Leader sequences of coronavirus are altered during infection.
Identifieur interne : 002E51 ( Ncbi/Curation ); précédent : 002E50; suivant : 002E52Leader sequences of coronavirus are altered during infection.
Auteurs : Li Liu [République populaire de Chine] ; Wei Chen [République populaire de Chine]Source :
- Frontiers in bioscience (Landmark edition) [ 1093-4715 ] ; 2018.
Descripteurs français
- KwdFr :
- ARN viral (génétique), Animaux, Cellules Vero, Génome viral (génétique), Humains, Protéines de la matrice virale (génétique), Régulation de l'expression des gènes viraux, Similitude de séquences d'acides nucléiques, Spécificité d'espèce, Syndrome respiratoire aigu sévère (virologie), Séquence nucléotidique, Virus du SRAS (), Virus du SRAS (génétique), Virus à ARN (), Virus à ARN (génétique).
- MESH :
- génétique : ARN viral, Génome viral, Protéines de la matrice virale, Virus du SRAS, Virus à ARN.
- virologie : Syndrome respiratoire aigu sévère.
- Animaux, Cellules Vero, Humains, Régulation de l'expression des gènes viraux, Similitude de séquences d'acides nucléiques, Spécificité d'espèce, Séquence nucléotidique, Virus du SRAS, Virus à ARN.
English descriptors
- KwdEn :
- Animals, Base Sequence, Chlorocebus aethiops, Gene Expression Regulation, Viral, Genome, Viral (genetics), Humans, RNA Viruses (classification), RNA Viruses (genetics), RNA, Viral (genetics), SARS Virus (classification), SARS Virus (genetics), Sequence Homology, Nucleic Acid, Severe Acute Respiratory Syndrome (virology), Species Specificity, Vero Cells, Viral Matrix Proteins (genetics).
- MESH :
- chemical , genetics : RNA, Viral, Viral Matrix Proteins.
- classification : RNA Viruses, SARS Virus.
- genetics : Genome, Viral, RNA Viruses, SARS Virus.
- virology : Severe Acute Respiratory Syndrome.
- Animals, Base Sequence, Chlorocebus aethiops, Gene Expression Regulation, Viral, Humans, Sequence Homology, Nucleic Acid, Species Specificity, Vero Cells.
Abstract
The life cycle of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) involves a unique process called discontinuous transcription by which a set of 3' coterminal subgenomic mRNAs (sgmRNA) with identical 5' leader sequences can be generated. The current study demonstrates that the replication intermediates of minus strand of subgenomic RNA (sgRNA) can be readily recovered from SARS-CoV infected cells. A novel sgmRNA (M-1) was identified as a short version of membrane (M) gene. Transcriptional regulatory sequences (TRS) of SARS-CoV and Mouse Hepatitis Virus (MHV) sgmRNAs contain a species specific core element (CE). The sizes of leader sequences in MHVs vary not only in different viral strains but also among different genes in the same strain. Leader alterations such as deletion and nucleotide substitution were observed in MHVs, while a dynamic one-orientation 'sequential deletion' was found among the leaders of 76 SARS-CoV isolates. These results imply that the leader sequence of coronavirus might be unstable and leader alterations during SARS-CoV transmission in humans might have negative impact on its viral infectivity.
DOI: 10.2741/4579
PubMed: 28930535
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pubmed:28930535Le document en format XML
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<term>Humans</term>
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<term>RNA Viruses (genetics)</term>
<term>RNA, Viral (genetics)</term>
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<term>Virus du SRAS</term>
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<term>Base Sequence</term>
<term>Chlorocebus aethiops</term>
<term>Gene Expression Regulation, Viral</term>
<term>Humans</term>
<term>Sequence Homology, Nucleic Acid</term>
<term>Species Specificity</term>
<term>Vero Cells</term>
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<term>Cellules Vero</term>
<term>Humains</term>
<term>Régulation de l'expression des gènes viraux</term>
<term>Similitude de séquences d'acides nucléiques</term>
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<front><div type="abstract" xml:lang="en">The life cycle of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) involves a unique process called discontinuous transcription by which a set of 3' coterminal subgenomic mRNAs (sgmRNA) with identical 5' leader sequences can be generated. The current study demonstrates that the replication intermediates of minus strand of subgenomic RNA (sgRNA) can be readily recovered from SARS-CoV infected cells. A novel sgmRNA (M-1) was identified as a short version of membrane (M) gene. Transcriptional regulatory sequences (TRS) of SARS-CoV and Mouse Hepatitis Virus (MHV) sgmRNAs contain a species specific core element (CE). The sizes of leader sequences in MHVs vary not only in different viral strains but also among different genes in the same strain. Leader alterations such as deletion and nucleotide substitution were observed in MHVs, while a dynamic one-orientation 'sequential deletion' was found among the leaders of 76 SARS-CoV isolates. These results imply that the leader sequence of coronavirus might be unstable and leader alterations during SARS-CoV transmission in humans might have negative impact on its viral infectivity.</div>
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