Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital
Identifieur interne : 001178 ( Ncbi/Merge ); précédent : 001177; suivant : 001179Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital
Auteurs : Kuo-Ming Yeh ; Tzong-Shi Chiueh ; L. K. Siu ; Jung-Chung Lin ; Paul K. S. Chan ; Ming-Yieh Peng ; Hsiang-Lin Wan ; Jenn-Han Chen ; Bor-Shen Hu ; Cherng-Lih Perng ; Jang-Jih Lu ; Feng-Yee ChangSource :
- Journal of Antimicrobial Chemotherapy [ 0305-7453 ] ; 2005.
Descripteurs français
- KwdFr :
- ARN viral (analyse), Adulte, Anticorps antiviraux (sang), Charge virale, Femelle, Humains, Hôpitaux, Immunisation passive, Immunoglobuline G (sang), Immunoglobuline M (sang), Maladies professionnelles (), Mâle, Personnel de santé, RT-PCR, Résultat thérapeutique, Syndrome respiratoire aigu sévère (), Sérums immuns (administration et posologie), Taïwan, Virus du SRAS (génétique), Virus du SRAS (immunologie).
- MESH :
- administration et posologie : Sérums immuns.
- analyse : ARN viral.
- génétique : Virus du SRAS.
- immunologie : Virus du SRAS.
- sang : Anticorps antiviraux, Immunoglobuline G, Immunoglobuline M.
- Adulte, Charge virale, Femelle, Humains, Hôpitaux, Immunisation passive, Maladies professionnelles, Mâle, Personnel de santé, RT-PCR, Résultat thérapeutique, Syndrome respiratoire aigu sévère, Taïwan.
- Wicri :
- geographic : Taïwan.
English descriptors
- KwdEn :
- Adult, Antibodies, Viral (blood), Female, Health Personnel, Hospitals, Humans, Immune Sera (administration & dosage), Immunization, Passive, Immunoglobulin G (blood), Immunoglobulin M (blood), Male, Occupational Diseases (therapy), RNA, Viral (analysis), Reverse Transcriptase Polymerase Chain Reaction, SARS Virus (genetics), SARS Virus (immunology), Severe Acute Respiratory Syndrome (therapy), Taiwan, Treatment Outcome, Viral Load.
- MESH :
- chemical , administration & dosage : Immune Sera.
- chemical , analysis : RNA, Viral.
- chemical , blood : Antibodies, Viral, Immunoglobulin G, Immunoglobulin M.
- geographic : Taiwan.
- genetics : SARS Virus.
- immunology : SARS Virus.
- therapy : Occupational Diseases, Severe Acute Respiratory Syndrome.
- Adult, Female, Health Personnel, Hospitals, Humans, Immunization, Passive, Male, Reverse Transcriptase Polymerase Chain Reaction, Treatment Outcome, Viral Load.
Abstract
Url:
DOI: 10.1093/jac/dki346
PubMed: 16183666
PubMed Central: 7110092
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PMC:7110092Le document en format XML
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K." last="Siu">L. K. Siu</name></author><author><name sortKey="Lin, Jung Chung" sort="Lin, Jung Chung" uniqKey="Lin J" first="Jung-Chung" last="Lin">Jung-Chung Lin</name></author><author><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K. S." last="Chan">Paul K. S. Chan</name></author><author><name sortKey="Peng, Ming Yieh" sort="Peng, Ming Yieh" uniqKey="Peng M" first="Ming-Yieh" last="Peng">Ming-Yieh Peng</name></author><author><name sortKey="Wan, Hsiang Lin" sort="Wan, Hsiang Lin" uniqKey="Wan H" first="Hsiang-Lin" last="Wan">Hsiang-Lin Wan</name></author><author><name sortKey="Chen, Jenn Han" sort="Chen, Jenn Han" uniqKey="Chen J" first="Jenn-Han" last="Chen">Jenn-Han Chen</name></author><author><name sortKey="Hu, Bor Shen" sort="Hu, Bor Shen" uniqKey="Hu B" first="Bor-Shen" last="Hu">Bor-Shen Hu</name></author><author><name sortKey="Perng, Cherng Lih" sort="Perng, Cherng Lih" uniqKey="Perng C" first="Cherng-Lih" last="Perng">Cherng-Lih Perng</name></author><author><name sortKey="Lu, Jang Jih" sort="Lu, Jang Jih" uniqKey="Lu J" first="Jang-Jih" last="Lu">Jang-Jih Lu</name></author><author><name sortKey="Chang, Feng Yee" sort="Chang, Feng Yee" uniqKey="Chang F" first="Feng-Yee" last="Chang">Feng-Yee Chang</name></author></analytic><series><title level="j">Journal of Antimicrobial Chemotherapy</title><idno type="ISSN">0305-7453</idno><idno type="eISSN">1460-2091</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antibodies, Viral (blood)</term><term>Female</term><term>Health Personnel</term><term>Hospitals</term><term>Humans</term><term>Immune Sera (administration & dosage)</term><term>Immunization, Passive</term><term>Immunoglobulin G (blood)</term><term>Immunoglobulin M (blood)</term><term>Male</term><term>Occupational Diseases (therapy)</term><term>RNA, Viral (analysis)</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>SARS Virus (genetics)</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (therapy)</term><term>Taiwan</term><term>Treatment Outcome</term><term>Viral Load</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (analyse)</term><term>Adulte</term><term>Anticorps antiviraux (sang)</term><term>Charge virale</term><term>Femelle</term><term>Humains</term><term>Hôpitaux</term><term>Immunisation passive</term><term>Immunoglobuline G (sang)</term><term>Immunoglobuline M (sang)</term><term>Maladies professionnelles ()</term><term>Mâle</term><term>Personnel de santé</term><term>RT-PCR</term><term>Résultat thérapeutique</term><term>Syndrome respiratoire aigu sévère ()</term><term>Sérums immuns (administration et posologie)</term><term>Taïwan</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Immune Sera</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin G</term><term>Immunoglobulin M</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Taiwan</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Sérums immuns</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Immunoglobuline G</term><term>Immunoglobuline M</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Occupational Diseases</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Health Personnel</term><term>Hospitals</term><term>Humans</term><term>Immunization, Passive</term><term>Male</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Treatment Outcome</term><term>Viral Load</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Charge virale</term><term>Femelle</term><term>Humains</term><term>Hôpitaux</term><term>Immunisation passive</term><term>Maladies professionnelles</term><term>Mâle</term><term>Personnel de santé</term><term>RT-PCR</term><term>Résultat thérapeutique</term><term>Syndrome respiratoire aigu sévère</term><term>Taïwan</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Taïwan</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p><italic>Objectives</italic>: To describe the immunological responses and clinical outcome of coronavirus (SARS) infected healthcare workers (HCW) who had been administered with convalescent plasma as a treatment.</p><p><italic>Methods</italic>: Convalescent plasma (500 mL) was obtained from each of three SARS patients and transfused into the three infected HCW. Donors were blood type O and seronegative for hepatitis B and C, HIV, syphilis and human T-cell lymphotropic virus types I and II (HTLV-I and -II). Serum antibody (IgG) titre was >640. Apharesis was performed with a CS 3000 plus cell separator followed by the forming of the convalescent phase plasma. As part of the routine check with donated plasma, the convalescent plasma was confirmed free of residual SARS-CoV by RT–PCR. Serial serum samples obtained from the recipients of the convalescent plasma were collected to undertake real-time quantitative RT–PCR for SARS-CoV for direct measurement of viral concentration. Specific immunoglobulin IgM and IgG concentrations were titrated using an antigen microarray developed in-house.</p><p><italic>Results</italic>: Viral load dropped from 495 × 10<sup>3</sup>, 76 × 10<sup>3</sup> or 650 × 10<sup>3</sup> copies/mL to zero or 1 copy/mL one day after transfusion. Anti-SARS-CoV IgM and IgG also increased in a time-dependent manner following transfusion. All three patients survived. One HCW became pregnant subsequently, delivering 13 months after discharge. Positive anti-SARS-CoV IgG was detected in the newborn. Passive transfer of anti-SARS-CoV antibody from the mother was considered as a possibility.</p><p><italic>Conclusions</italic>: All infected HCW whose condition had progressed severely and who had failed to respond to the available treatment, survived after transfusion with convalescent plasma.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><double pmid="16183666"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital</title><author><name sortKey="Yeh, Kuo Ming" sort="Yeh, Kuo Ming" uniqKey="Yeh K" first="Kuo-Ming" last="Yeh">Kuo-Ming Yeh</name></author><author><name sortKey="Chiueh, Tzong Shi" sort="Chiueh, Tzong Shi" uniqKey="Chiueh T" first="Tzong-Shi" last="Chiueh">Tzong-Shi Chiueh</name></author><author><name sortKey="Siu, L K" sort="Siu, L K" uniqKey="Siu L" first="L. K." last="Siu">L. K. Siu</name></author><author><name sortKey="Lin, Jung Chung" sort="Lin, Jung Chung" uniqKey="Lin J" first="Jung-Chung" last="Lin">Jung-Chung Lin</name></author><author><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K. S." last="Chan">Paul K. S. Chan</name></author><author><name sortKey="Peng, Ming Yieh" sort="Peng, Ming Yieh" uniqKey="Peng M" first="Ming-Yieh" last="Peng">Ming-Yieh Peng</name></author><author><name sortKey="Wan, Hsiang Lin" sort="Wan, Hsiang Lin" uniqKey="Wan H" first="Hsiang-Lin" last="Wan">Hsiang-Lin Wan</name></author><author><name sortKey="Chen, Jenn Han" sort="Chen, Jenn Han" uniqKey="Chen J" first="Jenn-Han" last="Chen">Jenn-Han Chen</name></author><author><name sortKey="Hu, Bor Shen" sort="Hu, Bor Shen" uniqKey="Hu B" first="Bor-Shen" last="Hu">Bor-Shen Hu</name></author><author><name sortKey="Perng, Cherng Lih" sort="Perng, Cherng Lih" uniqKey="Perng C" first="Cherng-Lih" last="Perng">Cherng-Lih Perng</name></author><author><name sortKey="Lu, Jang Jih" sort="Lu, Jang Jih" uniqKey="Lu J" first="Jang-Jih" last="Lu">Jang-Jih Lu</name></author><author><name sortKey="Chang, Feng Yee" sort="Chang, Feng Yee" uniqKey="Chang F" first="Feng-Yee" last="Chang">Feng-Yee Chang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16183666</idno><idno type="pmc">7110092</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110092</idno><idno type="RBID">PMC:7110092</idno><idno type="doi">10.1093/jac/dki346</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">001105</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001105</idno><idno type="wicri:Area/Pmc/Curation">001105</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001105</idno><idno type="wicri:Area/Pmc/Checkpoint">001340</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001340</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital</title><author><name sortKey="Yeh, Kuo Ming" sort="Yeh, Kuo Ming" uniqKey="Yeh K" first="Kuo-Ming" last="Yeh">Kuo-Ming Yeh</name></author><author><name sortKey="Chiueh, Tzong Shi" sort="Chiueh, Tzong Shi" uniqKey="Chiueh T" first="Tzong-Shi" last="Chiueh">Tzong-Shi Chiueh</name></author><author><name sortKey="Siu, L K" sort="Siu, L K" uniqKey="Siu L" first="L. K." last="Siu">L. K. Siu</name></author><author><name sortKey="Lin, Jung Chung" sort="Lin, Jung Chung" uniqKey="Lin J" first="Jung-Chung" last="Lin">Jung-Chung Lin</name></author><author><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K. S." last="Chan">Paul K. S. Chan</name></author><author><name sortKey="Peng, Ming Yieh" sort="Peng, Ming Yieh" uniqKey="Peng M" first="Ming-Yieh" last="Peng">Ming-Yieh Peng</name></author><author><name sortKey="Wan, Hsiang Lin" sort="Wan, Hsiang Lin" uniqKey="Wan H" first="Hsiang-Lin" last="Wan">Hsiang-Lin Wan</name></author><author><name sortKey="Chen, Jenn Han" sort="Chen, Jenn Han" uniqKey="Chen J" first="Jenn-Han" last="Chen">Jenn-Han Chen</name></author><author><name sortKey="Hu, Bor Shen" sort="Hu, Bor Shen" uniqKey="Hu B" first="Bor-Shen" last="Hu">Bor-Shen Hu</name></author><author><name sortKey="Perng, Cherng Lih" sort="Perng, Cherng Lih" uniqKey="Perng C" first="Cherng-Lih" last="Perng">Cherng-Lih Perng</name></author><author><name sortKey="Lu, Jang Jih" sort="Lu, Jang Jih" uniqKey="Lu J" first="Jang-Jih" last="Lu">Jang-Jih Lu</name></author><author><name sortKey="Chang, Feng Yee" sort="Chang, Feng Yee" uniqKey="Chang F" first="Feng-Yee" last="Chang">Feng-Yee Chang</name></author></analytic><series><title level="j">Journal of Antimicrobial Chemotherapy</title><idno type="ISSN">0305-7453</idno><idno type="eISSN">1460-2091</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p><italic>Objectives</italic>: To describe the immunological responses and clinical outcome of coronavirus (SARS) infected healthcare workers (HCW) who had been administered with convalescent plasma as a treatment.</p><p><italic>Methods</italic>: Convalescent plasma (500 mL) was obtained from each of three SARS patients and transfused into the three infected HCW. Donors were blood type O and seronegative for hepatitis B and C, HIV, syphilis and human T-cell lymphotropic virus types I and II (HTLV-I and -II). Serum antibody (IgG) titre was >640. Apharesis was performed with a CS 3000 plus cell separator followed by the forming of the convalescent phase plasma. As part of the routine check with donated plasma, the convalescent plasma was confirmed free of residual SARS-CoV by RT–PCR. Serial serum samples obtained from the recipients of the convalescent plasma were collected to undertake real-time quantitative RT–PCR for SARS-CoV for direct measurement of viral concentration. Specific immunoglobulin IgM and IgG concentrations were titrated using an antigen microarray developed in-house.</p><p><italic>Results</italic>: Viral load dropped from 495 × 10<sup>3</sup>, 76 × 10<sup>3</sup> or 650 × 10<sup>3</sup> copies/mL to zero or 1 copy/mL one day after transfusion. Anti-SARS-CoV IgM and IgG also increased in a time-dependent manner following transfusion. All three patients survived. One HCW became pregnant subsequently, delivering 13 months after discharge. Positive anti-SARS-CoV IgG was detected in the newborn. Passive transfer of anti-SARS-CoV antibody from the mother was considered as a possibility.</p><p><italic>Conclusions</italic>: All infected HCW whose condition had progressed severely and who had failed to respond to the available treatment, survived after transfusion with convalescent plasma.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital.</title><author><name sortKey="Yeh, Kuo Ming" sort="Yeh, Kuo Ming" uniqKey="Yeh K" first="Kuo-Ming" last="Yeh">Kuo-Ming Yeh</name><affiliation wicri:level="1"><nlm:affiliation>Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Cheng-Kung Road, Sec. 2, Neihu, Taipei, 114, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Cheng-Kung Road, Sec. 2, Neihu, Taipei, 114</wicri:regionArea><wicri:noRegion>114</wicri:noRegion></affiliation></author><author><name sortKey="Chiueh, Tzong Shi" sort="Chiueh, Tzong Shi" uniqKey="Chiueh T" first="Tzong-Shi" last="Chiueh">Tzong-Shi Chiueh</name></author><author><name sortKey="Siu, L K" sort="Siu, L K" uniqKey="Siu L" first="L K" last="Siu">L K Siu</name></author><author><name sortKey="Lin, Jung Chung" sort="Lin, Jung Chung" uniqKey="Lin J" first="Jung-Chung" last="Lin">Jung-Chung Lin</name></author><author><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K S" last="Chan">Paul K S. Chan</name></author><author><name sortKey="Peng, Ming Yieh" sort="Peng, Ming Yieh" uniqKey="Peng M" first="Ming-Yieh" last="Peng">Ming-Yieh Peng</name></author><author><name sortKey="Wan, Hsiang Lin" sort="Wan, Hsiang Lin" uniqKey="Wan H" first="Hsiang-Lin" last="Wan">Hsiang-Lin Wan</name></author><author><name sortKey="Chen, Jenn Han" sort="Chen, Jenn Han" uniqKey="Chen J" first="Jenn-Han" last="Chen">Jenn-Han Chen</name></author><author><name sortKey="Hu, Bor Shen" sort="Hu, Bor Shen" uniqKey="Hu B" first="Bor-Shen" last="Hu">Bor-Shen Hu</name></author><author><name sortKey="Perng, Cherng Lih" sort="Perng, Cherng Lih" uniqKey="Perng C" first="Cherng-Lih" last="Perng">Cherng-Lih Perng</name></author><author><name sortKey="Lu, Jang Jih" sort="Lu, Jang Jih" uniqKey="Lu J" first="Jang-Jih" last="Lu">Jang-Jih Lu</name></author><author><name sortKey="Chang, Feng Yee" sort="Chang, Feng Yee" uniqKey="Chang F" first="Feng-Yee" last="Chang">Feng-Yee Chang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="RBID">pubmed:16183666</idno><idno type="pmid">16183666</idno><idno type="doi">10.1093/jac/dki346</idno><idno type="wicri:Area/PubMed/Corpus">002526</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002526</idno><idno type="wicri:Area/PubMed/Curation">002526</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002526</idno><idno type="wicri:Area/PubMed/Checkpoint">002714</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002714</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital.</title><author><name sortKey="Yeh, Kuo Ming" sort="Yeh, Kuo Ming" uniqKey="Yeh K" first="Kuo-Ming" last="Yeh">Kuo-Ming Yeh</name><affiliation wicri:level="1"><nlm:affiliation>Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Cheng-Kung Road, Sec. 2, Neihu, Taipei, 114, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Cheng-Kung Road, Sec. 2, Neihu, Taipei, 114</wicri:regionArea><wicri:noRegion>114</wicri:noRegion></affiliation></author><author><name sortKey="Chiueh, Tzong Shi" sort="Chiueh, Tzong Shi" uniqKey="Chiueh T" first="Tzong-Shi" last="Chiueh">Tzong-Shi Chiueh</name></author><author><name sortKey="Siu, L K" sort="Siu, L K" uniqKey="Siu L" first="L K" last="Siu">L K Siu</name></author><author><name sortKey="Lin, Jung Chung" sort="Lin, Jung Chung" uniqKey="Lin J" first="Jung-Chung" last="Lin">Jung-Chung Lin</name></author><author><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K S" last="Chan">Paul K S. Chan</name></author><author><name sortKey="Peng, Ming Yieh" sort="Peng, Ming Yieh" uniqKey="Peng M" first="Ming-Yieh" last="Peng">Ming-Yieh Peng</name></author><author><name sortKey="Wan, Hsiang Lin" sort="Wan, Hsiang Lin" uniqKey="Wan H" first="Hsiang-Lin" last="Wan">Hsiang-Lin Wan</name></author><author><name sortKey="Chen, Jenn Han" sort="Chen, Jenn Han" uniqKey="Chen J" first="Jenn-Han" last="Chen">Jenn-Han Chen</name></author><author><name sortKey="Hu, Bor Shen" sort="Hu, Bor Shen" uniqKey="Hu B" first="Bor-Shen" last="Hu">Bor-Shen Hu</name></author><author><name sortKey="Perng, Cherng Lih" sort="Perng, Cherng Lih" uniqKey="Perng C" first="Cherng-Lih" last="Perng">Cherng-Lih Perng</name></author><author><name sortKey="Lu, Jang Jih" sort="Lu, Jang Jih" uniqKey="Lu J" first="Jang-Jih" last="Lu">Jang-Jih Lu</name></author><author><name sortKey="Chang, Feng Yee" sort="Chang, Feng Yee" uniqKey="Chang F" first="Feng-Yee" last="Chang">Feng-Yee Chang</name></author></analytic><series><title level="j">The Journal of antimicrobial chemotherapy</title><idno type="ISSN">0305-7453</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antibodies, Viral (blood)</term><term>Female</term><term>Health Personnel</term><term>Hospitals</term><term>Humans</term><term>Immune Sera (administration & dosage)</term><term>Immunization, Passive</term><term>Immunoglobulin G (blood)</term><term>Immunoglobulin M (blood)</term><term>Male</term><term>Occupational Diseases (therapy)</term><term>RNA, Viral (analysis)</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>SARS Virus (genetics)</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (therapy)</term><term>Taiwan</term><term>Treatment Outcome</term><term>Viral Load</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (analyse)</term><term>Adulte</term><term>Anticorps antiviraux (sang)</term><term>Charge virale</term><term>Femelle</term><term>Humains</term><term>Hôpitaux</term><term>Immunisation passive</term><term>Immunoglobuline G (sang)</term><term>Immunoglobuline M (sang)</term><term>Maladies professionnelles ()</term><term>Mâle</term><term>Personnel de santé</term><term>RT-PCR</term><term>Résultat thérapeutique</term><term>Syndrome respiratoire aigu sévère ()</term><term>Sérums immuns (administration et posologie)</term><term>Taïwan</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Immune Sera</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin G</term><term>Immunoglobulin M</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Taiwan</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Sérums immuns</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Immunoglobuline G</term><term>Immunoglobuline M</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Occupational Diseases</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Health Personnel</term><term>Hospitals</term><term>Humans</term><term>Immunization, Passive</term><term>Male</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Treatment Outcome</term><term>Viral Load</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Charge virale</term><term>Femelle</term><term>Humains</term><term>Hôpitaux</term><term>Immunisation passive</term><term>Maladies professionnelles</term><term>Mâle</term><term>Personnel de santé</term><term>RT-PCR</term><term>Résultat thérapeutique</term><term>Syndrome respiratoire aigu sévère</term><term>Taïwan</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Taïwan</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To describe the immunological responses and clinical outcome of coronavirus (SARS) infected healthcare workers (HCW) who had been administered with convalescent plasma as a treatment.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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