The 3a protein of severe acute respiratory syndrome-associated coronavirus induces apoptosis in Vero E6 cells.
Identifieur interne : 001009 ( Ncbi/Merge ); précédent : 001008; suivant : 001010The 3a protein of severe acute respiratory syndrome-associated coronavirus induces apoptosis in Vero E6 cells.
Auteurs : Patrick T W. Law [République populaire de Chine] ; Chi-Hang Wong [République populaire de Chine] ; Thomas C C. Au [République populaire de Chine] ; Chi-Pang Chuck [République populaire de Chine] ; Siu-Kai Kong [République populaire de Chine] ; Paul K S. Chan [République populaire de Chine] ; Ka-Fai To [République populaire de Chine] ; Anthony W I. Lo [République populaire de Chine] ; Judy Y W. Chan [République populaire de Chine] ; Yick-Keung Suen [République populaire de Chine] ; H Y Edwin Chan [République populaire de Chine] ; Kwok-Pui Fung [République populaire de Chine] ; Mary M Y. Waye [République populaire de Chine] ; Joseph J Y. Sung [République populaire de Chine] ; Y M Dennis Lo [République populaire de Chine] ; Stephen K W. Tsui [République populaire de Chine]Source :
- The Journal of general virology [ 0022-1317 ] ; 2005.
Descripteurs français
- KwdFr :
- Animaux, Apoptose, Cellules Vero, Humains, Intestins (virologie), Muqueuse intestinale (métabolisme), Poumon (métabolisme), Poumon (virologie), Protéines virales (métabolisme), Réticulum endoplasmique (métabolisme), Réticulum endoplasmique (virologie), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (métabolisme), Virus du SRAS (pathogénicité).
- MESH :
- métabolisme : Muqueuse intestinale, Poumon, Protéines virales, Réticulum endoplasmique, Virus du SRAS.
- pathogénicité : Virus du SRAS.
- virologie : Intestins, Poumon, Réticulum endoplasmique, Syndrome respiratoire aigu sévère.
- Animaux, Apoptose, Cellules Vero, Humains.
English descriptors
- KwdEn :
- Animals, Apoptosis, Chlorocebus aethiops, Endoplasmic Reticulum (metabolism), Endoplasmic Reticulum (virology), Humans, Intestinal Mucosa (metabolism), Intestines (virology), Lung (metabolism), Lung (virology), SARS Virus (metabolism), SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (virology), Vero Cells, Viral Proteins (metabolism).
- MESH :
- chemical , metabolism : Viral Proteins.
- metabolism : Endoplasmic Reticulum, Intestinal Mucosa, Lung, SARS Virus.
- pathogenicity : SARS Virus.
- virology : Endoplasmic Reticulum, Intestines, Lung, Severe Acute Respiratory Syndrome.
- Animals, Apoptosis, Chlorocebus aethiops, Humans, Vero Cells.
Abstract
An outbreak of severe acute respiratory syndrome (SARS) occurred in China and the first case emerged in mid-November 2002. The aetiological agent of this disease was found to be a previously unknown coronavirus, SARS-associated coronavirus (SARS-CoV). The detailed pathology of SARS-CoV infection and the host response to the viral infection are still not known. The 3a gene encodes a non-structural viral protein, which is predicted to be a transmembrane protein. In this study, it was shown that the 3a protein was expressed in the lungs and intestinal tissues of SARS patients and that the protein localized to the endoplasmic reticulum in 3a-transfected monkey kidney Vero E6 cells. In vitro experiments of chromatin condensation and DNA fragmentation suggested that the 3a protein may trigger apoptosis. These data showed that overexpression of a single SARS-CoV protein can induce apoptosis in vitro.
DOI: 10.1099/vir.0.80813-0
PubMed: 15958670
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002685
- to stream PubMed, to step Curation: 002685
- to stream PubMed, to step Checkpoint: 002443
Links to Exploration step
pubmed:15958670Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The 3a protein of severe acute respiratory syndrome-associated coronavirus induces apoptosis in Vero E6 cells.</title>
<author><name sortKey="Law, Patrick T W" sort="Law, Patrick T W" uniqKey="Law P" first="Patrick T W" last="Law">Patrick T W. Law</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wong, Chi Hang" sort="Wong, Chi Hang" uniqKey="Wong C" first="Chi-Hang" last="Wong">Chi-Hang Wong</name>
<affiliation wicri:level="4"><nlm:affiliation>Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Au, Thomas C C" sort="Au, Thomas C C" uniqKey="Au T" first="Thomas C C" last="Au">Thomas C C. Au</name>
<affiliation wicri:level="4"><nlm:affiliation>Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chuck, Chi Pang" sort="Chuck, Chi Pang" uniqKey="Chuck C" first="Chi-Pang" last="Chuck">Chi-Pang Chuck</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kong, Siu Kai" sort="Kong, Siu Kai" uniqKey="Kong S" first="Siu-Kai" last="Kong">Siu-Kai Kong</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K S" last="Chan">Paul K S. Chan</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Microbiology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="To, Ka Fai" sort="To, Ka Fai" uniqKey="To K" first="Ka-Fai" last="To">Ka-Fai To</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lo, Anthony W I" sort="Lo, Anthony W I" uniqKey="Lo A" first="Anthony W I" last="Lo">Anthony W I. Lo</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chan, Judy Y W" sort="Chan, Judy Y W" uniqKey="Chan J" first="Judy Y W" last="Chan">Judy Y W. Chan</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Suen, Yick Keung" sort="Suen, Yick Keung" uniqKey="Suen Y" first="Yick-Keung" last="Suen">Yick-Keung Suen</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chan, H Y Edwin" sort="Chan, H Y Edwin" uniqKey="Chan H" first="H Y Edwin" last="Chan">H Y Edwin Chan</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fung, Kwok Pui" sort="Fung, Kwok Pui" uniqKey="Fung K" first="Kwok-Pui" last="Fung">Kwok-Pui Fung</name>
<affiliation wicri:level="4"><nlm:affiliation>The Croucher Laboratory for Human Genomics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The Croucher Laboratory for Human Genomics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Waye, Mary M Y" sort="Waye, Mary M Y" uniqKey="Waye M" first="Mary M Y" last="Waye">Mary M Y. Waye</name>
<affiliation wicri:level="4"><nlm:affiliation>The Croucher Laboratory for Human Genomics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The Croucher Laboratory for Human Genomics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sung, Joseph J Y" sort="Sung, Joseph J Y" uniqKey="Sung J" first="Joseph J Y" last="Sung">Joseph J Y. Sung</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lo, Y M Dennis" sort="Lo, Y M Dennis" uniqKey="Lo Y" first="Y M Dennis" last="Lo">Y M Dennis Lo</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tsui, Stephen K W" sort="Tsui, Stephen K W" uniqKey="Tsui S" first="Stephen K W" last="Tsui">Stephen K W. Tsui</name>
<affiliation wicri:level="4"><nlm:affiliation>The Croucher Laboratory for Human Genomics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The Croucher Laboratory for Human Genomics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2005">2005</date>
<idno type="RBID">pubmed:15958670</idno>
<idno type="pmid">15958670</idno>
<idno type="doi">10.1099/vir.0.80813-0</idno>
<idno type="wicri:Area/PubMed/Corpus">002685</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002685</idno>
<idno type="wicri:Area/PubMed/Curation">002685</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002685</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002443</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002443</idno>
<idno type="wicri:Area/Ncbi/Merge">001009</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">The 3a protein of severe acute respiratory syndrome-associated coronavirus induces apoptosis in Vero E6 cells.</title>
<author><name sortKey="Law, Patrick T W" sort="Law, Patrick T W" uniqKey="Law P" first="Patrick T W" last="Law">Patrick T W. Law</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wong, Chi Hang" sort="Wong, Chi Hang" uniqKey="Wong C" first="Chi-Hang" last="Wong">Chi-Hang Wong</name>
<affiliation wicri:level="4"><nlm:affiliation>Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Au, Thomas C C" sort="Au, Thomas C C" uniqKey="Au T" first="Thomas C C" last="Au">Thomas C C. Au</name>
<affiliation wicri:level="4"><nlm:affiliation>Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chuck, Chi Pang" sort="Chuck, Chi Pang" uniqKey="Chuck C" first="Chi-Pang" last="Chuck">Chi-Pang Chuck</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kong, Siu Kai" sort="Kong, Siu Kai" uniqKey="Kong S" first="Siu-Kai" last="Kong">Siu-Kai Kong</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K S" last="Chan">Paul K S. Chan</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Microbiology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="To, Ka Fai" sort="To, Ka Fai" uniqKey="To K" first="Ka-Fai" last="To">Ka-Fai To</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lo, Anthony W I" sort="Lo, Anthony W I" uniqKey="Lo A" first="Anthony W I" last="Lo">Anthony W I. Lo</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chan, Judy Y W" sort="Chan, Judy Y W" uniqKey="Chan J" first="Judy Y W" last="Chan">Judy Y W. Chan</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Suen, Yick Keung" sort="Suen, Yick Keung" uniqKey="Suen Y" first="Yick-Keung" last="Suen">Yick-Keung Suen</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chan, H Y Edwin" sort="Chan, H Y Edwin" uniqKey="Chan H" first="H Y Edwin" last="Chan">H Y Edwin Chan</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fung, Kwok Pui" sort="Fung, Kwok Pui" uniqKey="Fung K" first="Kwok-Pui" last="Fung">Kwok-Pui Fung</name>
<affiliation wicri:level="4"><nlm:affiliation>The Croucher Laboratory for Human Genomics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The Croucher Laboratory for Human Genomics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Waye, Mary M Y" sort="Waye, Mary M Y" uniqKey="Waye M" first="Mary M Y" last="Waye">Mary M Y. Waye</name>
<affiliation wicri:level="4"><nlm:affiliation>The Croucher Laboratory for Human Genomics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The Croucher Laboratory for Human Genomics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sung, Joseph J Y" sort="Sung, Joseph J Y" uniqKey="Sung J" first="Joseph J Y" last="Sung">Joseph J Y. Sung</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lo, Y M Dennis" sort="Lo, Y M Dennis" uniqKey="Lo Y" first="Y M Dennis" last="Lo">Y M Dennis Lo</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tsui, Stephen K W" sort="Tsui, Stephen K W" uniqKey="Tsui S" first="Stephen K W" last="Tsui">Stephen K W. Tsui</name>
<affiliation wicri:level="4"><nlm:affiliation>The Croucher Laboratory for Human Genomics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The Croucher Laboratory for Human Genomics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of general virology</title>
<idno type="ISSN">0022-1317</idno>
<imprint><date when="2005" type="published">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Apoptosis</term>
<term>Chlorocebus aethiops</term>
<term>Endoplasmic Reticulum (metabolism)</term>
<term>Endoplasmic Reticulum (virology)</term>
<term>Humans</term>
<term>Intestinal Mucosa (metabolism)</term>
<term>Intestines (virology)</term>
<term>Lung (metabolism)</term>
<term>Lung (virology)</term>
<term>SARS Virus (metabolism)</term>
<term>SARS Virus (pathogenicity)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Vero Cells</term>
<term>Viral Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Apoptose</term>
<term>Cellules Vero</term>
<term>Humains</term>
<term>Intestins (virologie)</term>
<term>Muqueuse intestinale (métabolisme)</term>
<term>Poumon (métabolisme)</term>
<term>Poumon (virologie)</term>
<term>Protéines virales (métabolisme)</term>
<term>Réticulum endoplasmique (métabolisme)</term>
<term>Réticulum endoplasmique (virologie)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Virus du SRAS (métabolisme)</term>
<term>Virus du SRAS (pathogénicité)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Endoplasmic Reticulum</term>
<term>Intestinal Mucosa</term>
<term>Lung</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Muqueuse intestinale</term>
<term>Poumon</term>
<term>Protéines virales</term>
<term>Réticulum endoplasmique</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Intestins</term>
<term>Poumon</term>
<term>Réticulum endoplasmique</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Endoplasmic Reticulum</term>
<term>Intestines</term>
<term>Lung</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Apoptosis</term>
<term>Chlorocebus aethiops</term>
<term>Humans</term>
<term>Vero Cells</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Apoptose</term>
<term>Cellules Vero</term>
<term>Humains</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">An outbreak of severe acute respiratory syndrome (SARS) occurred in China and the first case emerged in mid-November 2002. The aetiological agent of this disease was found to be a previously unknown coronavirus, SARS-associated coronavirus (SARS-CoV). The detailed pathology of SARS-CoV infection and the host response to the viral infection are still not known. The 3a gene encodes a non-structural viral protein, which is predicted to be a transmembrane protein. In this study, it was shown that the 3a protein was expressed in the lungs and intestinal tissues of SARS patients and that the protein localized to the endoplasmic reticulum in 3a-transfected monkey kidney Vero E6 cells. In vitro experiments of chromatin condensation and DNA fragmentation suggested that the 3a protein may trigger apoptosis. These data showed that overexpression of a single SARS-CoV protein can induce apoptosis in vitro.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15958670</PMID>
<DateCompleted><Year>2005</Year>
<Month>07</Month>
<Day>28</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>03</Month>
<Day>06</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-1317</ISSN>
<JournalIssue CitedMedium="Print"><Volume>86</Volume>
<Issue>Pt 7</Issue>
<PubDate><Year>2005</Year>
<Month>Jul</Month>
</PubDate>
</JournalIssue>
<Title>The Journal of general virology</Title>
<ISOAbbreviation>J. Gen. Virol.</ISOAbbreviation>
</Journal>
<ArticleTitle>The 3a protein of severe acute respiratory syndrome-associated coronavirus induces apoptosis in Vero E6 cells.</ArticleTitle>
<Pagination><MedlinePgn>1921-1930</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1099/vir.0.80813-0</ELocationID>
<Abstract><AbstractText>An outbreak of severe acute respiratory syndrome (SARS) occurred in China and the first case emerged in mid-November 2002. The aetiological agent of this disease was found to be a previously unknown coronavirus, SARS-associated coronavirus (SARS-CoV). The detailed pathology of SARS-CoV infection and the host response to the viral infection are still not known. The 3a gene encodes a non-structural viral protein, which is predicted to be a transmembrane protein. In this study, it was shown that the 3a protein was expressed in the lungs and intestinal tissues of SARS patients and that the protein localized to the endoplasmic reticulum in 3a-transfected monkey kidney Vero E6 cells. In vitro experiments of chromatin condensation and DNA fragmentation suggested that the 3a protein may trigger apoptosis. These data showed that overexpression of a single SARS-CoV protein can induce apoptosis in vitro.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Law</LastName>
<ForeName>Patrick T W</ForeName>
<Initials>PTW</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wong</LastName>
<ForeName>Chi-Hang</ForeName>
<Initials>CH</Initials>
<AffiliationInfo><Affiliation>Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Au</LastName>
<ForeName>Thomas C C</ForeName>
<Initials>TCC</Initials>
<AffiliationInfo><Affiliation>Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chuck</LastName>
<ForeName>Chi-Pang</ForeName>
<Initials>CP</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kong</LastName>
<ForeName>Siu-Kai</ForeName>
<Initials>SK</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chan</LastName>
<ForeName>Paul K S</ForeName>
<Initials>PKS</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>To</LastName>
<ForeName>Ka-Fai</ForeName>
<Initials>KF</Initials>
<AffiliationInfo><Affiliation>Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lo</LastName>
<ForeName>Anthony W I</ForeName>
<Initials>AWI</Initials>
<AffiliationInfo><Affiliation>Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chan</LastName>
<ForeName>Judy Y W</ForeName>
<Initials>JYW</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Suen</LastName>
<ForeName>Yick-Keung</ForeName>
<Initials>YK</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chan</LastName>
<ForeName>H Y Edwin</ForeName>
<Initials>HYE</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fung</LastName>
<ForeName>Kwok-Pui</ForeName>
<Initials>KP</Initials>
<AffiliationInfo><Affiliation>The Croucher Laboratory for Human Genomics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Waye</LastName>
<ForeName>Mary M Y</ForeName>
<Initials>MMY</Initials>
<AffiliationInfo><Affiliation>The Croucher Laboratory for Human Genomics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sung</LastName>
<ForeName>Joseph J Y</ForeName>
<Initials>JJY</Initials>
<AffiliationInfo><Affiliation>Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lo</LastName>
<ForeName>Y M Dennis</ForeName>
<Initials>YMD</Initials>
<AffiliationInfo><Affiliation>Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tsui</LastName>
<ForeName>Stephen K W</ForeName>
<Initials>SKW</Initials>
<AffiliationInfo><Affiliation>The Croucher Laboratory for Human Genomics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>J Gen Virol</MedlineTA>
<NlmUniqueID>0077340</NlmUniqueID>
<ISSNLinking>0022-1317</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C487105">3a protein, severe acute respiratory syndrome coronavirus</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014764">Viral Proteins</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017209" MajorTopicYN="Y">Apoptosis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002522" MajorTopicYN="N">Chlorocebus aethiops</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004721" MajorTopicYN="N">Endoplasmic Reticulum</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007413" MajorTopicYN="N">Intestinal Mucosa</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007422" MajorTopicYN="N">Intestines</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014709" MajorTopicYN="N">Vero Cells</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014764" MajorTopicYN="N">Viral Proteins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year>
<Month>6</Month>
<Day>17</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2005</Year>
<Month>7</Month>
<Day>29</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2005</Year>
<Month>6</Month>
<Day>17</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">15958670</ArticleId>
<ArticleId IdType="doi">10.1099/vir.0.80813-0</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<settlement><li>Sha Tin</li>
</settlement>
<orgName><li>Université chinoise de Hong Kong</li>
</orgName>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Law, Patrick T W" sort="Law, Patrick T W" uniqKey="Law P" first="Patrick T W" last="Law">Patrick T W. Law</name>
</noRegion>
<name sortKey="Au, Thomas C C" sort="Au, Thomas C C" uniqKey="Au T" first="Thomas C C" last="Au">Thomas C C. Au</name>
<name sortKey="Chan, H Y Edwin" sort="Chan, H Y Edwin" uniqKey="Chan H" first="H Y Edwin" last="Chan">H Y Edwin Chan</name>
<name sortKey="Chan, Judy Y W" sort="Chan, Judy Y W" uniqKey="Chan J" first="Judy Y W" last="Chan">Judy Y W. Chan</name>
<name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K S" last="Chan">Paul K S. Chan</name>
<name sortKey="Chuck, Chi Pang" sort="Chuck, Chi Pang" uniqKey="Chuck C" first="Chi-Pang" last="Chuck">Chi-Pang Chuck</name>
<name sortKey="Fung, Kwok Pui" sort="Fung, Kwok Pui" uniqKey="Fung K" first="Kwok-Pui" last="Fung">Kwok-Pui Fung</name>
<name sortKey="Kong, Siu Kai" sort="Kong, Siu Kai" uniqKey="Kong S" first="Siu-Kai" last="Kong">Siu-Kai Kong</name>
<name sortKey="Lo, Anthony W I" sort="Lo, Anthony W I" uniqKey="Lo A" first="Anthony W I" last="Lo">Anthony W I. Lo</name>
<name sortKey="Lo, Y M Dennis" sort="Lo, Y M Dennis" uniqKey="Lo Y" first="Y M Dennis" last="Lo">Y M Dennis Lo</name>
<name sortKey="Suen, Yick Keung" sort="Suen, Yick Keung" uniqKey="Suen Y" first="Yick-Keung" last="Suen">Yick-Keung Suen</name>
<name sortKey="Sung, Joseph J Y" sort="Sung, Joseph J Y" uniqKey="Sung J" first="Joseph J Y" last="Sung">Joseph J Y. Sung</name>
<name sortKey="To, Ka Fai" sort="To, Ka Fai" uniqKey="To K" first="Ka-Fai" last="To">Ka-Fai To</name>
<name sortKey="Tsui, Stephen K W" sort="Tsui, Stephen K W" uniqKey="Tsui S" first="Stephen K W" last="Tsui">Stephen K W. Tsui</name>
<name sortKey="Waye, Mary M Y" sort="Waye, Mary M Y" uniqKey="Waye M" first="Mary M Y" last="Waye">Mary M Y. Waye</name>
<name sortKey="Wong, Chi Hang" sort="Wong, Chi Hang" uniqKey="Wong C" first="Chi-Hang" last="Wong">Chi-Hang Wong</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001009 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 001009 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Ncbi |étape= Merge |type= RBID |clé= pubmed:15958670 |texte= The 3a protein of severe acute respiratory syndrome-associated coronavirus induces apoptosis in Vero E6 cells. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:15958670" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |