Multi-Organ Lesions in Suckling Mice Infected with SARS-Associated Mammalian Reovirus Linked with Apoptosis Induced by Viral Proteins μ1 and σ1
Identifieur interne : 002856 ( Ncbi/Curation ); précédent : 002855; suivant : 002857Multi-Organ Lesions in Suckling Mice Infected with SARS-Associated Mammalian Reovirus Linked with Apoptosis Induced by Viral Proteins μ1 and σ1
Auteurs : Lihua Song ; Yongfeng Lu ; Jun He ; Yonghui Yu ; Tingting Zuo ; Yanwei Li ; Hong Zhu ; Qing DuanSource :
- PLoS ONE [ 1932-6203 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Animaux allaités, Apoptose, Cellules HEK293, Humains, Infections à Reoviridae (anatomopathologie), Infections à Reoviridae (génétique), Protéines de capside (génétique), Protéines de capside (métabolisme), Reoviridae (métabolisme), Reoviridae (physiologie), Souris, Virus du SRAS (physiologie).
- MESH :
- anatomopathologie : Infections à Reoviridae.
- génétique : Infections à Reoviridae, Protéines de capside.
- métabolisme : Protéines de capside, Reoviridae.
- physiologie : Reoviridae, Virus du SRAS.
- Animaux, Animaux allaités, Apoptose, Cellules HEK293, Humains, Souris.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Capsid Proteins.
- chemical , metabolism : Capsid Proteins.
- genetics : Reoviridae Infections.
- metabolism : Reoviridae.
- pathology : Reoviridae Infections.
- physiology : Reoviridae, SARS Virus.
- Animals, Animals, Suckling, Apoptosis, HEK293 Cells, Humans, Mice.
Abstract
We reported the isolation and characterization of a novel mammalian reassortant reovirus BYD1 that may have played an accomplice role with SARS-coronavirus during the 2003 SARS pandemic. The pathogenic mechanism of this novel reovirus is unknown. Reovirus pathogenicity has been associated with virus-induced apoptosis in cultured cells and
Url:
DOI: 10.1371/journal.pone.0092678
PubMed: 24664247
PubMed Central: 3963933
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PMC:3963933Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Multi-Organ Lesions in Suckling Mice Infected with SARS-Associated Mammalian Reovirus Linked with Apoptosis Induced by Viral Proteins μ1 and σ1</title><author><name sortKey="Song, Lihua" sort="Song, Lihua" uniqKey="Song L" first="Lihua" last="Song">Lihua Song</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Lu, Yongfeng" sort="Lu, Yongfeng" uniqKey="Lu Y" first="Yongfeng" last="Lu">Yongfeng Lu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="He, Jun" sort="He, Jun" uniqKey="He J" first="Jun" last="He">Jun He</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Yu, Yonghui" sort="Yu, Yonghui" uniqKey="Yu Y" first="Yonghui" last="Yu">Yonghui Yu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Zuo, Tingting" sort="Zuo, Tingting" uniqKey="Zuo T" first="Tingting" last="Zuo">Tingting Zuo</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Li, Yanwei" sort="Li, Yanwei" uniqKey="Li Y" first="Yanwei" last="Li">Yanwei Li</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Zhu, Hong" sort="Zhu, Hong" uniqKey="Zhu H" first="Hong" last="Zhu">Hong Zhu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Duan, Qing" sort="Duan, Qing" uniqKey="Duan Q" first="Qing" last="Duan">Qing Duan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24664247</idno><idno type="pmc">3963933</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963933</idno><idno type="RBID">PMC:3963933</idno><idno type="doi">10.1371/journal.pone.0092678</idno><date when="2014">2014</date><idno 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type="wicri:Area/Ncbi/Curation">002856</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Multi-Organ Lesions in Suckling Mice Infected with SARS-Associated Mammalian Reovirus Linked with Apoptosis Induced by Viral Proteins μ1 and σ1</title><author><name sortKey="Song, Lihua" sort="Song, Lihua" uniqKey="Song L" first="Lihua" last="Song">Lihua Song</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Lu, Yongfeng" sort="Lu, Yongfeng" uniqKey="Lu Y" first="Yongfeng" last="Lu">Yongfeng Lu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="He, Jun" sort="He, Jun" uniqKey="He J" first="Jun" last="He">Jun He</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Yu, Yonghui" sort="Yu, Yonghui" uniqKey="Yu Y" first="Yonghui" last="Yu">Yonghui Yu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Zuo, Tingting" sort="Zuo, Tingting" uniqKey="Zuo T" first="Tingting" last="Zuo">Tingting Zuo</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Li, Yanwei" sort="Li, Yanwei" uniqKey="Li Y" first="Yanwei" last="Li">Yanwei Li</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Zhu, Hong" sort="Zhu, Hong" uniqKey="Zhu H" first="Hong" last="Zhu">Hong Zhu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Duan, Qing" sort="Duan, Qing" uniqKey="Duan Q" first="Qing" last="Duan">Qing Duan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Animals, Suckling</term><term>Apoptosis</term><term>Capsid Proteins (genetics)</term><term>Capsid Proteins (metabolism)</term><term>HEK293 Cells</term><term>Humans</term><term>Mice</term><term>Reoviridae (metabolism)</term><term>Reoviridae (physiology)</term><term>Reoviridae Infections (genetics)</term><term>Reoviridae Infections (pathology)</term><term>SARS Virus (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Animaux allaités</term><term>Apoptose</term><term>Cellules HEK293</term><term>Humains</term><term>Infections à Reoviridae (anatomopathologie)</term><term>Infections à Reoviridae (génétique)</term><term>Protéines de capside (génétique)</term><term>Protéines de capside (métabolisme)</term><term>Reoviridae (métabolisme)</term><term>Reoviridae (physiologie)</term><term>Souris</term><term>Virus du SRAS (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Capsid Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Capsid Proteins</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à Reoviridae</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Reoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Infections à Reoviridae</term><term>Protéines de capside</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Reoviridae</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines de capside</term><term>Reoviridae</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Reoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Reoviridae</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Reoviridae</term><term>SARS Virus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Animals, Suckling</term><term>Apoptosis</term><term>HEK293 Cells</term><term>Humans</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Animaux allaités</term><term>Apoptose</term><term>Cellules HEK293</term><term>Humains</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We reported the isolation and characterization of a novel mammalian reassortant reovirus BYD1 that may have played an accomplice role with SARS-coronavirus during the 2003 SARS pandemic. The pathogenic mechanism of this novel reovirus is unknown. Reovirus pathogenicity has been associated with virus-induced apoptosis in cultured cells and <italic>in vivo</italic>. The reovirus outer capsid protein μ1 is recognized as the primary determinant of reovirus-induced apoptosis. Here, we investigated the apoptosis induced by BYD1, its outer capsid protein μ1, and its cell-attachment protein σ1 to understand the pathogenesis of BYD1. We also investigated BYD1 caused systemic complications in suckling mice. Under electron microscopy, BYD1-infected cells showed characteristics typical of apoptosis. Notably, ectopically expressed μ1 and σ1 induced similar pathological apoptosis, independent of BYD1 infection, in host cells in which they were expressed, which suggests that μ1 and σ1 are both apoptotic virulence factors. Consistent with previous reports of reovirus pathogenicity, suckling mice intracranially inoculated with BYD1 developed central nerve damage, myocarditis, and pneumonia. Collectively, our data suggest that BYD1 μ1- and σ1-induced apoptosis is involved in the multi-organ lesions in a suckling mouse BYD1 infection model.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Sabin, Ab" uniqKey="Sabin A">AB Sabin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tyler, Kl" uniqKey="Tyler K">KL Tyler</name></author><author><name sortKey="Barton, Es" uniqKey="Barton E">ES Barton</name></author><author><name sortKey="Ibach, Ml" uniqKey="Ibach M">ML Ibach</name></author><author><name sortKey="Robinson, C" uniqKey="Robinson C">C Robinson</name></author><author><name sortKey="Campbell, Ja" uniqKey="Campbell J">JA Campbell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johansson, Pj" uniqKey="Johansson P">PJ Johansson</name></author><author><name 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sortKey="Markotic, A" uniqKey="Markotic A">A Markotic</name></author><author><name sortKey="Hensley, L" uniqKey="Hensley L">L Hensley</name></author><author><name sortKey="Geisbert, T" uniqKey="Geisbert T">T Geisbert</name></author><author><name sortKey="Spik, K" uniqKey="Spik K">K Spik</name></author><author><name sortKey="Schmaljohn, C" uniqKey="Schmaljohn C">C Schmaljohn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yan, H" uniqKey="Yan H">H Yan</name></author><author><name sortKey="Xiao, G" uniqKey="Xiao G">G Xiao</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Hu, Y" uniqKey="Hu Y">Y Hu</name></author><author><name sortKey="Yuan, F" uniqKey="Yuan F">F Yuan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Law, Pt" uniqKey="Law P">PT Law</name></author><author><name sortKey="Wong, Ch" uniqKey="Wong C">CH Wong</name></author><author><name 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sortKey="Weiner, Hl" uniqKey="Weiner H">HL Weiner</name></author><author><name sortKey="Ault, Ka" uniqKey="Ault K">KA Ault</name></author><author><name sortKey="Fields, Bn" uniqKey="Fields B">BN Fields</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name></author><author><name sortKey="Zhong, S" uniqKey="Zhong S">S Zhong</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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