Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus.
Identifieur interne : 000184 ( Ncbi/Curation ); précédent : 000183; suivant : 000185Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus.
Auteurs : J. Cinatl [Allemagne] ; B. Morgenstern ; G. Bauer ; P. Chandra ; H. Rabenau ; H W DoerrSource :
- Lancet (London, England) [ 1474-547X ] ; 2003.
Descripteurs français
- KwdFr :
- MESH :
- pharmacologie : Acide glycyrrhizique, Antiviraux.
- physiologie : Coronavirus.
- traitement médicamenteux : Syndrome respiratoire aigu sévère.
- Animaux, Cellules Vero, Coronavirus, Glycyrrhiza, Humains, Réplication virale.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Antiviral Agents, Glycyrrhizic Acid.
- chemistry : Glycyrrhiza.
- drug effects : Coronavirus, Virus Replication.
- drug therapy : Severe Acute Respiratory Syndrome.
- physiology : Coronavirus.
- Animals, Chlorocebus aethiops, Humans, Vero Cells.
Abstract
The outbreak of SARS warrants the search for antiviral compounds to treat the disease. At present, no specific treatment has been identified for SARS-associated coronavirus infection. We assessed the antiviral potential of ribavirin, 6-azauridine, pyrazofurin, mycophenolic acid, and glycyrrhizin against two clinical isolates of coronavirus (FFM-1 and FFM-2) from patients with SARS admitted to the clinical centre of Frankfurt University, Germany. Of all the compounds, glycyrrhizin was the most active in inhibiting replication of the SARS-associated virus. Our findings suggest that glycyrrhizin should be assessed for treatment of SARS.
DOI: 10.1016/s0140-6736(03)13615-x
PubMed: 12814717
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pubmed:12814717Le document en format XML
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<front><div type="abstract" xml:lang="en">The outbreak of SARS warrants the search for antiviral compounds to treat the disease. At present, no specific treatment has been identified for SARS-associated coronavirus infection. We assessed the antiviral potential of ribavirin, 6-azauridine, pyrazofurin, mycophenolic acid, and glycyrrhizin against two clinical isolates of coronavirus (FFM-1 and FFM-2) from patients with SARS admitted to the clinical centre of Frankfurt University, Germany. Of all the compounds, glycyrrhizin was the most active in inhibiting replication of the SARS-associated virus. Our findings suggest that glycyrrhizin should be assessed for treatment of SARS.</div>
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