Serveur d'exploration SRAS

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[Preventive and therapeutic effects of recombinant IFN-alpha2b nasal spray on SARS-CoV infection in Macaca mulata].

Identifieur interne : 001238 ( Ncbi/Merge ); précédent : 001237; suivant : 001239

[Preventive and therapeutic effects of recombinant IFN-alpha2b nasal spray on SARS-CoV infection in Macaca mulata].

Auteurs : Hong Gao [République populaire de Chine] ; Li-Lan Zhang ; Qiang Wei ; Zhao-Jun Duan ; Xin-Ming Tu ; Zhi-Ai Yu ; Wei Deng ; Li-Ping Zhang ; Lin-Lin Bao ; Bin Zhang ; Wei Tong ; Yun-De Hou ; Bing-Lin Zhang ; Lan Huang ; Chuan Qin

Source :

RBID : pubmed:16261198

Descripteurs français

English descriptors

Abstract

To study the preventive and therapeutic effects of recombinant IFN-alpha2b for nasal spray on SARS-CoV infection in Macaca mulata (rhesus monkey).

PubMed: 16261198

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pubmed:16261198

Le document en format XML

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<div type="abstract" xml:lang="en">To study the preventive and therapeutic effects of recombinant IFN-alpha2b for nasal spray on SARS-CoV infection in Macaca mulata (rhesus monkey).</div>
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<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To study the preventive and therapeutic effects of recombinant IFN-alpha2b for nasal spray on SARS-CoV infection in Macaca mulata (rhesus monkey).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Ten rhesus monkeys were divided into two groups, 5 in interferon group, and 5 in control group. Before and after SARS-CoV attack, the virus was detected in samples such as pharyngeal swab in all the two groups by Real-time PCR (RT-PCR) and virus isolation was performed.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">After virus attack, the level of SARS-CoV-specific IgG and neutralizing antibody were induced by SARS-CoV in the interferon group was weaker than in control group. Hematology items showed no apparent changes after virus attack in treated group. Through pathological examination, the morphology of the lung tissues of two Macaques in the treated group was normal, while the other three displayed the interstitial pneumonia with the thickened septum and infiltration with mononuclear cells. Among which, one monkey showed part of thickened septum fused with each other. These lesions in the interferon treated animals were similar to those seen in the animals in control group, but with smaller scope of pathological changes. No significant abnormity was detected in other organs.</AbstractText>
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<name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name>
<name sortKey="Tong, Wei" sort="Tong, Wei" uniqKey="Tong W" first="Wei" last="Tong">Wei Tong</name>
<name sortKey="Tu, Xin Ming" sort="Tu, Xin Ming" uniqKey="Tu X" first="Xin-Ming" last="Tu">Xin-Ming Tu</name>
<name sortKey="Wei, Qiang" sort="Wei, Qiang" uniqKey="Wei Q" first="Qiang" last="Wei">Qiang Wei</name>
<name sortKey="Yu, Zhi Ai" sort="Yu, Zhi Ai" uniqKey="Yu Z" first="Zhi-Ai" last="Yu">Zhi-Ai Yu</name>
<name sortKey="Zhang, Bin" sort="Zhang, Bin" uniqKey="Zhang B" first="Bin" last="Zhang">Bin Zhang</name>
<name sortKey="Zhang, Bing Lin" sort="Zhang, Bing Lin" uniqKey="Zhang B" first="Bing-Lin" last="Zhang">Bing-Lin Zhang</name>
<name sortKey="Zhang, Li Lan" sort="Zhang, Li Lan" uniqKey="Zhang L" first="Li-Lan" last="Zhang">Li-Lan Zhang</name>
<name sortKey="Zhang, Li Ping" sort="Zhang, Li Ping" uniqKey="Zhang L" first="Li-Ping" last="Zhang">Li-Ping Zhang</name>
</noCountry>
<country name="République populaire de Chine">
<noRegion>
<name sortKey="Gao, Hong" sort="Gao, Hong" uniqKey="Gao H" first="Hong" last="Gao">Hong Gao</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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