The Virus-Host Interplay: Biogenesis of +RNA Replication Complexes.
Identifieur interne : 002B11 ( Ncbi/Curation ); précédent : 002B10; suivant : 002B12The Virus-Host Interplay: Biogenesis of +RNA Replication Complexes.
Auteurs : Colleen R. Reid [Canada] ; Adriana M. Airo [Canada] ; Tom C. Hobman [Canada]Source :
- Viruses [ 1999-4915 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- biosynthèse : ARN viral.
- physiologie : Virus à ARN.
- virologie : Membrane cellulaire.
- Animaux, Humains, Interactions hôte-pathogène, Réplication virale, Structures macromoléculaires.
English descriptors
- KwdEn :
- MESH :
- chemical , biosynthesis : RNA, Viral.
- chemical : Macromolecular Substances.
- physiology : RNA Viruses.
- virology : Cell Membrane.
- Animals, Host-Pathogen Interactions, Humans, Virus Replication.
Abstract
Positive-strand RNA (+RNA) viruses are an important group of human and animal pathogens that have significant global health and economic impacts. Notable members include West Nile virus, Dengue virus, Chikungunya, Severe acute respiratory syndrome (SARS) Coronavirus and enteroviruses of the Picornaviridae family.Unfortunately, prophylactic and therapeutic treatments against these pathogens are limited. +RNA viruses have limited coding capacity and thus rely extensively on host factors for successful infection and propagation. A common feature among these viruses is their ability to dramatically modify cellular membranes to serve as platforms for genome replication and assembly of new virions. These viral replication complexes (VRCs) serve two main functions: To increase replication efficiency by concentrating critical factors and to protect the viral genome from host anti-viral systems. This review summarizes current knowledge of critical host factors recruited to or demonstrated to be involved in the biogenesis and stabilization of +RNA virus VRCs.
DOI: 10.3390/v7082825
PubMed: 26287230
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pubmed:26287230Le document en format XML
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Airo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2E1, Canada. airo@ualberta.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2E1</wicri:regionArea><wicri:noRegion>AB T6G 2E1</wicri:noRegion></affiliation></author><author><name sortKey="Hobman, Tom C" sort="Hobman, Tom C" uniqKey="Hobman T" first="Tom C" last="Hobman">Tom C. 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Reid</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2E1, Canada. crreid1@ualberta.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2E1</wicri:regionArea><wicri:noRegion>AB T6G 2E1</wicri:noRegion></affiliation></author><author><name sortKey="Airo, Adriana M" sort="Airo, Adriana M" uniqKey="Airo A" first="Adriana M" last="Airo">Adriana M. Airo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2E1, Canada. airo@ualberta.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2E1</wicri:regionArea><wicri:noRegion>AB T6G 2E1</wicri:noRegion></affiliation></author><author><name sortKey="Hobman, Tom C" sort="Hobman, Tom C" uniqKey="Hobman T" first="Tom C" last="Hobman">Tom C. Hobman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2E1, Canada. tom.hobman@ualberta.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2E1</wicri:regionArea><wicri:noRegion>AB T6G 2E1</wicri:noRegion></affiliation></author></analytic><series><title level="j">Viruses</title><idno type="eISSN">1999-4915</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Membrane (virology)</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Macromolecular Substances</term><term>RNA Viruses (physiology)</term><term>RNA, Viral (biosynthesis)</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (biosynthèse)</term><term>Animaux</term><term>Humains</term><term>Interactions hôte-pathogène</term><term>Membrane cellulaire (virologie)</term><term>Réplication virale</term><term>Structures macromoléculaires</term><term>Virus à ARN (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Macromolecular Substances</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus à ARN</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>RNA Viruses</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Membrane cellulaire</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Cell Membrane</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Interactions hôte-pathogène</term><term>Réplication virale</term><term>Structures macromoléculaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Positive-strand RNA (+RNA) viruses are an important group of human and animal pathogens that have significant global health and economic impacts. Notable members include West Nile virus, Dengue virus, Chikungunya, Severe acute respiratory syndrome (SARS) Coronavirus and enteroviruses of the Picornaviridae family.Unfortunately, prophylactic and therapeutic treatments against these pathogens are limited. +RNA viruses have limited coding capacity and thus rely extensively on host factors for successful infection and propagation. A common feature among these viruses is their ability to dramatically modify cellular membranes to serve as platforms for genome replication and assembly of new virions. These viral replication complexes (VRCs) serve two main functions: To increase replication efficiency by concentrating critical factors and to protect the viral genome from host anti-viral systems. This review summarizes current knowledge of critical host factors recruited to or demonstrated to be involved in the biogenesis and stabilization of +RNA virus VRCs. </div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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