[Pathological and ultramicrostructural changes of tissues in a patient with severe acute respiratory syndrome].
Identifieur interne : 000248 ( Ncbi/Merge ); précédent : 000247; suivant : 000249[Pathological and ultramicrostructural changes of tissues in a patient with severe acute respiratory syndrome].
Auteurs : Ri-Quan Lai [République populaire de Chine] ; Xiao-Dong Feng ; Zhuo-Cai Wang ; Huang-Wen Lai ; Ye Tian ; Wei Zhang ; Chuan-Hong YangSource :
- Zhonghua bing li xue za zhi = Chinese journal of pathology [ 0529-5807 ] ; 2003.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Myocarde, Noeuds lymphatiques, Poumon, Syndrome respiratoire aigu sévère.
- Adulte d'âge moyen, Humains, Immunohistochimie, Microscopie électronique, Mâle.
English descriptors
- KwdEn :
- MESH :
Abstract
To study the morphological, ultramicrostructural and pathological changes of tissues from a patient with severe acute respiratory syndrome (SARS).
PubMed: 12882682
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pubmed:12882682Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Pathological and ultramicrostructural changes of tissues in a patient with severe acute respiratory syndrome].</title><author><name sortKey="Lai, Ri Quan" sort="Lai, Ri Quan" uniqKey="Lai R" first="Ri-Quan" last="Lai">Ri-Quan Lai</name><affiliation wicri:level="1"><nlm:affiliation>General Hospital of Guangzhou Command, Guangzhou 510010, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>General Hospital of Guangzhou Command, Guangzhou 510010</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Feng, Xiao Dong" sort="Feng, Xiao Dong" uniqKey="Feng X" first="Xiao-Dong" last="Feng">Xiao-Dong Feng</name></author><author><name sortKey="Wang, Zhuo Cai" sort="Wang, Zhuo Cai" uniqKey="Wang Z" first="Zhuo-Cai" last="Wang">Zhuo-Cai Wang</name></author><author><name sortKey="Lai, Huang Wen" sort="Lai, Huang Wen" uniqKey="Lai H" first="Huang-Wen" last="Lai">Huang-Wen Lai</name></author><author><name sortKey="Tian, Ye" sort="Tian, Ye" uniqKey="Tian Y" first="Ye" last="Tian">Ye Tian</name></author><author><name sortKey="Zhang, Wei" sort="Zhang, Wei" uniqKey="Zhang W" first="Wei" last="Zhang">Wei Zhang</name></author><author><name sortKey="Yang, Chuan Hong" sort="Yang, Chuan Hong" uniqKey="Yang C" first="Chuan-Hong" last="Yang">Chuan-Hong Yang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:12882682</idno><idno type="pmid">12882682</idno><idno type="wicri:Area/PubMed/Corpus">003260</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003260</idno><idno type="wicri:Area/PubMed/Curation">003260</idno><idno type="wicri:explorRef" wicri:stream="PubMed" 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sort="Feng, Xiao Dong" uniqKey="Feng X" first="Xiao-Dong" last="Feng">Xiao-Dong Feng</name></author><author><name sortKey="Wang, Zhuo Cai" sort="Wang, Zhuo Cai" uniqKey="Wang Z" first="Zhuo-Cai" last="Wang">Zhuo-Cai Wang</name></author><author><name sortKey="Lai, Huang Wen" sort="Lai, Huang Wen" uniqKey="Lai H" first="Huang-Wen" last="Lai">Huang-Wen Lai</name></author><author><name sortKey="Tian, Ye" sort="Tian, Ye" uniqKey="Tian Y" first="Ye" last="Tian">Ye Tian</name></author><author><name sortKey="Zhang, Wei" sort="Zhang, Wei" uniqKey="Zhang W" first="Wei" last="Zhang">Wei Zhang</name></author><author><name sortKey="Yang, Chuan Hong" sort="Yang, Chuan Hong" uniqKey="Yang C" first="Chuan-Hong" last="Yang">Chuan-Hong Yang</name></author></analytic><series><title level="j">Zhonghua bing li xue za zhi = Chinese journal of pathology</title><idno type="ISSN">0529-5807</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Humans</term><term>Immunohistochemistry</term><term>Lung (pathology)</term><term>Lymph Nodes (pathology)</term><term>Male</term><term>Microscopy, Electron</term><term>Middle Aged</term><term>Myocardium (pathology)</term><term>Severe Acute Respiratory Syndrome (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Humains</term><term>Immunohistochimie</term><term>Microscopie électronique</term><term>Myocarde (anatomopathologie)</term><term>Mâle</term><term>Noeuds lymphatiques (anatomopathologie)</term><term>Poumon (anatomopathologie)</term><term>Syndrome respiratoire aigu sévère (anatomopathologie)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Myocarde</term><term>Noeuds lymphatiques</term><term>Poumon</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term><term>Lymph Nodes</term><term>Myocardium</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Immunohistochemistry</term><term>Male</term><term>Microscopy, Electron</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Humains</term><term>Immunohistochimie</term><term>Microscopie électronique</term><term>Mâle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To study the morphological, ultramicrostructural and pathological changes of tissues from a patient with severe acute respiratory syndrome (SARS).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12882682</PMID><DateCompleted><Year>2004</Year><Month>01</Month><Day>06</Day></DateCompleted><DateRevised><Year>2016</Year><Month>08</Month><Day>18</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0529-5807</ISSN><JournalIssue CitedMedium="Print"><Volume>32</Volume><Issue>3</Issue><PubDate><Year>2003</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Zhonghua bing li xue za zhi = Chinese journal of pathology</Title><ISOAbbreviation>Zhonghua Bing Li Xue Za Zhi</ISOAbbreviation></Journal><ArticleTitle>[Pathological and ultramicrostructural changes of tissues in a patient with severe acute respiratory syndrome].</ArticleTitle><Pagination><MedlinePgn>205-8</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To study the morphological, ultramicrostructural and pathological changes of tissues from a patient with severe acute respiratory syndrome (SARS).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">One autopsy case of diagnosed SARS was investigated. Lung puncture was performed immediately after the patient died, and the autopsy was done after 12 h. The specimens from lymph nodes, spleen, small intestine, colon and bone marrow were studied by immunohistochemical technique. The antibodies used included CD20, CD45RO (UCHL-1), CD4, CD8, CD68 and CD34.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The principal lesions of the SARS case consisted of acute lobular intrastitial pneumonia, hyaloid membranes of pulmonic alveoli and hyperplasia and shedding of alveolar epithelium of. Virus-like inclusions occasionally contained cytoplasm of the alveolar epithelium, which were positive by histochemical staining. The adjacent blood-vessels were changed by hyperplasia and enlargement. The structures of lymph nodes and spleen were damaged with lymph follicles depletion and splenic nodules atrophy. The specific changes included reduction of lymphocytes and hyperplasia of histiocytes, depletion of the follicles of small intestine and colon wall, decreased hyperplasia of the bone marrow and increased number of the megakaryocyte. Meanwhile, in the immunohistochemical study, CD(20)(+) B cells were fully expressed in lymph nodes and spleen, and the CD45RO (UCHL-1)(+) T cells were scatteredly expressed. The number of CD4(+) help T cell was markedly decreased, while the number of CD8+ poisonal T cells increased, and the ratio of the former and latter was no more than 0.5. Under the electronic microscopy observation, virus-like particles with 80 - 160 nm diameter and halo or garland envelope were found in mononuclear macrophage and cytoplasm of alveolar epithelium.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The specific lesions of SARS consist of lobular intrastitial pneumonia with the formation of hyaline membranes of lung, haemorrhage, necrosis, inflammation of blood vessels and the damages of extralung lymphohemopioetic system. The damages were very similar to the pathological features of tissues infected by human immunodeficiency virus, in which numbers of T cells decreased and CD(4)(+) T cell/CD(8)(+) T cell ratio was no more than 0.5. According to the virus-like particles found in lung of the SARS case, it is considered that these virus-like particles may be a new kind of coronavirus which caused the "atypical pneumonia".</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lai</LastName><ForeName>Ri-quan</ForeName><Initials>RQ</Initials><AffiliationInfo><Affiliation>General Hospital of Guangzhou Command, Guangzhou 510010, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feng</LastName><ForeName>Xiao-dong</ForeName><Initials>XD</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Zhuo-cai</ForeName><Initials>ZC</Initials></Author><Author ValidYN="Y"><LastName>Lai</LastName><ForeName>Huang-wen</ForeName><Initials>HW</Initials></Author><Author ValidYN="Y"><LastName>Tian</LastName><ForeName>Ye</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Wei</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Chuan-hong</ForeName><Initials>CH</Initials></Author></AuthorList><Language>chi</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>China</Country><MedlineTA>Zhonghua Bing Li Xue Za Zhi</MedlineTA><NlmUniqueID>0005331</NlmUniqueID><ISSNLinking>0529-5807</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008198" MajorTopicYN="N">Lymph Nodes</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008854" MajorTopicYN="N">Microscopy, Electron</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009206" MajorTopicYN="N">Myocardium</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>7</Month><Day>29</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>1</Month><Day>7</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2003</Year><Month>7</Month><Day>29</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12882682</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Guangdong</li></region><settlement><li>Jiangmen</li></settlement></list><tree><noCountry><name sortKey="Feng, Xiao Dong" sort="Feng, Xiao Dong" uniqKey="Feng X" first="Xiao-Dong" last="Feng">Xiao-Dong Feng</name><name sortKey="Lai, Huang Wen" sort="Lai, Huang Wen" uniqKey="Lai H" first="Huang-Wen" last="Lai">Huang-Wen Lai</name><name sortKey="Tian, Ye" sort="Tian, Ye" uniqKey="Tian Y" first="Ye" last="Tian">Ye Tian</name><name sortKey="Wang, Zhuo Cai" sort="Wang, Zhuo Cai" uniqKey="Wang Z" first="Zhuo-Cai" last="Wang">Zhuo-Cai Wang</name><name sortKey="Yang, Chuan Hong" sort="Yang, Chuan Hong" uniqKey="Yang C" first="Chuan-Hong" last="Yang">Chuan-Hong Yang</name><name sortKey="Zhang, Wei" sort="Zhang, Wei" uniqKey="Zhang W" first="Wei" last="Zhang">Wei Zhang</name></noCountry><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Lai, Ri Quan" sort="Lai, Ri Quan" uniqKey="Lai R" first="Ri-Quan" last="Lai">Ri-Quan Lai</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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