SARS-CoV and emergent coronaviruses: viral determinants of interspecies transmission
Identifieur interne : 002430 ( Ncbi/Curation ); précédent : 002429; suivant : 002431SARS-CoV and emergent coronaviruses: viral determinants of interspecies transmission
Auteurs : Meagan Bolles [États-Unis] ; Eric Donaldson [États-Unis] ; Ralph Baric [États-Unis]Source :
- Current Opinion in Virology [ 1879-6257 ] ; 2011.
Descripteurs français
- KwdFr :
- Animaux, Chiroptera (virologie), Données de séquences moléculaires, Flambées de maladies, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (génétique), Humains, Phylogénie, Protéines de l'enveloppe virale (génétique), Réservoirs d'agents pathogènes (virologie), Santé publique, Syndrome respiratoire aigu sévère (transmission), Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Séquence nucléotidique, Virus du SRAS (croissance et développement), Virus du SRAS (génétique), Zoonoses (transmission), Zoonoses (virologie), Zoonoses (épidémiologie).
- MESH :
- croissance et développement : Virus du SRAS.
- génétique : Glycoprotéines membranaires, Protéines de l'enveloppe virale, Virus du SRAS.
- virologie : Chiroptera, Réservoirs d'agents pathogènes, Syndrome respiratoire aigu sévère, Zoonoses.
- épidémiologie : Syndrome respiratoire aigu sévère, Zoonoses.
- Animaux, Données de séquences moléculaires, Flambées de maladies, Glycoprotéine de spicule des coronavirus, Humains, Phylogénie, Santé publique, Séquence nucléotidique.
English descriptors
- KwdEn :
- Animals, Base Sequence, Chiroptera (virology), Disease Outbreaks, Disease Reservoirs (virology), Humans, Membrane Glycoproteins (genetics), Molecular Sequence Data, Phylogeny, Public Health, SARS Virus (genetics), SARS Virus (growth & development), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (transmission), Severe Acute Respiratory Syndrome (virology), Spike Glycoprotein, Coronavirus, Viral Envelope Proteins (genetics), Zoonoses (epidemiology), Zoonoses (transmission), Zoonoses (virology).
- MESH :
- chemical , genetics : Membrane Glycoproteins, Viral Envelope Proteins.
- epidemiology : Severe Acute Respiratory Syndrome, Zoonoses.
- genetics : SARS Virus.
- growth & development : SARS Virus.
- transmission : Severe Acute Respiratory Syndrome, Zoonoses.
- virology : Chiroptera, Disease Reservoirs, Severe Acute Respiratory Syndrome, Zoonoses.
- Animals, Base Sequence, Disease Outbreaks, Humans, Molecular Sequence Data, Phylogeny, Public Health, Spike Glycoprotein, Coronavirus.
Abstract
► Coronaviruses maintain a diverse phylogeny by distinct molecular mechanisms. ► BatCoV phylogenetics and receptor use may suggest a direct emergence of SARS-CoV. ► SARS Spike–receptor binding is the minimum determinant of cross-species transmission. ► Mutation and recombination-driven changes to Spike drive CoV host range expansion. ► Novel structural modeling tools allow assessment of receptor-binding determinants.
Url:
DOI: 10.1016/j.coviro.2011.10.012
PubMed: 22180768
PubMed Central: 3237677
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PMC:3237677Le document en format XML
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<front><div type="abstract" xml:lang="en"><title>Highlights</title>
<p>► Coronaviruses maintain a diverse phylogeny by distinct molecular mechanisms. ► BatCoV phylogenetics and receptor use may suggest a direct emergence of SARS-CoV. ► SARS Spike–receptor binding is the minimum determinant of cross-species transmission. ► Mutation and recombination-driven changes to Spike drive CoV host range expansion. ► Novel structural modeling tools allow assessment of receptor-binding determinants.</p>
</div>
</front>
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