On the mechanisms of bananin activity against severe acute respiratory syndrome coronavirus
Identifieur interne : 002264 ( Ncbi/Curation ); précédent : 002263; suivant : 002265On the mechanisms of bananin activity against severe acute respiratory syndrome coronavirus
Auteurs : Zai Wang ; Jian-Dong Huang ; Kin-Ling Wong ; Pei-Gang Wang ; Hao-Jie Zhang ; Julian A. Tanner ; Ottavia Spiga ; Andrea Bernini ; Bo-Jian Zheng ; Neri NiccolaiSource :
- The Febs Journal [ 1742-464X ] ; 2010.
Descripteurs français
- KwdFr :
- Adamantane (), Adamantane (analogues et dérivés), Adamantane (métabolisme), Adamantane (pharmacologie), Adamantane (usage thérapeutique), Biologie informatique, Eau (), Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (génétique), Helicase (), Helicase (génétique), Helicase (métabolisme), Interactions hydrophobes et hydrophiles, Liaison aux protéines (génétique), Liaison hydrogène, Modèles moléculaires, Mutation faux-sens (génétique), Protéines de l'enveloppe virale (génétique), Protéines de la matrice virale (génétique), Protéines virales (), Protéines virales (génétique), Protéines virales (métabolisme), Pyridines (), Pyridines (métabolisme), Pyridines (pharmacologie), Pyridines (usage thérapeutique), RNA helicases (), RNA helicases (génétique), RNA helicases (métabolisme), Résistance virale aux médicaments (génétique), Sites de fixation (génétique), Structure quaternaire des protéines, Syndrome respiratoire aigu sévère (traitement médicamenteux), Virus du SRAS (), Virus du SRAS (génétique), Électricité statique.
- MESH :
- analogues et dérivés : Adamantane.
- génétique : Glycoprotéines membranaires, Helicase, Liaison aux protéines, Mutation faux-sens, Protéines de l'enveloppe virale, Protéines de la matrice virale, Protéines virales, RNA helicases, Résistance virale aux médicaments, Sites de fixation, Virus du SRAS.
- métabolisme : Adamantane, Helicase, Protéines virales, Pyridines, RNA helicases.
- pharmacologie : Adamantane, Pyridines.
- traitement médicamenteux : Syndrome respiratoire aigu sévère.
- usage thérapeutique : Adamantane, Pyridines.
- Adamantane, Biologie informatique, Eau, Glycoprotéine de spicule des coronavirus, Helicase, Interactions hydrophobes et hydrophiles, Liaison hydrogène, Modèles moléculaires, Protéines virales, Pyridines, RNA helicases, Structure quaternaire des protéines, Virus du SRAS, Électricité statique.
English descriptors
- KwdEn :
- Adamantane (analogs & derivatives), Adamantane (chemistry), Adamantane (metabolism), Adamantane (pharmacology), Adamantane (therapeutic use), Binding Sites (genetics), Computational Biology, DNA Helicases (chemistry), DNA Helicases (genetics), DNA Helicases (metabolism), Drug Resistance, Viral (genetics), Hydrogen Bonding, Hydrophobic and Hydrophilic Interactions, Membrane Glycoproteins (genetics), Models, Molecular, Mutation, Missense (genetics), Protein Binding (genetics), Protein Structure, Quaternary, Pyridines (chemistry), Pyridines (metabolism), Pyridines (pharmacology), Pyridines (therapeutic use), RNA Helicases (chemistry), RNA Helicases (genetics), RNA Helicases (metabolism), SARS Virus (drug effects), SARS Virus (genetics), Severe Acute Respiratory Syndrome (drug therapy), Spike Glycoprotein, Coronavirus, Static Electricity, Viral Envelope Proteins (genetics), Viral Matrix Proteins (genetics), Viral Proteins (chemistry), Viral Proteins (genetics), Viral Proteins (metabolism), Water (chemistry).
- MESH :
- chemical , analogs & derivatives : Adamantane.
- chemical , chemistry : Adamantane, DNA Helicases, Pyridines, RNA Helicases, Viral Proteins, Water.
- chemical , genetics : DNA Helicases, Membrane Glycoproteins, RNA Helicases, Viral Envelope Proteins, Viral Matrix Proteins, Viral Proteins.
- chemical , metabolism : Adamantane, DNA Helicases, Pyridines, RNA Helicases, Viral Proteins.
- chemical , pharmacology : Adamantane, Pyridines.
- chemical , therapeutic use : Adamantane, Pyridines.
- drug effects : SARS Virus.
- drug therapy : Severe Acute Respiratory Syndrome.
- genetics : Binding Sites, Drug Resistance, Viral, Mutation, Missense, Protein Binding, SARS Virus.
- Computational Biology, Hydrogen Bonding, Hydrophobic and Hydrophilic Interactions, Models, Molecular, Protein Structure, Quaternary, Spike Glycoprotein, Coronavirus, Static Electricity.
Abstract
In a previous study, severe acute respiratory syndrome coronavirus (SARS‐CoV) was cultured in the presence of bananin, an effective adamantane‐related molecule with antiviral activity. In the present study, we show that all bananin‐resistant variants exhibit mutations in helicase and membrane protein, although no evidence of bananin interference on their mutual interaction has been found. A structural analysis on protein sequence mutations found in SARS‐CoV bananin‐resistant variants was performed. The S259/L mutation of SARS‐CoV helicase is always found in all the identified bananin‐resistant variants, suggesting a primary role of this mutation site for bananin activity. From a structural analysis of SARS‐CoV predicted helicase structure, S259 is found in a hydrophilic surface pocket, far from the enzyme active sites and outside the helicase dimer interface. The S/L substitution causes a pocket volume reduction that weakens the interaction between bananin and SARS‐CoV mutated helicase, suggesting a possible mechanism for bananin antiviral activity.
Url:
DOI: 10.1111/j.1742-4658.2010.07961.x
PubMed: 21134131
PubMed Central: 7164005
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PMC:7164005Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adamantane (analogs & derivatives)</term>
<term>Adamantane (chemistry)</term>
<term>Adamantane (metabolism)</term>
<term>Adamantane (pharmacology)</term>
<term>Adamantane (therapeutic use)</term>
<term>Binding Sites (genetics)</term>
<term>Computational Biology</term>
<term>DNA Helicases (chemistry)</term>
<term>DNA Helicases (genetics)</term>
<term>DNA Helicases (metabolism)</term>
<term>Drug Resistance, Viral (genetics)</term>
<term>Hydrogen Bonding</term>
<term>Hydrophobic and Hydrophilic Interactions</term>
<term>Membrane Glycoproteins (genetics)</term>
<term>Models, Molecular</term>
<term>Mutation, Missense (genetics)</term>
<term>Protein Binding (genetics)</term>
<term>Protein Structure, Quaternary</term>
<term>Pyridines (chemistry)</term>
<term>Pyridines (metabolism)</term>
<term>Pyridines (pharmacology)</term>
<term>Pyridines (therapeutic use)</term>
<term>RNA Helicases (chemistry)</term>
<term>RNA Helicases (genetics)</term>
<term>RNA Helicases (metabolism)</term>
<term>SARS Virus (drug effects)</term>
<term>SARS Virus (genetics)</term>
<term>Severe Acute Respiratory Syndrome (drug therapy)</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Static Electricity</term>
<term>Viral Envelope Proteins (genetics)</term>
<term>Viral Matrix Proteins (genetics)</term>
<term>Viral Proteins (chemistry)</term>
<term>Viral Proteins (genetics)</term>
<term>Viral Proteins (metabolism)</term>
<term>Water (chemistry)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adamantane ()</term>
<term>Adamantane (analogues et dérivés)</term>
<term>Adamantane (métabolisme)</term>
<term>Adamantane (pharmacologie)</term>
<term>Adamantane (usage thérapeutique)</term>
<term>Biologie informatique</term>
<term>Eau ()</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Glycoprotéines membranaires (génétique)</term>
<term>Helicase ()</term>
<term>Helicase (génétique)</term>
<term>Helicase (métabolisme)</term>
<term>Interactions hydrophobes et hydrophiles</term>
<term>Liaison aux protéines (génétique)</term>
<term>Liaison hydrogène</term>
<term>Modèles moléculaires</term>
<term>Mutation faux-sens (génétique)</term>
<term>Protéines de l'enveloppe virale (génétique)</term>
<term>Protéines de la matrice virale (génétique)</term>
<term>Protéines virales ()</term>
<term>Protéines virales (génétique)</term>
<term>Protéines virales (métabolisme)</term>
<term>Pyridines ()</term>
<term>Pyridines (métabolisme)</term>
<term>Pyridines (pharmacologie)</term>
<term>Pyridines (usage thérapeutique)</term>
<term>RNA helicases ()</term>
<term>RNA helicases (génétique)</term>
<term>RNA helicases (métabolisme)</term>
<term>Résistance virale aux médicaments (génétique)</term>
<term>Sites de fixation (génétique)</term>
<term>Structure quaternaire des protéines</term>
<term>Syndrome respiratoire aigu sévère (traitement médicamenteux)</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (génétique)</term>
<term>Électricité statique</term>
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<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Adamantane</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Adamantane</term>
<term>DNA Helicases</term>
<term>Pyridines</term>
<term>RNA Helicases</term>
<term>Viral Proteins</term>
<term>Water</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA Helicases</term>
<term>Membrane Glycoproteins</term>
<term>RNA Helicases</term>
<term>Viral Envelope Proteins</term>
<term>Viral Matrix Proteins</term>
<term>Viral Proteins</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adamantane</term>
<term>DNA Helicases</term>
<term>Pyridines</term>
<term>RNA Helicases</term>
<term>Viral Proteins</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Adamantane</term>
<term>Pyridines</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adamantane</term>
<term>Pyridines</term>
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<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Adamantane</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>SARS Virus</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Binding Sites</term>
<term>Drug Resistance, Viral</term>
<term>Mutation, Missense</term>
<term>Protein Binding</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéines membranaires</term>
<term>Helicase</term>
<term>Liaison aux protéines</term>
<term>Mutation faux-sens</term>
<term>Protéines de l'enveloppe virale</term>
<term>Protéines de la matrice virale</term>
<term>Protéines virales</term>
<term>RNA helicases</term>
<term>Résistance virale aux médicaments</term>
<term>Sites de fixation</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Adamantane</term>
<term>Helicase</term>
<term>Protéines virales</term>
<term>Pyridines</term>
<term>RNA helicases</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Adamantane</term>
<term>Pyridines</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Adamantane</term>
<term>Pyridines</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Computational Biology</term>
<term>Hydrogen Bonding</term>
<term>Hydrophobic and Hydrophilic Interactions</term>
<term>Models, Molecular</term>
<term>Protein Structure, Quaternary</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Static Electricity</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adamantane</term>
<term>Biologie informatique</term>
<term>Eau</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Helicase</term>
<term>Interactions hydrophobes et hydrophiles</term>
<term>Liaison hydrogène</term>
<term>Modèles moléculaires</term>
<term>Protéines virales</term>
<term>Pyridines</term>
<term>RNA helicases</term>
<term>Structure quaternaire des protéines</term>
<term>Virus du SRAS</term>
<term>Électricité statique</term>
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<front><div type="abstract" xml:lang="en"><p>In a previous study, severe acute respiratory syndrome coronavirus (SARS‐CoV) was cultured in the presence of bananin, an effective adamantane‐related molecule with antiviral activity. In the present study, we show that all bananin‐resistant variants exhibit mutations in helicase and membrane protein, although no evidence of bananin interference on their mutual interaction has been found. A structural analysis on protein sequence mutations found in SARS‐CoV bananin‐resistant variants was performed. The S259/L mutation of SARS‐CoV helicase is always found in all the identified bananin‐resistant variants, suggesting a primary role of this mutation site for bananin activity. From a structural analysis of SARS‐CoV predicted helicase structure, S259 is found in a hydrophilic surface pocket, far from the enzyme active sites and outside the helicase dimer interface. The S/L substitution causes a pocket volume reduction that weakens the interaction between bananin and SARS‐CoV mutated helicase, suggesting a possible mechanism for bananin antiviral activity.</p>
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