Role for nonstructural protein 1 of severe acute respiratory syndrome coronavirus in chemokine dysregulation.
Identifieur interne : 001683 ( Ncbi/Curation ); précédent : 001682; suivant : 001684Role for nonstructural protein 1 of severe acute respiratory syndrome coronavirus in chemokine dysregulation.
Auteurs : Anna H Y. Law [République populaire de Chine] ; Davy C W. Lee ; Benny K W. Cheung ; Howard C H. Yim ; Allan S Y. LauSource :
- Journal of virology [ 0022-538X ] ; 2007.
Descripteurs français
- KwdFr :
- Chimiokine CCL3, Chimiokine CCL5, Chimiokine CXCL10, Chimiokines (génétique), Chimiokines (métabolisme), Chimiokines CC (génétique), Chimiokines CC (métabolisme), Chimiokines CXC (génétique), Chimiokines CXC (métabolisme), Facteur de transcription NF-kappa B (génétique), Facteur de transcription NF-kappa B (métabolisme), Muqueuse respiratoire (cytologie), Muqueuse respiratoire (virologie), Protéines de l'enveloppe virale (physiologie), Protéines de la matrice virale (physiologie), Protéines virales non structurales (métabolisme), Régulation de l'expression des gènes, Virus du SRAS (métabolisme), Virus du SRAS (pathogénicité).
- MESH :
- cytologie : Muqueuse respiratoire.
- génétique : Chimiokines, Chimiokines CC, Chimiokines CXC, Facteur de transcription NF-kappa B.
- métabolisme : Chimiokines, Chimiokines CC, Chimiokines CXC, Facteur de transcription NF-kappa B, Protéines virales non structurales, Virus du SRAS.
- pathogénicité : Virus du SRAS.
- physiologie : Protéines de l'enveloppe virale, Protéines de la matrice virale.
- virologie : Muqueuse respiratoire.
- Chimiokine CCL3, Chimiokine CCL5, Chimiokine CXCL10, Régulation de l'expression des gènes.
English descriptors
- KwdEn :
- Chemokine CCL3, Chemokine CCL5, Chemokine CXCL10, Chemokines (genetics), Chemokines (metabolism), Chemokines, CC (genetics), Chemokines, CC (metabolism), Chemokines, CXC (genetics), Chemokines, CXC (metabolism), Gene Expression Regulation, NF-kappa B (genetics), NF-kappa B (metabolism), Respiratory Mucosa (cytology), Respiratory Mucosa (virology), SARS Virus (metabolism), SARS Virus (pathogenicity), Viral Envelope Proteins (physiology), Viral Matrix Proteins (physiology), Viral Nonstructural Proteins (metabolism).
- MESH :
- chemical , genetics : Chemokines, Chemokines, CC, Chemokines, CXC, NF-kappa B.
- chemical , metabolism : Chemokines, Chemokines, CC, Chemokines, CXC, NF-kappa B, Viral Nonstructural Proteins.
- chemical , physiology : Viral Envelope Proteins, Viral Matrix Proteins.
- chemical : Chemokine CCL3, Chemokine CCL5, Chemokine CXCL10.
- cytology : Respiratory Mucosa.
- metabolism : SARS Virus.
- pathogenicity : SARS Virus.
- virology : Respiratory Mucosa.
- Gene Expression Regulation.
Abstract
Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by a novel coronavirus. Since its associated morbidity and mortality have been postulated to be due to immune dysregulation, we investigated which of the viral proteins is responsible for chemokine overexpression. To delineate the viral and cellular factor interactions, the role of four SARS coronavirus proteins, including nonstructural protein 1 (nsp-1), nsp-5, envelope, and membrane, were examined in terms of cytokine induction. Our results showed that the SARS coronavirus nsp-1 plays an important role in CCL5, CXCL10, and CCL3 expression in human lung epithelial cells via the activation of NF-kappaB.
DOI: 10.1128/JVI.02336-05
PubMed: 17035307
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pubmed:17035307Le document en format XML
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<author><name sortKey="Law, Anna H Y" sort="Law, Anna H Y" uniqKey="Law A" first="Anna H Y" last="Law">Anna H Y. Law</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Special Administrative Region</wicri:noRegion>
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<author><name sortKey="Lee, Davy C W" sort="Lee, Davy C W" uniqKey="Lee D" first="Davy C W" last="Lee">Davy C W. Lee</name>
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<author><name sortKey="Cheung, Benny K W" sort="Cheung, Benny K W" uniqKey="Cheung B" first="Benny K W" last="Cheung">Benny K W. Cheung</name>
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<author><name sortKey="Yim, Howard C H" sort="Yim, Howard C H" uniqKey="Yim H" first="Howard C H" last="Yim">Howard C H. Yim</name>
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<author><name sortKey="Lau, Allan S Y" sort="Lau, Allan S Y" uniqKey="Lau A" first="Allan S Y" last="Lau">Allan S Y. Lau</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chemokine CCL3</term>
<term>Chemokine CCL5</term>
<term>Chemokine CXCL10</term>
<term>Chemokines (genetics)</term>
<term>Chemokines (metabolism)</term>
<term>Chemokines, CC (genetics)</term>
<term>Chemokines, CC (metabolism)</term>
<term>Chemokines, CXC (genetics)</term>
<term>Chemokines, CXC (metabolism)</term>
<term>Gene Expression Regulation</term>
<term>NF-kappa B (genetics)</term>
<term>NF-kappa B (metabolism)</term>
<term>Respiratory Mucosa (cytology)</term>
<term>Respiratory Mucosa (virology)</term>
<term>SARS Virus (metabolism)</term>
<term>SARS Virus (pathogenicity)</term>
<term>Viral Envelope Proteins (physiology)</term>
<term>Viral Matrix Proteins (physiology)</term>
<term>Viral Nonstructural Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Chimiokine CCL3</term>
<term>Chimiokine CCL5</term>
<term>Chimiokine CXCL10</term>
<term>Chimiokines (génétique)</term>
<term>Chimiokines (métabolisme)</term>
<term>Chimiokines CC (génétique)</term>
<term>Chimiokines CC (métabolisme)</term>
<term>Chimiokines CXC (génétique)</term>
<term>Chimiokines CXC (métabolisme)</term>
<term>Facteur de transcription NF-kappa B (génétique)</term>
<term>Facteur de transcription NF-kappa B (métabolisme)</term>
<term>Muqueuse respiratoire (cytologie)</term>
<term>Muqueuse respiratoire (virologie)</term>
<term>Protéines de l'enveloppe virale (physiologie)</term>
<term>Protéines de la matrice virale (physiologie)</term>
<term>Protéines virales non structurales (métabolisme)</term>
<term>Régulation de l'expression des gènes</term>
<term>Virus du SRAS (métabolisme)</term>
<term>Virus du SRAS (pathogénicité)</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Chemokines</term>
<term>Chemokines, CC</term>
<term>Chemokines, CXC</term>
<term>NF-kappa B</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Chemokines</term>
<term>Chemokines, CC</term>
<term>Chemokines, CXC</term>
<term>NF-kappa B</term>
<term>Viral Nonstructural Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Viral Envelope Proteins</term>
<term>Viral Matrix Proteins</term>
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<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Chemokine CCL3</term>
<term>Chemokine CCL5</term>
<term>Chemokine CXCL10</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Muqueuse respiratoire</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Respiratory Mucosa</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Chimiokines</term>
<term>Chimiokines CC</term>
<term>Chimiokines CXC</term>
<term>Facteur de transcription NF-kappa B</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Chimiokines</term>
<term>Chimiokines CC</term>
<term>Chimiokines CXC</term>
<term>Facteur de transcription NF-kappa B</term>
<term>Protéines virales non structurales</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term>
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<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Protéines de l'enveloppe virale</term>
<term>Protéines de la matrice virale</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Muqueuse respiratoire</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Respiratory Mucosa</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Gene Expression Regulation</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Chimiokine CCL3</term>
<term>Chimiokine CCL5</term>
<term>Chimiokine CXCL10</term>
<term>Régulation de l'expression des gènes</term>
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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by a novel coronavirus. Since its associated morbidity and mortality have been postulated to be due to immune dysregulation, we investigated which of the viral proteins is responsible for chemokine overexpression. To delineate the viral and cellular factor interactions, the role of four SARS coronavirus proteins, including nonstructural protein 1 (nsp-1), nsp-5, envelope, and membrane, were examined in terms of cytokine induction. Our results showed that the SARS coronavirus nsp-1 plays an important role in CCL5, CXCL10, and CCL3 expression in human lung epithelial cells via the activation of NF-kappaB.</div>
</front>
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