Structure-based design and synthesis of highly potent SARS-CoV 3CL protease inhibitors.
Identifieur interne : 001A48 ( Ncbi/Curation ); précédent : 001A47; suivant : 001A49Structure-based design and synthesis of highly potent SARS-CoV 3CL protease inhibitors.
Auteurs : Yi-Ming Shao [République populaire de Chine] ; Wen-Bin Yang ; Hung-Pin Peng ; Min-Feng Hsu ; Keng-Chang Tsai ; Tun-Hsun Kuo ; Andrew H-J Wang ; Po-Huang Liang ; Chun-Hung Lin ; An-Suei Yang ; Chi-Huey WongSource :
- Chembiochem : a European journal of chemical biology [ 1439-4227 ] ; 2007.
Descripteurs français
- KwdFr :
- Chimie pharmaceutique (), Conception de médicament, Conformation des protéines, Conformation moléculaire, Cristallisation, Cristallographie aux rayons X (), Cysteine endopeptidases, Inhibiteurs de protéases (pharmacologie), Inhibiteurs de protéases (synthèse chimique), Liaison hydrogène, Ligands, Modèles chimiques, Protéines virales (antagonistes et inhibiteurs), Rayons X, Virus du SRAS (enzymologie).
- MESH :
- antagonistes et inhibiteurs : Protéines virales.
- enzymologie : Virus du SRAS.
- pharmacologie : Inhibiteurs de protéases.
- synthèse chimique : Inhibiteurs de protéases.
- Chimie pharmaceutique, Conception de médicament, Conformation des protéines, Conformation moléculaire, Cristallisation, Cristallographie aux rayons X, Cysteine endopeptidases, Liaison hydrogène, Ligands, Modèles chimiques, Rayons X.
English descriptors
- KwdEn :
- Chemistry, Pharmaceutical (methods), Crystallization, Crystallography, X-Ray (methods), Cysteine Endopeptidases, Drug Design, Hydrogen Bonding, Ligands, Models, Chemical, Molecular Conformation, Protease Inhibitors (chemical synthesis), Protease Inhibitors (pharmacology), Protein Conformation, SARS Virus (enzymology), Viral Proteins (antagonists & inhibitors), X-Rays.
- MESH :
- chemical , antagonists & inhibitors : Viral Proteins.
- chemical , chemical synthesis : Protease Inhibitors.
- chemical , pharmacology : Protease Inhibitors.
- chemical : Cysteine Endopeptidases, Ligands.
- enzymology : SARS Virus.
- methods : Chemistry, Pharmaceutical, Crystallography, X-Ray.
- Crystallization, Drug Design, Hydrogen Bonding, Models, Chemical, Molecular Conformation, Protein Conformation, X-Rays.
DOI: 10.1002/cbic.200700254
PubMed: 17722121
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