Analysis of human coronavirus 229E spike and nucleoprotein genes demonstrates genetic drift between chronologically distinct strains.
Identifieur interne : 001449 ( Ncbi/Curation ); précédent : 001448; suivant : 001450Analysis of human coronavirus 229E spike and nucleoprotein genes demonstrates genetic drift between chronologically distinct strains.
Auteurs : Doris Chibo [Australie] ; Chris BirchSource :
- The Journal of general virology [ 0022-1317 ] ; 2006.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Australie, Chronologie comme sujet, Coronavirus humain 229E (génétique), Données de séquences moléculaires, Dérive génétique, Enfant, Enfant d'âge préscolaire, Femelle, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (génétique), Gènes viraux, Humains, Hémagglutinines virales (génétique), Infections à coronavirus (virologie), Mâle, Nourrisson, Protéines de l'enveloppe virale (génétique), Protéines virales (génétique).
- MESH :
- génétique : Coronavirus humain 229E, Glycoprotéines membranaires, Hémagglutinines virales, Protéines de l'enveloppe virale, Protéines virales.
- virologie : Infections à coronavirus.
- Adolescent, Adulte, Adulte d'âge moyen, Australie, Chronologie comme sujet, Données de séquences moléculaires, Dérive génétique, Enfant, Enfant d'âge préscolaire, Femelle, Glycoprotéine de spicule des coronavirus, Gènes viraux, Humains, Mâle, Nourrisson.
- Wicri :
- geographic : Australie.
English descriptors
- KwdEn :
- Adolescent, Adult, Australia, Child, Child, Preschool, Chronology as Topic, Coronavirus 229E, Human (genetics), Coronavirus Infections (virology), Female, Genes, Viral, Genetic Drift, Hemagglutinins, Viral (genetics), Humans, Infant, Male, Membrane Glycoproteins (genetics), Middle Aged, Molecular Sequence Data, Spike Glycoprotein, Coronavirus, Viral Envelope Proteins (genetics), Viral Proteins (genetics).
- MESH :
- chemical , genetics : Hemagglutinins, Viral, Membrane Glycoproteins, Viral Envelope Proteins, Viral Proteins.
- geographic : Australia, Spike Glycoprotein, Coronavirus.
- genetics : Coronavirus 229E, Human.
- virology : Coronavirus Infections.
- Adolescent, Adult, Child, Child, Preschool, Chronology as Topic, Female, Genes, Viral, Genetic Drift, Humans, Infant, Male, Middle Aged, Molecular Sequence Data.
Abstract
Historically, coronaviruses have been recognized as a cause of minor respiratory infections in humans. However, the recent identification of three novel human coronaviruses, one causing severe acute respiratory syndrome (SARS), has prompted further examination of these viruses. Previous studies of geographically and chronologically distinct Human coronavirus 229E (HCoV-229E) isolates have found only limited variation within S gene nucleotide sequences. In contrast, analysis of the S genes of contemporary Human coronavirus OC43 variants identified in Belgium revealed two distinct viruses circulating during 2003 and 2004. Here, the S and N gene sequences of 25 HCoV-229E variants identified in Victoria, Australia, between 1979 and 2004 in patients with symptomatic infections were determined. Phylogenetic analysis showed clustering of the isolates into four groups, with evidence of increasing divergence with time. Evidence of positive selection in the S gene was also established.
DOI: 10.1099/vir.0.81662-0
PubMed: 16603522
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pubmed:16603522Le document en format XML
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However, the recent identification of three novel human coronaviruses, one causing severe acute respiratory syndrome (SARS), has prompted further examination of these viruses. Previous studies of geographically and chronologically distinct Human coronavirus 229E (HCoV-229E) isolates have found only limited variation within S gene nucleotide sequences. In contrast, analysis of the S genes of contemporary Human coronavirus OC43 variants identified in Belgium revealed two distinct viruses circulating during 2003 and 2004. Here, the S and N gene sequences of 25 HCoV-229E variants identified in Victoria, Australia, between 1979 and 2004 in patients with symptomatic infections were determined. Phylogenetic analysis showed clustering of the isolates into four groups, with evidence of increasing divergence with time. Evidence of positive selection in the S gene was also established.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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