SrasV1, Ncbi, Merge, bibRecord, 000C32

Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway.

Identifieur interne : 000C32 ( Ncbi/Merge ); précédent : 000C31; suivant : 000C33

Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway.

Auteurs : Yee-Joo Tan [Singapour] ; Burtram C. Fielding ; Phuay-Yee Goh ; Shuo Shen ; Timothy H P. Tan ; Seng Gee Lim ; Wanjin Hong

Source :

Journal of virology [ 0022-538X ] ; 2004.

RBID : pubmed:15564512

Descripteurs français

KwdFr :
- Animaux, Apoptose, Caspase-3, Caspases (métabolisme), Cellules COS, Cellules HeLa, Cellules Vero, Humains, Lignée cellulaire, Protéines de la matrice virale, Protéines membranaires (génétique), Protéines membranaires (métabolisme), Protéines virales (génétique), Protéines virales (métabolisme), Virus du SRAS (génétique), Virus du SRAS (pathogénicité).
MESH :
- génétique : Protéines membranaires, Protéines virales, Virus du SRAS.
- métabolisme : Caspases, Protéines membranaires, Protéines virales.
- pathogénicité : Virus du SRAS.
- Animaux, Apoptose, Caspase-3, Cellules COS, Cellules HeLa, Cellules Vero, Humains, Lignée cellulaire, Protéines de la matrice virale.

English descriptors

KwdEn :
- Animals, Apoptosis, COS Cells, Caspase 3, Caspases (metabolism), Cell Line, Chlorocebus aethiops, HeLa Cells, Humans, Membrane Proteins (genetics), Membrane Proteins (metabolism), SARS Virus (genetics), SARS Virus (pathogenicity), Vero Cells, Viral Matrix Proteins, Viral Proteins (genetics), Viral Proteins (metabolism).
MESH :
- chemical , genetics : Membrane Proteins, Viral Proteins.
- chemical , metabolism : Caspases, Membrane Proteins, Viral Proteins.
- chemical : Caspase 3, Viral Matrix Proteins.
- genetics : SARS Virus.
- pathogenicity : SARS Virus.
- Animals, Apoptosis, COS Cells, Cell Line, Chlorocebus aethiops, HeLa Cells, Humans, Vero Cells.

Abstract

Besides genes that are homologous to proteins found in other coronaviruses, the severe acute respiratory syndrome coronavirus genome also contains nine other potential open reading frames. Previously, we have characterized the expression and cellular localization of two of these "accessory" viral proteins, 3a (previously termed U274) and 7a (previously termed U122). In this study, we further examined whether they can induce apoptosis, which has been observed clinically. We showed that the overexpression of 7a, but not of 3a or the viral structural proteins, nucleocapsid, membrane, and envelope, induces apoptosis. 7a induces apoptosis via a caspase-dependent pathway and in cell lines derived from different organs, including lung, kidney, and liver.

DOI: 10.1128/JVI.78.24.14043-14047.2004
PubMed: 15564512

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 002A30
to stream PubMed, to step Curation: 002A30
to stream PubMed, to step Checkpoint: 002B64

Links to Exploration step

pubmed:15564512

Le document en format XML

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<tree><noCountry><name sortKey="Fielding, Burtram C" sort="Fielding, Burtram C" uniqKey="Fielding B" first="Burtram C" last="Fielding">Burtram C. Fielding</name>
<name sortKey="Goh, Phuay Yee" sort="Goh, Phuay Yee" uniqKey="Goh P" first="Phuay-Yee" last="Goh">Phuay-Yee Goh</name>
<name sortKey="Hong, Wanjin" sort="Hong, Wanjin" uniqKey="Hong W" first="Wanjin" last="Hong">Wanjin Hong</name>
<name sortKey="Lim, Seng Gee" sort="Lim, Seng Gee" uniqKey="Lim S" first="Seng Gee" last="Lim">Seng Gee Lim</name>
<name sortKey="Shen, Shuo" sort="Shen, Shuo" uniqKey="Shen S" first="Shuo" last="Shen">Shuo Shen</name>
<name sortKey="Tan, Timothy H P" sort="Tan, Timothy H P" uniqKey="Tan T" first="Timothy H P" last="Tan">Timothy H P. Tan</name>
</noCountry>
<country name="Singapour"><noRegion><name sortKey="Tan, Yee Joo" sort="Tan, Yee Joo" uniqKey="Tan Y" first="Yee-Joo" last="Tan">Yee-Joo Tan</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Ncbi/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C32 | SxmlIndent | more

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{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    Ncbi
   |étape=   Merge
   |type=    RBID
   |clé=     pubmed:15564512
   |texte=   Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway.
}}

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HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i   -Sk "pubmed:15564512" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a SrasV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

	Serveur d'exploration SRAS
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Serveur d'exploration SRAS

Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway.

Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway.

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