Virus-specific RNA and Antibody from Convalescent-phase SARS Patients Discharged from Hospital
Identifieur interne : 000B59 ( Ncbi/Merge ); précédent : 000B58; suivant : 000B60Virus-specific RNA and Antibody from Convalescent-phase SARS Patients Discharged from Hospital
Auteurs : Hoe Nam Leong [Singapour] ; Kwai Peng Chan [Singapour] ; Ali S. Khan [États-Unis, Suisse] ; Lynette Oon [Singapour] ; Su Yun Se-Thoe [Singapour] ; Xin Lai Bai [Singapour] ; Daniel Yeo [Singapour] ; Yee Sin Leo [Singapour] ; Brenda Ang [Singapour] ; Thomas G. Ksiazek [États-Unis] ; Ai Ee Ling [Singapour]Source :
- Emerging Infectious Diseases [ 1080-6040 ] ; 2004.
Descripteurs français
- KwdFr :
- MESH :
- analyse : ARN viral, Anticorps antiviraux.
- immunologie : Syndrome respiratoire aigu sévère, Virus du SRAS.
- virologie : Fèces.
- Adolescent, Adulte, Convalescence, Facteurs temps, Femelle, Humains, Mâle, Études transversales.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Antibodies, Viral, RNA, Viral.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome.
- virology : Feces.
- Adolescent, Adult, Convalescence, Cross-Sectional Studies, Female, Humans, Male, Time Factors.
Abstract
The prevalence of SARS-CoV in bodily excretions was determined.
Url:
DOI: 10.3201/eid1010.040026
PubMed: 15504259
PubMed Central: 3323266
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Khan</name><affiliation wicri:level="2"><nlm:aff id="aff3">Centers for Diseases Control and Prevention, Atlanta, Georgia, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Centers for Diseases Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">Global Outbreak Alert and Response Network, Geneva, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Global Outbreak Alert and Response Network, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Oon, Lynette" sort="Oon, Lynette" uniqKey="Oon L" first="Lynette" last="Oon">Lynette Oon</name><affiliation wicri:level="1"><nlm:aff id="aff2">Singapore General Hospital, Singapore;</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore General Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Se Thoe, Su Yun" sort="Se Thoe, Su Yun" uniqKey="Se Thoe S" first="Su Yun" last="Se-Thoe">Su Yun Se-Thoe</name><affiliation wicri:level="1"><nlm:aff id="aff2">Singapore General Hospital, Singapore;</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore General Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Bai, Xin Lai" sort="Bai, Xin Lai" uniqKey="Bai X" first="Xin Lai" last="Bai">Xin Lai Bai</name><affiliation wicri:level="1"><nlm:aff id="aff2">Singapore General Hospital, Singapore;</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore General Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Yeo, Daniel" sort="Yeo, Daniel" uniqKey="Yeo D" first="Daniel" last="Yeo">Daniel Yeo</name><affiliation wicri:level="1"><nlm:aff id="aff1">Tan Tock Seng Hospital, Singapore;</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Tan Tock Seng Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Leo, Yee Sin" sort="Leo, Yee Sin" uniqKey="Leo Y" first="Yee Sin" last="Leo">Yee Sin Leo</name><affiliation wicri:level="1"><nlm:aff id="aff1">Tan Tock Seng Hospital, Singapore;</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Tan Tock Seng Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Ang, Brenda" sort="Ang, Brenda" uniqKey="Ang B" first="Brenda" last="Ang">Brenda Ang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Tan Tock Seng Hospital, Singapore;</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Tan Tock Seng Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Ksiazek, Thomas G" sort="Ksiazek, Thomas G" uniqKey="Ksiazek T" first="Thomas G." last="Ksiazek">Thomas G. Ksiazek</name><affiliation wicri:level="2"><nlm:aff id="aff3">Centers for Diseases Control and Prevention, Atlanta, Georgia, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Centers for Diseases Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Ling, Ai Ee" sort="Ling, Ai Ee" uniqKey="Ling A" first="Ai Ee" last="Ling">Ai Ee Ling</name><affiliation wicri:level="1"><nlm:aff id="aff2">Singapore General Hospital, Singapore;</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore General Hospital</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15504259</idno><idno type="pmc">3323266</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323266</idno><idno type="RBID">PMC:3323266</idno><idno type="doi">10.3201/eid1010.040026</idno><date when="2004">2004</date><idno type="wicri:Area/Pmc/Corpus">000F60</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000F60</idno><idno type="wicri:Area/Pmc/Curation">000F60</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000F60</idno><idno type="wicri:Area/Pmc/Checkpoint">001415</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001415</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Virus-specific RNA and Antibody from Convalescent-phase SARS Patients Discharged from Hospital</title><author><name sortKey="Leong, Hoe Nam" sort="Leong, Hoe Nam" uniqKey="Leong H" first="Hoe Nam" last="Leong">Hoe Nam Leong</name><affiliation wicri:level="1"><nlm:aff id="aff1">Tan Tock Seng Hospital, Singapore;</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Tan Tock Seng Hospital</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Singapore General Hospital, Singapore;</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore General Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Chan, Kwai Peng" sort="Chan, Kwai Peng" uniqKey="Chan K" first="Kwai Peng" last="Chan">Kwai Peng Chan</name><affiliation wicri:level="1"><nlm:aff id="aff2">Singapore General Hospital, Singapore;</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore General Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Khan, Ali S" sort="Khan, Ali S" uniqKey="Khan A" first="Ali S." last="Khan">Ali S. Khan</name><affiliation wicri:level="2"><nlm:aff id="aff3">Centers for Diseases Control and Prevention, Atlanta, Georgia, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Centers for Diseases Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">Global Outbreak Alert and Response Network, Geneva, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Global Outbreak Alert and Response Network, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Oon, Lynette" sort="Oon, Lynette" uniqKey="Oon L" first="Lynette" last="Oon">Lynette Oon</name><affiliation wicri:level="1"><nlm:aff id="aff2">Singapore General Hospital, Singapore;</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore General Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Se Thoe, Su Yun" sort="Se Thoe, Su Yun" uniqKey="Se Thoe S" first="Su Yun" last="Se-Thoe">Su Yun Se-Thoe</name><affiliation wicri:level="1"><nlm:aff id="aff2">Singapore General Hospital, Singapore;</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore General Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Bai, Xin Lai" sort="Bai, Xin Lai" uniqKey="Bai X" first="Xin Lai" last="Bai">Xin Lai Bai</name><affiliation wicri:level="1"><nlm:aff id="aff2">Singapore General Hospital, Singapore;</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore General Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Yeo, Daniel" sort="Yeo, Daniel" uniqKey="Yeo D" first="Daniel" last="Yeo">Daniel Yeo</name><affiliation wicri:level="1"><nlm:aff id="aff1">Tan Tock Seng Hospital, Singapore;</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Tan Tock Seng Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Leo, Yee Sin" sort="Leo, Yee Sin" uniqKey="Leo Y" first="Yee Sin" last="Leo">Yee Sin Leo</name><affiliation wicri:level="1"><nlm:aff id="aff1">Tan Tock Seng Hospital, Singapore;</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Tan Tock Seng Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Ang, Brenda" sort="Ang, Brenda" uniqKey="Ang B" first="Brenda" last="Ang">Brenda Ang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Tan Tock Seng Hospital, Singapore;</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Tan Tock Seng Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Ksiazek, Thomas G" sort="Ksiazek, Thomas G" uniqKey="Ksiazek T" first="Thomas G." last="Ksiazek">Thomas G. Ksiazek</name><affiliation wicri:level="2"><nlm:aff id="aff3">Centers for Diseases Control and Prevention, Atlanta, Georgia, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Centers for Diseases Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Ling, Ai Ee" sort="Ling, Ai Ee" uniqKey="Ling A" first="Ai Ee" last="Ling">Ai Ee Ling</name><affiliation wicri:level="1"><nlm:aff id="aff2">Singapore General Hospital, Singapore;</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore General Hospital</wicri:regionArea></affiliation></author></analytic><series><title level="j">Emerging Infectious Diseases</title><idno type="ISSN">1080-6040</idno><idno type="eISSN">1080-6059</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The prevalence of SARS-CoV in bodily excretions was determined.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Virus-specific RNA and antibody from convalescent-phase SARS patients discharged from hospital.</title><author><name sortKey="Leong, Hoe Nam" sort="Leong, Hoe Nam" uniqKey="Leong H" first="Hoe Nam" last="Leong">Hoe Nam Leong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore 308433. hoe_nam@yahoo.com.sg</nlm:affiliation><country wicri:rule="url">Singapour</country></affiliation></author><author><name sortKey="Chan, Kwai Peng" sort="Chan, Kwai Peng" uniqKey="Chan K" first="Kwai Peng" last="Chan">Kwai Peng Chan</name></author><author><name sortKey="Khan, Ali S" sort="Khan, Ali S" uniqKey="Khan A" first="Ali S" last="Khan">Ali S. Khan</name></author><author><name sortKey="Oon, Lynette" sort="Oon, Lynette" uniqKey="Oon L" first="Lynette" last="Oon">Lynette Oon</name></author><author><name sortKey="Se Thoe, Su Yun" sort="Se Thoe, Su Yun" uniqKey="Se Thoe S" first="Su Yun" last="Se-Thoe">Su Yun Se-Thoe</name></author><author><name sortKey="Bai, Xin Lai" sort="Bai, Xin Lai" uniqKey="Bai X" first="Xin Lai" last="Bai">Xin Lai Bai</name></author><author><name sortKey="Yeo, Daniel" sort="Yeo, Daniel" uniqKey="Yeo D" first="Daniel" last="Yeo">Daniel Yeo</name></author><author><name sortKey="Leo, Yee Sin" sort="Leo, Yee Sin" uniqKey="Leo Y" first="Yee Sin" last="Leo">Yee Sin Leo</name></author><author><name sortKey="Ang, Brenda" sort="Ang, Brenda" uniqKey="Ang B" first="Brenda" last="Ang">Brenda Ang</name></author><author><name sortKey="Ksiazek, Thomas G" sort="Ksiazek, Thomas G" uniqKey="Ksiazek T" first="Thomas G" last="Ksiazek">Thomas G. Ksiazek</name></author><author><name sortKey="Ling, Ai Ee" sort="Ling, Ai Ee" uniqKey="Ling A" first="Ai Ee" last="Ling">Ai Ee Ling</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15504259</idno><idno type="pmid">15504259</idno><idno type="doi">10.3201/eid1010.040026</idno><idno type="wicri:Area/PubMed/Corpus">002A84</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002A84</idno><idno type="wicri:Area/PubMed/Curation">002A84</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002A84</idno><idno type="wicri:Area/PubMed/Checkpoint">002949</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002949</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Virus-specific RNA and antibody from convalescent-phase SARS patients discharged from hospital.</title><author><name sortKey="Leong, Hoe Nam" sort="Leong, Hoe Nam" uniqKey="Leong H" first="Hoe Nam" last="Leong">Hoe Nam Leong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore 308433. hoe_nam@yahoo.com.sg</nlm:affiliation><country wicri:rule="url">Singapour</country></affiliation></author><author><name sortKey="Chan, Kwai Peng" sort="Chan, Kwai Peng" uniqKey="Chan K" first="Kwai Peng" last="Chan">Kwai Peng Chan</name></author><author><name sortKey="Khan, Ali S" sort="Khan, Ali S" uniqKey="Khan A" first="Ali S" last="Khan">Ali S. Khan</name></author><author><name sortKey="Oon, Lynette" sort="Oon, Lynette" uniqKey="Oon L" first="Lynette" last="Oon">Lynette Oon</name></author><author><name sortKey="Se Thoe, Su Yun" sort="Se Thoe, Su Yun" uniqKey="Se Thoe S" first="Su Yun" last="Se-Thoe">Su Yun Se-Thoe</name></author><author><name sortKey="Bai, Xin Lai" sort="Bai, Xin Lai" uniqKey="Bai X" first="Xin Lai" last="Bai">Xin Lai Bai</name></author><author><name sortKey="Yeo, Daniel" sort="Yeo, Daniel" uniqKey="Yeo D" first="Daniel" last="Yeo">Daniel Yeo</name></author><author><name sortKey="Leo, Yee Sin" sort="Leo, Yee Sin" uniqKey="Leo Y" first="Yee Sin" last="Leo">Yee Sin Leo</name></author><author><name sortKey="Ang, Brenda" sort="Ang, Brenda" uniqKey="Ang B" first="Brenda" last="Ang">Brenda Ang</name></author><author><name sortKey="Ksiazek, Thomas G" sort="Ksiazek, Thomas G" uniqKey="Ksiazek T" first="Thomas G" last="Ksiazek">Thomas G. Ksiazek</name></author><author><name sortKey="Ling, Ai Ee" sort="Ling, Ai Ee" uniqKey="Ling A" first="Ai Ee" last="Ling">Ai Ee Ling</name></author></analytic><series><title level="j">Emerging infectious diseases</title><idno type="ISSN">1080-6040</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Antibodies, Viral (analysis)</term><term>Convalescence</term><term>Cross-Sectional Studies</term><term>Feces (virology)</term><term>Female</term><term>Humans</term><term>Male</term><term>RNA, Viral (analysis)</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Time Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (analyse)</term><term>Adolescent</term><term>Adulte</term><term>Anticorps antiviraux (analyse)</term><term>Convalescence</term><term>Facteurs temps</term><term>Femelle</term><term>Fèces (virologie)</term><term>Humains</term><term>Mâle</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Virus du SRAS (immunologie)</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Viral</term><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ARN viral</term><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Fèces</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Feces</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Convalescence</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Convalescence</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Études transversales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus (SARS-CoV). In a longitudinal cross-sectional study, we determined the prevalence of virus in bodily excretions and time of seroconversion in discharged patients with SARS. Conjunctival, throat, stool, and urine specimens were collected weekly from 64 patients and tested for SARS-CoV RNA by real-time polymerase chain reaction; serum samples were collected weekly and tested for SARS-CoV antibody with indirect enzyme immunoassay and immunofluorescence assay. In total, 126 conjunctival, 124 throat swab, 116 stool, and 124 urine specimens were analyzed. Five patients had positive stool samples, collected in weeks 5-9. Two patients seroconverted in weeks 7 and 8; the others were seropositive at the first serum sample collection. In this study, 5 (7.8%) of 64 patients continued to shed viral RNA in stool samples only, for up to week 8 of illness. Most seroconversions occurred by week 6 of illness.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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