Pneumonitis and Multi-Organ System Disease in Common Marmosets (Callithrix jacchus) Infected with the Severe Acute Respiratory Syndrome-Associated Coronavirus
Identifieur interne : 001085 ( Ncbi/Merge ); précédent : 001084; suivant : 001086Pneumonitis and Multi-Organ System Disease in Common Marmosets (Callithrix jacchus) Infected with the Severe Acute Respiratory Syndrome-Associated Coronavirus
Auteurs : Thomas C. Greenough ; Angela Carville [États-Unis] ; James Coderre ; Mohan Somasundaran ; John L. Sullivan ; Katherine Luzuriaga ; Keith Mansfield [États-Unis]Source :
- The American Journal of Pathology [ 0002-9440 ] ; 2005.
Descripteurs français
- KwdFr :
- ARN viral (analyse), Animaux, Callithrix, Coeur (virologie), Hépatocytes (anatomopathologie), Hépatocytes (virologie), Inflammation (étiologie), Maladies des singes (anatomopathologie), Maladies des singes (virologie), Myocarde (anatomopathologie), Noeuds lymphatiques (anatomopathologie), Noeuds lymphatiques (virologie), Pneumopathie infectieuse (anatomopathologie), Pneumopathie infectieuse (virologie), Poumon (anatomopathologie), Poumon (virologie), Répartition dans les tissus, Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (génétique), Virus du SRAS (isolement et purification).
- MESH :
- analyse : ARN viral.
- anatomopathologie : Hépatocytes, Maladies des singes, Myocarde, Noeuds lymphatiques, Pneumopathie infectieuse, Poumon, Syndrome respiratoire aigu sévère.
- génétique : Virus du SRAS.
- isolement et purification : Virus du SRAS.
- virologie : Coeur, Hépatocytes, Maladies des singes, Noeuds lymphatiques, Pneumopathie infectieuse, Poumon, Syndrome respiratoire aigu sévère.
- étiologie : Inflammation.
- Animaux, Callithrix, Répartition dans les tissus.
English descriptors
- KwdEn :
- Animals, Callithrix, Heart (virology), Hepatocytes (pathology), Hepatocytes (virology), Inflammation (etiology), Lung (pathology), Lung (virology), Lymph Nodes (pathology), Lymph Nodes (virology), Monkey Diseases (pathology), Monkey Diseases (virology), Myocardium (pathology), Pneumonia (pathology), Pneumonia (virology), RNA, Viral (analysis), SARS Virus (genetics), SARS Virus (isolation & purification), Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (virology), Tissue Distribution.
- MESH :
- chemical , analysis : RNA, Viral.
- etiology : Inflammation.
- genetics : SARS Virus.
- isolation & purification : SARS Virus.
- pathology : Hepatocytes, Lung, Lymph Nodes, Monkey Diseases, Myocardium, Pneumonia, Severe Acute Respiratory Syndrome.
- virology : Heart, Hepatocytes, Lung, Lymph Nodes, Monkey Diseases, Pneumonia, Severe Acute Respiratory Syndrome.
- Animals, Callithrix, Tissue Distribution.
Abstract
Severe acute respiratory syndrome (SARS) is a significant emerging infectious disease. Humans infected with the etiological agent, SARS-associated coronavirus (SARS-CoV), primarily present with pneumonitis but may also develop hepatic, gastrointestinal, and renal pathology. We inoculated common marmosets (
Url:
DOI: 10.1016/S0002-9440(10)62989-6
PubMed: 16049331
PubMed Central: 1603565
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PMC:1603565Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Pneumonitis and Multi-Organ System Disease in Common Marmosets (<italic>Callithrix jacchus</italic>
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</affiliation>
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<author><name sortKey="Luzuriaga, Katherine" sort="Luzuriaga, Katherine" uniqKey="Luzuriaga K" first="Katherine" last="Luzuriaga">Katherine Luzuriaga</name>
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<author><name sortKey="Mansfield, Keith" sort="Mansfield, Keith" uniqKey="Mansfield K" first="Keith" last="Mansfield">Keith Mansfield</name>
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<series><title level="j">The American Journal of Pathology</title>
<idno type="ISSN">0002-9440</idno>
<idno type="eISSN">1525-2191</idno>
<imprint><date when="2005">2005</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Callithrix</term>
<term>Heart (virology)</term>
<term>Hepatocytes (pathology)</term>
<term>Hepatocytes (virology)</term>
<term>Inflammation (etiology)</term>
<term>Lung (pathology)</term>
<term>Lung (virology)</term>
<term>Lymph Nodes (pathology)</term>
<term>Lymph Nodes (virology)</term>
<term>Monkey Diseases (pathology)</term>
<term>Monkey Diseases (virology)</term>
<term>Myocardium (pathology)</term>
<term>Pneumonia (pathology)</term>
<term>Pneumonia (virology)</term>
<term>RNA, Viral (analysis)</term>
<term>SARS Virus (genetics)</term>
<term>SARS Virus (isolation & purification)</term>
<term>Severe Acute Respiratory Syndrome (pathology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Tissue Distribution</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (analyse)</term>
<term>Animaux</term>
<term>Callithrix</term>
<term>Coeur (virologie)</term>
<term>Hépatocytes (anatomopathologie)</term>
<term>Hépatocytes (virologie)</term>
<term>Inflammation (étiologie)</term>
<term>Maladies des singes (anatomopathologie)</term>
<term>Maladies des singes (virologie)</term>
<term>Myocarde (anatomopathologie)</term>
<term>Noeuds lymphatiques (anatomopathologie)</term>
<term>Noeuds lymphatiques (virologie)</term>
<term>Pneumopathie infectieuse (anatomopathologie)</term>
<term>Pneumopathie infectieuse (virologie)</term>
<term>Poumon (anatomopathologie)</term>
<term>Poumon (virologie)</term>
<term>Répartition dans les tissus</term>
<term>Syndrome respiratoire aigu sévère (anatomopathologie)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Virus du SRAS (génétique)</term>
<term>Virus du SRAS (isolement et purification)</term>
</keywords>
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<term>Noeuds lymphatiques</term>
<term>Pneumopathie infectieuse</term>
<term>Poumon</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term>
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</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Hepatocytes</term>
<term>Lung</term>
<term>Lymph Nodes</term>
<term>Monkey Diseases</term>
<term>Myocardium</term>
<term>Pneumonia</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Coeur</term>
<term>Hépatocytes</term>
<term>Maladies des singes</term>
<term>Noeuds lymphatiques</term>
<term>Pneumopathie infectieuse</term>
<term>Poumon</term>
<term>Syndrome respiratoire aigu sévère</term>
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<term>Callithrix</term>
<term>Tissue Distribution</term>
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<front><div type="abstract" xml:lang="en"><p>Severe acute respiratory syndrome (SARS) is a significant emerging infectious disease. Humans infected with the etiological agent, SARS-associated coronavirus (SARS-CoV), primarily present with pneumonitis but may also develop hepatic, gastrointestinal, and renal pathology. We inoculated common marmosets (<bold><italic>Callithrix jacchus</italic>
</bold>
) with the objective of developing a small nonhuman primate model of SARS. Two groups of <bold><italic>C. jacchus</italic>
</bold>
were inoculated intratracheally with cell culture supernatant containing SARS-CoV. In a time course pathogenesis study, animals were evaluated at 2, 4, and 7 days after infection for morphological changes and evidence of viral replication. All animals developed a multifocal mononuclear cell interstitial pneumonitis, accompanied by multinucleated syncytial cells, edema, and bronchiolitis in most animals. Viral antigen localized primarily to infected alveolar macrophages and type-1 pneumocytes by immunohistochemistry. Viral RNA was detected in all animals from pulmonary tissue extracts obtained at necropsy. Viral RNA was also detected in tracheobronchial lymph node and myocardium, together with inflammatory changes, in some animals. Hepatic inflammation was observed in most animals, predominantly as a multifocal lymphocytic hepatitis accompanied by necrosis of individual hepatocytes. These findings identify the common marmoset as a promising nonhuman primate to study SARS-CoV pathogenesis.</p>
</div>
</front>
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</TEI>
<double pmid="16049331"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pneumonitis and Multi-Organ System Disease in Common Marmosets (<italic>Callithrix jacchus</italic>
) Infected with the Severe Acute Respiratory Syndrome-Associated Coronavirus</title>
<author><name sortKey="Greenough, Thomas C" sort="Greenough, Thomas C" uniqKey="Greenough T" first="Thomas C." last="Greenough">Thomas C. Greenough</name>
<affiliation><nlm:aff id="aff1">Department of Pediatrics, University of Massachusetts Medical School, Worcester</nlm:aff>
<wicri:noCountry code="subfield">Worcester</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Carville, Angela" sort="Carville, Angela" uniqKey="Carville A" first="Angela" last="Carville">Angela Carville</name>
<affiliation wicri:level="2"><nlm:aff id="aff2">Department of Pathology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Pathology, New England Primate Research Center, Harvard Medical School, Southborough</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Coderre, James" sort="Coderre, James" uniqKey="Coderre J" first="James" last="Coderre">James Coderre</name>
<affiliation><nlm:aff id="aff1">Department of Pediatrics, University of Massachusetts Medical School, Worcester</nlm:aff>
<wicri:noCountry code="subfield">Worcester</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Somasundaran, Mohan" sort="Somasundaran, Mohan" uniqKey="Somasundaran M" first="Mohan" last="Somasundaran">Mohan Somasundaran</name>
<affiliation><nlm:aff id="aff1">Department of Pediatrics, University of Massachusetts Medical School, Worcester</nlm:aff>
<wicri:noCountry code="subfield">Worcester</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sullivan, John L" sort="Sullivan, John L" uniqKey="Sullivan J" first="John L." last="Sullivan">John L. Sullivan</name>
<affiliation><nlm:aff id="aff1">Department of Pediatrics, University of Massachusetts Medical School, Worcester</nlm:aff>
<wicri:noCountry code="subfield">Worcester</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Luzuriaga, Katherine" sort="Luzuriaga, Katherine" uniqKey="Luzuriaga K" first="Katherine" last="Luzuriaga">Katherine Luzuriaga</name>
<affiliation><nlm:aff id="aff1">Department of Pediatrics, University of Massachusetts Medical School, Worcester</nlm:aff>
<wicri:noCountry code="subfield">Worcester</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mansfield, Keith" sort="Mansfield, Keith" uniqKey="Mansfield K" first="Keith" last="Mansfield">Keith Mansfield</name>
<affiliation wicri:level="2"><nlm:aff id="aff2">Department of Pathology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Pathology, New England Primate Research Center, Harvard Medical School, Southborough</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
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<idno type="pmid">16049331</idno>
<idno type="pmc">1603565</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1603565</idno>
<idno type="RBID">PMC:1603565</idno>
<idno type="doi">10.1016/S0002-9440(10)62989-6</idno>
<date when="2005">2005</date>
<idno type="wicri:Area/Pmc/Corpus">000D76</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D76</idno>
<idno type="wicri:Area/Pmc/Curation">000D76</idno>
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<idno type="wicri:Area/Pmc/Checkpoint">001280</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001280</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Pneumonitis and Multi-Organ System Disease in Common Marmosets (<italic>Callithrix jacchus</italic>
) Infected with the Severe Acute Respiratory Syndrome-Associated Coronavirus</title>
<author><name sortKey="Greenough, Thomas C" sort="Greenough, Thomas C" uniqKey="Greenough T" first="Thomas C." last="Greenough">Thomas C. Greenough</name>
<affiliation><nlm:aff id="aff1">Department of Pediatrics, University of Massachusetts Medical School, Worcester</nlm:aff>
<wicri:noCountry code="subfield">Worcester</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Carville, Angela" sort="Carville, Angela" uniqKey="Carville A" first="Angela" last="Carville">Angela Carville</name>
<affiliation wicri:level="2"><nlm:aff id="aff2">Department of Pathology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Pathology, New England Primate Research Center, Harvard Medical School, Southborough</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Coderre, James" sort="Coderre, James" uniqKey="Coderre J" first="James" last="Coderre">James Coderre</name>
<affiliation><nlm:aff id="aff1">Department of Pediatrics, University of Massachusetts Medical School, Worcester</nlm:aff>
<wicri:noCountry code="subfield">Worcester</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Somasundaran, Mohan" sort="Somasundaran, Mohan" uniqKey="Somasundaran M" first="Mohan" last="Somasundaran">Mohan Somasundaran</name>
<affiliation><nlm:aff id="aff1">Department of Pediatrics, University of Massachusetts Medical School, Worcester</nlm:aff>
<wicri:noCountry code="subfield">Worcester</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sullivan, John L" sort="Sullivan, John L" uniqKey="Sullivan J" first="John L." last="Sullivan">John L. Sullivan</name>
<affiliation><nlm:aff id="aff1">Department of Pediatrics, University of Massachusetts Medical School, Worcester</nlm:aff>
<wicri:noCountry code="subfield">Worcester</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Luzuriaga, Katherine" sort="Luzuriaga, Katherine" uniqKey="Luzuriaga K" first="Katherine" last="Luzuriaga">Katherine Luzuriaga</name>
<affiliation><nlm:aff id="aff1">Department of Pediatrics, University of Massachusetts Medical School, Worcester</nlm:aff>
<wicri:noCountry code="subfield">Worcester</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mansfield, Keith" sort="Mansfield, Keith" uniqKey="Mansfield K" first="Keith" last="Mansfield">Keith Mansfield</name>
<affiliation wicri:level="2"><nlm:aff id="aff2">Department of Pathology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Pathology, New England Primate Research Center, Harvard Medical School, Southborough</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">The American Journal of Pathology</title>
<idno type="ISSN">0002-9440</idno>
<idno type="eISSN">1525-2191</idno>
<imprint><date when="2005">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Severe acute respiratory syndrome (SARS) is a significant emerging infectious disease. Humans infected with the etiological agent, SARS-associated coronavirus (SARS-CoV), primarily present with pneumonitis but may also develop hepatic, gastrointestinal, and renal pathology. We inoculated common marmosets (<bold><italic>Callithrix jacchus</italic>
</bold>
) with the objective of developing a small nonhuman primate model of SARS. Two groups of <bold><italic>C. jacchus</italic>
</bold>
were inoculated intratracheally with cell culture supernatant containing SARS-CoV. In a time course pathogenesis study, animals were evaluated at 2, 4, and 7 days after infection for morphological changes and evidence of viral replication. All animals developed a multifocal mononuclear cell interstitial pneumonitis, accompanied by multinucleated syncytial cells, edema, and bronchiolitis in most animals. Viral antigen localized primarily to infected alveolar macrophages and type-1 pneumocytes by immunohistochemistry. Viral RNA was detected in all animals from pulmonary tissue extracts obtained at necropsy. Viral RNA was also detected in tracheobronchial lymph node and myocardium, together with inflammatory changes, in some animals. Hepatic inflammation was observed in most animals, predominantly as a multifocal lymphocytic hepatitis accompanied by necrosis of individual hepatocytes. These findings identify the common marmoset as a promising nonhuman primate to study SARS-CoV pathogenesis.</p>
</div>
</front>
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<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus.</title>
<author><name sortKey="Greenough, Thomas C" sort="Greenough, Thomas C" uniqKey="Greenough T" first="Thomas C" last="Greenough">Thomas C. Greenough</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, USA. thomas.greenough@umassmed.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Carville, Angela" sort="Carville, Angela" uniqKey="Carville A" first="Angela" last="Carville">Angela Carville</name>
</author>
<author><name sortKey="Coderre, James" sort="Coderre, James" uniqKey="Coderre J" first="James" last="Coderre">James Coderre</name>
</author>
<author><name sortKey="Somasundaran, Mohan" sort="Somasundaran, Mohan" uniqKey="Somasundaran M" first="Mohan" last="Somasundaran">Mohan Somasundaran</name>
</author>
<author><name sortKey="Sullivan, John L" sort="Sullivan, John L" uniqKey="Sullivan J" first="John L" last="Sullivan">John L. Sullivan</name>
</author>
<author><name sortKey="Luzuriaga, Katherine" sort="Luzuriaga, Katherine" uniqKey="Luzuriaga K" first="Katherine" last="Luzuriaga">Katherine Luzuriaga</name>
</author>
<author><name sortKey="Mansfield, Keith" sort="Mansfield, Keith" uniqKey="Mansfield K" first="Keith" last="Mansfield">Keith Mansfield</name>
</author>
</titleStmt>
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<date when="2005">2005</date>
<idno type="RBID">pubmed:16049331</idno>
<idno type="pmid">16049331</idno>
<idno type="doi">10.1016/S0002-9440(10)62989-6</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus.</title>
<author><name sortKey="Greenough, Thomas C" sort="Greenough, Thomas C" uniqKey="Greenough T" first="Thomas C" last="Greenough">Thomas C. Greenough</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, USA. thomas.greenough@umassmed.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Carville, Angela" sort="Carville, Angela" uniqKey="Carville A" first="Angela" last="Carville">Angela Carville</name>
</author>
<author><name sortKey="Coderre, James" sort="Coderre, James" uniqKey="Coderre J" first="James" last="Coderre">James Coderre</name>
</author>
<author><name sortKey="Somasundaran, Mohan" sort="Somasundaran, Mohan" uniqKey="Somasundaran M" first="Mohan" last="Somasundaran">Mohan Somasundaran</name>
</author>
<author><name sortKey="Sullivan, John L" sort="Sullivan, John L" uniqKey="Sullivan J" first="John L" last="Sullivan">John L. Sullivan</name>
</author>
<author><name sortKey="Luzuriaga, Katherine" sort="Luzuriaga, Katherine" uniqKey="Luzuriaga K" first="Katherine" last="Luzuriaga">Katherine Luzuriaga</name>
</author>
<author><name sortKey="Mansfield, Keith" sort="Mansfield, Keith" uniqKey="Mansfield K" first="Keith" last="Mansfield">Keith Mansfield</name>
</author>
</analytic>
<series><title level="j">The American journal of pathology</title>
<idno type="ISSN">0002-9440</idno>
<imprint><date when="2005" type="published">2005</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Callithrix</term>
<term>Heart (virology)</term>
<term>Hepatocytes (pathology)</term>
<term>Hepatocytes (virology)</term>
<term>Inflammation (etiology)</term>
<term>Lung (pathology)</term>
<term>Lung (virology)</term>
<term>Lymph Nodes (pathology)</term>
<term>Lymph Nodes (virology)</term>
<term>Monkey Diseases (pathology)</term>
<term>Monkey Diseases (virology)</term>
<term>Myocardium (pathology)</term>
<term>Pneumonia (pathology)</term>
<term>Pneumonia (virology)</term>
<term>RNA, Viral (analysis)</term>
<term>SARS Virus (genetics)</term>
<term>SARS Virus (isolation & purification)</term>
<term>Severe Acute Respiratory Syndrome (pathology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Tissue Distribution</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (analyse)</term>
<term>Animaux</term>
<term>Callithrix</term>
<term>Coeur (virologie)</term>
<term>Hépatocytes (anatomopathologie)</term>
<term>Hépatocytes (virologie)</term>
<term>Inflammation (étiologie)</term>
<term>Maladies des singes (anatomopathologie)</term>
<term>Maladies des singes (virologie)</term>
<term>Myocarde (anatomopathologie)</term>
<term>Noeuds lymphatiques (anatomopathologie)</term>
<term>Noeuds lymphatiques (virologie)</term>
<term>Pneumopathie infectieuse (anatomopathologie)</term>
<term>Pneumopathie infectieuse (virologie)</term>
<term>Poumon (anatomopathologie)</term>
<term>Poumon (virologie)</term>
<term>Répartition dans les tissus</term>
<term>Syndrome respiratoire aigu sévère (anatomopathologie)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Virus du SRAS (génétique)</term>
<term>Virus du SRAS (isolement et purification)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ARN viral</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Hépatocytes</term>
<term>Maladies des singes</term>
<term>Myocarde</term>
<term>Noeuds lymphatiques</term>
<term>Pneumopathie infectieuse</term>
<term>Poumon</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Hepatocytes</term>
<term>Lung</term>
<term>Lymph Nodes</term>
<term>Monkey Diseases</term>
<term>Myocardium</term>
<term>Pneumonia</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Coeur</term>
<term>Hépatocytes</term>
<term>Maladies des singes</term>
<term>Noeuds lymphatiques</term>
<term>Pneumopathie infectieuse</term>
<term>Poumon</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Heart</term>
<term>Hepatocytes</term>
<term>Lung</term>
<term>Lymph Nodes</term>
<term>Monkey Diseases</term>
<term>Pneumonia</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Inflammation</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Callithrix</term>
<term>Tissue Distribution</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Callithrix</term>
<term>Répartition dans les tissus</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a significant emerging infectious disease. Humans infected with the etiological agent, SARS-associated coronavirus (SARS-CoV), primarily present with pneumonitis but may also develop hepatic, gastrointestinal, and renal pathology. We inoculated common marmosets (Callithrix jacchus) with the objective of developing a small nonhuman primate model of SARS. Two groups of C. jacchus were inoculated intratracheally with cell culture supernatant containing SARS-CoV. In a time course pathogenesis study, animals were evaluated at 2, 4, and 7 days after infection for morphological changes and evidence of viral replication. All animals developed a multifocal mononuclear cell interstitial pneumonitis, accompanied by multinucleated syncytial cells, edema, and bronchiolitis in most animals. Viral antigen localized primarily to infected alveolar macrophages and type-1 pneumocytes by immunohistochemistry. Viral RNA was detected in all animals from pulmonary tissue extracts obtained at necropsy. Viral RNA was also detected in tracheobronchial lymph node and myocardium, together with inflammatory changes, in some animals. Hepatic inflammation was observed in most animals, predominantly as a multifocal lymphocytic hepatitis accompanied by necrosis of individual hepatocytes. These findings identify the common marmoset as a promising nonhuman primate to study SARS-CoV pathogenesis.</div>
</front>
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