[Preventive and therapeutic effects of recombinant IFN-alpha2b nasal spray on SARS-CoV infection in Macaca mulata].
Identifieur interne : 001238 ( Ncbi/Merge ); précédent : 001237; suivant : 001239[Preventive and therapeutic effects of recombinant IFN-alpha2b nasal spray on SARS-CoV infection in Macaca mulata].
Auteurs : Hong Gao [République populaire de Chine] ; Li-Lan Zhang ; Qiang Wei ; Zhao-Jun Duan ; Xin-Ming Tu ; Zhi-Ai Yu ; Wei Deng ; Li-Ping Zhang ; Lin-Lin Bao ; Bin Zhang ; Wei Tong ; Yun-De Hou ; Bing-Lin Zhang ; Lan Huang ; Chuan QinSource :
- Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology [ 1003-9279 ] ; 2005.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (usage thérapeutique), Attribution aléatoire, Cellules Vero, Femelle, Interféron alpha (usage thérapeutique), Macaca mulatta, Maladies des singes (), Maladies des singes (traitement médicamenteux), Maladies des singes (virologie), Modèles animaux de maladie humaine, Mâle, Poumon (), Poumon (anatomopathologie), Poumon (virologie), Protéines recombinantes, Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (traitement médicamenteux), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (), Virus du SRAS (isolement et purification).
- MESH :
- anatomopathologie : Poumon.
- isolement et purification : Virus du SRAS.
- traitement médicamenteux : Maladies des singes, Syndrome respiratoire aigu sévère.
- usage thérapeutique : Antiviraux, Interféron alpha.
- virologie : Maladies des singes, Poumon, Syndrome respiratoire aigu sévère.
- Animaux, Attribution aléatoire, Cellules Vero, Femelle, Macaca mulatta, Maladies des singes, Modèles animaux de maladie humaine, Mâle, Poumon, Protéines recombinantes, Syndrome respiratoire aigu sévère, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (therapeutic use), Chlorocebus aethiops, Disease Models, Animal, Female, Interferon alpha-2, Interferon-alpha (therapeutic use), Lung (drug effects), Lung (pathology), Lung (virology), Macaca mulatta, Male, Monkey Diseases (drug therapy), Monkey Diseases (prevention & control), Monkey Diseases (virology), Random Allocation, Recombinant Proteins, SARS Virus (drug effects), SARS Virus (isolation & purification), Severe Acute Respiratory Syndrome (drug therapy), Severe Acute Respiratory Syndrome (prevention & control), Severe Acute Respiratory Syndrome (virology), Vero Cells.
- MESH :
- chemical , therapeutic use : Antiviral Agents, Interferon-alpha.
- drug effects : Lung, SARS Virus.
- drug therapy : Monkey Diseases, Severe Acute Respiratory Syndrome.
- isolation & purification : SARS Virus.
- pathology : Lung.
- prevention & control : Monkey Diseases, Severe Acute Respiratory Syndrome.
- virology : Lung, Monkey Diseases, Severe Acute Respiratory Syndrome.
- Animals, Chlorocebus aethiops, Disease Models, Animal, Female, Interferon alpha-2, Macaca mulatta, Male, Random Allocation, Recombinant Proteins, Vero Cells.
Abstract
To study the preventive and therapeutic effects of recombinant IFN-alpha2b for nasal spray on SARS-CoV infection in Macaca mulata (rhesus monkey).
PubMed: 16261198
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002470
- to stream PubMed, to step Curation: 002470
- to stream PubMed, to step Checkpoint: 002355
Links to Exploration step
pubmed:16261198Le document en format XML
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type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Li Lan" sort="Zhang, Li Lan" uniqKey="Zhang L" first="Li-Lan" last="Zhang">Li-Lan Zhang</name></author><author><name sortKey="Wei, Qiang" sort="Wei, Qiang" uniqKey="Wei Q" first="Qiang" last="Wei">Qiang Wei</name></author><author><name sortKey="Duan, Zhao Jun" sort="Duan, Zhao Jun" uniqKey="Duan Z" first="Zhao-Jun" last="Duan">Zhao-Jun Duan</name></author><author><name sortKey="Tu, Xin Ming" sort="Tu, Xin Ming" uniqKey="Tu X" first="Xin-Ming" last="Tu">Xin-Ming Tu</name></author><author><name sortKey="Yu, Zhi Ai" sort="Yu, Zhi Ai" uniqKey="Yu Z" first="Zhi-Ai" last="Yu">Zhi-Ai Yu</name></author><author><name sortKey="Deng, Wei" sort="Deng, Wei" uniqKey="Deng W" first="Wei" last="Deng">Wei Deng</name></author><author><name sortKey="Zhang, Li Ping" sort="Zhang, Li Ping" uniqKey="Zhang L" first="Li-Ping" last="Zhang">Li-Ping Zhang</name></author><author><name sortKey="Bao, Lin Lin" sort="Bao, 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aléatoire</term><term>Cellules Vero</term><term>Femelle</term><term>Macaca mulatta</term><term>Maladies des singes</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Poumon</term><term>Protéines recombinantes</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To study the preventive and therapeutic effects of recombinant IFN-alpha2b for nasal spray on SARS-CoV infection in Macaca mulata (rhesus monkey).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16261198</PMID><DateCompleted><Year>2008</Year><Month>12</Month><Day>22</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1003-9279</ISSN><JournalIssue CitedMedium="Print"><Volume>19</Volume><Issue>3</Issue><PubDate><Year>2005</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology</Title><ISOAbbreviation>Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi</ISOAbbreviation></Journal><ArticleTitle>[Preventive and therapeutic effects of recombinant IFN-alpha2b nasal spray on SARS-CoV infection in Macaca mulata].</ArticleTitle><Pagination><MedlinePgn>207-10</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To study the preventive and therapeutic effects of recombinant IFN-alpha2b for nasal spray on SARS-CoV infection in Macaca mulata (rhesus monkey).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Ten rhesus monkeys were divided into two groups, 5 in interferon group, and 5 in control group. Before and after SARS-CoV attack, the virus was detected in samples such as pharyngeal swab in all the two groups by Real-time PCR (RT-PCR) and virus isolation was performed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">After virus attack, the level of SARS-CoV-specific IgG and neutralizing antibody were induced by SARS-CoV in the interferon group was weaker than in control group. Hematology items showed no apparent changes after virus attack in treated group. Through pathological examination, the morphology of the lung tissues of two Macaques in the treated group was normal, while the other three displayed the interstitial pneumonia with the thickened septum and infiltration with mononuclear cells. Among which, one monkey showed part of thickened septum fused with each other. These lesions in the interferon treated animals were similar to those seen in the animals in control group, but with smaller scope of pathological changes. No significant abnormity was detected in other organs.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Recombinant IFN-alpha2b could effectively interdict or weaken SARS-CoV injury in monkeys.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Hong</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Institute of Laboratory Animals Science, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Li-lan</ForeName><Initials>LL</Initials></Author><Author ValidYN="Y"><LastName>Wei</LastName><ForeName>Qiang</ForeName><Initials>Q</Initials></Author><Author ValidYN="Y"><LastName>Duan</LastName><ForeName>Zhao-jun</ForeName><Initials>ZJ</Initials></Author><Author ValidYN="Y"><LastName>Tu</LastName><ForeName>Xin-ming</ForeName><Initials>XM</Initials></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Zhi-ai</ForeName><Initials>ZA</Initials></Author><Author ValidYN="Y"><LastName>Deng</LastName><ForeName>Wei</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Li-ping</ForeName><Initials>LP</Initials></Author><Author ValidYN="Y"><LastName>Bao</LastName><ForeName>Lin-lin</ForeName><Initials>LL</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Bin</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Tong</LastName><ForeName>Wei</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Hou</LastName><ForeName>Yun-de</ForeName><Initials>YD</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Bing-lin</ForeName><Initials>BL</Initials></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Lan</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Qin</LastName><ForeName>Chuan</ForeName><Initials>C</Initials></Author></AuthorList><Language>chi</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>China</Country><MedlineTA>Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi</MedlineTA><NlmUniqueID>9602873</NlmUniqueID><ISSNLinking>1003-9279</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000077190">Interferon alpha-2</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016898">Interferon-alpha</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011994">Recombinant Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002522" MajorTopicYN="N">Chlorocebus aethiops</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000077190" MajorTopicYN="N">Interferon alpha-2</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016898" MajorTopicYN="N">Interferon-alpha</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008253" MajorTopicYN="N">Macaca mulatta</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008992" MajorTopicYN="N">Monkey Diseases</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011897" MajorTopicYN="N">Random Allocation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011994" MajorTopicYN="N">Recombinant Proteins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014709" MajorTopicYN="N">Vero Cells</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>11</Month><Day>2</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>12</Month><Day>23</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>11</Month><Day>2</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16261198</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><noCountry><name sortKey="Bao, Lin Lin" sort="Bao, Lin Lin" uniqKey="Bao L" first="Lin-Lin" last="Bao">Lin-Lin Bao</name><name sortKey="Deng, Wei" sort="Deng, Wei" uniqKey="Deng W" first="Wei" last="Deng">Wei Deng</name><name sortKey="Duan, Zhao Jun" sort="Duan, Zhao Jun" uniqKey="Duan Z" first="Zhao-Jun" last="Duan">Zhao-Jun Duan</name><name sortKey="Hou, Yun De" sort="Hou, Yun De" uniqKey="Hou Y" first="Yun-De" last="Hou">Yun-De Hou</name><name sortKey="Huang, Lan" sort="Huang, Lan" uniqKey="Huang L" first="Lan" last="Huang">Lan Huang</name><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><name sortKey="Tong, Wei" sort="Tong, Wei" uniqKey="Tong W" first="Wei" last="Tong">Wei Tong</name><name sortKey="Tu, Xin Ming" sort="Tu, Xin Ming" uniqKey="Tu X" first="Xin-Ming" last="Tu">Xin-Ming Tu</name><name sortKey="Wei, Qiang" sort="Wei, Qiang" uniqKey="Wei Q" first="Qiang" last="Wei">Qiang Wei</name><name sortKey="Yu, Zhi Ai" sort="Yu, Zhi Ai" uniqKey="Yu Z" first="Zhi-Ai" last="Yu">Zhi-Ai Yu</name><name sortKey="Zhang, Bin" sort="Zhang, Bin" uniqKey="Zhang B" first="Bin" last="Zhang">Bin Zhang</name><name sortKey="Zhang, Bing Lin" sort="Zhang, Bing Lin" uniqKey="Zhang B" first="Bing-Lin" last="Zhang">Bing-Lin Zhang</name><name sortKey="Zhang, Li Lan" sort="Zhang, Li Lan" uniqKey="Zhang L" first="Li-Lan" last="Zhang">Li-Lan Zhang</name><name sortKey="Zhang, Li Ping" sort="Zhang, Li Ping" uniqKey="Zhang L" first="Li-Ping" last="Zhang">Li-Ping Zhang</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Gao, Hong" sort="Gao, Hong" uniqKey="Gao H" first="Hong" last="Gao">Hong Gao</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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