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Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus.

Identifieur interne : 000D27 ( Ncbi/Curation ); précédent : 000D26; suivant : 000D28

Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus.

Auteurs : Sara Akerström [Suède] ; Mehrdad Mousavi-Jazi ; Jonas Klingström ; Mikael Leijon ; Ake Lundkvist ; Ali Mirazimi

Source :

Journal of virology [ 0022-538X ] ; 2005.

RBID : pubmed:15650225

Descripteurs français

KwdFr :
- Animaux, Cellules Vero, Humains, Monoxyde d'azote (métabolisme), Monoxyde d'azote (pharmacologie), N-Acétyl-S-nitroso-pénicillamine (pharmacologie), Nitric oxide synthase (métabolisme), Nitric oxide synthase type II, Réplication virale (), Virus du SRAS (), Virus du SRAS (physiologie).
MESH :
- métabolisme : Monoxyde d'azote, Nitric oxide synthase.
- pharmacologie : Monoxyde d'azote, N-Acétyl-S-nitroso-pénicillamine.
- physiologie : Virus du SRAS.
- Animaux, Cellules Vero, Humains, Nitric oxide synthase type II, Réplication virale, Virus du SRAS.

English descriptors

KwdEn :
- Animals, Chlorocebus aethiops, Humans, Nitric Oxide (metabolism), Nitric Oxide (pharmacology), Nitric Oxide Synthase (metabolism), Nitric Oxide Synthase Type II, S-Nitroso-N-Acetylpenicillamine (pharmacology), SARS Virus (drug effects), SARS Virus (physiology), Vero Cells, Virus Replication (drug effects).
MESH :
- chemical , metabolism : Nitric Oxide, Nitric Oxide Synthase.
- chemical , pharmacology : Nitric Oxide, S-Nitroso-N-Acetylpenicillamine.
- drug effects : SARS Virus, Virus Replication.
- physiology : SARS Virus.
- Animals, Chlorocebus aethiops, Humans, Nitric Oxide Synthase Type II, Vero Cells.

Abstract

Nitric oxide (NO) is an important signaling molecule between cells which has been shown to have an inhibitory effect on some virus infections. The purpose of this study was to examine whether NO inhibits the replication cycle of the severe acute respiratory syndrome coronavirus (SARS CoV) in vitro. We found that an organic NO donor, S-nitroso-N-acetylpenicillamine, significantly inhibited the replication cycle of SARS CoV in a concentration-dependent manner. We also show here that NO inhibits viral protein and RNA synthesis. Furthermore, we demonstrate that NO generated by inducible nitric oxide synthase, an enzyme that produces NO, inhibits the SARS CoV replication cycle.

DOI: 10.1128/JVI.79.3.1966-1969.2005
PubMed: 15650225

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pubmed:15650225

Le document en format XML

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<term>Nitric Oxide (pharmacology)</term>
<term>Nitric Oxide Synthase (metabolism)</term>
<term>Nitric Oxide Synthase Type II</term>
<term>S-Nitroso-N-Acetylpenicillamine (pharmacology)</term>
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<term>SARS Virus (physiology)</term>
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<term>Virus du SRAS ()</term>
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<term>Vero Cells</term>
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<term>Cellules Vero</term>
<term>Humains</term>
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<front><div type="abstract" xml:lang="en">Nitric oxide (NO) is an important signaling molecule between cells which has been shown to have an inhibitory effect on some virus infections. The purpose of this study was to examine whether NO inhibits the replication cycle of the severe acute respiratory syndrome coronavirus (SARS CoV) in vitro. We found that an organic NO donor, S-nitroso-N-acetylpenicillamine, significantly inhibited the replication cycle of SARS CoV in a concentration-dependent manner. We also show here that NO inhibits viral protein and RNA synthesis. Furthermore, we demonstrate that NO generated by inducible nitric oxide synthase, an enzyme that produces NO, inhibits the SARS CoV replication cycle.</div>
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Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus.

Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

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Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki