A novel subset of putative stem/progenitor CD34+Oct-4+ cells is the major target for SARS coronavirus in human lung.
Identifieur interne : 001A80 ( Ncbi/Curation ); précédent : 001A79; suivant : 001A81A novel subset of putative stem/progenitor CD34+Oct-4+ cells is the major target for SARS coronavirus in human lung.
Auteurs : Yongxiong Chen [République populaire de Chine] ; Vera Sau-Fong Chan ; Bojian Zheng ; Kelvin Yuen-Kwong Chan ; Xiaoning Xu ; Leo Yuk-Fai To ; Fang-Ping Huang ; Ui-Soon Khoo ; Chen-Lung Steve LinSource :
- The Journal of experimental medicine [ 1540-9538 ] ; 2007.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Alvéoles pulmonaires (anatomopathologie), Antigènes CD34 (analyse), Antigènes viraux (analyse), Autopsie, Cellules souches (physiologie), Facteur de transcription Oct-3 (analyse), Femelle, Humains, Kératines (analyse), Mâle, Poumon (anatomopathologie), Poumon (physiologie), Poumon (virologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Surfactants pulmonaires (analyse), Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (mortalité), Virus du SRAS (pathogénicité).
- MESH :
- analyse : Antigènes CD34, Antigènes viraux, Facteur de transcription Oct-3, Kératines, Surfactants pulmonaires.
- anatomopathologie : Alvéoles pulmonaires, Poumon, Syndrome respiratoire aigu sévère.
- mortalité : Syndrome respiratoire aigu sévère.
- pathogénicité : Virus du SRAS.
- physiologie : Cellules souches, Poumon.
- virologie : Poumon.
- Adulte d'âge moyen, Autopsie, Femelle, Humains, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Antigens, CD34 (analysis), Antigens, Viral (analysis), Autopsy, Female, Humans, Keratins (analysis), Lung (pathology), Lung (physiology), Lung (virology), Male, Middle Aged, Octamer Transcription Factor-3 (analysis), Pulmonary Alveoli (pathology), Pulmonary Surfactants (analysis), SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (mortality), Severe Acute Respiratory Syndrome (pathology), Stem Cells (physiology).
- MESH :
- chemical , analysis : Antigens, CD34, Antigens, Viral, Keratins, Octamer Transcription Factor-3, Pulmonary Surfactants.
- mortality : Severe Acute Respiratory Syndrome.
- pathogenicity : SARS Virus.
- pathology : Lung, Pulmonary Alveoli, Severe Acute Respiratory Syndrome.
- physiology : Lung, Stem Cells.
- virology : Lung.
- Aged, Aged, 80 and over, Autopsy, Female, Humans, Male, Middle Aged.
Abstract
Identification of the nature of severe acute respiratory syndrome (SARS)-infected cells is crucial toward understanding the pathogenesis. Using multicolor colocalization techniques, we previously reported that SARS(+) cells in the lung of fatally infected patients expressed the only known functional receptor, angiotensin-converting enzyme 2, and also a binding receptor, liver/lymph node-specific ICAM-3-grabbing non-integrin (CD209L). In this study, we show that SARS-infected cells also express the stem/progenitor cell markers CD34 and Oct-4, and do not express cytokeratin or surfactant. These putative lung stem/progenitor cells can also be identified in some non-SARS individuals and can be infected by SARS-coronavirus ex vivo. Infection of these cells may contribute to the loss of lung repair capacity that leads to respiratory failure as clinically observed.
DOI: 10.1084/jem.20070462
PubMed: 17923501
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pubmed:17923501Le document en format XML
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(analyse)</term><term>Femelle</term><term>Humains</term><term>Kératines (analyse)</term><term>Mâle</term><term>Poumon (anatomopathologie)</term><term>Poumon (physiologie)</term><term>Poumon (virologie)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Surfactants pulmonaires (analyse)</term><term>Syndrome respiratoire aigu sévère (anatomopathologie)</term><term>Syndrome respiratoire aigu sévère (mortalité)</term><term>Virus du SRAS (pathogénicité)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antigens, CD34</term><term>Antigens, Viral</term><term>Keratins</term><term>Octamer Transcription Factor-3</term><term>Pulmonary Surfactants</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Antigènes CD34</term><term>Antigènes viraux</term><term>Facteur de transcription Oct-3</term><term>Kératines</term><term>Surfactants pulmonaires</term></keywords><keywords scheme="MESH" 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Using multicolor colocalization techniques, we previously reported that SARS(+) cells in the lung of fatally infected patients expressed the only known functional receptor, angiotensin-converting enzyme 2, and also a binding receptor, liver/lymph node-specific ICAM-3-grabbing non-integrin (CD209L). In this study, we show that SARS-infected cells also express the stem/progenitor cell markers CD34 and Oct-4, and do not express cytokeratin or surfactant. These putative lung stem/progenitor cells can also be identified in some non-SARS individuals and can be infected by SARS-coronavirus ex vivo. Infection of these cells may contribute to the loss of lung repair capacity that leads to respiratory failure as clinically observed.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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