Plant lectins are potent inhibitors of coronaviruses by interfering with two targets in the viral replication cycle.
Identifieur interne : 001927 ( Ncbi/Curation ); précédent : 001926; suivant : 001928Plant lectins are potent inhibitors of coronaviruses by interfering with two targets in the viral replication cycle.
Auteurs : Els Keyaerts [Belgique] ; Leen Vijgen ; Christophe Pannecouque ; Els Van Damme ; Willy Peumans ; Herman Egberink ; Jan Balzarini ; Marc Van RanstSource :
- Antiviral research [ 0166-3542 ] ; 2007.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (métabolisme), Antiviraux (pharmacologie), Chats, Coronavirus félin (), Coronavirus félin (physiologie), Humains, Lectines végétales (métabolisme), Lectines végétales (pharmacologie), Lignée cellulaire, Liliaceae, Pénétration virale (), Réplication virale (), Virus du SRAS (), Virus du SRAS (physiologie).
- MESH :
- métabolisme : Antiviraux, Lectines végétales.
- pharmacologie : Antiviraux, Lectines végétales.
- physiologie : Coronavirus félin, Virus du SRAS.
- Animaux, Chats, Coronavirus félin, Humains, Lignée cellulaire, Liliaceae, Pénétration virale, Réplication virale, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (metabolism), Antiviral Agents (pharmacology), Cats, Cell Line, Coronavirus, Feline (drug effects), Coronavirus, Feline (physiology), Humans, Liliaceae, Plant Lectins (metabolism), Plant Lectins (pharmacology), SARS Virus (drug effects), SARS Virus (physiology), Virus Internalization (drug effects), Virus Replication (drug effects).
- MESH :
- chemical , metabolism : Antiviral Agents, Plant Lectins.
- chemical , pharmacology : Antiviral Agents, Plant Lectins.
- drug effects : Coronavirus, Feline, SARS Virus, Virus Internalization, Virus Replication.
- physiology : Coronavirus, Feline, SARS Virus.
- Animals, Cats, Cell Line, Humans, Liliaceae.
Abstract
We describe the antiviral activity of plant lectins with specificity for different glycan structures against the severe acute respiratory syndrome coronavirus (SARS-CoV) and the feline infectious peritonitis virus (FIPV) in vitro. The SARS-CoV emerged in 2002 as an important cause of severe lower respiratory tract infection in humans, and FIPV infection causes a chronic and often fatal peritonitis in cats. A unique collection of 33 plant lectins with different specificities were evaluated. The plant lectins possessed marked antiviral properties against both coronaviruses with EC(50) values in the lower microgram/ml range (middle nanomolar range), being non-toxic (CC(50)) at 50-100 microg/ml. The strongest anti-coronavirus activity was found predominantly among the mannose-binding lectins. In addition, a number of galactose-, N-acetylgalactosamine-, glucose-, and N-acetylglucosamine-specific plant agglutinines exhibited anti-coronaviral activity. A significant correlation (with an r-value of 0.70) between the EC(50) values of the 10 mannose-specific plant lectins effective against the two coronaviruses was found. In contrast, little correlation was seen between the activity of other types of lectins. Two targets of possible antiviral intervention were identified in the replication cycle of SARS-CoV. The first target is located early in the replication cycle, most probably viral attachment, and the second target is located at the end of the infectious virus cycle.
DOI: 10.1016/j.antiviral.2007.03.003
PubMed: 17428553
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Vijgen</name></author><author><name sortKey="Pannecouque, Christophe" sort="Pannecouque, Christophe" uniqKey="Pannecouque C" first="Christophe" last="Pannecouque">Christophe Pannecouque</name></author><author><name sortKey="Van Damme, Els" sort="Van Damme, Els" uniqKey="Van Damme E" first="Els" last="Van Damme">Els Van Damme</name></author><author><name sortKey="Peumans, Willy" sort="Peumans, Willy" uniqKey="Peumans W" first="Willy" last="Peumans">Willy Peumans</name></author><author><name sortKey="Egberink, Herman" sort="Egberink, Herman" uniqKey="Egberink H" first="Herman" last="Egberink">Herman Egberink</name></author><author><name sortKey="Balzarini, Jan" sort="Balzarini, Jan" uniqKey="Balzarini J" first="Jan" last="Balzarini">Jan Balzarini</name></author><author><name sortKey="Van Ranst, Marc" sort="Van Ranst, Marc" uniqKey="Van Ranst M" first="Marc" last="Van Ranst">Marc Van Ranst</name></author></analytic><series><title level="j">Antiviral research</title><idno 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(SARS-CoV) and the feline infectious peritonitis virus (FIPV) in vitro. The SARS-CoV emerged in 2002 as an important cause of severe lower respiratory tract infection in humans, and FIPV infection causes a chronic and often fatal peritonitis in cats. A unique collection of 33 plant lectins with different specificities were evaluated. The plant lectins possessed marked antiviral properties against both coronaviruses with EC(50) values in the lower microgram/ml range (middle nanomolar range), being non-toxic (CC(50)) at 50-100 microg/ml. The strongest anti-coronavirus activity was found predominantly among the mannose-binding lectins. In addition, a number of galactose-, N-acetylgalactosamine-, glucose-, and N-acetylglucosamine-specific plant agglutinines exhibited anti-coronaviral activity. A significant correlation (with an r-value of 0.70) between the EC(50) values of the 10 mannose-specific plant lectins effective against the two coronaviruses was found. In contrast, little correlation was seen between the activity of other types of lectins. Two targets of possible antiviral intervention were identified in the replication cycle of SARS-CoV. The first target is located early in the replication cycle, most probably viral attachment, and the second target is located at the end of the infectious virus cycle.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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