Ezrin interacts with the SARS coronavirus Spike protein and restrains infection at the entry stage.
Identifieur interne : 002589 ( Ncbi/Curation ); précédent : 002588; suivant : 002590Ezrin interacts with the SARS coronavirus Spike protein and restrains infection at the entry stage.
Auteurs : Jean Kaoru Millet [République populaire de Chine] ; François Kien ; Chung-Yan Cheung ; Yu-Lam Siu ; Wing-Lim Chan ; Huiying Li ; Hiu-Lan Leung ; Martial Jaume ; Roberto Bruzzone ; Joseph S Malik Peiris ; Ralf Marius Altmeyer ; Béatrice NalSource :
- PloS one [ 1932-6203 ] ; 2012.
Descripteurs français
- KwdFr :
- Animaux, Banque de gènes, Cellules HEK293, Cellules HeLa, Cellules Vero, Cytosol (métabolisme), Données de séquences moléculaires, Famille multigénique, Glutathione transferase (métabolisme), Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (), Glycoprotéines membranaires (métabolisme), Humains, Liaison aux protéines, Membrane cellulaire (métabolisme), Mutation, Protéines de l'enveloppe virale (), Protéines de l'enveloppe virale (métabolisme), Protéines du cytosquelette (), Similitude de séquences d'acides aminés, Sites de fixation, Structure tertiaire des protéines, Séquence d'acides aminés, Techniques de double hybride, Virus du SRAS (métabolisme).
- MESH :
- métabolisme : Cytosol, Glutathione transferase, Glycoprotéines membranaires, Membrane cellulaire, Protéines de l'enveloppe virale, Virus du SRAS.
- Animaux, Banque de gènes, Cellules HEK293, Cellules HeLa, Cellules Vero, Données de séquences moléculaires, Famille multigénique, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires, Humains, Liaison aux protéines, Mutation, Protéines de l'enveloppe virale, Protéines du cytosquelette, Similitude de séquences d'acides aminés, Sites de fixation, Structure tertiaire des protéines, Séquence d'acides aminés, Techniques de double hybride.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Binding Sites, Cell Membrane (metabolism), Cytoskeletal Proteins (chemistry), Cytosol (metabolism), Gene Library, Glutathione Transferase (metabolism), HEK293 Cells, HeLa Cells, Humans, Membrane Glycoproteins (chemistry), Membrane Glycoproteins (metabolism), Molecular Sequence Data, Multigene Family, Mutation, Protein Binding, Protein Structure, Tertiary, SARS Virus (metabolism), Sequence Homology, Amino Acid, Spike Glycoprotein, Coronavirus, Two-Hybrid System Techniques, Vero Cells, Viral Envelope Proteins (chemistry), Viral Envelope Proteins (metabolism).
- MESH :
- chemical , chemistry : Cytoskeletal Proteins, Membrane Glycoproteins, Viral Envelope Proteins.
- metabolism : Cell Membrane, Cytosol, Glutathione Transferase, Membrane Glycoproteins, SARS Virus, Viral Envelope Proteins.
- Amino Acid Sequence, Animals, Binding Sites, Gene Library, HEK293 Cells, HeLa Cells, Humans, Molecular Sequence Data, Multigene Family, Mutation, Protein Binding, Protein Structure, Tertiary, Sequence Homology, Amino Acid, Spike Glycoprotein, Coronavirus, Two-Hybrid System Techniques, Vero Cells.
Abstract
Entry of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) and its envelope fusion with host cell membrane are controlled by a series of complex molecular mechanisms, largely dependent on the viral envelope glycoprotein Spike (S). There are still many unknowns on the implication of cellular factors that regulate the entry process.
DOI: 10.1371/journal.pone.0049566
PubMed: 23185364
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Links to Exploration step
pubmed:23185364Le document en format XML
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last="Cheung">Chung-Yan Cheung</name></author><author><name sortKey="Siu, Yu Lam" sort="Siu, Yu Lam" uniqKey="Siu Y" first="Yu-Lam" last="Siu">Yu-Lam Siu</name></author><author><name sortKey="Chan, Wing Lim" sort="Chan, Wing Lim" uniqKey="Chan W" first="Wing-Lim" last="Chan">Wing-Lim Chan</name></author><author><name sortKey="Li, Huiying" sort="Li, Huiying" uniqKey="Li H" first="Huiying" last="Li">Huiying Li</name></author><author><name sortKey="Leung, Hiu Lan" sort="Leung, Hiu Lan" uniqKey="Leung H" first="Hiu-Lan" last="Leung">Hiu-Lan Leung</name></author><author><name sortKey="Jaume, Martial" sort="Jaume, Martial" uniqKey="Jaume M" first="Martial" last="Jaume">Martial Jaume</name></author><author><name sortKey="Bruzzone, Roberto" sort="Bruzzone, Roberto" uniqKey="Bruzzone R" first="Roberto" last="Bruzzone">Roberto Bruzzone</name></author><author><name sortKey="Peiris, Joseph S Malik" sort="Peiris, Joseph S Malik" uniqKey="Peiris J" first="Joseph S Malik" last="Peiris">Joseph S Malik 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sortKey="Cheung, Chung Yan" sort="Cheung, Chung Yan" uniqKey="Cheung C" first="Chung-Yan" last="Cheung">Chung-Yan Cheung</name></author><author><name sortKey="Siu, Yu Lam" sort="Siu, Yu Lam" uniqKey="Siu Y" first="Yu-Lam" last="Siu">Yu-Lam Siu</name></author><author><name sortKey="Chan, Wing Lim" sort="Chan, Wing Lim" uniqKey="Chan W" first="Wing-Lim" last="Chan">Wing-Lim Chan</name></author><author><name sortKey="Li, Huiying" sort="Li, Huiying" uniqKey="Li H" first="Huiying" last="Li">Huiying Li</name></author><author><name sortKey="Leung, Hiu Lan" sort="Leung, Hiu Lan" uniqKey="Leung H" first="Hiu-Lan" last="Leung">Hiu-Lan Leung</name></author><author><name sortKey="Jaume, Martial" sort="Jaume, Martial" uniqKey="Jaume M" first="Martial" last="Jaume">Martial Jaume</name></author><author><name sortKey="Bruzzone, Roberto" sort="Bruzzone, Roberto" uniqKey="Bruzzone R" first="Roberto" last="Bruzzone">Roberto Bruzzone</name></author><author><name sortKey="Peiris, Joseph S Malik" sort="Peiris, Joseph S Malik" uniqKey="Peiris J" first="Joseph S Malik" last="Peiris">Joseph S Malik Peiris</name></author><author><name sortKey="Altmeyer, Ralf Marius" sort="Altmeyer, Ralf Marius" uniqKey="Altmeyer R" first="Ralf Marius" last="Altmeyer">Ralf Marius Altmeyer</name></author><author><name sortKey="Nal, Beatrice" sort="Nal, Beatrice" uniqKey="Nal B" first="Béatrice" last="Nal">Béatrice Nal</name></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Binding Sites</term><term>Cell Membrane (metabolism)</term><term>Cytoskeletal Proteins (chemistry)</term><term>Cytosol (metabolism)</term><term>Gene Library</term><term>Glutathione Transferase (metabolism)</term><term>HEK293 Cells</term><term>HeLa Cells</term><term>Humans</term><term>Membrane Glycoproteins (chemistry)</term><term>Membrane Glycoproteins (metabolism)</term><term>Molecular Sequence Data</term><term>Multigene Family</term><term>Mutation</term><term>Protein Binding</term><term>Protein Structure, Tertiary</term><term>SARS Virus (metabolism)</term><term>Sequence Homology, Amino Acid</term><term>Spike Glycoprotein, Coronavirus</term><term>Two-Hybrid System Techniques</term><term>Vero Cells</term><term>Viral Envelope Proteins (chemistry)</term><term>Viral Envelope Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Banque de gènes</term><term>Cellules HEK293</term><term>Cellules HeLa</term><term>Cellules Vero</term><term>Cytosol (métabolisme)</term><term>Données de séquences moléculaires</term><term>Famille multigénique</term><term>Glutathione transferase (métabolisme)</term><term>Glycoprotéine de spicule des coronavirus</term><term>Glycoprotéines membranaires ()</term><term>Glycoprotéines membranaires (métabolisme)</term><term>Humains</term><term>Liaison aux protéines</term><term>Membrane cellulaire (métabolisme)</term><term>Mutation</term><term>Protéines de l'enveloppe virale ()</term><term>Protéines de l'enveloppe virale (métabolisme)</term><term>Protéines du cytosquelette ()</term><term>Similitude de séquences d'acides aminés</term><term>Sites de fixation</term><term>Structure tertiaire des protéines</term><term>Séquence d'acides aminés</term><term>Techniques de double hybride</term><term>Virus du SRAS (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Cytoskeletal Proteins</term><term>Membrane Glycoproteins</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Membrane</term><term>Cytosol</term><term>Glutathione Transferase</term><term>Membrane Glycoproteins</term><term>SARS Virus</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytosol</term><term>Glutathione transferase</term><term>Glycoprotéines membranaires</term><term>Membrane cellulaire</term><term>Protéines de l'enveloppe virale</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Binding Sites</term><term>Gene Library</term><term>HEK293 Cells</term><term>HeLa Cells</term><term>Humans</term><term>Molecular Sequence Data</term><term>Multigene Family</term><term>Mutation</term><term>Protein Binding</term><term>Protein Structure, Tertiary</term><term>Sequence Homology, Amino Acid</term><term>Spike Glycoprotein, Coronavirus</term><term>Two-Hybrid System Techniques</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Banque de gènes</term><term>Cellules HEK293</term><term>Cellules HeLa</term><term>Cellules Vero</term><term>Données de séquences moléculaires</term><term>Famille multigénique</term><term>Glycoprotéine de spicule des coronavirus</term><term>Glycoprotéines membranaires</term><term>Humains</term><term>Liaison aux protéines</term><term>Mutation</term><term>Protéines de l'enveloppe virale</term><term>Protéines du cytosquelette</term><term>Similitude de séquences d'acides aminés</term><term>Sites de fixation</term><term>Structure tertiaire des protéines</term><term>Séquence d'acides aminés</term><term>Techniques de double hybride</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Entry of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) and its envelope fusion with host cell membrane are controlled by a series of complex molecular mechanisms, largely dependent on the viral envelope glycoprotein Spike (S). There are still many unknowns on the implication of cellular factors that regulate the entry process.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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