Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis.
Identifieur interne : 000810 ( Ncbi/Curation ); précédent : 000809; suivant : 000811Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis.
Auteurs : I. Hamming [Pays-Bas] ; W. Timens ; M L C. Bulthuis ; A T Lely ; G J. Navis ; H. Van GoorSource :
- The Journal of pathology [ 0022-3417 ] ; 2004.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Alvéoles pulmonaires (), Alvéoles pulmonaires (anatomopathologie), Artères (), Cellules épithéliales (), Entérocytes (), Femelle, Humains, Immunohistochimie (), Intestin grêle (), Intestin grêle (anatomopathologie), Muscles lisses (), Muscles lisses vasculaires (), Mâle, Peau (), Peptidyl-Dipeptidase A (analyse), Protéines virales (analyse), Récepteurs viraux (analyse), Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (virologie), Veines (), Virus du SRAS (métabolisme).
- MESH :
- analyse : Peptidyl-Dipeptidase A, Protéines virales, Récepteurs viraux.
- anatomopathologie : Alvéoles pulmonaires, Intestin grêle, Syndrome respiratoire aigu sévère.
- métabolisme : Virus du SRAS.
- virologie : Syndrome respiratoire aigu sévère.
- Adulte d'âge moyen, Alvéoles pulmonaires, Artères, Cellules épithéliales, Entérocytes, Femelle, Humains, Immunohistochimie, Intestin grêle, Muscles lisses, Muscles lisses vasculaires, Mâle, Peau, Veines.
English descriptors
- KwdEn :
- Arteries (chemistry), Enterocytes (chemistry), Epithelial Cells (chemistry), Female, Humans, Immunohistochemistry (methods), Intestine, Small (chemistry), Intestine, Small (pathology), Male, Middle Aged, Muscle, Smooth (chemistry), Muscle, Smooth, Vascular (chemistry), Peptidyl-Dipeptidase A (analysis), Pulmonary Alveoli (chemistry), Pulmonary Alveoli (pathology), Receptors, Virus (analysis), SARS Virus (metabolism), Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (virology), Skin (chemistry), Veins (chemistry), Viral Proteins (analysis).
- MESH :
- chemical , analysis : Peptidyl-Dipeptidase A, Receptors, Virus, Viral Proteins.
- chemistry : Arteries, Enterocytes, Epithelial Cells, Intestine, Small, Muscle, Smooth, Muscle, Smooth, Vascular, Pulmonary Alveoli, Skin, Veins.
- metabolism : SARS Virus.
- methods : Immunohistochemistry.
- pathology : Intestine, Small, Pulmonary Alveoli, Severe Acute Respiratory Syndrome.
- virology : Severe Acute Respiratory Syndrome.
- Female, Humans, Male, Middle Aged.
Abstract
Severe acute respiratory syndrome (SARS) is an acute infectious disease that spreads mainly via the respiratory route. A distinct coronavirus (SARS-CoV) has been identified as the aetiological agent of SARS. Recently, a metallopeptidase named angiotensin-converting enzyme 2 (ACE2) has been identified as the functional receptor for SARS-CoV. Although ACE2 mRNA is known to be present in virtually all organs, its protein expression is largely unknown. Since identifying the possible route of infection has major implications for understanding the pathogenesis and future treatment strategies for SARS, the present study investigated the localization of ACE2 protein in various human organs (oral and nasal mucosa, nasopharynx, lung, stomach, small intestine, colon, skin, lymph nodes, thymus, bone marrow, spleen, liver, kidney, and brain). The most remarkable finding was the surface expression of ACE2 protein on lung alveolar epithelial cells and enterocytes of the small intestine. Furthermore, ACE2 was present in arterial and venous endothelial cells and arterial smooth muscle cells in all organs studied. In conclusion, ACE2 is abundantly present in humans in the epithelia of the lung and small intestine, which might provide possible routes of entry for the SARS-CoV. This epithelial expression, together with the presence of ACE2 in vascular endothelium, also provides a first step in understanding the pathogenesis of the main SARS disease manifestations.
DOI: 10.1002/path.1570
PubMed: 15141377
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A first step in understanding SARS pathogenesis.</title><author><name sortKey="Hamming, I" sort="Hamming, I" uniqKey="Hamming I" first="I" last="Hamming">I. Hamming</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Laboratory Medicine, University Hospital Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University Hospital Groningen</wicri:regionArea><wicri:noRegion>University Hospital Groningen</wicri:noRegion></affiliation></author><author><name sortKey="Timens, W" sort="Timens, W" uniqKey="Timens W" first="W" last="Timens">W. Timens</name></author><author><name sortKey="Bulthuis, M L C" sort="Bulthuis, M L C" uniqKey="Bulthuis M" first="M L C" last="Bulthuis">M L C. Bulthuis</name></author><author><name sortKey="Lely, A T" sort="Lely, A T" uniqKey="Lely A" first="A T" last="Lely">A T Lely</name></author><author><name sortKey="Navis, G J" sort="Navis, G J" uniqKey="Navis G" first="G J" last="Navis">G J. Navis</name></author><author><name sortKey="Van Goor, H" sort="Van Goor, H" uniqKey="Van Goor H" first="H" last="Van Goor">H. Van Goor</name></author></analytic><series><title level="j">The Journal of pathology</title><idno type="ISSN">0022-3417</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arteries (chemistry)</term><term>Enterocytes (chemistry)</term><term>Epithelial Cells (chemistry)</term><term>Female</term><term>Humans</term><term>Immunohistochemistry (methods)</term><term>Intestine, Small (chemistry)</term><term>Intestine, Small (pathology)</term><term>Male</term><term>Middle Aged</term><term>Muscle, Smooth (chemistry)</term><term>Muscle, Smooth, Vascular (chemistry)</term><term>Peptidyl-Dipeptidase A (analysis)</term><term>Pulmonary Alveoli (chemistry)</term><term>Pulmonary Alveoli (pathology)</term><term>Receptors, Virus (analysis)</term><term>SARS Virus (metabolism)</term><term>Severe Acute Respiratory Syndrome (pathology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Skin (chemistry)</term><term>Veins (chemistry)</term><term>Viral Proteins (analysis)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Alvéoles pulmonaires ()</term><term>Alvéoles pulmonaires (anatomopathologie)</term><term>Artères ()</term><term>Cellules épithéliales ()</term><term>Entérocytes ()</term><term>Femelle</term><term>Humains</term><term>Immunohistochimie ()</term><term>Intestin grêle ()</term><term>Intestin grêle (anatomopathologie)</term><term>Muscles lisses ()</term><term>Muscles lisses vasculaires ()</term><term>Mâle</term><term>Peau ()</term><term>Peptidyl-Dipeptidase A (analyse)</term><term>Protéines virales (analyse)</term><term>Récepteurs viraux (analyse)</term><term>Syndrome respiratoire aigu sévère (anatomopathologie)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Veines ()</term><term>Virus du SRAS (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Peptidyl-Dipeptidase A</term><term>Receptors, Virus</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Peptidyl-Dipeptidase A</term><term>Protéines virales</term><term>Récepteurs viraux</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Alvéoles pulmonaires</term><term>Intestin grêle</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Arteries</term><term>Enterocytes</term><term>Epithelial Cells</term><term>Intestine, Small</term><term>Muscle, Smooth</term><term>Muscle, Smooth, Vascular</term><term>Pulmonary Alveoli</term><term>Skin</term><term>Veins</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunohistochemistry</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Intestine, Small</term><term>Pulmonary Alveoli</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Alvéoles pulmonaires</term><term>Artères</term><term>Cellules épithéliales</term><term>Entérocytes</term><term>Femelle</term><term>Humains</term><term>Immunohistochimie</term><term>Intestin grêle</term><term>Muscles lisses</term><term>Muscles lisses vasculaires</term><term>Mâle</term><term>Peau</term><term>Veines</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is an acute infectious disease that spreads mainly via the respiratory route. A distinct coronavirus (SARS-CoV) has been identified as the aetiological agent of SARS. Recently, a metallopeptidase named angiotensin-converting enzyme 2 (ACE2) has been identified as the functional receptor for SARS-CoV. Although ACE2 mRNA is known to be present in virtually all organs, its protein expression is largely unknown. Since identifying the possible route of infection has major implications for understanding the pathogenesis and future treatment strategies for SARS, the present study investigated the localization of ACE2 protein in various human organs (oral and nasal mucosa, nasopharynx, lung, stomach, small intestine, colon, skin, lymph nodes, thymus, bone marrow, spleen, liver, kidney, and brain). The most remarkable finding was the surface expression of ACE2 protein on lung alveolar epithelial cells and enterocytes of the small intestine. Furthermore, ACE2 was present in arterial and venous endothelial cells and arterial smooth muscle cells in all organs studied. In conclusion, ACE2 is abundantly present in humans in the epithelia of the lung and small intestine, which might provide possible routes of entry for the SARS-CoV. This epithelial expression, together with the presence of ACE2 in vascular endothelium, also provides a first step in understanding the pathogenesis of the main SARS disease manifestations.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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