Correlation between TGF‐β1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain‐like protease
Identifieur interne : 003D90 ( Ncbi/Curation ); précédent : 003D89; suivant : 003D91Correlation between TGF‐β1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain‐like protease
Auteurs : Shih-Wen Li ; Tsuey-Ching Yang ; Lei Wan ; Ying-Ju Lin ; Fuu-Jen Tsai ; Chien-Chen Lai ; Cheng-Wen LinSource :
- Proteomics [ 1615-9853 ] ; 2012.
Abstract
Severe acute respiratory syndrome (
Url:
DOI: 10.1002/pmic.201200225
PubMed: NONE
PubMed Central: 7168038
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‐β1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain‐like protease</title>
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‐β1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain‐like protease</title>
<author><name sortKey="Li, Shih En" sort="Li, Shih En" uniqKey="Li S" first="Shih-Wen" last="Li">Shih-Wen Li</name>
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<front><div type="abstract" xml:lang="en"><p>Severe acute respiratory syndrome (<styled-content style="fixed-case" toggle="no">SARS</styled-content>
) coronavirus (<styled-content style="fixed-case" toggle="no">SARS</styled-content>
‐<styled-content style="fixed-case" toggle="no">C</styled-content>
o<styled-content style="fixed-case" toggle="no">V</styled-content>
) papain‐like protease (<styled-content style="fixed-case" toggle="no">PL</styled-content>
pro), a deubiquitinating enzyme, demonstrates inactivation of interferon (<styled-content style="fixed-case" toggle="no">IFN</styled-content>
) regulatory factor 3 and <styled-content style="fixed-case" toggle="no">NF</styled-content>
‐κ<styled-content style="fixed-case" toggle="no">B</styled-content>
, reduction of IFN induction, and suppression of type I <styled-content style="fixed-case" toggle="no">IFN</styled-content>
signaling pathway. This study investigates cytokine expression and proteomic change induced by <styled-content style="fixed-case" toggle="no">SARS</styled-content>
‐<styled-content style="fixed-case" toggle="no">C</styled-content>
o<styled-content style="fixed-case" toggle="no">V PL</styled-content>
pro in human promonocyte cells. PLpro significantly increased <styled-content style="fixed-case" toggle="no">TGF</styled-content>
‐β1 m<styled-content style="fixed-case" toggle="no">RNA</styled-content>
expression (greater than fourfold) and protein production (greater than threefold). Proteomic analysis, <styled-content style="fixed-case" toggle="no">W</styled-content>
estern blot, and quantitative real‐time <styled-content style="fixed-case" toggle="no">PCR</styled-content>
assays indicated <styled-content style="fixed-case" toggle="no">PL</styled-content>
pro upregulating <styled-content style="fixed-case" toggle="no">TGF</styled-content>
‐β1‐associated genes: <styled-content style="fixed-case" toggle="no">HSP</styled-content>
27, protein disulfide isomerase <styled-content style="fixed-case" toggle="no">A</styled-content>
3 precursor, glial fibrillary acidic protein, vimentin, retinal dehydrogenase 2, and glutathione transferase omega‐1. PLpro‐activated ubiquitin proteasome pathway via upregulation of ubiquitin‐conjugating enzyme <styled-content style="fixed-case" toggle="no">E</styled-content>
2–25k and proteasome subunit alpha type 5. Proteasome inhibitor <styled-content style="fixed-case" toggle="no">MG</styled-content>
‐132 significantly reduced expression of <styled-content style="fixed-case" toggle="no">TGF</styled-content>
‐β1 and vimentin. <styled-content style="fixed-case" toggle="no">PL</styled-content>
pro upregulated <styled-content style="fixed-case" toggle="no">HSP</styled-content>
27, linking with activation of p38 <styled-content style="fixed-case" toggle="no">MAPK</styled-content>
and <styled-content style="fixed-case" toggle="no">ERK</styled-content>
1/2 signaling. Treatment with <styled-content style="fixed-case" toggle="no">SB</styled-content>
203580 and <styled-content style="fixed-case" toggle="no">U</styled-content>
0126 reduced <styled-content style="fixed-case" toggle="no">PL</styled-content>
pro‐induced expression of <styled-content style="fixed-case" toggle="no">TGF</styled-content>
‐β1, vimentin, and type I collagen. Results point to <styled-content style="fixed-case" toggle="no">SARS</styled-content>
‐<styled-content style="fixed-case" toggle="no">C</styled-content>
o<styled-content style="fixed-case" toggle="no">V PL</styled-content>
pro triggering <styled-content style="fixed-case" toggle="no">TGF</styled-content>
‐β1 production via ubiquitin proteasome, p38 <styled-content style="fixed-case" toggle="no">MAPK</styled-content>
, and <styled-content style="fixed-case" toggle="no">ERK</styled-content>
1/2‐mediated signaling.</p>
</div>
</front>
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