An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus.
Identifieur interne : 000F46 ( Ncbi/Curation ); précédent : 000F45; suivant : 000F47An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus.
Auteurs : Chuan Qin ; Jianwei Wang ; Qiang Wei ; Mingpeng She ; Wayne A. Marasco ; Hong Jiang ; Xinming Tu ; Hua Zhu ; Lili Ren ; Hong Gao ; Li Guo ; Lan Huang ; Renquan Yang ; Zhe Cong ; Lan Guo ; Yanbin Wang ; Yali Liu ; Yili Sun ; Shumin Duan ; Jianguo Qu ; Liangbiao Chen ; Wei Tong ; Li Ruan ; Peimao Liu ; Hua Zhang ; Jianmin Zhang ; Huiyuan Zhang ; Depei Liu ; Qian Liu ; Tao Hong ; Wei HeSource :
- The Journal of pathology [ 0022-3417 ] ; 2005.
Descripteurs français
- KwdFr :
- ARN viral (analyse), Alvéoles pulmonaires (anatomopathologie), Animaux, Hémorragie (), Hémorragie (anatomopathologie), Immunoglobuline G (sang), Lymphocytes (anatomopathologie), Macaca mulatta, Macrophages (anatomopathologie), Microscopie électronique (), Modèles animaux de maladie humaine, Pharynx (virologie), Pneumopathies interstitielles (), Pneumopathies interstitielles (anatomopathologie), Poumon (anatomopathologie), Réplication virale, Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (sang), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS.
- MESH :
- analyse : ARN viral.
- anatomopathologie : Alvéoles pulmonaires, Hémorragie, Lymphocytes, Macrophages, Pneumopathies interstitielles, Poumon, Syndrome respiratoire aigu sévère.
- sang : Immunoglobuline G, Syndrome respiratoire aigu sévère.
- virologie : Pharynx, Syndrome respiratoire aigu sévère.
- Animaux, Hémorragie, Macaca mulatta, Microscopie électronique, Modèles animaux de maladie humaine, Pneumopathies interstitielles, Réplication virale, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Disease Models, Animal, Hemorrhage (complications), Hemorrhage (pathology), Immunoglobulin G (blood), Lung (pathology), Lung Diseases, Interstitial (complications), Lung Diseases, Interstitial (pathology), Lymphocytes (pathology), Macaca mulatta, Macrophages (pathology), Microscopy, Electron (methods), Pharynx (virology), Pulmonary Alveoli (pathology), RNA, Viral (analysis), SARS Virus, Severe Acute Respiratory Syndrome (blood), Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (virology), Virus Replication.
- MESH :
- chemical , analysis : RNA, Viral.
- chemical , blood : Immunoglobulin G.
- blood : Severe Acute Respiratory Syndrome.
- complications : Hemorrhage, Lung Diseases, Interstitial.
- methods : Microscopy, Electron.
- pathology : Hemorrhage, Lung, Lung Diseases, Interstitial, Lymphocytes, Macrophages, Pulmonary Alveoli, Severe Acute Respiratory Syndrome.
- virology : Pharynx, Severe Acute Respiratory Syndrome.
- Animals, Disease Models, Animal, Macaca mulatta, SARS Virus, Virus Replication.
Abstract
A new SARS animal model was established by inoculating SARS coronavirus (SARS-CoV) into rhesus macaques (Macaca mulatta) through the nasal cavity. Pathological pulmonary changes were successively detected on days 5-60 after virus inoculation. All eight animals showed a transient fever 2-3 days after inoculation. Immunological, molecular biological, and pathological studies support the establishment of this SARS animal model. Firstly, SARS-CoV-specific IgGs were detected in the sera of macaques from 11 to 60 days after inoculation. Secondly, SARS-CoV RNA could be detected in pharyngeal swab samples using nested RT-PCR in all infected animals from 5 days after virus inoculation. Finally, histopathological changes of interstitial pneumonia were found in the lungs during the 60 days after viral inoculation: these changes were less marked at later time points, indicating that an active healing process together with resolution of an acute inflammatory response was taking place in these animals. This animal model should provide insight into the mechanisms of SARS-CoV-related pulmonary disease and greatly facilitate the development of vaccines and therapeutics against SARS.
DOI: 10.1002/path.1769
PubMed: 15892035
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002742
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :002742
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002838
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000F46
Links to Exploration step
pubmed:15892035Curation
No country items
Chuan Qin<affiliation><nlm:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021.</nlm:affiliation><wicri:noCountry code="subField">100021</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus.</title><author><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><affiliation><nlm:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021.</nlm:affiliation><wicri:noCountry code="subField">100021</wicri:noCountry></affiliation></author><author><name sortKey="Wang, Jianwei" sort="Wang, Jianwei" uniqKey="Wang J" first="Jianwei" last="Wang">Jianwei Wang</name></author><author><name sortKey="Wei, Qiang" sort="Wei, Qiang" uniqKey="Wei Q" first="Qiang" last="Wei">Qiang Wei</name></author><author><name sortKey="She, Mingpeng" sort="She, Mingpeng" uniqKey="She M" first="Mingpeng" last="She">Mingpeng She</name></author><author><name sortKey="Marasco, Wayne A" sort="Marasco, Wayne A" uniqKey="Marasco W" first="Wayne A" last="Marasco">Wayne A. Marasco</name></author><author><name sortKey="Jiang, Hong" sort="Jiang, Hong" uniqKey="Jiang H" first="Hong" last="Jiang">Hong Jiang</name></author><author><name sortKey="Tu, Xinming" sort="Tu, Xinming" uniqKey="Tu X" first="Xinming" last="Tu">Xinming Tu</name></author><author><name sortKey="Zhu, Hua" sort="Zhu, Hua" uniqKey="Zhu H" first="Hua" last="Zhu">Hua Zhu</name></author><author><name sortKey="Ren, Lili" sort="Ren, Lili" uniqKey="Ren L" first="Lili" last="Ren">Lili Ren</name></author><author><name sortKey="Gao, Hong" sort="Gao, Hong" uniqKey="Gao H" first="Hong" last="Gao">Hong Gao</name></author><author><name sortKey="Guo, Li" sort="Guo, Li" uniqKey="Guo L" first="Li" last="Guo">Li Guo</name></author><author><name sortKey="Huang, Lan" sort="Huang, Lan" uniqKey="Huang L" first="Lan" last="Huang">Lan Huang</name></author><author><name sortKey="Yang, Renquan" sort="Yang, Renquan" uniqKey="Yang R" first="Renquan" last="Yang">Renquan Yang</name></author><author><name sortKey="Cong, Zhe" sort="Cong, Zhe" uniqKey="Cong Z" first="Zhe" last="Cong">Zhe Cong</name></author><author><name sortKey="Guo, Lan" sort="Guo, Lan" uniqKey="Guo L" first="Lan" last="Guo">Lan Guo</name></author><author><name sortKey="Wang, Yanbin" sort="Wang, Yanbin" uniqKey="Wang Y" first="Yanbin" last="Wang">Yanbin Wang</name></author><author><name sortKey="Liu, Yali" sort="Liu, Yali" uniqKey="Liu Y" first="Yali" last="Liu">Yali Liu</name></author><author><name sortKey="Sun, Yili" sort="Sun, Yili" uniqKey="Sun Y" first="Yili" last="Sun">Yili Sun</name></author><author><name sortKey="Duan, Shumin" sort="Duan, Shumin" uniqKey="Duan S" first="Shumin" last="Duan">Shumin Duan</name></author><author><name sortKey="Qu, Jianguo" sort="Qu, Jianguo" uniqKey="Qu J" first="Jianguo" last="Qu">Jianguo Qu</name></author><author><name sortKey="Chen, Liangbiao" sort="Chen, Liangbiao" uniqKey="Chen L" first="Liangbiao" last="Chen">Liangbiao Chen</name></author><author><name sortKey="Tong, Wei" sort="Tong, Wei" uniqKey="Tong W" first="Wei" last="Tong">Wei Tong</name></author><author><name sortKey="Ruan, Li" sort="Ruan, Li" uniqKey="Ruan L" first="Li" last="Ruan">Li Ruan</name></author><author><name sortKey="Liu, Peimao" sort="Liu, Peimao" uniqKey="Liu P" first="Peimao" last="Liu">Peimao Liu</name></author><author><name sortKey="Zhang, Hua" sort="Zhang, Hua" uniqKey="Zhang H" first="Hua" last="Zhang">Hua Zhang</name></author><author><name sortKey="Zhang, Jianmin" sort="Zhang, Jianmin" uniqKey="Zhang J" first="Jianmin" last="Zhang">Jianmin Zhang</name></author><author><name sortKey="Zhang, Huiyuan" sort="Zhang, Huiyuan" uniqKey="Zhang H" first="Huiyuan" last="Zhang">Huiyuan Zhang</name></author><author><name sortKey="Liu, Depei" sort="Liu, Depei" uniqKey="Liu D" first="Depei" last="Liu">Depei Liu</name></author><author><name sortKey="Liu, Qian" sort="Liu, Qian" uniqKey="Liu Q" first="Qian" last="Liu">Qian Liu</name></author><author><name sortKey="Hong, Tao" sort="Hong, Tao" uniqKey="Hong T" first="Tao" last="Hong">Tao Hong</name></author><author><name sortKey="He, Wei" sort="He, Wei" uniqKey="He W" first="Wei" last="He">Wei He</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="RBID">pubmed:15892035</idno><idno type="pmid">15892035</idno><idno type="doi">10.1002/path.1769</idno><idno type="wicri:Area/PubMed/Corpus">002742</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002742</idno><idno type="wicri:Area/PubMed/Curation">002742</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002742</idno><idno type="wicri:Area/PubMed/Checkpoint">002838</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002838</idno><idno type="wicri:Area/Ncbi/Merge">000F46</idno><idno type="wicri:Area/Ncbi/Curation">000F46</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus.</title><author><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><affiliation><nlm:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021.</nlm:affiliation><wicri:noCountry code="subField">100021</wicri:noCountry></affiliation></author><author><name sortKey="Wang, Jianwei" sort="Wang, Jianwei" uniqKey="Wang J" first="Jianwei" last="Wang">Jianwei Wang</name></author><author><name sortKey="Wei, Qiang" sort="Wei, Qiang" uniqKey="Wei Q" first="Qiang" last="Wei">Qiang Wei</name></author><author><name sortKey="She, Mingpeng" sort="She, Mingpeng" uniqKey="She M" first="Mingpeng" last="She">Mingpeng She</name></author><author><name sortKey="Marasco, Wayne A" sort="Marasco, Wayne A" uniqKey="Marasco W" first="Wayne A" last="Marasco">Wayne A. Marasco</name></author><author><name sortKey="Jiang, Hong" sort="Jiang, Hong" uniqKey="Jiang H" first="Hong" last="Jiang">Hong Jiang</name></author><author><name sortKey="Tu, Xinming" sort="Tu, Xinming" uniqKey="Tu X" first="Xinming" last="Tu">Xinming Tu</name></author><author><name sortKey="Zhu, Hua" sort="Zhu, Hua" uniqKey="Zhu H" first="Hua" last="Zhu">Hua Zhu</name></author><author><name sortKey="Ren, Lili" sort="Ren, Lili" uniqKey="Ren L" first="Lili" last="Ren">Lili Ren</name></author><author><name sortKey="Gao, Hong" sort="Gao, Hong" uniqKey="Gao H" first="Hong" last="Gao">Hong Gao</name></author><author><name sortKey="Guo, Li" sort="Guo, Li" uniqKey="Guo L" first="Li" last="Guo">Li Guo</name></author><author><name sortKey="Huang, Lan" sort="Huang, Lan" uniqKey="Huang L" first="Lan" last="Huang">Lan Huang</name></author><author><name sortKey="Yang, Renquan" sort="Yang, Renquan" uniqKey="Yang R" first="Renquan" last="Yang">Renquan Yang</name></author><author><name sortKey="Cong, Zhe" sort="Cong, Zhe" uniqKey="Cong Z" first="Zhe" last="Cong">Zhe Cong</name></author><author><name sortKey="Guo, Lan" sort="Guo, Lan" uniqKey="Guo L" first="Lan" last="Guo">Lan Guo</name></author><author><name sortKey="Wang, Yanbin" sort="Wang, Yanbin" uniqKey="Wang Y" first="Yanbin" last="Wang">Yanbin Wang</name></author><author><name sortKey="Liu, Yali" sort="Liu, Yali" uniqKey="Liu Y" first="Yali" last="Liu">Yali Liu</name></author><author><name sortKey="Sun, Yili" sort="Sun, Yili" uniqKey="Sun Y" first="Yili" last="Sun">Yili Sun</name></author><author><name sortKey="Duan, Shumin" sort="Duan, Shumin" uniqKey="Duan S" first="Shumin" last="Duan">Shumin Duan</name></author><author><name sortKey="Qu, Jianguo" sort="Qu, Jianguo" uniqKey="Qu J" first="Jianguo" last="Qu">Jianguo Qu</name></author><author><name sortKey="Chen, Liangbiao" sort="Chen, Liangbiao" uniqKey="Chen L" first="Liangbiao" last="Chen">Liangbiao Chen</name></author><author><name sortKey="Tong, Wei" sort="Tong, Wei" uniqKey="Tong W" first="Wei" last="Tong">Wei Tong</name></author><author><name sortKey="Ruan, Li" sort="Ruan, Li" uniqKey="Ruan L" first="Li" last="Ruan">Li Ruan</name></author><author><name sortKey="Liu, Peimao" sort="Liu, Peimao" uniqKey="Liu P" first="Peimao" last="Liu">Peimao Liu</name></author><author><name sortKey="Zhang, Hua" sort="Zhang, Hua" uniqKey="Zhang H" first="Hua" last="Zhang">Hua Zhang</name></author><author><name sortKey="Zhang, Jianmin" sort="Zhang, Jianmin" uniqKey="Zhang J" first="Jianmin" last="Zhang">Jianmin Zhang</name></author><author><name sortKey="Zhang, Huiyuan" sort="Zhang, Huiyuan" uniqKey="Zhang H" first="Huiyuan" last="Zhang">Huiyuan Zhang</name></author><author><name sortKey="Liu, Depei" sort="Liu, Depei" uniqKey="Liu D" first="Depei" last="Liu">Depei Liu</name></author><author><name sortKey="Liu, Qian" sort="Liu, Qian" uniqKey="Liu Q" first="Qian" last="Liu">Qian Liu</name></author><author><name sortKey="Hong, Tao" sort="Hong, Tao" uniqKey="Hong T" first="Tao" last="Hong">Tao Hong</name></author><author><name sortKey="He, Wei" sort="He, Wei" uniqKey="He W" first="Wei" last="He">Wei He</name></author></analytic><series><title level="j">The Journal of pathology</title><idno type="ISSN">0022-3417</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Hemorrhage (complications)</term><term>Hemorrhage (pathology)</term><term>Immunoglobulin G (blood)</term><term>Lung (pathology)</term><term>Lung Diseases, Interstitial (complications)</term><term>Lung Diseases, Interstitial (pathology)</term><term>Lymphocytes (pathology)</term><term>Macaca mulatta</term><term>Macrophages (pathology)</term><term>Microscopy, Electron (methods)</term><term>Pharynx (virology)</term><term>Pulmonary Alveoli (pathology)</term><term>RNA, Viral (analysis)</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome (blood)</term><term>Severe Acute Respiratory Syndrome (pathology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (analyse)</term><term>Alvéoles pulmonaires (anatomopathologie)</term><term>Animaux</term><term>Hémorragie ()</term><term>Hémorragie (anatomopathologie)</term><term>Immunoglobuline G (sang)</term><term>Lymphocytes (anatomopathologie)</term><term>Macaca mulatta</term><term>Macrophages (anatomopathologie)</term><term>Microscopie électronique ()</term><term>Modèles animaux de maladie humaine</term><term>Pharynx (virologie)</term><term>Pneumopathies interstitielles ()</term><term>Pneumopathies interstitielles (anatomopathologie)</term><term>Poumon (anatomopathologie)</term><term>Réplication virale</term><term>Syndrome respiratoire aigu sévère (anatomopathologie)</term><term>Syndrome respiratoire aigu sévère (sang)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Alvéoles pulmonaires</term><term>Hémorragie</term><term>Lymphocytes</term><term>Macrophages</term><term>Pneumopathies interstitielles</term><term>Poumon</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Hemorrhage</term><term>Lung Diseases, Interstitial</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Microscopy, Electron</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Hemorrhage</term><term>Lung</term><term>Lung Diseases, Interstitial</term><term>Lymphocytes</term><term>Macrophages</term><term>Pulmonary Alveoli</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Immunoglobuline G</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Pharynx</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Pharynx</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Macaca mulatta</term><term>SARS Virus</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Hémorragie</term><term>Macaca mulatta</term><term>Microscopie électronique</term><term>Modèles animaux de maladie humaine</term><term>Pneumopathies interstitielles</term><term>Réplication virale</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A new SARS animal model was established by inoculating SARS coronavirus (SARS-CoV) into rhesus macaques (Macaca mulatta) through the nasal cavity. Pathological pulmonary changes were successively detected on days 5-60 after virus inoculation. All eight animals showed a transient fever 2-3 days after inoculation. Immunological, molecular biological, and pathological studies support the establishment of this SARS animal model. Firstly, SARS-CoV-specific IgGs were detected in the sera of macaques from 11 to 60 days after inoculation. Secondly, SARS-CoV RNA could be detected in pharyngeal swab samples using nested RT-PCR in all infected animals from 5 days after virus inoculation. Finally, histopathological changes of interstitial pneumonia were found in the lungs during the 60 days after viral inoculation: these changes were less marked at later time points, indicating that an active healing process together with resolution of an acute inflammatory response was taking place in these animals. This animal model should provide insight into the mechanisms of SARS-CoV-related pulmonary disease and greatly facilitate the development of vaccines and therapeutics against SARS.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F46 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000F46 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= pubmed:15892035
|texte= An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:15892035" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |