SrasV1, Ncbi, Merge, bibRecord, 000D80

Induction of Th1 type response by DNA vaccinations with N, M, and E genes against SARS-CoV in mice.

Identifieur interne : 000D80 ( Ncbi/Merge ); précédent : 000D79; suivant : 000D81

Induction of Th1 type response by DNA vaccinations with N, M, and E genes against SARS-CoV in mice.

Auteurs : Huali Jin [République populaire de Chine] ; Chong Xiao ; Ze Chen ; Youmin Kang ; Yijie Ma ; Kaichun Zhu ; Qifa Xie ; Yixian Tu ; Yang Yu ; Bin Wang

Source :

Biochemical and biophysical research communications [ 0006-291X ] ; 2005.

RBID : pubmed:15707974

Descripteurs français

English descriptors

KwdEn :
- Adjuvants, Immunologic (metabolism), Animals, Chemotherapy, Adjuvant (methods), Cytokines (immunology), Female, Genetic Therapy (methods), Levamisole (administration & dosage), Lymphocyte Activation (drug effects), Lymphocyte Activation (genetics), Lymphocyte Activation (immunology), Mice, Mice, Inbred BALB C, Nucleocapsid Proteins (genetics), Nucleocapsid Proteins (immunology), Severe Acute Respiratory Syndrome (genetics), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (prevention & control), Th1 Cells (drug effects), Th1 Cells (immunology), Vaccines, DNA (administration & dosage), Vaccines, DNA (genetics).
MESH :
- chemical , administration & dosage : Levamisole, Vaccines, DNA.
- chemical , genetics : Nucleocapsid Proteins, Vaccines, DNA.
- chemical , immunology : Cytokines, Nucleocapsid Proteins.
- chemical , metabolism : Adjuvants, Immunologic.
- drug effects : Lymphocyte Activation, Th1 Cells.
- genetics : Lymphocyte Activation, Severe Acute Respiratory Syndrome.
- immunology : Lymphocyte Activation, Severe Acute Respiratory Syndrome, Th1 Cells.
- methods : Chemotherapy, Adjuvant, Genetic Therapy.
- prevention & control : Severe Acute Respiratory Syndrome.
- Animals, Female, Mice, Mice, Inbred BALB C.

Abstract

Vaccination against the SARS-CoV infection is an attractive means to control the spread of viruses in public. In this study, we employed a DNA vaccine technology with the levamisole, our newly discovered chemical adjuvant, to generate Th1 type of response. To avoid the enhancement antibody issue, genes encoding the nucleocapsid, membrane, and envelope protein of SARS-CoV were cloned and their expressions in mammalian cells were determined. After the intramuscular introduction into animals, we observed that the constructs of the E, M, and N genes could induce high levels of specific antibodies, T cell proliferations, IFN-gamma, DTH responses, and in vivo cytotoxic T cells activities specifically against SARS-CoV antigens. The highest immune responses were generated by the construct encoding the nucleocapsid protein. The results suggest that the N, M, and E genes could be used as the targets to prevent SARS-CoV infection in the DNA vaccine development.

DOI: 10.1016/j.bbrc.2005.01.048
PubMed: 15707974

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 002891
to stream PubMed, to step Curation: 002891
to stream PubMed, to step Checkpoint: 002657

Links to Exploration step

pubmed:15707974

Le document en format XML

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<front><div type="abstract" xml:lang="en">Vaccination against the SARS-CoV infection is an attractive means to control the spread of viruses in public. In this study, we employed a DNA vaccine technology with the levamisole, our newly discovered chemical adjuvant, to generate Th1 type of response. To avoid the enhancement antibody issue, genes encoding the nucleocapsid, membrane, and envelope protein of SARS-CoV were cloned and their expressions in mammalian cells were determined. After the intramuscular introduction into animals, we observed that the constructs of the E, M, and N genes could induce high levels of specific antibodies, T cell proliferations, IFN-gamma, DTH responses, and in vivo cytotoxic T cells activities specifically against SARS-CoV antigens. The highest immune responses were generated by the construct encoding the nucleocapsid protein. The results suggest that the N, M, and E genes could be used as the targets to prevent SARS-CoV infection in the DNA vaccine development.</div>
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<name sortKey="Ma, Yijie" sort="Ma, Yijie" uniqKey="Ma Y" first="Yijie" last="Ma">Yijie Ma</name>
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Induction of Th1 type response by DNA vaccinations with N, M, and E genes against SARS-CoV in mice.

Induction of Th1 type response by DNA vaccinations with N, M, and E genes against SARS-CoV in mice.

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