Preparation and development of equine hyperimmune globulin F(ab')2 against severe acute respiratory syndrome coronavirus.
Identifieur interne : 001267 ( Ncbi/Merge ); précédent : 001266; suivant : 001268Preparation and development of equine hyperimmune globulin F(ab')2 against severe acute respiratory syndrome coronavirus.
Auteurs : Jia-Hai Lu [République populaire de Chine] ; Zhong-Min Guo ; Wen-Yu Han ; Guo-Ling Wang ; Ding-Mei Zhang ; Yi-Fei Wang ; Sheng-Yun Sun ; Qin-He Yang ; Huan-Ying Zheng ; Bing L. Wong ; Nan-Shan ZhongSource :
- Acta pharmacologica Sinica [ 1671-4083 ] ; 2005.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (), Anticorps antiviraux (isolement et purification), Equus caballus, Fragments Fab d'immunoglobuline (), Fragments Fab d'immunoglobuline (isolement et purification), Humains, Immunisation, Immunoglobuline G (), Immunoglobuline G (isolement et purification), Syndrome respiratoire aigu sévère (virologie), Sérums immuns (immunologie), Test ELISA, Tests de neutralisation, Virus du SRAS (immunologie), Virus du SRAS (isolement et purification).
- MESH :
- immunologie : Sérums immuns, Virus du SRAS.
- isolement et purification : Anticorps antiviraux, Fragments Fab d'immunoglobuline, Immunoglobuline G, Virus du SRAS.
- virologie : Syndrome respiratoire aigu sévère.
- Animaux, Anticorps antiviraux, Equus caballus, Fragments Fab d'immunoglobuline, Humains, Immunisation, Immunoglobuline G, Test ELISA, Tests de neutralisation.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (chemistry), Antibodies, Viral (isolation & purification), Enzyme-Linked Immunosorbent Assay, Horses, Humans, Immune Sera (immunology), Immunization, Immunoglobulin Fab Fragments (chemistry), Immunoglobulin Fab Fragments (isolation & purification), Immunoglobulin G (chemistry), Immunoglobulin G (isolation & purification), Neutralization Tests, SARS Virus (immunology), SARS Virus (isolation & purification), Severe Acute Respiratory Syndrome (virology).
- MESH :
- chemical , chemistry : Antibodies, Viral, Immunoglobulin Fab Fragments, Immunoglobulin G.
- chemical , immunology : Immune Sera.
- chemical , isolation & purification : Antibodies, Viral, Immunoglobulin Fab Fragments, Immunoglobulin G.
- immunology : SARS Virus.
- isolation & purification : SARS Virus.
- virology : Severe Acute Respiratory Syndrome.
- Animals, Enzyme-Linked Immunosorbent Assay, Horses, Humans, Immunization, Neutralization Tests.
Abstract
The resurgence of severe acute respiratory syndrome (SARS) is still a threat because the causative agent remaining in animal reservoirs is not fully understood, and sporadic cases continue to be reported. Developing high titers of anti-SARS hyperimmune globulin to provide an alternative pathway for emergent future prevention and treatment of SARS.
DOI: 10.1111/j.1745-7254.2005.00210.x
PubMed: 16297347
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002444
- to stream PubMed, to step Curation: 002444
- to stream PubMed, to step Checkpoint: 002575
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pubmed:16297347Le document en format XML
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Wong</name></author><author><name sortKey="Zhong, Nan Shan" sort="Zhong, Nan Shan" uniqKey="Zhong N" first="Nan-Shan" last="Zhong">Nan-Shan Zhong</name></author></analytic><series><title level="j">Acta pharmacologica Sinica</title><idno type="ISSN">1671-4083</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral (chemistry)</term><term>Antibodies, Viral (isolation & purification)</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Horses</term><term>Humans</term><term>Immune Sera (immunology)</term><term>Immunization</term><term>Immunoglobulin Fab Fragments (chemistry)</term><term>Immunoglobulin Fab Fragments (isolation & purification)</term><term>Immunoglobulin G (chemistry)</term><term>Immunoglobulin G (isolation & purification)</term><term>Neutralization Tests</term><term>SARS Virus (immunology)</term><term>SARS Virus (isolation & purification)</term><term>Severe Acute Respiratory Syndrome (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux ()</term><term>Anticorps antiviraux (isolement et purification)</term><term>Equus caballus</term><term>Fragments Fab d'immunoglobuline ()</term><term>Fragments Fab d'immunoglobuline (isolement et purification)</term><term>Humains</term><term>Immunisation</term><term>Immunoglobuline G ()</term><term>Immunoglobuline G (isolement et purification)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Sérums immuns (immunologie)</term><term>Test ELISA</term><term>Tests de neutralisation</term><term>Virus du SRAS (immunologie)</term><term>Virus du SRAS (isolement et purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin Fab Fragments</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Immune Sera</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin Fab Fragments</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Sérums immuns</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Anticorps antiviraux</term><term>Fragments Fab d'immunoglobuline</term><term>Immunoglobuline G</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Horses</term><term>Humans</term><term>Immunization</term><term>Neutralization Tests</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux</term><term>Equus caballus</term><term>Fragments Fab d'immunoglobuline</term><term>Humains</term><term>Immunisation</term><term>Immunoglobuline G</term><term>Test ELISA</term><term>Tests de neutralisation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The resurgence of severe acute respiratory syndrome (SARS) is still a threat because the causative agent remaining in animal reservoirs is not fully understood, and sporadic cases continue to be reported. Developing high titers of anti-SARS hyperimmune globulin to provide an alternative pathway for emergent future prevention and treatment of SARS.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16297347</PMID><DateCompleted><Year>2007</Year><Month>09</Month><Day>04</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>25</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1671-4083</ISSN><JournalIssue CitedMedium="Print"><Volume>26</Volume><Issue>12</Issue><PubDate><Year>2005</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Acta pharmacologica Sinica</Title><ISOAbbreviation>Acta Pharmacol. Sin.</ISOAbbreviation></Journal><ArticleTitle>Preparation and development of equine hyperimmune globulin F(ab')2 against severe acute respiratory syndrome coronavirus.</ArticleTitle><Pagination><MedlinePgn>1479-84</MedlinePgn></Pagination><Abstract><AbstractText Label="AIM" NlmCategory="OBJECTIVE">The resurgence of severe acute respiratory syndrome (SARS) is still a threat because the causative agent remaining in animal reservoirs is not fully understood, and sporadic cases continue to be reported. Developing high titers of anti-SARS hyperimmune globulin to provide an alternative pathway for emergent future prevention and treatment of SARS.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">SARS coronavirus (CoV)F69 (AY313906) and Z2-Y3 (AY394989) were isolated and identified from 2 different Cantonese onset SARS patients. Immunogen was prepared from SARS-CoV F69 strain. Six health horses were immunized 4 times and serum was collected periodically to measure the profile of specific IgG and neutralizing antibodies using indirect enzyme-linked immunosorbent assay and a microneutralization test. Sera were collected in large amounts at the peak, where IgG was precipitated using ammonium sulphate and subsequently digested with pepsin. The product was then purified using anion-exchange chromatography to obtain F(ab')2 fragments.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The specific IgG and neutralizing antibody titers peaked at approximately week 7 after the first immunization, with a maximum value of 1:14210. The sera collected at the peak were then purified. Fragment of approximately 15 g F(ab')2 was obtained from 1litre antiserum and the purity was above 90% with the titer of 1:5120, which could neutralize the other strain (SARS-CoV Z2-Y3) as well.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">This research provides a viable strategy for the prevention and treatment of SARS coronavirus infection with equine hyperimmune globulin, with the purpose of combating any resurgence of SARS.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Jia-Hai</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Sun Yat-sen University, Guangzhou 510080, China. jiahailu@yahoo.com.cn</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Zhong-Min</ForeName><Initials>ZM</Initials></Author><Author ValidYN="Y"><LastName>Han</LastName><ForeName>Wen-Yu</ForeName><Initials>WY</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Guo-Ling</ForeName><Initials>GL</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Ding-Mei</ForeName><Initials>DM</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yi-Fei</ForeName><Initials>YF</Initials></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Sheng-Yun</ForeName><Initials>SY</Initials></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Qin-He</ForeName><Initials>QH</Initials></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Huan-Ying</ForeName><Initials>HY</Initials></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>Bing L</ForeName><Initials>BL</Initials></Author><Author ValidYN="Y"><LastName>Zhong</LastName><ForeName>Nan-Shan</ForeName><Initials>NS</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Acta Pharmacol Sin</MedlineTA><NlmUniqueID>100956087</NlmUniqueID><ISSNLinking>1671-4083</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007106">Immune Sera</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007140">Immunoglobulin Fab Fragments</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004797" MajorTopicYN="N">Enzyme-Linked Immunosorbent Assay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006736" MajorTopicYN="N">Horses</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007106" MajorTopicYN="N">Immune Sera</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007114" MajorTopicYN="N">Immunization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007140" MajorTopicYN="N">Immunoglobulin Fab Fragments</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009500" MajorTopicYN="N">Neutralization Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate 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sort="Han, Wen Yu" uniqKey="Han W" first="Wen-Yu" last="Han">Wen-Yu Han</name><name sortKey="Sun, Sheng Yun" sort="Sun, Sheng Yun" uniqKey="Sun S" first="Sheng-Yun" last="Sun">Sheng-Yun Sun</name><name sortKey="Wang, Guo Ling" sort="Wang, Guo Ling" uniqKey="Wang G" first="Guo-Ling" last="Wang">Guo-Ling Wang</name><name sortKey="Wang, Yi Fei" sort="Wang, Yi Fei" uniqKey="Wang Y" first="Yi-Fei" last="Wang">Yi-Fei Wang</name><name sortKey="Wong, Bing L" sort="Wong, Bing L" uniqKey="Wong B" first="Bing L" last="Wong">Bing L. Wong</name><name sortKey="Yang, Qin He" sort="Yang, Qin He" uniqKey="Yang Q" first="Qin-He" last="Yang">Qin-He Yang</name><name sortKey="Zhang, Ding Mei" sort="Zhang, Ding Mei" uniqKey="Zhang D" first="Ding-Mei" last="Zhang">Ding-Mei Zhang</name><name sortKey="Zheng, Huan Ying" sort="Zheng, Huan Ying" uniqKey="Zheng H" first="Huan-Ying" last="Zheng">Huan-Ying Zheng</name><name sortKey="Zhong, Nan Shan" sort="Zhong, Nan Shan" uniqKey="Zhong N" first="Nan-Shan" last="Zhong">Nan-Shan Zhong</name></noCountry><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Lu, Jia Hai" sort="Lu, Jia Hai" uniqKey="Lu J" first="Jia-Hai" last="Lu">Jia-Hai Lu</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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