SrasV1, Ncbi, Curation, bibRecord, 002372

Inhibitors of SARS-CoV entry – Identification using an internally-controlled dual envelope pseudovirion assay

Identifieur interne : 002372 ( Ncbi/Curation ); précédent : 002371; suivant : 002373

Inhibitors of SARS-CoV entry – Identification using an internally-controlled dual envelope pseudovirion assay

Auteurs : Yanchen Zhou [États-Unis] ; Juliet Agudelo [États-Unis] ; Kai Lu [États-Unis] ; David H. Goetz [États-Unis] ; Elizabeth Hansell [États-Unis] ; Yen Ting Chen [États-Unis] ; William R. Roush [États-Unis] ; James Mckerrow [États-Unis] ; Charles S. Craik [États-Unis] ; Sean M. Amberg [États-Unis] ; Graham Simmons [États-Unis]

Source :

Antiviral Research [ 0166-3542 ] ; 2011.

RBID : PMC:3205982

Descripteurs français

English descriptors

KwdEn :
- Antiviral Agents (pharmacology), Drug Evaluation, Preclinical (methods), Drug Evaluation, Preclinical (standards), High-Throughput Screening Assays (methods), High-Throughput Screening Assays (standards), Humans, Microbial Sensitivity Tests (methods), Microbial Sensitivity Tests (standards), SARS Virus (drug effects), Virus Cultivation (methods), Virus Cultivation (standards), Virus Internalization (drug effects).
MESH :
- chemical , pharmacology : Antiviral Agents.
- drug effects : SARS Virus, Virus Internalization.
- methods : Drug Evaluation, Preclinical, High-Throughput Screening Assays, Microbial Sensitivity Tests, Virus Cultivation.
- standards : Drug Evaluation, Preclinical, High-Throughput Screening Assays, Microbial Sensitivity Tests, Virus Cultivation.
- Humans.

Abstract

Highlights

► We describe a novel assay for screening inhibitors of viral entry. ► The inclusion of an internal control envelope controls for specificity. ► This assay system can be adapted for most enveloped viruses. ► Examples of screens for inhibitors of SARS-CoV entry were performed. ► A number of compounds were identified that inhibit SARS-CoV entry and replication.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205982

DOI: 10.1016/j.antiviral.2011.07.016
PubMed: 21820471
PubMed Central: 3205982

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PMC:3205982

Le document en format XML

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<front><div type="abstract" xml:lang="en"><title>Highlights</title>
<p>► We describe a novel assay for screening inhibitors of viral entry. ► The inclusion of an internal control envelope controls for specificity. ► This assay system can be adapted for most enveloped viruses. ► Examples of screens for inhibitors of SARS-CoV entry were performed. ► A number of compounds were identified that inhibit SARS-CoV entry and replication.</p>
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</author>
<author><name sortKey="Bailey, K" uniqKey="Bailey K">K. Bailey</name>
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<author><name sortKey="Montgomery, R" uniqKey="Montgomery R">R. Montgomery</name>
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<author><name sortKey="Lauridsen, L" uniqKey="Lauridsen L">L. Lauridsen</name>
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<author><name sortKey="Chan, P K" uniqKey="Chan P">P.K. Chan</name>
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<author><name sortKey="Sidwell, R W" uniqKey="Sidwell R">R.W. Sidwell</name>
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<author><name sortKey="Felbor, U" uniqKey="Felbor U">U. Felbor</name>
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<author><name sortKey="Whelan, S P" uniqKey="Whelan S">S.P. Whelan</name>
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<author><name sortKey="Cunningham, J M" uniqKey="Cunningham J">J.M. Cunningham</name>
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</analytic>
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<author><name sortKey="Chen, B K" uniqKey="Chen B">B.K. Chen</name>
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<author><name sortKey="Landau, N R" uniqKey="Landau N">N.R. Landau</name>
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<biblStruct><analytic><author><name sortKey="Deming, D" uniqKey="Deming D">D. Deming</name>
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<author><name sortKey="Sheahan, T" uniqKey="Sheahan T">T. Sheahan</name>
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<author><name sortKey="Yount, B" uniqKey="Yount B">B. Yount</name>
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Inhibitors of SARS-CoV entry – Identification using an internally-controlled dual envelope pseudovirion assay

Inhibitors of SARS-CoV entry – Identification using an internally-controlled dual envelope pseudovirion assay

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