Delivery to the lower respiratory tract is required for effective immunization with Newcastle disease virus-vectored vaccines intended for humans.
Identifieur interne : 001E35 ( Ncbi/Curation ); précédent : 001E34; suivant : 001E36Delivery to the lower respiratory tract is required for effective immunization with Newcastle disease virus-vectored vaccines intended for humans.
Auteurs : Joshua M. Dinapoli [États-Unis] ; Jerrold M. Ward ; Lily Cheng ; Lijuan Yang ; Subbiah Elankumaran ; Brian R. Murphy ; Siba K. Samal ; Peter L. Collins ; Alexander BukreyevSource :
- Vaccine [ 0264-410X ] ; 2009.
Descripteurs français
- KwdFr :
- Animaux, Humains, Poumon (anatomopathologie), Poumon (immunologie), Vaccination (), Vaccins antiviraux (administration et posologie), Vaccins antiviraux (génétique), Vaccins antiviraux (immunologie), Vaccins synthétiques (administration et posologie), Vaccins synthétiques (génétique), Vaccins synthétiques (immunologie), Vecteurs génétiques, Virus de la maladie de Newcastle (génétique), Virus de la maladie de Newcastle (immunologie), Virus du SRAS (génétique), Virus du SRAS (immunologie).
- MESH :
- administration et posologie : Vaccins antiviraux, Vaccins synthétiques.
- anatomopathologie : Poumon.
- génétique : Vaccins antiviraux, Vaccins synthétiques, Virus de la maladie de Newcastle, Virus du SRAS.
- immunologie : Poumon, Vaccins antiviraux, Vaccins synthétiques, Virus de la maladie de Newcastle, Virus du SRAS.
- Animaux, Humains, Vaccination, Vecteurs génétiques.
English descriptors
- KwdEn :
- Animals, Chlorocebus aethiops, Genetic Vectors, Humans, Lung (immunology), Lung (pathology), Newcastle disease virus (genetics), Newcastle disease virus (immunology), SARS Virus (genetics), SARS Virus (immunology), Vaccination (methods), Vaccines, Synthetic (administration & dosage), Vaccines, Synthetic (genetics), Vaccines, Synthetic (immunology), Viral Vaccines (administration & dosage), Viral Vaccines (genetics), Viral Vaccines (immunology).
- MESH :
- chemical , administration & dosage : Vaccines, Synthetic, Viral Vaccines.
- genetics : Newcastle disease virus, SARS Virus, Vaccines, Synthetic, Viral Vaccines.
- immunology : Lung, Newcastle disease virus, SARS Virus, Vaccines, Synthetic, Viral Vaccines.
- methods : Vaccination.
- pathology : Lung.
- Animals, Chlorocebus aethiops, Genetic Vectors, Humans.
Abstract
Newcastle disease virus (NDV), an avian virus, is being evaluated for the development of vectored human vaccines against emerging pathogens. Previous studies of NDV-vectored vaccines in a mouse model suggested their potency after delivery by injection or by the intranasal route. We compared the efficacy of various routes of delivery of NDV-vectored vaccines in a non-human primate model. While delivery of an NDV-vectored vaccine by the combined intranasal/intratracheal route elicited protective immune responses, delivery by the subcutaneous route or the intranasal route alone elicited limited or no protective immune responses, suggesting the necessity for vaccine delivery to the lower respiratory tract. Furthermore, direct comparison of a vaccine based on an NDV mesogenic strain (NDV-BC) with a similarly designed NDV vector based on a modified lentogenic strain carrying a polybasic F cleavage site (NDV-VF) suggested that the two NDV strains were similar in immunogenicity and were equally protective.
DOI: 10.1016/j.vaccine.2009.01.009
PubMed: 19168110
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Dinapoli</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-8007, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-8007</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Ward, Jerrold M" sort="Ward, Jerrold M" uniqKey="Ward J" first="Jerrold M" last="Ward">Jerrold M. 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Previous studies of NDV-vectored vaccines in a mouse model suggested their potency after delivery by injection or by the intranasal route. We compared the efficacy of various routes of delivery of NDV-vectored vaccines in a non-human primate model. While delivery of an NDV-vectored vaccine by the combined intranasal/intratracheal route elicited protective immune responses, delivery by the subcutaneous route or the intranasal route alone elicited limited or no protective immune responses, suggesting the necessity for vaccine delivery to the lower respiratory tract. Furthermore, direct comparison of a vaccine based on an NDV mesogenic strain (NDV-BC) with a similarly designed NDV vector based on a modified lentogenic strain carrying a polybasic F cleavage site (NDV-VF) suggested that the two NDV strains were similar in immunogenicity and were equally protective.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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