The putative protein 6 of the severe acute respiratory syndrome-associated coronavirus: expression and functional characterization.
Identifieur interne : 001283 ( Ncbi/Merge ); précédent : 001282; suivant : 001284The putative protein 6 of the severe acute respiratory syndrome-associated coronavirus: expression and functional characterization.
Auteurs : Hua Geng [République populaire de Chine] ; Yuet-Man Liu ; Wai-Sing Chan ; Anthony Wing-Ip Lo ; Deborah Mun-Yee Au ; Mary Miu-Yee Waye ; Yuan-Yuan HoSource :
- FEBS letters [ 0014-5793 ] ; 2005.
Descripteurs français
- KwdFr :
- ADN (biosynthèse), Animaux, Cadres ouverts de lecture, Cellules CHO, Cellules Vero, Cricetinae, Données de séquences moléculaires, Expression des gènes, Humains, Immunohistochimie, Intestins (anatomopathologie), Lignée cellulaire, Microscopie confocale, Muqueuse intestinale (métabolisme), Noyau de la cellule (métabolisme), Poumon (anatomopathologie), Poumon (métabolisme), Protéines de fusion recombinantes (), Protéines de fusion recombinantes (métabolisme), Protéines virales (), Protéines virales (génétique), Protéines virales (métabolisme), Protéines à fluorescence verte (métabolisme), Réticulum endoplasmique (métabolisme), Syndrome respiratoire aigu sévère (métabolisme), Syndrome respiratoire aigu sévère (virologie), Séquence d'acides aminés, Virus du SRAS (), Études cas-témoins.
- MESH :
- anatomopathologie : Intestins, Poumon.
- biosynthèse : ADN.
- génétique : Protéines virales.
- métabolisme : Muqueuse intestinale, Noyau de la cellule, Poumon, Protéines de fusion recombinantes, Protéines virales, Protéines à fluorescence verte, Réticulum endoplasmique, Syndrome respiratoire aigu sévère.
- virologie : Syndrome respiratoire aigu sévère.
- Animaux, Cadres ouverts de lecture, Cellules CHO, Cellules Vero, Cricetinae, Données de séquences moléculaires, Expression des gènes, Humains, Immunohistochimie, Lignée cellulaire, Microscopie confocale, Protéines de fusion recombinantes, Protéines virales, Séquence d'acides aminés, Virus du SRAS, Études cas-témoins.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, CHO Cells, Case-Control Studies, Cell Line, Cell Nucleus (metabolism), Chlorocebus aethiops, Cricetinae, DNA (biosynthesis), Endoplasmic Reticulum (metabolism), Gene Expression, Green Fluorescent Proteins (metabolism), Humans, Immunohistochemistry, Intestinal Mucosa (metabolism), Intestines (pathology), Lung (metabolism), Lung (pathology), Microscopy, Confocal, Molecular Sequence Data, Open Reading Frames, Recombinant Fusion Proteins (chemistry), Recombinant Fusion Proteins (metabolism), SARS Virus (chemistry), Severe Acute Respiratory Syndrome (metabolism), Severe Acute Respiratory Syndrome (virology), Vero Cells, Viral Proteins (chemistry), Viral Proteins (genetics), Viral Proteins (metabolism).
- MESH :
- chemical , biosynthesis : DNA.
- chemical , chemistry : Recombinant Fusion Proteins, Viral Proteins.
- chemistry : SARS Virus.
- chemical , genetics : Viral Proteins.
- metabolism : Cell Nucleus, Endoplasmic Reticulum, Green Fluorescent Proteins, Intestinal Mucosa, Lung, Recombinant Fusion Proteins, Severe Acute Respiratory Syndrome, Viral Proteins.
- pathology : Intestines, Lung.
- virology : Severe Acute Respiratory Syndrome.
- Amino Acid Sequence, Animals, CHO Cells, Case-Control Studies, Cell Line, Chlorocebus aethiops, Cricetinae, Gene Expression, Humans, Immunohistochemistry, Microscopy, Confocal, Molecular Sequence Data, Open Reading Frames, Vero Cells.
Abstract
The SARS-CoV open reading frame 6 (ORF6) is transcribed into mRNA6 and encodes a putative 7.5 kDa accessory protein, SARS 6, with unknown function. In this study, we have confirmed the SARS 6 protein expression in lung and intestine tissues of the SARS patients and in SARS-CoV infected Vero E6 cells by immunohistochemistry. Further studies by immunoblot and confocal microscopy analyses revealed the expression and the endoplasmic reticulum (ER) localization of the recombinant SARS 6 protein in mammalian cells. Expression of SARS 6 protein in mammalian cells elicits biological activity of stimulating cellular DNA synthesis.
DOI: 10.1016/j.febslet.2005.11.007
PubMed: 16310783
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002429
- to stream PubMed, to step Curation: 002429
- to stream PubMed, to step Checkpoint: 002421
Links to Exploration step
pubmed:16310783Le document en format XML
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<term>Animals</term>
<term>CHO Cells</term>
<term>Case-Control Studies</term>
<term>Cell Line</term>
<term>Cell Nucleus (metabolism)</term>
<term>Chlorocebus aethiops</term>
<term>Cricetinae</term>
<term>DNA (biosynthesis)</term>
<term>Endoplasmic Reticulum (metabolism)</term>
<term>Gene Expression</term>
<term>Green Fluorescent Proteins (metabolism)</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Intestinal Mucosa (metabolism)</term>
<term>Intestines (pathology)</term>
<term>Lung (metabolism)</term>
<term>Lung (pathology)</term>
<term>Microscopy, Confocal</term>
<term>Molecular Sequence Data</term>
<term>Open Reading Frames</term>
<term>Recombinant Fusion Proteins (chemistry)</term>
<term>Recombinant Fusion Proteins (metabolism)</term>
<term>SARS Virus (chemistry)</term>
<term>Severe Acute Respiratory Syndrome (metabolism)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Vero Cells</term>
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<term>Lignée cellulaire</term>
<term>Microscopie confocale</term>
<term>Muqueuse intestinale (métabolisme)</term>
<term>Noyau de la cellule (métabolisme)</term>
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<term>Protéines de fusion recombinantes ()</term>
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<term>Protéines virales (métabolisme)</term>
<term>Protéines à fluorescence verte (métabolisme)</term>
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<term>Syndrome respiratoire aigu sévère (métabolisme)</term>
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<term>Séquence d'acides aminés</term>
<term>Virus du SRAS ()</term>
<term>Études cas-témoins</term>
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<term>Lung</term>
<term>Recombinant Fusion Proteins</term>
<term>Severe Acute Respiratory Syndrome</term>
<term>Viral Proteins</term>
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<term>Noyau de la cellule</term>
<term>Poumon</term>
<term>Protéines de fusion recombinantes</term>
<term>Protéines virales</term>
<term>Protéines à fluorescence verte</term>
<term>Réticulum endoplasmique</term>
<term>Syndrome respiratoire aigu sévère</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Intestines</term>
<term>Lung</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
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<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
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<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>CHO Cells</term>
<term>Case-Control Studies</term>
<term>Cell Line</term>
<term>Chlorocebus aethiops</term>
<term>Cricetinae</term>
<term>Gene Expression</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Microscopy, Confocal</term>
<term>Molecular Sequence Data</term>
<term>Open Reading Frames</term>
<term>Vero Cells</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cadres ouverts de lecture</term>
<term>Cellules CHO</term>
<term>Cellules Vero</term>
<term>Cricetinae</term>
<term>Données de séquences moléculaires</term>
<term>Expression des gènes</term>
<term>Humains</term>
<term>Immunohistochimie</term>
<term>Lignée cellulaire</term>
<term>Microscopie confocale</term>
<term>Protéines de fusion recombinantes</term>
<term>Protéines virales</term>
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<front><div type="abstract" xml:lang="en">The SARS-CoV open reading frame 6 (ORF6) is transcribed into mRNA6 and encodes a putative 7.5 kDa accessory protein, SARS 6, with unknown function. In this study, we have confirmed the SARS 6 protein expression in lung and intestine tissues of the SARS patients and in SARS-CoV infected Vero E6 cells by immunohistochemistry. Further studies by immunoblot and confocal microscopy analyses revealed the expression and the endoplasmic reticulum (ER) localization of the recombinant SARS 6 protein in mammalian cells. Expression of SARS 6 protein in mammalian cells elicits biological activity of stimulating cellular DNA synthesis.</div>
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<ArticleTitle>The putative protein 6 of the severe acute respiratory syndrome-associated coronavirus: expression and functional characterization.</ArticleTitle>
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<Abstract><AbstractText>The SARS-CoV open reading frame 6 (ORF6) is transcribed into mRNA6 and encodes a putative 7.5 kDa accessory protein, SARS 6, with unknown function. In this study, we have confirmed the SARS 6 protein expression in lung and intestine tissues of the SARS patients and in SARS-CoV infected Vero E6 cells by immunohistochemistry. Further studies by immunoblot and confocal microscopy analyses revealed the expression and the endoplasmic reticulum (ER) localization of the recombinant SARS 6 protein in mammalian cells. Expression of SARS 6 protein in mammalian cells elicits biological activity of stimulating cellular DNA synthesis.</AbstractText>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Geng</LastName>
<ForeName>Hua</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry, MMW509C, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</Affiliation>
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<Author ValidYN="Y"><LastName>Waye</LastName>
<ForeName>Mary Miu-Yee</ForeName>
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<ForeName>Yuan-Yuan</ForeName>
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<ReferenceList><Reference><Citation>J Mol Biol. 2003 Aug 29;331(5):991-1004</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12927536</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>DNA Cell Biol. 2002 Sep;21(9):679-88</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12396611</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Mol Cell Biol. 1994 Dec;14(12):8399-407</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7969175</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Clin Pathol. 2004 Mar;57(3):260-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14990596</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2005 Sep;79(17):11335-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16103185</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Gen Virol. 2003 Sep;84(Pt 9):2305-2315</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12917450</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2004 Jul;78(13):6723-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15194747</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Neuron. 1995 Feb;14(2):211-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7531985</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virology. 2003 Aug 15;313(1):91-104</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12951024</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Science. 2003 May 30;300(5624):1394-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12730500</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2003 Jan;77(1):1-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12477805</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2004 Jul;78(14):7311-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15220404</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Mod Pathol. 2005 Nov;18(11):1432-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15920543</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1977-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12671062</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Blood. 2001 Aug 1;98(3):823-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11468184</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1986-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12682352</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>N Engl J Med. 2003 Jul 10;349(2):187-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12853594</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet. 2003 Nov 29;362(9398):1807-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14654320</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Med Virol. 2004 Sep;74(1):1-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15258961</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virology. 1999 Oct 25;263(2):313-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10544105</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Gen Virol. 2005 Jul;86(Pt 7):1921-1930</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15958670</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Curr Opin Microbiol. 2004 Aug;7(4):412-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15358261</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>République populaire de Chine</li>
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<settlement><li>Sha Tin</li>
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<name sortKey="Liu, Yuet Man" sort="Liu, Yuet Man" uniqKey="Liu Y" first="Yuet-Man" last="Liu">Yuet-Man Liu</name>
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