The SARS-CoV S glycoprotein.
Identifieur interne : 000B87 ( Ncbi/Curation ); précédent : 000B86; suivant : 000B88The SARS-CoV S glycoprotein.
Auteurs : X. Xiao [États-Unis] ; D S DimitrovSource :
- Cellular and molecular life sciences : CMLS [ 1420-682X ] ; 2004.
Descripteurs français
- KwdFr :
- Animaux, Fusion cellulaire, Glycoprotéine de spicule des coronavirus, Glycoprotéines (), Glycoprotéines membranaires (), Glycoprotéines membranaires (physiologie), Humains, Protéines de fusion virale, Protéines de l'enveloppe virale (), Protéines de l'enveloppe virale (physiologie), Structure tertiaire des protéines, Virus du SRAS (métabolisme).
- MESH :
- métabolisme : Virus du SRAS.
- physiologie : Glycoprotéines membranaires, Protéines de l'enveloppe virale.
- Animaux, Fusion cellulaire, Glycoprotéine de spicule des coronavirus, Glycoprotéines, Glycoprotéines membranaires, Humains, Protéines de fusion virale, Protéines de l'enveloppe virale, Structure tertiaire des protéines.
English descriptors
- KwdEn :
- Animals, Cell Fusion, Glycoproteins (chemistry), Humans, Membrane Glycoproteins (chemistry), Membrane Glycoproteins (physiology), Protein Structure, Tertiary, SARS Virus (metabolism), Spike Glycoprotein, Coronavirus, Viral Envelope Proteins (chemistry), Viral Envelope Proteins (physiology), Viral Fusion Proteins.
- MESH :
- chemical , chemistry : Glycoproteins, Membrane Glycoproteins, Viral Envelope Proteins.
- chemical , physiology : Membrane Glycoproteins, Viral Envelope Proteins.
- metabolism : SARS Virus.
- Animals, Cell Fusion, Humans, Protein Structure, Tertiary, Spike Glycoprotein, Coronavirus, Viral Fusion Proteins.
Abstract
The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. Recent rapid advances in our knowledge of the structure and function of this protein have lead to the development of a number of candidate vaccine immunogens and SARS-CoV entry inhibitors.
DOI: 10.1007/s00018-004-4257-y
PubMed: 15526150
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pubmed:15526150Le document en format XML
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Protein Interactions Group, LECB, CCR, NCI-Frederick, NIH, Building 469, Room 105, Frederick, Maryland 21702-1201</wicri:regionArea>
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<author><name sortKey="Dimitrov, D S" sort="Dimitrov, D S" uniqKey="Dimitrov D" first="D S" last="Dimitrov">D S Dimitrov</name>
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<series><title level="j">Cellular and molecular life sciences : CMLS</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Cell Fusion</term>
<term>Glycoproteins (chemistry)</term>
<term>Humans</term>
<term>Membrane Glycoproteins (chemistry)</term>
<term>Membrane Glycoproteins (physiology)</term>
<term>Protein Structure, Tertiary</term>
<term>SARS Virus (metabolism)</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Viral Envelope Proteins (chemistry)</term>
<term>Viral Envelope Proteins (physiology)</term>
<term>Viral Fusion Proteins</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Fusion cellulaire</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Glycoprotéines ()</term>
<term>Glycoprotéines membranaires ()</term>
<term>Glycoprotéines membranaires (physiologie)</term>
<term>Humains</term>
<term>Protéines de fusion virale</term>
<term>Protéines de l'enveloppe virale ()</term>
<term>Protéines de l'enveloppe virale (physiologie)</term>
<term>Structure tertiaire des protéines</term>
<term>Virus du SRAS (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Glycoproteins</term>
<term>Membrane Glycoproteins</term>
<term>Viral Envelope Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Membrane Glycoproteins</term>
<term>Viral Envelope Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Glycoprotéines membranaires</term>
<term>Protéines de l'enveloppe virale</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Fusion</term>
<term>Humans</term>
<term>Protein Structure, Tertiary</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Viral Fusion Proteins</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Fusion cellulaire</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Glycoprotéines</term>
<term>Glycoprotéines membranaires</term>
<term>Humains</term>
<term>Protéines de fusion virale</term>
<term>Protéines de l'enveloppe virale</term>
<term>Structure tertiaire des protéines</term>
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<front><div type="abstract" xml:lang="en">The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. Recent rapid advances in our knowledge of the structure and function of this protein have lead to the development of a number of candidate vaccine immunogens and SARS-CoV entry inhibitors.</div>
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