SrasV1, Ncbi, Merge, bibRecord, 001062

Adenoviral expression of a truncated S1 subunit of SARS-CoV spike protein results in specific humoral immune responses against SARS-CoV in rats.

Identifieur interne : 001062 ( Ncbi/Merge ); précédent : 001061; suivant : 001063

Adenoviral expression of a truncated S1 subunit of SARS-CoV spike protein results in specific humoral immune responses against SARS-CoV in rats.

Auteurs : Ran-Yi Liu [République populaire de Chine] ; Li-Zhi Wu ; Bi-Jun Huang ; Jia-Ling Huang ; Yan-Ling Zhang ; Miao-La Ke ; Jun-Mei Wang ; Wei-Ping Tan ; Ru-Hua Zhang ; Han-Kui Chen ; Yi-Xin Zeng ; Wenlin Huang

Source :

Virus research [ 0168-1702 ] ; 2005.

RBID : pubmed:16022898

Descripteurs français

English descriptors

KwdEn :
- Adenoviridae (genetics), Adenoviridae (metabolism), Animals, Antibodies, Viral (blood), Antibody Specificity, Cell Line, Chlorocebus aethiops, Genetic Vectors, Humans, Membrane Glycoproteins (chemistry), Membrane Glycoproteins (genetics), Membrane Glycoproteins (immunology), Membrane Glycoproteins (metabolism), Neutralization Tests, Rats, Rats, Wistar, SARS Virus (genetics), SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (prevention & control), Severe Acute Respiratory Syndrome (virology), Spike Glycoprotein, Coronavirus, Vaccination, Vero Cells, Viral Envelope Proteins (chemistry), Viral Envelope Proteins (genetics), Viral Envelope Proteins (immunology), Viral Envelope Proteins (metabolism), Viral Vaccines (administration & dosage), Viral Vaccines (genetics), Viral Vaccines (immunology).
MESH :
- chemical , administration & dosage : Viral Vaccines.
- chemical , blood : Antibodies, Viral.
- chemical , chemistry : Membrane Glycoproteins, Viral Envelope Proteins.
- genetics : Adenoviridae, Membrane Glycoproteins, SARS Virus, Viral Envelope Proteins, Viral Vaccines.
- chemical , immunology : Membrane Glycoproteins, SARS Virus, Severe Acute Respiratory Syndrome, Viral Envelope Proteins, Viral Vaccines.
- metabolism : Adenoviridae, Membrane Glycoproteins, Viral Envelope Proteins.
- prevention & control : Severe Acute Respiratory Syndrome.
- virology : Severe Acute Respiratory Syndrome.
- Animals, Antibody Specificity, Cell Line, Chlorocebus aethiops, Genetic Vectors, Humans, Neutralization Tests, Rats, Rats, Wistar, Spike Glycoprotein, Coronavirus, Vaccination, Vero Cells.

Abstract

The causative agent of severe acute respiratory syndrome (SARS) has been identified as SARS-associated coronavirus (SARS-CoV), but the prophylactic treatment of SARS-CoV is still under investigation. We constructed a recombinant adenovirus containing a truncated N-terminal fragment of the SARS-CoV Spike (S) gene (from--45 to 1469, designated Ad-S(N)), which encoded a truncated S protein (490 amino-acid residues, a part of 672 amino-acid S1 subunit), and investigated whether this construct could induce effective immunity against SARS-CoV in Wistar rats. Rats were immunized either subcutaneously or intranasally with Ad-S(N) once a week for three consecutive weeks. Our results showed that all of the immunized animals generated humoral immunity against the SARS-CoV spike protein, and the sera of immunized rats showed strong capable of protecting from SARS-CoV infection in vitro. Histopathological examination did not find evident side effects in the immunized animals. These results indicate that an adenoviral-based vaccine carrying an N-terminal fragment of the Spike gene is able to elicit strong SARS-CoV-specific humoral immune responses in rats, and may be useful for the development of a protective vaccine against SARS-CoV infection.

DOI: 10.1016/j.virusres.2005.02.009
PubMed: 16022898

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 002639
to stream PubMed, to step Curation: 002639
to stream PubMed, to step Checkpoint: 002845

Links to Exploration step

pubmed:16022898

Le document en format XML

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<term>Antibody Specificity</term>
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<term>Chlorocebus aethiops</term>
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<term>Membrane Glycoproteins (genetics)</term>
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<term>Membrane Glycoproteins (metabolism)</term>
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<term>Rats, Wistar</term>
<term>SARS Virus (genetics)</term>
<term>SARS Virus (immunology)</term>
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<term>Vero Cells</term>
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<term>Cellules Vero</term>
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<term>Glycoprotéines membranaires ()</term>
<term>Glycoprotéines membranaires (génétique)</term>
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<term>Humains</term>
<term>Lignée cellulaire</term>
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<term>Protéines de l'enveloppe virale (génétique)</term>
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<front><div type="abstract" xml:lang="en">The causative agent of severe acute respiratory syndrome (SARS) has been identified as SARS-associated coronavirus (SARS-CoV), but the prophylactic treatment of SARS-CoV is still under investigation. We constructed a recombinant adenovirus containing a truncated N-terminal fragment of the SARS-CoV Spike (S) gene (from--45 to 1469, designated Ad-S(N)), which encoded a truncated S protein (490 amino-acid residues, a part of 672 amino-acid S1 subunit), and investigated whether this construct could induce effective immunity against SARS-CoV in Wistar rats. Rats were immunized either subcutaneously or intranasally with Ad-S(N) once a week for three consecutive weeks. Our results showed that all of the immunized animals generated humoral immunity against the SARS-CoV spike protein, and the sera of immunized rats showed strong capable of protecting from SARS-CoV infection in vitro. Histopathological examination did not find evident side effects in the immunized animals. These results indicate that an adenoviral-based vaccine carrying an N-terminal fragment of the Spike gene is able to elicit strong SARS-CoV-specific humoral immune responses in rats, and may be useful for the development of a protective vaccine against SARS-CoV infection.</div>
</front>
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<Abstract><AbstractText>The causative agent of severe acute respiratory syndrome (SARS) has been identified as SARS-associated coronavirus (SARS-CoV), but the prophylactic treatment of SARS-CoV is still under investigation. We constructed a recombinant adenovirus containing a truncated N-terminal fragment of the SARS-CoV Spike (S) gene (from--45 to 1469, designated Ad-S(N)), which encoded a truncated S protein (490 amino-acid residues, a part of 672 amino-acid S1 subunit), and investigated whether this construct could induce effective immunity against SARS-CoV in Wistar rats. Rats were immunized either subcutaneously or intranasally with Ad-S(N) once a week for three consecutive weeks. Our results showed that all of the immunized animals generated humoral immunity against the SARS-CoV spike protein, and the sera of immunized rats showed strong capable of protecting from SARS-CoV infection in vitro. Histopathological examination did not find evident side effects in the immunized animals. These results indicate that an adenoviral-based vaccine carrying an N-terminal fragment of the Spike gene is able to elicit strong SARS-CoV-specific humoral immune responses in rats, and may be useful for the development of a protective vaccine against SARS-CoV infection.</AbstractText>
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<Author ValidYN="Y"><LastName>Huang</LastName>
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<Author ValidYN="Y"><LastName>Huang</LastName>
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<Author ValidYN="Y"><LastName>Zhang</LastName>
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<Author ValidYN="Y"><LastName>Ke</LastName>
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<Author ValidYN="Y"><LastName>Wang</LastName>
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<Author ValidYN="Y"><LastName>Huang</LastName>
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Adenoviral expression of a truncated S1 subunit of SARS-CoV spike protein results in specific humoral immune responses against SARS-CoV in rats.

Adenoviral expression of a truncated S1 subunit of SARS-CoV spike protein results in specific humoral immune responses against SARS-CoV in rats.

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