Serveur d'exploration SRAS

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Angiotensin-converting enzyme 2 protects from severe acute lung failure

Identifieur interne : 001045 ( Ncbi/Merge ); précédent : 001044; suivant : 001046

Angiotensin-converting enzyme 2 protects from severe acute lung failure

Auteurs : Yumiko Imai [Autriche] ; Keiji Kuba [Autriche] ; Shuan Rao [République populaire de Chine] ; Yi Huan [République populaire de Chine] ; Feng Guo [République populaire de Chine] ; Bin Guan [République populaire de Chine] ; Peng Yang [République populaire de Chine] ; Renu Sarao [Autriche] ; Teiji Wada [Autriche] ; Howard Leong-Poi [Canada] ; Michael A. Crackower [Canada] ; Akiyoshi Fukamizu [Japon] ; Chi-Chung Hui [Canada] ; Lutz Hein [Allemagne] ; Stefan Uhlig [Allemagne] ; Arthur S. Slutsky [Canada] ; Chengyu Jiang [République populaire de Chine] ; Josef M. Penninger [Autriche]

Source :

RBID : PMC:7094998

Descripteurs français

English descriptors

Abstract

Drug hope for SARS

The SARS (severe acute respiratory syndrome) epidemic of 2003 caused almost 800 deaths, many of them due to acute respiratory distress syndrome (ARDS) as a complication. There are no effective drugs available for treating ARDS, but new work in mice suggests that ACE2 (angiotensin-converting enzyme 2) might be an option. ACE2 can protect mice from lung injury in an ARDS-like syndrome, whereas other components of the renin–angiotensin system for controlling blood pressure and salt balance actually make the condition worse. ACE2 is expressed in the healthy lung but downregulated by lung injury and it was shown recently (Nature426, 450–454; 2003) to be a receptor for the SARS coronavirus.

Supplementary information

The online version of this article (doi:10.1038/nature03712) contains supplementary material, which is available to authorized users.


Url:
DOI: 10.1038/nature03712
PubMed: 16001071
PubMed Central: 7094998

Links toward previous steps (curation, corpus...)


Links to Exploration step

PMC:7094998

Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Angiotensin-converting enzyme 2 protects from severe acute lung failure</title>
<author>
<name sortKey="Imai, Yumiko" sort="Imai, Yumiko" uniqKey="Imai Y" first="Yumiko" last="Imai">Yumiko Imai</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.417521.4</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 0008 2788</institution-id>
<institution>IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences,</institution>
</institution-wrap>
A-1030 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A-1030 Vienna</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kuba, Keiji" sort="Kuba, Keiji" uniqKey="Kuba K" first="Keiji" last="Kuba">Keiji Kuba</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.417521.4</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 0008 2788</institution-id>
<institution>IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences,</institution>
</institution-wrap>
A-1030 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A-1030 Vienna</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Rao, Shuan" sort="Rao, Shuan" uniqKey="Rao S" first="Shuan" last="Rao">Shuan Rao</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff2">National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing</wicri:regionArea>
<placeName>
<settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Huan, Yi" sort="Huan, Yi" uniqKey="Huan Y" first="Yi" last="Huan">Yi Huan</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff2">National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing</wicri:regionArea>
<placeName>
<settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Guo, Feng" sort="Guo, Feng" uniqKey="Guo F" first="Feng" last="Guo">Feng Guo</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff2">National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing</wicri:regionArea>
<placeName>
<settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Guan, Bin" sort="Guan, Bin" uniqKey="Guan B" first="Bin" last="Guan">Bin Guan</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff2">National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing</wicri:regionArea>
<placeName>
<settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Yang, Peng" sort="Yang, Peng" uniqKey="Yang P" first="Peng" last="Yang">Peng Yang</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff2">National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing</wicri:regionArea>
<placeName>
<settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Sarao, Renu" sort="Sarao, Renu" uniqKey="Sarao R" first="Renu" last="Sarao">Renu Sarao</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.417521.4</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 0008 2788</institution-id>
<institution>IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences,</institution>
</institution-wrap>
A-1030 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A-1030 Vienna</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wada, Teiji" sort="Wada, Teiji" uniqKey="Wada T" first="Teiji" last="Wada">Teiji Wada</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.417521.4</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 0008 2788</institution-id>
<institution>IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences,</institution>
</institution-wrap>
A-1030 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A-1030 Vienna</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Leong Poi, Howard" sort="Leong Poi, Howard" uniqKey="Leong Poi H" first="Howard" last="Leong-Poi">Howard Leong-Poi</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff3">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.415502.7</institution-id>
<institution>Department of Cardiology,</institution>
<institution>St. Michael's Hospital,</institution>
</institution-wrap>
Ontario M5B 1W8 Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Ontario M5B 1W8 Toronto</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Crackower, Michael A" sort="Crackower, Michael A" uniqKey="Crackower M" first="Michael A." last="Crackower">Michael A. Crackower</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff4">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.292545.d</institution-id>
<institution>Department of Biochemistry and Molecular Biology,</institution>
<institution>Merck Frosst Centre for Therapeutic Research,</institution>
</institution-wrap>
Quebec H3R 4P8 Montreal, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Quebec H3R 4P8 Montreal</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Fukamizu, Akiyoshi" sort="Fukamizu, Akiyoshi" uniqKey="Fukamizu A" first="Akiyoshi" last="Fukamizu">Akiyoshi Fukamizu</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff5">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.20515.33</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 2369 4728</institution-id>
<institution>Center for Tsukuba Advanced Research Alliance,</institution>
<institution>University of Tsukuba,</institution>
</institution-wrap>
305-8577 Tsukuba, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>305-8577 Tsukuba</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hui, Chi Chung" sort="Hui, Chi Chung" uniqKey="Hui C" first="Chi-Chung" last="Hui">Chi-Chung Hui</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff6">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.17063.33</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 2157 2938</institution-id>
<institution>Program in Developmental Biology, The Hospital for Sick Children and Department of Molecular and Medical Genetics,</institution>
<institution>University of Toronto,</institution>
</institution-wrap>
Ontario MG5 1X8 Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Ontario MG5 1X8 Toronto</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hein, Lutz" sort="Hein, Lutz" uniqKey="Hein L" first="Lutz" last="Hein">Lutz Hein</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff7">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.5963.9</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Freiburg,</institution>
</institution-wrap>
79104 Freiburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>79104 Freiburg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Uhlig, Stefan" sort="Uhlig, Stefan" uniqKey="Uhlig S" first="Stefan" last="Uhlig">Stefan Uhlig</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff8">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.418187.3</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 0493 9170</institution-id>
<institution>Division of Pulmonary Pharmacology,</institution>
<institution>Research Center Borstel,</institution>
</institution-wrap>
23845 Borstel, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>23845 Borstel</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Slutsky, Arthur S" sort="Slutsky, Arthur S" uniqKey="Slutsky A" first="Arthur S." last="Slutsky">Arthur S. Slutsky</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff9">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.17063.33</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 2157 2938</institution-id>
<institution>Department of Medicine and Interdepartmental Division of Critical Care,</institution>
<institution>University of Toronto, St. Michael's Hospital,</institution>
</institution-wrap>
Ontario M5B 1W8 Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Ontario M5B 1W8 Toronto</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Jiang, Chengyu" sort="Jiang, Chengyu" uniqKey="Jiang C" first="Chengyu" last="Jiang">Chengyu Jiang</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff2">National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing</wicri:regionArea>
<placeName>
<settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Penninger, Josef M" sort="Penninger, Josef M" uniqKey="Penninger J" first="Josef M." last="Penninger">Josef M. Penninger</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.417521.4</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 0008 2788</institution-id>
<institution>IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences,</institution>
</institution-wrap>
A-1030 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A-1030 Vienna</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PMC</idno>
<idno type="pmid">16001071</idno>
<idno type="pmc">7094998</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094998</idno>
<idno type="RBID">PMC:7094998</idno>
<idno type="doi">10.1038/nature03712</idno>
<date when="2005">2005</date>
<idno type="wicri:Area/Pmc/Corpus">000448</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000448</idno>
<idno type="wicri:Area/Pmc/Curation">000448</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000448</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001393</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001393</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:16001071</idno>
<idno type="wicri:Area/PubMed/Corpus">002654</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002654</idno>
<idno type="wicri:Area/PubMed/Curation">002654</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002654</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002833</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002833</idno>
<idno type="wicri:Area/Ncbi/Merge">001045</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en" level="a" type="main">Angiotensin-converting enzyme 2 protects from severe acute lung failure</title>
<author>
<name sortKey="Imai, Yumiko" sort="Imai, Yumiko" uniqKey="Imai Y" first="Yumiko" last="Imai">Yumiko Imai</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.417521.4</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 0008 2788</institution-id>
<institution>IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences,</institution>
</institution-wrap>
A-1030 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A-1030 Vienna</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kuba, Keiji" sort="Kuba, Keiji" uniqKey="Kuba K" first="Keiji" last="Kuba">Keiji Kuba</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.417521.4</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 0008 2788</institution-id>
<institution>IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences,</institution>
</institution-wrap>
A-1030 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A-1030 Vienna</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Rao, Shuan" sort="Rao, Shuan" uniqKey="Rao S" first="Shuan" last="Rao">Shuan Rao</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff2">National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing</wicri:regionArea>
<placeName>
<settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Huan, Yi" sort="Huan, Yi" uniqKey="Huan Y" first="Yi" last="Huan">Yi Huan</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff2">National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing</wicri:regionArea>
<placeName>
<settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Guo, Feng" sort="Guo, Feng" uniqKey="Guo F" first="Feng" last="Guo">Feng Guo</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff2">National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing</wicri:regionArea>
<placeName>
<settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Guan, Bin" sort="Guan, Bin" uniqKey="Guan B" first="Bin" last="Guan">Bin Guan</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff2">National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing</wicri:regionArea>
<placeName>
<settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Yang, Peng" sort="Yang, Peng" uniqKey="Yang P" first="Peng" last="Yang">Peng Yang</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff2">National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing</wicri:regionArea>
<placeName>
<settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Sarao, Renu" sort="Sarao, Renu" uniqKey="Sarao R" first="Renu" last="Sarao">Renu Sarao</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.417521.4</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 0008 2788</institution-id>
<institution>IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences,</institution>
</institution-wrap>
A-1030 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A-1030 Vienna</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wada, Teiji" sort="Wada, Teiji" uniqKey="Wada T" first="Teiji" last="Wada">Teiji Wada</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.417521.4</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 0008 2788</institution-id>
<institution>IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences,</institution>
</institution-wrap>
A-1030 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A-1030 Vienna</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Leong Poi, Howard" sort="Leong Poi, Howard" uniqKey="Leong Poi H" first="Howard" last="Leong-Poi">Howard Leong-Poi</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff3">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.415502.7</institution-id>
<institution>Department of Cardiology,</institution>
<institution>St. Michael's Hospital,</institution>
</institution-wrap>
Ontario M5B 1W8 Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Ontario M5B 1W8 Toronto</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Crackower, Michael A" sort="Crackower, Michael A" uniqKey="Crackower M" first="Michael A." last="Crackower">Michael A. Crackower</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff4">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.292545.d</institution-id>
<institution>Department of Biochemistry and Molecular Biology,</institution>
<institution>Merck Frosst Centre for Therapeutic Research,</institution>
</institution-wrap>
Quebec H3R 4P8 Montreal, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Quebec H3R 4P8 Montreal</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Fukamizu, Akiyoshi" sort="Fukamizu, Akiyoshi" uniqKey="Fukamizu A" first="Akiyoshi" last="Fukamizu">Akiyoshi Fukamizu</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff5">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.20515.33</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 2369 4728</institution-id>
<institution>Center for Tsukuba Advanced Research Alliance,</institution>
<institution>University of Tsukuba,</institution>
</institution-wrap>
305-8577 Tsukuba, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>305-8577 Tsukuba</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hui, Chi Chung" sort="Hui, Chi Chung" uniqKey="Hui C" first="Chi-Chung" last="Hui">Chi-Chung Hui</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff6">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.17063.33</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 2157 2938</institution-id>
<institution>Program in Developmental Biology, The Hospital for Sick Children and Department of Molecular and Medical Genetics,</institution>
<institution>University of Toronto,</institution>
</institution-wrap>
Ontario MG5 1X8 Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Ontario MG5 1X8 Toronto</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hein, Lutz" sort="Hein, Lutz" uniqKey="Hein L" first="Lutz" last="Hein">Lutz Hein</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff7">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.5963.9</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Freiburg,</institution>
</institution-wrap>
79104 Freiburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>79104 Freiburg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Uhlig, Stefan" sort="Uhlig, Stefan" uniqKey="Uhlig S" first="Stefan" last="Uhlig">Stefan Uhlig</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff8">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.418187.3</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 0493 9170</institution-id>
<institution>Division of Pulmonary Pharmacology,</institution>
<institution>Research Center Borstel,</institution>
</institution-wrap>
23845 Borstel, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>23845 Borstel</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Slutsky, Arthur S" sort="Slutsky, Arthur S" uniqKey="Slutsky A" first="Arthur S." last="Slutsky">Arthur S. Slutsky</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff9">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.17063.33</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 2157 2938</institution-id>
<institution>Department of Medicine and Interdepartmental Division of Critical Care,</institution>
<institution>University of Toronto, St. Michael's Hospital,</institution>
</institution-wrap>
Ontario M5B 1W8 Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Ontario M5B 1W8 Toronto</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Jiang, Chengyu" sort="Jiang, Chengyu" uniqKey="Jiang C" first="Chengyu" last="Jiang">Chengyu Jiang</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff2">National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing</wicri:regionArea>
<placeName>
<settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Penninger, Josef M" sort="Penninger, Josef M" uniqKey="Penninger J" first="Josef M." last="Penninger">Josef M. Penninger</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.417521.4</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 0008 2788</institution-id>
<institution>IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences,</institution>
</institution-wrap>
A-1030 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A-1030 Vienna</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Nature</title>
<idno type="ISSN">0028-0836</idno>
<idno type="eISSN">1476-4687</idno>
<imprint>
<date when="2005">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Acids (pharmacology)</term>
<term>Acute Disease</term>
<term>Analysis of Variance</term>
<term>Angiotensin II (metabolism)</term>
<term>Animals</term>
<term>Capillary Permeability</term>
<term>Carboxypeptidases (deficiency)</term>
<term>Carboxypeptidases (genetics)</term>
<term>Carboxypeptidases (metabolism)</term>
<term>Disease Models, Animal</term>
<term>Gene Deletion</term>
<term>Humans</term>
<term>Lung (pathology)</term>
<term>Lung (physiopathology)</term>
<term>Lung Diseases (enzymology)</term>
<term>Lung Diseases (genetics)</term>
<term>Lung Diseases (pathology)</term>
<term>Lung Diseases (physiopathology)</term>
<term>Mice</term>
<term>Mice, Knockout</term>
<term>Mice, Transgenic</term>
<term>Oxygen (blood)</term>
<term>Peptidyl-Dipeptidase A</term>
<term>Pulmonary Edema (pathology)</term>
<term>Pulmonary Edema (physiopathology)</term>
<term>Receptor, Angiotensin, Type 1 (metabolism)</term>
<term>Receptor, Angiotensin, Type 2 (metabolism)</term>
<term>Respiratory Distress Syndrome, Adult (enzymology)</term>
<term>Respiratory Distress Syndrome, Adult (genetics)</term>
<term>Respiratory Distress Syndrome, Adult (pathology)</term>
<term>Sepsis (enzymology)</term>
<term>Sepsis (genetics)</term>
<term>Sepsis (pathology)</term>
<term>Transgenes (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Acides (pharmacologie)</term>
<term>Analyse de variance</term>
<term>Angiotensine-II (métabolisme)</term>
<term>Animaux</term>
<term>Carboxypeptidases (déficit)</term>
<term>Carboxypeptidases (génétique)</term>
<term>Carboxypeptidases (métabolisme)</term>
<term>Délétion de gène</term>
<term>Humains</term>
<term>Maladie aigüe</term>
<term>Maladies pulmonaires (anatomopathologie)</term>
<term>Maladies pulmonaires (enzymologie)</term>
<term>Maladies pulmonaires (génétique)</term>
<term>Maladies pulmonaires (physiopathologie)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Oedème pulmonaire (anatomopathologie)</term>
<term>Oedème pulmonaire (physiopathologie)</term>
<term>Oxygène (sang)</term>
<term>Peptidyl-Dipeptidase A</term>
<term>Perméabilité capillaire</term>
<term>Poumon (anatomopathologie)</term>
<term>Poumon (physiopathologie)</term>
<term>Récepteur de type 1 à l'angiotensine-II (métabolisme)</term>
<term>Récepteur de type 2 à l'angiotensine-II (métabolisme)</term>
<term>Sepsie (anatomopathologie)</term>
<term>Sepsie (enzymologie)</term>
<term>Sepsie (génétique)</term>
<term>Souris</term>
<term>Souris knockout</term>
<term>Souris transgéniques</term>
<term>Syndrome de détresse respiratoire de l'adulte (anatomopathologie)</term>
<term>Syndrome de détresse respiratoire de l'adulte (enzymologie)</term>
<term>Syndrome de détresse respiratoire de l'adulte (génétique)</term>
<term>Transgènes (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en">
<term>Oxygen</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en">
<term>Carboxypeptidases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en">
<term>Carboxypeptidases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en">
<term>Angiotensin II</term>
<term>Carboxypeptidases</term>
<term>Receptor, Angiotensin, Type 1</term>
<term>Receptor, Angiotensin, Type 2</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en">
<term>Acids</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr">
<term>Maladies pulmonaires</term>
<term>Oedème pulmonaire</term>
<term>Poumon</term>
<term>Sepsie</term>
<term>Syndrome de détresse respiratoire de l'adulte</term>
</keywords>
<keywords scheme="MESH" qualifier="déficit" xml:lang="fr">
<term>Carboxypeptidases</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr">
<term>Maladies pulmonaires</term>
<term>Sepsie</term>
<term>Syndrome de détresse respiratoire de l'adulte</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en">
<term>Lung Diseases</term>
<term>Respiratory Distress Syndrome, Adult</term>
<term>Sepsis</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en">
<term>Lung Diseases</term>
<term>Respiratory Distress Syndrome, Adult</term>
<term>Sepsis</term>
<term>Transgenes</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr">
<term>Carboxypeptidases</term>
<term>Maladies pulmonaires</term>
<term>Sepsie</term>
<term>Syndrome de détresse respiratoire de l'adulte</term>
<term>Transgènes</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr">
<term>Angiotensine-II</term>
<term>Carboxypeptidases</term>
<term>Récepteur de type 1 à l'angiotensine-II</term>
<term>Récepteur de type 2 à l'angiotensine-II</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>Lung</term>
<term>Lung Diseases</term>
<term>Pulmonary Edema</term>
<term>Respiratory Distress Syndrome, Adult</term>
<term>Sepsis</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr">
<term>Acides</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr">
<term>Maladies pulmonaires</term>
<term>Oedème pulmonaire</term>
<term>Poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en">
<term>Lung</term>
<term>Lung Diseases</term>
<term>Pulmonary Edema</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr">
<term>Oxygène</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Acute Disease</term>
<term>Analysis of Variance</term>
<term>Animals</term>
<term>Capillary Permeability</term>
<term>Disease Models, Animal</term>
<term>Gene Deletion</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Knockout</term>
<term>Mice, Transgenic</term>
<term>Peptidyl-Dipeptidase A</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Analyse de variance</term>
<term>Animaux</term>
<term>Délétion de gène</term>
<term>Humains</term>
<term>Maladie aigüe</term>
<term>Modèles animaux de maladie humaine</term>
<term>Peptidyl-Dipeptidase A</term>
<term>Perméabilité capillaire</term>
<term>Souris</term>
<term>Souris knockout</term>
<term>Souris transgéniques</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<title>Drug hope for SARS</title>
<p id="Par1">The SARS (severe acute respiratory syndrome) epidemic of 2003 caused almost 800 deaths, many of them due to acute respiratory distress syndrome (ARDS) as a complication. There are no effective drugs available for treating ARDS, but new work in mice suggests that ACE2 (angiotensin-converting enzyme 2) might be an option. ACE2 can protect mice from lung injury in an ARDS-like syndrome, whereas other components of the renin–angiotensin system for controlling blood pressure and salt balance actually make the condition worse. ACE2 is expressed in the healthy lung but downregulated by lung injury and it was shown recently (
<italic>Nature</italic>
<bold>426</bold>
, 450–454; 2003) to be a receptor for the SARS coronavirus.</p>
<sec>
<title>Supplementary information</title>
<p>The online version of this article (doi:10.1038/nature03712) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
<back>
<div1 type="bibliography">
<listBibl>
<biblStruct>
<analytic>
<author>
<name sortKey="Hudson, Ld" uniqKey="Hudson L">LD Hudson</name>
</author>
<author>
<name sortKey="Milberg, Ja" uniqKey="Milberg J">JA Milberg</name>
</author>
<author>
<name sortKey="Anardi, D" uniqKey="Anardi D">D Anardi</name>
</author>
<author>
<name sortKey="Maunder, Rj" uniqKey="Maunder R">RJ Maunder</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Ware, Lb" uniqKey="Ware L">LB Ware</name>
</author>
<author>
<name sortKey="Matthay, Ma" uniqKey="Matthay M">MA Matthay</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Vincent, Jl" uniqKey="Vincent J">JL Vincent</name>
</author>
<author>
<name sortKey="Sakr, Y" uniqKey="Sakr Y">Y Sakr</name>
</author>
<author>
<name sortKey="Ranieri, Vm" uniqKey="Ranieri V">VM Ranieri</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Ksiazek, Tg" uniqKey="Ksiazek T">TG Ksiazek</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Donoghue, M" uniqKey="Donoghue M">M Donoghue</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Tipnis, Sr" uniqKey="Tipnis S">SR Tipnis</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Crackower, Ma" uniqKey="Crackower M">MA Crackower</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Li, W" uniqKey="Li W">W Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Hamming, I" uniqKey="Hamming I">I Hamming</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Skeggs, Lt" uniqKey="Skeggs L">LT Skeggs</name>
</author>
<author>
<name sortKey="Dorer, Fe" uniqKey="Dorer F">FE Dorer</name>
</author>
<author>
<name sortKey="Levine, M" uniqKey="Levine M">M Levine</name>
</author>
<author>
<name sortKey="Lentz, Ke" uniqKey="Lentz K">KE Lentz</name>
</author>
<author>
<name sortKey="Kahn, Jr" uniqKey="Kahn J">JR Kahn</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Corvol, P" uniqKey="Corvol P">P Corvol</name>
</author>
<author>
<name sortKey="Williams, Ta" uniqKey="Williams T">TA Williams</name>
</author>
<author>
<name sortKey="Soubrier, F" uniqKey="Soubrier F">F Soubrier</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Boehm, M" uniqKey="Boehm M">M Boehm</name>
</author>
<author>
<name sortKey="Nabel, Eg" uniqKey="Nabel E">EG Nabel</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Tsang, Kw" uniqKey="Tsang K">KW Tsang</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Lee, N" uniqKey="Lee N">N Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Poutanen, Sm" uniqKey="Poutanen S">SM Poutanen</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Tran, Th" uniqKey="Tran T">TH Tran</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Nagase, T" uniqKey="Nagase T">T Nagase</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Imai, Y" uniqKey="Imai Y">Y Imai</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Martin, El" uniqKey="Martin E">EL Martin</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Krege, Jh" uniqKey="Krege J">JH Krege</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Inagami, T" uniqKey="Inagami T">T Inagami</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Gasc, Jm" uniqKey="Gasc J">JM Gasc</name>
</author>
<author>
<name sortKey="Shanmugam, S" uniqKey="Shanmugam S">S Shanmugam</name>
</author>
<author>
<name sortKey="Sibony, M" uniqKey="Sibony M">M Sibony</name>
</author>
<author>
<name sortKey="Corvol, P" uniqKey="Corvol P">P Corvol</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Sugaya, T" uniqKey="Sugaya T">T Sugaya</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Hein, L" uniqKey="Hein L">L Hein</name>
</author>
<author>
<name sortKey="Barsh, Gs" uniqKey="Barsh G">GS Barsh</name>
</author>
<author>
<name sortKey="Pratt, Re" uniqKey="Pratt R">RE Pratt</name>
</author>
<author>
<name sortKey="Dzau, Vj" uniqKey="Dzau V">VJ Dzau</name>
</author>
<author>
<name sortKey="Kobilka, Bk" uniqKey="Kobilka B">BK Kobilka</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Plante, Ge" uniqKey="Plante G">GE Plante</name>
</author>
<author>
<name sortKey="Chakir, M" uniqKey="Chakir M">M Chakir</name>
</author>
<author>
<name sortKey="Ettaouil, K" uniqKey="Ettaouil K">K Ettaouil</name>
</author>
<author>
<name sortKey="Lehoux, S" uniqKey="Lehoux S">S Lehoux</name>
</author>
<author>
<name sortKey="Sirois, P" uniqKey="Sirois P">P Sirois</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Roy, Bj" uniqKey="Roy B">BJ Roy</name>
</author>
<author>
<name sortKey="Pitts, Vh" uniqKey="Pitts V">VH Pitts</name>
</author>
<author>
<name sortKey="Townsley, Mi" uniqKey="Townsley M">MI Townsley</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Goggel, R" uniqKey="Goggel R">R Goggel</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Hansen, Tn" uniqKey="Hansen T">TN Hansen</name>
</author>
<author>
<name sortKey="Le Blanc, Al" uniqKey="Le Blanc A">AL Le Blanc</name>
</author>
<author>
<name sortKey="Gest, Al" uniqKey="Gest A">AL Gest</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Marshall, Rp" uniqKey="Marshall R">RP Marshall</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<double pmid="16001071">
<pmc>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Angiotensin-converting enzyme 2 protects from severe acute lung failure</title>
<author>
<name sortKey="Imai, Yumiko" sort="Imai, Yumiko" uniqKey="Imai Y" first="Yumiko" last="Imai">Yumiko Imai</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.417521.4</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 0008 2788</institution-id>
<institution>IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences,</institution>
</institution-wrap>
A-1030 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A-1030 Vienna</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kuba, Keiji" sort="Kuba, Keiji" uniqKey="Kuba K" first="Keiji" last="Kuba">Keiji Kuba</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.417521.4</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 0008 2788</institution-id>
<institution>IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences,</institution>
</institution-wrap>
A-1030 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A-1030 Vienna</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Rao, Shuan" sort="Rao, Shuan" uniqKey="Rao S" first="Shuan" last="Rao">Shuan Rao</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff2">National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing</wicri:regionArea>
<placeName>
<settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Huan, Yi" sort="Huan, Yi" uniqKey="Huan Y" first="Yi" last="Huan">Yi Huan</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff2">National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing</wicri:regionArea>
<placeName>
<settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Guo, Feng" sort="Guo, Feng" uniqKey="Guo F" first="Feng" last="Guo">Feng Guo</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff2">National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing</wicri:regionArea>
<placeName>
<settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Guan, Bin" sort="Guan, Bin" uniqKey="Guan B" first="Bin" last="Guan">Bin Guan</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff2">National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing</wicri:regionArea>
<placeName>
<settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Yang, Peng" sort="Yang, Peng" uniqKey="Yang P" first="Peng" last="Yang">Peng Yang</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff2">National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing</wicri:regionArea>
<placeName>
<settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Sarao, Renu" sort="Sarao, Renu" uniqKey="Sarao R" first="Renu" last="Sarao">Renu Sarao</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.417521.4</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 0008 2788</institution-id>
<institution>IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences,</institution>
</institution-wrap>
A-1030 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A-1030 Vienna</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wada, Teiji" sort="Wada, Teiji" uniqKey="Wada T" first="Teiji" last="Wada">Teiji Wada</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.417521.4</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 0008 2788</institution-id>
<institution>IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences,</institution>
</institution-wrap>
A-1030 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A-1030 Vienna</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Leong Poi, Howard" sort="Leong Poi, Howard" uniqKey="Leong Poi H" first="Howard" last="Leong-Poi">Howard Leong-Poi</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff3">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.415502.7</institution-id>
<institution>Department of Cardiology,</institution>
<institution>St. Michael's Hospital,</institution>
</institution-wrap>
Ontario M5B 1W8 Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Ontario M5B 1W8 Toronto</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Crackower, Michael A" sort="Crackower, Michael A" uniqKey="Crackower M" first="Michael A." last="Crackower">Michael A. Crackower</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff4">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.292545.d</institution-id>
<institution>Department of Biochemistry and Molecular Biology,</institution>
<institution>Merck Frosst Centre for Therapeutic Research,</institution>
</institution-wrap>
Quebec H3R 4P8 Montreal, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Quebec H3R 4P8 Montreal</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Fukamizu, Akiyoshi" sort="Fukamizu, Akiyoshi" uniqKey="Fukamizu A" first="Akiyoshi" last="Fukamizu">Akiyoshi Fukamizu</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff5">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.20515.33</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 2369 4728</institution-id>
<institution>Center for Tsukuba Advanced Research Alliance,</institution>
<institution>University of Tsukuba,</institution>
</institution-wrap>
305-8577 Tsukuba, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>305-8577 Tsukuba</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hui, Chi Chung" sort="Hui, Chi Chung" uniqKey="Hui C" first="Chi-Chung" last="Hui">Chi-Chung Hui</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff6">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.17063.33</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 2157 2938</institution-id>
<institution>Program in Developmental Biology, The Hospital for Sick Children and Department of Molecular and Medical Genetics,</institution>
<institution>University of Toronto,</institution>
</institution-wrap>
Ontario MG5 1X8 Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Ontario MG5 1X8 Toronto</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hein, Lutz" sort="Hein, Lutz" uniqKey="Hein L" first="Lutz" last="Hein">Lutz Hein</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff7">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.5963.9</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Freiburg,</institution>
</institution-wrap>
79104 Freiburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>79104 Freiburg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Uhlig, Stefan" sort="Uhlig, Stefan" uniqKey="Uhlig S" first="Stefan" last="Uhlig">Stefan Uhlig</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff8">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.418187.3</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 0493 9170</institution-id>
<institution>Division of Pulmonary Pharmacology,</institution>
<institution>Research Center Borstel,</institution>
</institution-wrap>
23845 Borstel, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>23845 Borstel</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Slutsky, Arthur S" sort="Slutsky, Arthur S" uniqKey="Slutsky A" first="Arthur S." last="Slutsky">Arthur S. Slutsky</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff9">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.17063.33</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 2157 2938</institution-id>
<institution>Department of Medicine and Interdepartmental Division of Critical Care,</institution>
<institution>University of Toronto, St. Michael's Hospital,</institution>
</institution-wrap>
Ontario M5B 1W8 Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Ontario M5B 1W8 Toronto</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Jiang, Chengyu" sort="Jiang, Chengyu" uniqKey="Jiang C" first="Chengyu" last="Jiang">Chengyu Jiang</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff2">National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing</wicri:regionArea>
<placeName>
<settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Penninger, Josef M" sort="Penninger, Josef M" uniqKey="Penninger J" first="Josef M." last="Penninger">Josef M. Penninger</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.417521.4</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 0008 2788</institution-id>
<institution>IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences,</institution>
</institution-wrap>
A-1030 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A-1030 Vienna</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PMC</idno>
<idno type="pmid">16001071</idno>
<idno type="pmc">7094998</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094998</idno>
<idno type="RBID">PMC:7094998</idno>
<idno type="doi">10.1038/nature03712</idno>
<date when="2005">2005</date>
<idno type="wicri:Area/Pmc/Corpus">000448</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000448</idno>
<idno type="wicri:Area/Pmc/Curation">000448</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000448</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001393</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001393</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en" level="a" type="main">Angiotensin-converting enzyme 2 protects from severe acute lung failure</title>
<author>
<name sortKey="Imai, Yumiko" sort="Imai, Yumiko" uniqKey="Imai Y" first="Yumiko" last="Imai">Yumiko Imai</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.417521.4</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 0008 2788</institution-id>
<institution>IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences,</institution>
</institution-wrap>
A-1030 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A-1030 Vienna</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kuba, Keiji" sort="Kuba, Keiji" uniqKey="Kuba K" first="Keiji" last="Kuba">Keiji Kuba</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.417521.4</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 0008 2788</institution-id>
<institution>IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences,</institution>
</institution-wrap>
A-1030 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A-1030 Vienna</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Rao, Shuan" sort="Rao, Shuan" uniqKey="Rao S" first="Shuan" last="Rao">Shuan Rao</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff2">National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing</wicri:regionArea>
<placeName>
<settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Huan, Yi" sort="Huan, Yi" uniqKey="Huan Y" first="Yi" last="Huan">Yi Huan</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff2">National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing</wicri:regionArea>
<placeName>
<settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Guo, Feng" sort="Guo, Feng" uniqKey="Guo F" first="Feng" last="Guo">Feng Guo</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff2">National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing</wicri:regionArea>
<placeName>
<settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Guan, Bin" sort="Guan, Bin" uniqKey="Guan B" first="Bin" last="Guan">Bin Guan</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff2">National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing</wicri:regionArea>
<placeName>
<settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Yang, Peng" sort="Yang, Peng" uniqKey="Yang P" first="Peng" last="Yang">Peng Yang</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff2">National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing</wicri:regionArea>
<placeName>
<settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Sarao, Renu" sort="Sarao, Renu" uniqKey="Sarao R" first="Renu" last="Sarao">Renu Sarao</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.417521.4</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 0008 2788</institution-id>
<institution>IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences,</institution>
</institution-wrap>
A-1030 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A-1030 Vienna</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wada, Teiji" sort="Wada, Teiji" uniqKey="Wada T" first="Teiji" last="Wada">Teiji Wada</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.417521.4</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 0008 2788</institution-id>
<institution>IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences,</institution>
</institution-wrap>
A-1030 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A-1030 Vienna</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Leong Poi, Howard" sort="Leong Poi, Howard" uniqKey="Leong Poi H" first="Howard" last="Leong-Poi">Howard Leong-Poi</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff3">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.415502.7</institution-id>
<institution>Department of Cardiology,</institution>
<institution>St. Michael's Hospital,</institution>
</institution-wrap>
Ontario M5B 1W8 Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Ontario M5B 1W8 Toronto</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Crackower, Michael A" sort="Crackower, Michael A" uniqKey="Crackower M" first="Michael A." last="Crackower">Michael A. Crackower</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff4">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.292545.d</institution-id>
<institution>Department of Biochemistry and Molecular Biology,</institution>
<institution>Merck Frosst Centre for Therapeutic Research,</institution>
</institution-wrap>
Quebec H3R 4P8 Montreal, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Quebec H3R 4P8 Montreal</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Fukamizu, Akiyoshi" sort="Fukamizu, Akiyoshi" uniqKey="Fukamizu A" first="Akiyoshi" last="Fukamizu">Akiyoshi Fukamizu</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff5">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.20515.33</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 2369 4728</institution-id>
<institution>Center for Tsukuba Advanced Research Alliance,</institution>
<institution>University of Tsukuba,</institution>
</institution-wrap>
305-8577 Tsukuba, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>305-8577 Tsukuba</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hui, Chi Chung" sort="Hui, Chi Chung" uniqKey="Hui C" first="Chi-Chung" last="Hui">Chi-Chung Hui</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff6">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.17063.33</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 2157 2938</institution-id>
<institution>Program in Developmental Biology, The Hospital for Sick Children and Department of Molecular and Medical Genetics,</institution>
<institution>University of Toronto,</institution>
</institution-wrap>
Ontario MG5 1X8 Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Ontario MG5 1X8 Toronto</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hein, Lutz" sort="Hein, Lutz" uniqKey="Hein L" first="Lutz" last="Hein">Lutz Hein</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff7">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.5963.9</institution-id>
<institution>Department of Pharmacology,</institution>
<institution>University of Freiburg,</institution>
</institution-wrap>
79104 Freiburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>79104 Freiburg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Uhlig, Stefan" sort="Uhlig, Stefan" uniqKey="Uhlig S" first="Stefan" last="Uhlig">Stefan Uhlig</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff8">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.418187.3</institution-id>
<institution-id institution-id-type="ISNI">0000 0004 0493 9170</institution-id>
<institution>Division of Pulmonary Pharmacology,</institution>
<institution>Research Center Borstel,</institution>
</institution-wrap>
23845 Borstel, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>23845 Borstel</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Slutsky, Arthur S" sort="Slutsky, Arthur S" uniqKey="Slutsky A" first="Arthur S." last="Slutsky">Arthur S. Slutsky</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff9">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.17063.33</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 2157 2938</institution-id>
<institution>Department of Medicine and Interdepartmental Division of Critical Care,</institution>
<institution>University of Toronto, St. Michael's Hospital,</institution>
</institution-wrap>
Ontario M5B 1W8 Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Ontario M5B 1W8 Toronto</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Jiang, Chengyu" sort="Jiang, Chengyu" uniqKey="Jiang C" first="Chengyu" last="Jiang">Chengyu Jiang</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff2">National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing</wicri:regionArea>
<placeName>
<settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Penninger, Josef M" sort="Penninger, Josef M" uniqKey="Penninger J" first="Josef M." last="Penninger">Josef M. Penninger</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.417521.4</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 0008 2788</institution-id>
<institution>IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences,</institution>
</institution-wrap>
A-1030 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>A-1030 Vienna</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Nature</title>
<idno type="ISSN">0028-0836</idno>
<idno type="eISSN">1476-4687</idno>
<imprint>
<date when="2005">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<title>Drug hope for SARS</title>
<p id="Par1">The SARS (severe acute respiratory syndrome) epidemic of 2003 caused almost 800 deaths, many of them due to acute respiratory distress syndrome (ARDS) as a complication. There are no effective drugs available for treating ARDS, but new work in mice suggests that ACE2 (angiotensin-converting enzyme 2) might be an option. ACE2 can protect mice from lung injury in an ARDS-like syndrome, whereas other components of the renin–angiotensin system for controlling blood pressure and salt balance actually make the condition worse. ACE2 is expressed in the healthy lung but downregulated by lung injury and it was shown recently (
<italic>Nature</italic>
<bold>426</bold>
, 450–454; 2003) to be a receptor for the SARS coronavirus.</p>
<sec>
<title>Supplementary information</title>
<p>The online version of this article (doi:10.1038/nature03712) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
<back>
<div1 type="bibliography">
<listBibl>
<biblStruct>
<analytic>
<author>
<name sortKey="Hudson, Ld" uniqKey="Hudson L">LD Hudson</name>
</author>
<author>
<name sortKey="Milberg, Ja" uniqKey="Milberg J">JA Milberg</name>
</author>
<author>
<name sortKey="Anardi, D" uniqKey="Anardi D">D Anardi</name>
</author>
<author>
<name sortKey="Maunder, Rj" uniqKey="Maunder R">RJ Maunder</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Ware, Lb" uniqKey="Ware L">LB Ware</name>
</author>
<author>
<name sortKey="Matthay, Ma" uniqKey="Matthay M">MA Matthay</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Vincent, Jl" uniqKey="Vincent J">JL Vincent</name>
</author>
<author>
<name sortKey="Sakr, Y" uniqKey="Sakr Y">Y Sakr</name>
</author>
<author>
<name sortKey="Ranieri, Vm" uniqKey="Ranieri V">VM Ranieri</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Ksiazek, Tg" uniqKey="Ksiazek T">TG Ksiazek</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Donoghue, M" uniqKey="Donoghue M">M Donoghue</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Tipnis, Sr" uniqKey="Tipnis S">SR Tipnis</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Crackower, Ma" uniqKey="Crackower M">MA Crackower</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Li, W" uniqKey="Li W">W Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Hamming, I" uniqKey="Hamming I">I Hamming</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Skeggs, Lt" uniqKey="Skeggs L">LT Skeggs</name>
</author>
<author>
<name sortKey="Dorer, Fe" uniqKey="Dorer F">FE Dorer</name>
</author>
<author>
<name sortKey="Levine, M" uniqKey="Levine M">M Levine</name>
</author>
<author>
<name sortKey="Lentz, Ke" uniqKey="Lentz K">KE Lentz</name>
</author>
<author>
<name sortKey="Kahn, Jr" uniqKey="Kahn J">JR Kahn</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Corvol, P" uniqKey="Corvol P">P Corvol</name>
</author>
<author>
<name sortKey="Williams, Ta" uniqKey="Williams T">TA Williams</name>
</author>
<author>
<name sortKey="Soubrier, F" uniqKey="Soubrier F">F Soubrier</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Boehm, M" uniqKey="Boehm M">M Boehm</name>
</author>
<author>
<name sortKey="Nabel, Eg" uniqKey="Nabel E">EG Nabel</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Tsang, Kw" uniqKey="Tsang K">KW Tsang</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Lee, N" uniqKey="Lee N">N Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Poutanen, Sm" uniqKey="Poutanen S">SM Poutanen</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Tran, Th" uniqKey="Tran T">TH Tran</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Nagase, T" uniqKey="Nagase T">T Nagase</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Imai, Y" uniqKey="Imai Y">Y Imai</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Martin, El" uniqKey="Martin E">EL Martin</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Krege, Jh" uniqKey="Krege J">JH Krege</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Inagami, T" uniqKey="Inagami T">T Inagami</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Gasc, Jm" uniqKey="Gasc J">JM Gasc</name>
</author>
<author>
<name sortKey="Shanmugam, S" uniqKey="Shanmugam S">S Shanmugam</name>
</author>
<author>
<name sortKey="Sibony, M" uniqKey="Sibony M">M Sibony</name>
</author>
<author>
<name sortKey="Corvol, P" uniqKey="Corvol P">P Corvol</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Sugaya, T" uniqKey="Sugaya T">T Sugaya</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Hein, L" uniqKey="Hein L">L Hein</name>
</author>
<author>
<name sortKey="Barsh, Gs" uniqKey="Barsh G">GS Barsh</name>
</author>
<author>
<name sortKey="Pratt, Re" uniqKey="Pratt R">RE Pratt</name>
</author>
<author>
<name sortKey="Dzau, Vj" uniqKey="Dzau V">VJ Dzau</name>
</author>
<author>
<name sortKey="Kobilka, Bk" uniqKey="Kobilka B">BK Kobilka</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Plante, Ge" uniqKey="Plante G">GE Plante</name>
</author>
<author>
<name sortKey="Chakir, M" uniqKey="Chakir M">M Chakir</name>
</author>
<author>
<name sortKey="Ettaouil, K" uniqKey="Ettaouil K">K Ettaouil</name>
</author>
<author>
<name sortKey="Lehoux, S" uniqKey="Lehoux S">S Lehoux</name>
</author>
<author>
<name sortKey="Sirois, P" uniqKey="Sirois P">P Sirois</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Roy, Bj" uniqKey="Roy B">BJ Roy</name>
</author>
<author>
<name sortKey="Pitts, Vh" uniqKey="Pitts V">VH Pitts</name>
</author>
<author>
<name sortKey="Townsley, Mi" uniqKey="Townsley M">MI Townsley</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Goggel, R" uniqKey="Goggel R">R Goggel</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Hansen, Tn" uniqKey="Hansen T">TN Hansen</name>
</author>
<author>
<name sortKey="Le Blanc, Al" uniqKey="Le Blanc A">AL Le Blanc</name>
</author>
<author>
<name sortKey="Gest, Al" uniqKey="Gest A">AL Gest</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Marshall, Rp" uniqKey="Marshall R">RP Marshall</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</pmc>
<pubmed>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Angiotensin-converting enzyme 2 protects from severe acute lung failure.</title>
<author>
<name sortKey="Imai, Yumiko" sort="Imai, Yumiko" uniqKey="Imai Y" first="Yumiko" last="Imai">Yumiko Imai</name>
<affiliation wicri:level="1">
<nlm:affiliation>IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna A-1030, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna A-1030</wicri:regionArea>
<placeName>
<settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kuba, Keiji" sort="Kuba, Keiji" uniqKey="Kuba K" first="Keiji" last="Kuba">Keiji Kuba</name>
</author>
<author>
<name sortKey="Rao, Shuan" sort="Rao, Shuan" uniqKey="Rao S" first="Shuan" last="Rao">Shuan Rao</name>
</author>
<author>
<name sortKey="Huan, Yi" sort="Huan, Yi" uniqKey="Huan Y" first="Yi" last="Huan">Yi Huan</name>
</author>
<author>
<name sortKey="Guo, Feng" sort="Guo, Feng" uniqKey="Guo F" first="Feng" last="Guo">Feng Guo</name>
</author>
<author>
<name sortKey="Guan, Bin" sort="Guan, Bin" uniqKey="Guan B" first="Bin" last="Guan">Bin Guan</name>
</author>
<author>
<name sortKey="Yang, Peng" sort="Yang, Peng" uniqKey="Yang P" first="Peng" last="Yang">Peng Yang</name>
</author>
<author>
<name sortKey="Sarao, Renu" sort="Sarao, Renu" uniqKey="Sarao R" first="Renu" last="Sarao">Renu Sarao</name>
</author>
<author>
<name sortKey="Wada, Teiji" sort="Wada, Teiji" uniqKey="Wada T" first="Teiji" last="Wada">Teiji Wada</name>
</author>
<author>
<name sortKey="Leong Poi, Howard" sort="Leong Poi, Howard" uniqKey="Leong Poi H" first="Howard" last="Leong-Poi">Howard Leong-Poi</name>
</author>
<author>
<name sortKey="Crackower, Michael A" sort="Crackower, Michael A" uniqKey="Crackower M" first="Michael A" last="Crackower">Michael A. Crackower</name>
</author>
<author>
<name sortKey="Fukamizu, Akiyoshi" sort="Fukamizu, Akiyoshi" uniqKey="Fukamizu A" first="Akiyoshi" last="Fukamizu">Akiyoshi Fukamizu</name>
</author>
<author>
<name sortKey="Hui, Chi Chung" sort="Hui, Chi Chung" uniqKey="Hui C" first="Chi-Chung" last="Hui">Chi-Chung Hui</name>
</author>
<author>
<name sortKey="Hein, Lutz" sort="Hein, Lutz" uniqKey="Hein L" first="Lutz" last="Hein">Lutz Hein</name>
</author>
<author>
<name sortKey="Uhlig, Stefan" sort="Uhlig, Stefan" uniqKey="Uhlig S" first="Stefan" last="Uhlig">Stefan Uhlig</name>
</author>
<author>
<name sortKey="Slutsky, Arthur S" sort="Slutsky, Arthur S" uniqKey="Slutsky A" first="Arthur S" last="Slutsky">Arthur S. Slutsky</name>
</author>
<author>
<name sortKey="Jiang, Chengyu" sort="Jiang, Chengyu" uniqKey="Jiang C" first="Chengyu" last="Jiang">Chengyu Jiang</name>
</author>
<author>
<name sortKey="Penninger, Josef M" sort="Penninger, Josef M" uniqKey="Penninger J" first="Josef M" last="Penninger">Josef M. Penninger</name>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PubMed</idno>
<date when="2005">2005</date>
<idno type="RBID">pubmed:16001071</idno>
<idno type="pmid">16001071</idno>
<idno type="doi">10.1038/nature03712</idno>
<idno type="wicri:Area/PubMed/Corpus">002654</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002654</idno>
<idno type="wicri:Area/PubMed/Curation">002654</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002654</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002833</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002833</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en">Angiotensin-converting enzyme 2 protects from severe acute lung failure.</title>
<author>
<name sortKey="Imai, Yumiko" sort="Imai, Yumiko" uniqKey="Imai Y" first="Yumiko" last="Imai">Yumiko Imai</name>
<affiliation wicri:level="1">
<nlm:affiliation>IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna A-1030, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna A-1030</wicri:regionArea>
<placeName>
<settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kuba, Keiji" sort="Kuba, Keiji" uniqKey="Kuba K" first="Keiji" last="Kuba">Keiji Kuba</name>
</author>
<author>
<name sortKey="Rao, Shuan" sort="Rao, Shuan" uniqKey="Rao S" first="Shuan" last="Rao">Shuan Rao</name>
</author>
<author>
<name sortKey="Huan, Yi" sort="Huan, Yi" uniqKey="Huan Y" first="Yi" last="Huan">Yi Huan</name>
</author>
<author>
<name sortKey="Guo, Feng" sort="Guo, Feng" uniqKey="Guo F" first="Feng" last="Guo">Feng Guo</name>
</author>
<author>
<name sortKey="Guan, Bin" sort="Guan, Bin" uniqKey="Guan B" first="Bin" last="Guan">Bin Guan</name>
</author>
<author>
<name sortKey="Yang, Peng" sort="Yang, Peng" uniqKey="Yang P" first="Peng" last="Yang">Peng Yang</name>
</author>
<author>
<name sortKey="Sarao, Renu" sort="Sarao, Renu" uniqKey="Sarao R" first="Renu" last="Sarao">Renu Sarao</name>
</author>
<author>
<name sortKey="Wada, Teiji" sort="Wada, Teiji" uniqKey="Wada T" first="Teiji" last="Wada">Teiji Wada</name>
</author>
<author>
<name sortKey="Leong Poi, Howard" sort="Leong Poi, Howard" uniqKey="Leong Poi H" first="Howard" last="Leong-Poi">Howard Leong-Poi</name>
</author>
<author>
<name sortKey="Crackower, Michael A" sort="Crackower, Michael A" uniqKey="Crackower M" first="Michael A" last="Crackower">Michael A. Crackower</name>
</author>
<author>
<name sortKey="Fukamizu, Akiyoshi" sort="Fukamizu, Akiyoshi" uniqKey="Fukamizu A" first="Akiyoshi" last="Fukamizu">Akiyoshi Fukamizu</name>
</author>
<author>
<name sortKey="Hui, Chi Chung" sort="Hui, Chi Chung" uniqKey="Hui C" first="Chi-Chung" last="Hui">Chi-Chung Hui</name>
</author>
<author>
<name sortKey="Hein, Lutz" sort="Hein, Lutz" uniqKey="Hein L" first="Lutz" last="Hein">Lutz Hein</name>
</author>
<author>
<name sortKey="Uhlig, Stefan" sort="Uhlig, Stefan" uniqKey="Uhlig S" first="Stefan" last="Uhlig">Stefan Uhlig</name>
</author>
<author>
<name sortKey="Slutsky, Arthur S" sort="Slutsky, Arthur S" uniqKey="Slutsky A" first="Arthur S" last="Slutsky">Arthur S. Slutsky</name>
</author>
<author>
<name sortKey="Jiang, Chengyu" sort="Jiang, Chengyu" uniqKey="Jiang C" first="Chengyu" last="Jiang">Chengyu Jiang</name>
</author>
<author>
<name sortKey="Penninger, Josef M" sort="Penninger, Josef M" uniqKey="Penninger J" first="Josef M" last="Penninger">Josef M. Penninger</name>
</author>
</analytic>
<series>
<title level="j">Nature</title>
<idno type="eISSN">1476-4687</idno>
<imprint>
<date when="2005" type="published">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Acids (pharmacology)</term>
<term>Acute Disease</term>
<term>Analysis of Variance</term>
<term>Angiotensin II (metabolism)</term>
<term>Animals</term>
<term>Capillary Permeability</term>
<term>Carboxypeptidases (deficiency)</term>
<term>Carboxypeptidases (genetics)</term>
<term>Carboxypeptidases (metabolism)</term>
<term>Disease Models, Animal</term>
<term>Gene Deletion</term>
<term>Humans</term>
<term>Lung (pathology)</term>
<term>Lung (physiopathology)</term>
<term>Lung Diseases (enzymology)</term>
<term>Lung Diseases (genetics)</term>
<term>Lung Diseases (pathology)</term>
<term>Lung Diseases (physiopathology)</term>
<term>Mice</term>
<term>Mice, Knockout</term>
<term>Mice, Transgenic</term>
<term>Oxygen (blood)</term>
<term>Peptidyl-Dipeptidase A</term>
<term>Pulmonary Edema (pathology)</term>
<term>Pulmonary Edema (physiopathology)</term>
<term>Receptor, Angiotensin, Type 1 (metabolism)</term>
<term>Receptor, Angiotensin, Type 2 (metabolism)</term>
<term>Respiratory Distress Syndrome, Adult (enzymology)</term>
<term>Respiratory Distress Syndrome, Adult (genetics)</term>
<term>Respiratory Distress Syndrome, Adult (pathology)</term>
<term>Sepsis (enzymology)</term>
<term>Sepsis (genetics)</term>
<term>Sepsis (pathology)</term>
<term>Transgenes (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Acides (pharmacologie)</term>
<term>Analyse de variance</term>
<term>Angiotensine-II (métabolisme)</term>
<term>Animaux</term>
<term>Carboxypeptidases (déficit)</term>
<term>Carboxypeptidases (génétique)</term>
<term>Carboxypeptidases (métabolisme)</term>
<term>Délétion de gène</term>
<term>Humains</term>
<term>Maladie aigüe</term>
<term>Maladies pulmonaires (anatomopathologie)</term>
<term>Maladies pulmonaires (enzymologie)</term>
<term>Maladies pulmonaires (génétique)</term>
<term>Maladies pulmonaires (physiopathologie)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Oedème pulmonaire (anatomopathologie)</term>
<term>Oedème pulmonaire (physiopathologie)</term>
<term>Oxygène (sang)</term>
<term>Peptidyl-Dipeptidase A</term>
<term>Perméabilité capillaire</term>
<term>Poumon (anatomopathologie)</term>
<term>Poumon (physiopathologie)</term>
<term>Récepteur de type 1 à l'angiotensine-II (métabolisme)</term>
<term>Récepteur de type 2 à l'angiotensine-II (métabolisme)</term>
<term>Sepsie (anatomopathologie)</term>
<term>Sepsie (enzymologie)</term>
<term>Sepsie (génétique)</term>
<term>Souris</term>
<term>Souris knockout</term>
<term>Souris transgéniques</term>
<term>Syndrome de détresse respiratoire de l'adulte (anatomopathologie)</term>
<term>Syndrome de détresse respiratoire de l'adulte (enzymologie)</term>
<term>Syndrome de détresse respiratoire de l'adulte (génétique)</term>
<term>Transgènes (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en">
<term>Oxygen</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en">
<term>Carboxypeptidases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en">
<term>Carboxypeptidases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en">
<term>Angiotensin II</term>
<term>Carboxypeptidases</term>
<term>Receptor, Angiotensin, Type 1</term>
<term>Receptor, Angiotensin, Type 2</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en">
<term>Acids</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr">
<term>Maladies pulmonaires</term>
<term>Oedème pulmonaire</term>
<term>Poumon</term>
<term>Sepsie</term>
<term>Syndrome de détresse respiratoire de l'adulte</term>
</keywords>
<keywords scheme="MESH" qualifier="déficit" xml:lang="fr">
<term>Carboxypeptidases</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr">
<term>Maladies pulmonaires</term>
<term>Sepsie</term>
<term>Syndrome de détresse respiratoire de l'adulte</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en">
<term>Lung Diseases</term>
<term>Respiratory Distress Syndrome, Adult</term>
<term>Sepsis</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en">
<term>Lung Diseases</term>
<term>Respiratory Distress Syndrome, Adult</term>
<term>Sepsis</term>
<term>Transgenes</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr">
<term>Carboxypeptidases</term>
<term>Maladies pulmonaires</term>
<term>Sepsie</term>
<term>Syndrome de détresse respiratoire de l'adulte</term>
<term>Transgènes</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr">
<term>Angiotensine-II</term>
<term>Carboxypeptidases</term>
<term>Récepteur de type 1 à l'angiotensine-II</term>
<term>Récepteur de type 2 à l'angiotensine-II</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>Lung</term>
<term>Lung Diseases</term>
<term>Pulmonary Edema</term>
<term>Respiratory Distress Syndrome, Adult</term>
<term>Sepsis</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr">
<term>Acides</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr">
<term>Maladies pulmonaires</term>
<term>Oedème pulmonaire</term>
<term>Poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en">
<term>Lung</term>
<term>Lung Diseases</term>
<term>Pulmonary Edema</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr">
<term>Oxygène</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Acute Disease</term>
<term>Analysis of Variance</term>
<term>Animals</term>
<term>Capillary Permeability</term>
<term>Disease Models, Animal</term>
<term>Gene Deletion</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Knockout</term>
<term>Mice, Transgenic</term>
<term>Peptidyl-Dipeptidase A</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Analyse de variance</term>
<term>Animaux</term>
<term>Délétion de gène</term>
<term>Humains</term>
<term>Maladie aigüe</term>
<term>Modèles animaux de maladie humaine</term>
<term>Peptidyl-Dipeptidase A</term>
<term>Perméabilité capillaire</term>
<term>Souris</term>
<term>Souris knockout</term>
<term>Souris transgéniques</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Acute respiratory distress syndrome (ARDS), the most severe form of acute lung injury, is a devastating clinical syndrome with a high mortality rate (30-60%) (refs 1-3). Predisposing factors for ARDS are diverse and include sepsis, aspiration, pneumonias and infections with the severe acute respiratory syndrome (SARS) coronavirus. At present, there are no effective drugs for improving the clinical outcome of ARDS. Angiotensin-converting enzyme (ACE) and ACE2 are homologues with different key functions in the renin-angiotensin system. ACE cleaves angiotensin I to generate angiotensin II, whereas ACE2 inactivates angiotensin II and is a negative regulator of the system. ACE2 has also recently been identified as a potential SARS virus receptor and is expressed in lungs. Here we report that ACE2 and the angiotensin II type 2 receptor (AT2) protect mice from severe acute lung injury induced by acid aspiration or sepsis. However, other components of the renin-angiotensin system, including ACE, angiotensin II and the angiotensin II type 1a receptor (AT1a), promote disease pathogenesis, induce lung oedemas and impair lung function. We show that mice deficient for Ace show markedly improved disease, and also that recombinant ACE2 can protect mice from severe acute lung injury. Our data identify a critical function for ACE2 in acute lung injury, pointing to a possible therapy for a syndrome affecting millions of people worldwide every year.</div>
</front>
</TEI>
</pubmed>
</double>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001045 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 001045 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    Ncbi
   |étape=   Merge
   |type=    RBID
   |clé=     PMC:7094998
   |texte=   Angiotensin-converting enzyme 2 protects from severe acute lung failure
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i   -Sk "pubmed:16001071" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a SrasV1 

Wicri

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021