[Replication and transmission mechanisms of highly pathogenic human coronaviruses].
Identifieur interne : 003B10 ( Ncbi/Curation ); précédent : 003B09; suivant : 003B11[Replication and transmission mechanisms of highly pathogenic human coronaviruses].
Auteurs : Yeyan He [République populaire de Chine] ; Chanying Zheng [République populaire de Chine]Source :
- Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences [ 1008-9292 ] ; 2020.
Descripteurs français
- KwdFr :
- Animaux, Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Humains, Infections à coronavirus (immunologie), Infections à coronavirus (transmission), Infections à coronavirus (virologie), Pandémies, Pneumopathie virale (immunologie), Pneumopathie virale (transmission), Pneumopathie virale (virologie), Réplication virale (physiologie), Virus du SRAS (physiologie).
- MESH :
- immunologie : Infections à coronavirus, Pneumopathie virale.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Réplication virale, Virus du SRAS.
- virologie : Infections à coronavirus, Pneumopathie virale.
- transmission : Animaux, Humains, Infections à coronavirus, Pandémies, Pneumopathie virale.
English descriptors
- KwdEn :
- Animals, Betacoronavirus (physiology), Coronavirus Infections (immunology), Coronavirus Infections (transmission), Coronavirus Infections (virology), Humans, Middle East Respiratory Syndrome Coronavirus (physiology), Pandemics, Pneumonia, Viral (immunology), Pneumonia, Viral (transmission), Pneumonia, Viral (virology), SARS Virus (physiology), Virus Replication (physiology).
- MESH :
- immunology : Coronavirus Infections, Pneumonia, Viral.
- physiology : Betacoronavirus, Middle East Respiratory Syndrome Coronavirus, SARS Virus, Virus Replication.
- transmission : Coronavirus Infections, Pneumonia, Viral.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Animals, Humans, Pandemics.
Abstract
The three known human highly pathogenic coronaviruses are severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus, (MERS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Human highly pathogenic coronaviruses are composed of non-structural proteins, structural proteins and accessory proteins. Viral particles recognize host receptors via spike glycoprotein (S protein), enter host cells by membrane fusion, replicate in host cells through large replication-transcription complexes, and promote proliferation by interfering with and suppressing the host's immune response. Human highly pathogenic coronaviruses are hosted by humans and vertebrates. Viral particles are transmitted through droplets, contact and aerosols or likely through digestive tract, urine, eyes and other routes. This review discusses the mechanisms of proliferation and transmission of highly pathogenic human coronaviruses based on the results of existing research, providing basis for future study on interrupting the transmission and pathogenicity of human highly pathogenic coronaviruses.
PubMed: 32298055
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pubmed:32298055Le document en format XML
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<front><div type="abstract" xml:lang="en">The three known human highly pathogenic coronaviruses are severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus, (MERS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Human highly pathogenic coronaviruses are composed of non-structural proteins, structural proteins and accessory proteins. Viral particles recognize host receptors via spike glycoprotein (S protein), enter host cells by membrane fusion, replicate in host cells through large replication-transcription complexes, and promote proliferation by interfering with and suppressing the host's immune response. Human highly pathogenic coronaviruses are hosted by humans and vertebrates. Viral particles are transmitted through droplets, contact and aerosols or likely through digestive tract, urine, eyes and other routes. This review discusses the mechanisms of proliferation and transmission of highly pathogenic human coronaviruses based on the results of existing research, providing basis for future study on interrupting the transmission and pathogenicity of human highly pathogenic coronaviruses.</div>
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