SrasV1, Ncbi, Merge, bibRecord, 000E66

The adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus.

Identifieur interne : 000E66 ( Ncbi/Merge ); précédent : 000E65; suivant : 000E67

The adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus.

Auteurs : Julian A. Tanner [République populaire de Chine] ; Bo-Jian Zheng ; Jie Zhou ; Rory M. Watt ; Jie-Qing Jiang ; Kin-Ling Wong ; Yong-Ping Lin ; Lin-Yu Lu ; Ming-Liang He ; Hsiang-Fu Kung ; Andreas J. Kesel ; Jian-Dong Huang

Source :

Chemistry & biology [ 1074-5521 ] ; 2005.

RBID : pubmed:15797214

Descripteurs français

KwdFr :
- Adamantane (), Adamantane (analogues et dérivés), Adamantane (pharmacologie), Animaux, Antienzymes (), Antienzymes (pharmacologie), Antiviraux (), Antiviraux (pharmacologie), Cellules cultivées, Helicase (antagonistes et inhibiteurs), Helicase (métabolisme), Macaca mulatta, Pyridines (), Pyridines (pharmacologie), Relation dose-effet des médicaments, Réplication virale (), Réplication virale (physiologie), Virus du SRAS (), Virus du SRAS (enzymologie), Virus du SRAS (physiologie).
MESH :
- analogues et dérivés : Adamantane.
- antagonistes et inhibiteurs : Helicase.
- enzymologie : Virus du SRAS.
- métabolisme : Helicase.
- pharmacologie : Adamantane, Antienzymes, Antiviraux, Pyridines.
- physiologie : Réplication virale, Virus du SRAS.
- Adamantane, Animaux, Antienzymes, Antiviraux, Cellules cultivées, Macaca mulatta, Pyridines, Relation dose-effet des médicaments, Réplication virale, Virus du SRAS.

English descriptors

KwdEn :
- Adamantane (analogs & derivatives), Adamantane (chemistry), Adamantane (pharmacology), Animals, Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Cells, Cultured, DNA Helicases (antagonists & inhibitors), DNA Helicases (metabolism), Dose-Response Relationship, Drug, Enzyme Inhibitors (chemistry), Enzyme Inhibitors (pharmacology), Macaca mulatta, Pyridines (chemistry), Pyridines (pharmacology), SARS Virus (drug effects), SARS Virus (enzymology), SARS Virus (physiology), Virus Replication (drug effects), Virus Replication (physiology).
MESH :
- chemical , analogs & derivatives : Adamantane.
- chemical , antagonists & inhibitors : DNA Helicases.
- chemical , chemistry : Adamantane, Antiviral Agents, Enzyme Inhibitors, Pyridines.
- chemical , metabolism : DNA Helicases.
- chemical , pharmacology : Adamantane, Antiviral Agents, Enzyme Inhibitors, Pyridines.
- drug effects : SARS Virus, Virus Replication.
- enzymology : SARS Virus.
- physiology : SARS Virus, Virus Replication.
- Animals, Cells, Cultured, Dose-Response Relationship, Drug, Macaca mulatta.

Abstract

Bananins are a class of antiviral compounds with a unique structural signature incorporating a trioxa-adamantane moiety covalently bound to a pyridoxal derivative. Six members of this class of compounds: bananin, iodobananin, vanillinbananin, ansabananin, eubananin, and adeninobananin were synthesized and tested as inhibitors of the SARS Coronavirus (SCV) helicase. Bananin, iodobananin, vanillinbananin, and eubananin were effective inhibitors of the ATPase activity of the SCV helicase with IC50 values in the range 0.5-3 microM. A similar trend, though at slightly higher inhibitor concentrations, was observed for inhibition of the helicase activities, using a FRET-based fluorescent assay. In a cell culture system of SCV, bananin exhibited an EC50 of less than 10 microM and a CC50 of over 300 microM. Kinetics of inhibition are consistent with bananin inhibiting an intracellular process or processes involved in SCV replication.

DOI: 10.1016/j.chembiol.2005.01.006
PubMed: 15797214

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 002816
to stream PubMed, to step Curation: 002816
to stream PubMed, to step Checkpoint: 002440

Links to Exploration step

pubmed:15797214

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus.</title>
<author><name sortKey="Tanner, Julian A" sort="Tanner, Julian A" uniqKey="Tanner J" first="Julian A" last="Tanner">Julian A. Tanner</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, University of Hong Kong, Pokfulam, Hong Kong, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Biochemistry, University of Hong Kong, Pokfulam, Hong Kong</wicri:regionArea>
<wicri:noRegion>Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name>
</author>
<author><name sortKey="Zhou, Jie" sort="Zhou, Jie" uniqKey="Zhou J" first="Jie" last="Zhou">Jie Zhou</name>
</author>
<author><name sortKey="Watt, Rory M" sort="Watt, Rory M" uniqKey="Watt R" first="Rory M" last="Watt">Rory M. Watt</name>
</author>
<author><name sortKey="Jiang, Jie Qing" sort="Jiang, Jie Qing" uniqKey="Jiang J" first="Jie-Qing" last="Jiang">Jie-Qing Jiang</name>
</author>
<author><name sortKey="Wong, Kin Ling" sort="Wong, Kin Ling" uniqKey="Wong K" first="Kin-Ling" last="Wong">Kin-Ling Wong</name>
</author>
<author><name sortKey="Lin, Yong Ping" sort="Lin, Yong Ping" uniqKey="Lin Y" first="Yong-Ping" last="Lin">Yong-Ping Lin</name>
</author>
<author><name sortKey="Lu, Lin Yu" sort="Lu, Lin Yu" uniqKey="Lu L" first="Lin-Yu" last="Lu">Lin-Yu Lu</name>
</author>
<author><name sortKey="He, Ming Liang" sort="He, Ming Liang" uniqKey="He M" first="Ming-Liang" last="He">Ming-Liang He</name>
</author>
<author><name sortKey="Kung, Hsiang Fu" sort="Kung, Hsiang Fu" uniqKey="Kung H" first="Hsiang-Fu" last="Kung">Hsiang-Fu Kung</name>
</author>
<author><name sortKey="Kesel, Andreas J" sort="Kesel, Andreas J" uniqKey="Kesel A" first="Andreas J" last="Kesel">Andreas J. Kesel</name>
</author>
<author><name sortKey="Huang, Jian Dong" sort="Huang, Jian Dong" uniqKey="Huang J" first="Jian-Dong" last="Huang">Jian-Dong Huang</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2005">2005</date>
<idno type="RBID">pubmed:15797214</idno>
<idno type="pmid">15797214</idno>
<idno type="doi">10.1016/j.chembiol.2005.01.006</idno>
<idno type="wicri:Area/PubMed/Corpus">002816</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002816</idno>
<idno type="wicri:Area/PubMed/Curation">002816</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002816</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002440</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002440</idno>
<idno type="wicri:Area/Ncbi/Merge">000E66</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">The adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus.</title>
<author><name sortKey="Tanner, Julian A" sort="Tanner, Julian A" uniqKey="Tanner J" first="Julian A" last="Tanner">Julian A. Tanner</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, University of Hong Kong, Pokfulam, Hong Kong, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Biochemistry, University of Hong Kong, Pokfulam, Hong Kong</wicri:regionArea>
<wicri:noRegion>Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name>
</author>
<author><name sortKey="Zhou, Jie" sort="Zhou, Jie" uniqKey="Zhou J" first="Jie" last="Zhou">Jie Zhou</name>
</author>
<author><name sortKey="Watt, Rory M" sort="Watt, Rory M" uniqKey="Watt R" first="Rory M" last="Watt">Rory M. Watt</name>
</author>
<author><name sortKey="Jiang, Jie Qing" sort="Jiang, Jie Qing" uniqKey="Jiang J" first="Jie-Qing" last="Jiang">Jie-Qing Jiang</name>
</author>
<author><name sortKey="Wong, Kin Ling" sort="Wong, Kin Ling" uniqKey="Wong K" first="Kin-Ling" last="Wong">Kin-Ling Wong</name>
</author>
<author><name sortKey="Lin, Yong Ping" sort="Lin, Yong Ping" uniqKey="Lin Y" first="Yong-Ping" last="Lin">Yong-Ping Lin</name>
</author>
<author><name sortKey="Lu, Lin Yu" sort="Lu, Lin Yu" uniqKey="Lu L" first="Lin-Yu" last="Lu">Lin-Yu Lu</name>
</author>
<author><name sortKey="He, Ming Liang" sort="He, Ming Liang" uniqKey="He M" first="Ming-Liang" last="He">Ming-Liang He</name>
</author>
<author><name sortKey="Kung, Hsiang Fu" sort="Kung, Hsiang Fu" uniqKey="Kung H" first="Hsiang-Fu" last="Kung">Hsiang-Fu Kung</name>
</author>
<author><name sortKey="Kesel, Andreas J" sort="Kesel, Andreas J" uniqKey="Kesel A" first="Andreas J" last="Kesel">Andreas J. Kesel</name>
</author>
<author><name sortKey="Huang, Jian Dong" sort="Huang, Jian Dong" uniqKey="Huang J" first="Jian-Dong" last="Huang">Jian-Dong Huang</name>
</author>
</analytic>
<series><title level="j">Chemistry & biology</title>
<idno type="ISSN">1074-5521</idno>
<imprint><date when="2005" type="published">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adamantane (analogs & derivatives)</term>
<term>Adamantane (chemistry)</term>
<term>Adamantane (pharmacology)</term>
<term>Animals</term>
<term>Antiviral Agents (chemistry)</term>
<term>Antiviral Agents (pharmacology)</term>
<term>Cells, Cultured</term>
<term>DNA Helicases (antagonists & inhibitors)</term>
<term>DNA Helicases (metabolism)</term>
<term>Dose-Response Relationship, Drug</term>
<term>Enzyme Inhibitors (chemistry)</term>
<term>Enzyme Inhibitors (pharmacology)</term>
<term>Macaca mulatta</term>
<term>Pyridines (chemistry)</term>
<term>Pyridines (pharmacology)</term>
<term>SARS Virus (drug effects)</term>
<term>SARS Virus (enzymology)</term>
<term>SARS Virus (physiology)</term>
<term>Virus Replication (drug effects)</term>
<term>Virus Replication (physiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adamantane ()</term>
<term>Adamantane (analogues et dérivés)</term>
<term>Adamantane (pharmacologie)</term>
<term>Animaux</term>
<term>Antienzymes ()</term>
<term>Antienzymes (pharmacologie)</term>
<term>Antiviraux ()</term>
<term>Antiviraux (pharmacologie)</term>
<term>Cellules cultivées</term>
<term>Helicase (antagonistes et inhibiteurs)</term>
<term>Helicase (métabolisme)</term>
<term>Macaca mulatta</term>
<term>Pyridines ()</term>
<term>Pyridines (pharmacologie)</term>
<term>Relation dose-effet des médicaments</term>
<term>Réplication virale ()</term>
<term>Réplication virale (physiologie)</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (enzymologie)</term>
<term>Virus du SRAS (physiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Adamantane</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>DNA Helicases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Adamantane</term>
<term>Antiviral Agents</term>
<term>Enzyme Inhibitors</term>
<term>Pyridines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>DNA Helicases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Adamantane</term>
<term>Antiviral Agents</term>
<term>Enzyme Inhibitors</term>
<term>Pyridines</term>
</keywords>
<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Adamantane</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Helicase</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>SARS Virus</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Helicase</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Adamantane</term>
<term>Antienzymes</term>
<term>Antiviraux</term>
<term>Pyridines</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Réplication virale</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cells, Cultured</term>
<term>Dose-Response Relationship, Drug</term>
<term>Macaca mulatta</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adamantane</term>
<term>Animaux</term>
<term>Antienzymes</term>
<term>Antiviraux</term>
<term>Cellules cultivées</term>
<term>Macaca mulatta</term>
<term>Pyridines</term>
<term>Relation dose-effet des médicaments</term>
<term>Réplication virale</term>
<term>Virus du SRAS</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Bananins are a class of antiviral compounds with a unique structural signature incorporating a trioxa-adamantane moiety covalently bound to a pyridoxal derivative. Six members of this class of compounds: bananin, iodobananin, vanillinbananin, ansabananin, eubananin, and adeninobananin were synthesized and tested as inhibitors of the SARS Coronavirus (SCV) helicase. Bananin, iodobananin, vanillinbananin, and eubananin were effective inhibitors of the ATPase activity of the SCV helicase with IC50 values in the range 0.5-3 microM. A similar trend, though at slightly higher inhibitor concentrations, was observed for inhibition of the helicase activities, using a FRET-based fluorescent assay. In a cell culture system of SCV, bananin exhibited an EC50 of less than 10 microM and a CC50 of over 300 microM. Kinetics of inhibition are consistent with bananin inhibiting an intracellular process or processes involved in SCV replication.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15797214</PMID>
<DateCompleted><Year>2005</Year>
<Month>08</Month>
<Day>09</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>03</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">1074-5521</ISSN>
<JournalIssue CitedMedium="Print"><Volume>12</Volume>
<Issue>3</Issue>
<PubDate><Year>2005</Year>
<Month>Mar</Month>
</PubDate>
</JournalIssue>
<Title>Chemistry & biology</Title>
<ISOAbbreviation>Chem. Biol.</ISOAbbreviation>
</Journal>
<ArticleTitle>The adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus.</ArticleTitle>
<Pagination><MedlinePgn>303-11</MedlinePgn>
</Pagination>
<Abstract><AbstractText>Bananins are a class of antiviral compounds with a unique structural signature incorporating a trioxa-adamantane moiety covalently bound to a pyridoxal derivative. Six members of this class of compounds: bananin, iodobananin, vanillinbananin, ansabananin, eubananin, and adeninobananin were synthesized and tested as inhibitors of the SARS Coronavirus (SCV) helicase. Bananin, iodobananin, vanillinbananin, and eubananin were effective inhibitors of the ATPase activity of the SCV helicase with IC50 values in the range 0.5-3 microM. A similar trend, though at slightly higher inhibitor concentrations, was observed for inhibition of the helicase activities, using a FRET-based fluorescent assay. In a cell culture system of SCV, bananin exhibited an EC50 of less than 10 microM and a CC50 of over 300 microM. Kinetics of inhibition are consistent with bananin inhibiting an intracellular process or processes involved in SCV replication.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tanner</LastName>
<ForeName>Julian A</ForeName>
<Initials>JA</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry, University of Hong Kong, Pokfulam, Hong Kong, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zheng</LastName>
<ForeName>Bo-Jian</ForeName>
<Initials>BJ</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zhou</LastName>
<ForeName>Jie</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Watt</LastName>
<ForeName>Rory M</ForeName>
<Initials>RM</Initials>
</Author>
<Author ValidYN="Y"><LastName>Jiang</LastName>
<ForeName>Jie-Qing</ForeName>
<Initials>JQ</Initials>
</Author>
<Author ValidYN="Y"><LastName>Wong</LastName>
<ForeName>Kin-Ling</ForeName>
<Initials>KL</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lin</LastName>
<ForeName>Yong-Ping</ForeName>
<Initials>YP</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lu</LastName>
<ForeName>Lin-Yu</ForeName>
<Initials>LY</Initials>
</Author>
<Author ValidYN="Y"><LastName>He</LastName>
<ForeName>Ming-Liang</ForeName>
<Initials>ML</Initials>
</Author>
<Author ValidYN="Y"><LastName>Kung</LastName>
<ForeName>Hsiang-Fu</ForeName>
<Initials>HF</Initials>
</Author>
<Author ValidYN="Y"><LastName>Kesel</LastName>
<ForeName>Andreas J</ForeName>
<Initials>AJ</Initials>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Jian-Dong</ForeName>
<Initials>JD</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Chem Biol</MedlineTA>
<NlmUniqueID>9500160</NlmUniqueID>
<ISSNLinking>1074-5521</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D004791">Enzyme Inhibitors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011725">Pyridines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C487581">bananin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.6.4.-</RegistryNumber>
<NameOfSubstance UI="D004265">DNA Helicases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>PJY633525U</RegistryNumber>
<NameOfSubstance UI="D000218">Adamantane</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000218" MajorTopicYN="N">Adamantane</DescriptorName>
<QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004265" MajorTopicYN="N">DNA Helicases</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004791" MajorTopicYN="N">Enzyme Inhibitors</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008253" MajorTopicYN="N">Macaca mulatta</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011725" MajorTopicYN="N">Pyridines</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2004</Year>
<Month>08</Month>
<Day>08</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2004</Year>
<Month>12</Month>
<Day>16</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2005</Year>
<Month>01</Month>
<Day>12</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2005</Year>
<Month>3</Month>
<Day>31</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2005</Year>
<Month>8</Month>
<Day>10</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2005</Year>
<Month>3</Month>
<Day>31</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">15797214</ArticleId>
<ArticleId IdType="pii">S1074-5521(05)00027-X</ArticleId>
<ArticleId IdType="doi">10.1016/j.chembiol.2005.01.006</ArticleId>
<ArticleId IdType="pmc">PMC7110988</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Chem Biol. 2004 Sep;11(9):1293-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15380189</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Antivir Ther. 2004 Jun;9(3):365-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15259899</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Antimicrob Agents Chemother. 1982 Dec;22(6):1031-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6297383</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Neural Transm Suppl. 1994;43:91-104</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7884411</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>FEBS Lett. 2004 Jun 4;567(2-3):253-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15178332</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Gen Virol. 2003 Sep;84(Pt 9):2305-2315</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12917450</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13190-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14585926</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet. 2003 Jun 14;361(9374):2045-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12814717</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Antiviral Res. 2002 Sep;55(3):397-412</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12206878</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1953-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12690092</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>JAMA. 2003 Jun 4;289(21):2801-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12734147</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Med. 2002 Apr;8(4):386-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11927945</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2004 Jun;78(11):5619-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15140959</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Gen Virol. 1999 Mar;80 ( Pt 3):701-709</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10092010</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Bioorg Med Chem. 2003 Oct 15;11(21):4599-613</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14527557</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochem Biophys Res Commun. 2002 Aug 2;295(5):1102-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12135608</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochemistry. 1994 Sep 20;33(37):11307-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7727381</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Curr Cancer Drug Targets. 2003 Oct;3(5):325-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14529384</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10012-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15226499</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1967-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12690091</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochemistry. 2004 May 4;43(17):4906-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15109248</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>JAMA. 2003 Nov 26;290(20):2665-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14645307</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>JAMA. 1969 May 19;208(7):1168-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">5818715</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2000 Jun;74(11):5213-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10799597</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Science. 2003 Jun 13;300(5626):1763-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12746549</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Science. 1964 May 15;144(3620):862-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14151624</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 2003 Oct 10;278(41):39578-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12917423</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Respirology. 2004 Jun;9(2):173-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15182266</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Bioorg Med Chem. 1999 Feb;7(2):359-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10218829</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 1998 Mar 27;273(13):7390-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9516436</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Science. 2003 May 30;300(5624):1394-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12730500</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Anal Biochem. 1988 Jun;171(2):266-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3044186</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 1999 Jul;73(7):5274-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10364273</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Science. 2003 May 30;300(5624):1399-404</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12730501</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet. 2003 Apr 19;361(9366):1319-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12711465</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Med. 2002 Apr;8(4):392-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11927946</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Ann Pharmacother. 1995 Mar;29(3):299-310</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7606077</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><noCountry><name sortKey="He, Ming Liang" sort="He, Ming Liang" uniqKey="He M" first="Ming-Liang" last="He">Ming-Liang He</name>
<name sortKey="Huang, Jian Dong" sort="Huang, Jian Dong" uniqKey="Huang J" first="Jian-Dong" last="Huang">Jian-Dong Huang</name>
<name sortKey="Jiang, Jie Qing" sort="Jiang, Jie Qing" uniqKey="Jiang J" first="Jie-Qing" last="Jiang">Jie-Qing Jiang</name>
<name sortKey="Kesel, Andreas J" sort="Kesel, Andreas J" uniqKey="Kesel A" first="Andreas J" last="Kesel">Andreas J. Kesel</name>
<name sortKey="Kung, Hsiang Fu" sort="Kung, Hsiang Fu" uniqKey="Kung H" first="Hsiang-Fu" last="Kung">Hsiang-Fu Kung</name>
<name sortKey="Lin, Yong Ping" sort="Lin, Yong Ping" uniqKey="Lin Y" first="Yong-Ping" last="Lin">Yong-Ping Lin</name>
<name sortKey="Lu, Lin Yu" sort="Lu, Lin Yu" uniqKey="Lu L" first="Lin-Yu" last="Lu">Lin-Yu Lu</name>
<name sortKey="Watt, Rory M" sort="Watt, Rory M" uniqKey="Watt R" first="Rory M" last="Watt">Rory M. Watt</name>
<name sortKey="Wong, Kin Ling" sort="Wong, Kin Ling" uniqKey="Wong K" first="Kin-Ling" last="Wong">Kin-Ling Wong</name>
<name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name>
<name sortKey="Zhou, Jie" sort="Zhou, Jie" uniqKey="Zhou J" first="Jie" last="Zhou">Jie Zhou</name>
</noCountry>
<country name="République populaire de Chine"><noRegion><name sortKey="Tanner, Julian A" sort="Tanner, Julian A" uniqKey="Tanner J" first="Julian A" last="Tanner">Julian A. Tanner</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Ncbi/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E66 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000E66 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    Ncbi
   |étape=   Merge
   |type=    RBID
   |clé=     pubmed:15797214
   |texte=   The adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i   -Sk "pubmed:15797214" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a SrasV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration SRAS

The adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus.

The adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki