Synthesis, modification and docking studies of 5-sulfonyl isatin derivatives as SARS-CoV 3C-like protease inhibitors
Identifieur interne : 002794 ( Ncbi/Curation ); précédent : 002793; suivant : 002795Synthesis, modification and docking studies of 5-sulfonyl isatin derivatives as SARS-CoV 3C-like protease inhibitors
Auteurs : Wei Liu [République populaire de Chine] ; He-Min Zhu [République populaire de Chine] ; Guo-Jun Niu [République populaire de Chine] ; En-Zhi Shi [République populaire de Chine] ; Jie Chen [République populaire de Chine] ; Bo Sun [République populaire de Chine] ; Wei-Qiang Chen [République populaire de Chine] ; Hong-Gang Zhou [République populaire de Chine] ; Cheng Yang [République populaire de Chine]Source :
- Bioorganic & Medicinal Chemistry [ 0968-0896 ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Virus du SRAS.
- pharmacologie : Inhibiteurs de protéases.
- synthèse chimique : Isatine.
- Humains, Inhibiteurs de protéases, Isatine, Relation structure-activité, Structure moléculaire, Virus du SRAS.
English descriptors
- KwdEn :
- MESH :
- chemical , chemical synthesis : Isatin.
- chemical , chemistry : Isatin, Protease Inhibitors.
- chemical , pharmacology : Protease Inhibitors.
- drug effects : SARS Virus.
- metabolism : SARS Virus.
- Humans, Molecular Structure, Structure-Activity Relationship.
Abstract
Url:
DOI: 10.1016/j.bmc.2013.11.028
PubMed: 24316352
PubMed Central: 7111328
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PMC:7111328Le document en format XML
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<term>Isatin (chemical synthesis)</term>
<term>Isatin (chemistry)</term>
<term>Molecular Structure</term>
<term>Protease Inhibitors (chemistry)</term>
<term>Protease Inhibitors (pharmacology)</term>
<term>SARS Virus (drug effects)</term>
<term>SARS Virus (metabolism)</term>
<term>Structure-Activity Relationship</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Humains</term>
<term>Inhibiteurs de protéases ()</term>
<term>Inhibiteurs de protéases (pharmacologie)</term>
<term>Isatine ()</term>
<term>Isatine (synthèse chimique)</term>
<term>Relation structure-activité</term>
<term>Structure moléculaire</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (métabolisme)</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Isatin</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Isatin</term>
<term>Protease Inhibitors</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Protease Inhibitors</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>SARS Virus</term>
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<term>Structure-Activity Relationship</term>
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<term>Inhibiteurs de protéases</term>
<term>Isatine</term>
<term>Relation structure-activité</term>
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</TEI>
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