ksiazek T">TG Ksiazek</name></author><author><name sortKey="Erdman, D" uniqKey="Erdman D">D Erdman</name></author><author><name sortKey="Goldsmith, Cs" uniqKey="Goldsmith C">CS Goldsmith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name></author><author><name sortKey="Hui, D" uniqKey="Hui D">D Hui</name></author><author><name sortKey="Wu, A" uniqKey="Wu A">A Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dandekar, Aa" uniqKey="Dandekar A">AA Dandekar</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dandekar, Aa" uniqKey="Dandekar A">AA 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of Cellular Immunology, National Institute for Infectious Diseases Lazzaro Spallanzani, Istituto di Ricovero e Cura a Carattere Scientifico, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Agrati, Chiara" sort="Agrati, Chiara" uniqKey="Agrati C" first="Chiara" last="Agrati">Chiara Agrati</name></author><author><name sortKey="Castilletti, Concetta" sort="Castilletti, Concetta" uniqKey="Castilletti C" first="Concetta" last="Castilletti">Concetta Castilletti</name></author><author><name sortKey="Bordi, Licia" sort="Bordi, Licia" uniqKey="Bordi L" first="Licia" last="Bordi">Licia Bordi</name></author><author><name sortKey="Gioia, Cristiana" sort="Gioia, Cristiana" uniqKey="Gioia C" first="Cristiana" last="Gioia">Cristiana Gioia</name></author><author><name sortKey="Horejsh, Douglas" sort="Horejsh, Douglas" uniqKey="Horejsh D" first="Douglas" last="Horejsh">Douglas Horejsh</name></author><author><name sortKey="Ippolito, Giuseppe" sort="Ippolito, Giuseppe" uniqKey="Ippolito G" first="Giuseppe" last="Ippolito">Giuseppe Ippolito</name></author><author><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K S" last="Chan">Paul K S. Chan</name></author><author><name sortKey="Hui, David S C" sort="Hui, David S C" uniqKey="Hui D" first="David S C" last="Hui">David S C. Hui</name></author><author><name sortKey="Sung, Joseph J Y" sort="Sung, Joseph J Y" uniqKey="Sung J" first="Joseph J Y" last="Sung">Joseph J Y. Sung</name></author><author><name sortKey="Capobianchi, Maria Rosaria" sort="Capobianchi, Maria Rosaria" uniqKey="Capobianchi M" first="Maria Rosaria" last="Capobianchi">Maria Rosaria Capobianchi</name></author><author><name sortKey="Malkovsky, Miroslav" sort="Malkovsky, Miroslav" uniqKey="Malkovsky M" first="Miroslav" last="Malkovsky">Miroslav Malkovsky</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="RBID">pubmed:16586361</idno><idno type="pmid">16586361</idno><idno type="doi">10.1086/502975</idno><idno type="wicri:Area/PubMed/Corpus">002288</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002288</idno><idno type="wicri:Area/PubMed/Curation">002288</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002288</idno><idno type="wicri:Area/PubMed/Checkpoint">002293</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002293</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Anti-severe acute respiratory syndrome coronavirus immune responses: the role played by V gamma 9V delta 2 T cells.</title><author><name sortKey="Poccia, Fabrizio" sort="Poccia, Fabrizio" uniqKey="Poccia F" first="Fabrizio" last="Poccia">Fabrizio Poccia</name><affiliation wicri:level="3"><nlm:affiliation>Unit of Cellular Immunology, National Institute for Infectious Diseases Lazzaro Spallanzani, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy. poccia@inmi.it</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Cellular Immunology, National Institute for Infectious Diseases Lazzaro Spallanzani, Istituto di Ricovero e Cura a Carattere Scientifico, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Agrati, Chiara" sort="Agrati, Chiara" uniqKey="Agrati C" first="Chiara" last="Agrati">Chiara Agrati</name></author><author><name sortKey="Castilletti, Concetta" sort="Castilletti, Concetta" uniqKey="Castilletti C" first="Concetta" last="Castilletti">Concetta Castilletti</name></author><author><name sortKey="Bordi, Licia" sort="Bordi, Licia" uniqKey="Bordi L" first="Licia" last="Bordi">Licia Bordi</name></author><author><name sortKey="Gioia, Cristiana" sort="Gioia, Cristiana" uniqKey="Gioia C" first="Cristiana" last="Gioia">Cristiana Gioia</name></author><author><name sortKey="Horejsh, Douglas" sort="Horejsh, Douglas" uniqKey="Horejsh D" first="Douglas" last="Horejsh">Douglas Horejsh</name></author><author><name sortKey="Ippolito, Giuseppe" sort="Ippolito, Giuseppe" uniqKey="Ippolito G" first="Giuseppe" last="Ippolito">Giuseppe Ippolito</name></author><author><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K S" last="Chan">Paul K S. Chan</name></author><author><name sortKey="Hui, David S C" sort="Hui, David S C" uniqKey="Hui D" first="David S C" last="Hui">David S C. Hui</name></author><author><name sortKey="Sung, Joseph J Y" sort="Sung, Joseph J Y" uniqKey="Sung J" first="Joseph J Y" last="Sung">Joseph J Y. Sung</name></author><author><name sortKey="Capobianchi, Maria Rosaria" sort="Capobianchi, Maria Rosaria" uniqKey="Capobianchi M" first="Maria Rosaria" last="Capobianchi">Maria Rosaria Capobianchi</name></author><author><name sortKey="Malkovsky, Miroslav" sort="Malkovsky, Miroslav" uniqKey="Malkovsky M" first="Miroslav" last="Malkovsky">Miroslav Malkovsky</name></author></analytic><series><title level="j">The Journal of infectious diseases</title><idno type="ISSN">0022-1899</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antibodies, Viral (blood)</term><term>Female</term><term>Humans</term><term>Immunoglobulin G (blood)</term><term>Immunologic Memory</term><term>Male</term><term>Receptors, Antigen, T-Cell, gamma-delta (analysis)</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>T-Lymphocyte Subsets (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Anticorps antiviraux (sang)</term><term>Femelle</term><term>Humains</term><term>Immunoglobuline G (sang)</term><term>Mâle</term><term>Mémoire immunologique</term><term>Récepteur lymphocytaire T antigène, gamma-delta (analyse)</term><term>Sous-populations de lymphocytes T (immunologie)</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Receptors, Antigen, T-Cell, gamma-delta</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Récepteur lymphocytaire T antigène, gamma-delta</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Sous-populations de lymphocytes T</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term><term>T-Lymphocyte Subsets</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Immunologic Memory</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Mémoire immunologique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus (SARS-CoV) strain. Analyses of T cell repertoires in health care workers who survived SARS-CoV infection during the 2003 outbreak revealed that their effector memory V gamma 9V delta 2 T cell populations were selectively expanded ~3 months after the onset of disease. No such expansion of their alpha beta T cell pools was detected. The expansion of the V gamma 9V delta 2 T cell population was associated with higher anti-SARS-CoV immunoglobulin G titers. In addition, in vitro experiments demonstrated that stimulated V gamma 9V delta 2 T cells display an interferon- gamma -dependent anti-SARS-CoV activity and are able to directly kill SARS-CoV-infected target cells. These findings are compatible with the possibility that V gamma 9V delta 2 T cells play a protective role during SARS.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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