SrasV1, Ncbi, Checkpoint, bibRecord, 002F40

Nasal priming by a murine coronavirus provides protective immunity against lethal heterologous virus pneumonia

Identifieur interne : 002F40 ( Ncbi/Checkpoint ); précédent : 002F39; suivant : 002F41

Nasal priming by a murine coronavirus provides protective immunity against lethal heterologous virus pneumonia

Auteurs : Xiaoyang Hua ; Rahul Vijay ; Rudragouda Channappanavar ; Jeremiah Athmer ; David K. Meyerholz [États-Unis] ; Nitin Pagedar ; Stephen Tilley [États-Unis] ; Stanley Perlman

Source :

JCI Insight [ 2379-3708 ] ; ????.

RBID : PMC:6124400

Descripteurs français

KwdFr :
- Activation des macrophages, Administration par voie nasale, Animaux, Femelle, Humains, Immunité innée, Immunité muqueuse, Macrophages (immunologie), Modèles animaux de maladie humaine, Muqueuse nasale (cytologie), Muqueuse nasale (immunologie), Muqueuse nasale (virologie), Pneumopathie virale (), Pneumopathie virale (immunologie), Pneumopathie virale (mortalité), Pneumopathie virale (virologie), Poumon (cytologie), Poumon (immunologie), Poumon (virologie), Souris, Vaccins contre les hépatites virales (administration et posologie), Virus de l'hépatite murine (immunologie), Virus de la grippe A (immunologie), Virus de la grippe A (pathogénicité), Virus du SRAS (immunologie), Virus du SRAS (pathogénicité).
MESH :
- administration et posologie : Vaccins contre les hépatites virales.
- cytologie : Muqueuse nasale, Poumon.
- immunologie : Macrophages, Muqueuse nasale, Pneumopathie virale, Poumon, Virus de l'hépatite murine, Virus de la grippe A, Virus du SRAS.
- mortalité : Pneumopathie virale.
- pathogénicité : Virus de la grippe A, Virus du SRAS.
- virologie : Muqueuse nasale, Pneumopathie virale, Poumon.
- Activation des macrophages, Administration par voie nasale, Animaux, Femelle, Humains, Immunité innée, Immunité muqueuse, Modèles animaux de maladie humaine, Pneumopathie virale, Souris.

English descriptors

KwdEn :
- Administration, Intranasal, Animals, Disease Models, Animal, Female, Humans, Immunity, Innate, Immunity, Mucosal, Influenza A virus (immunology), Influenza A virus (pathogenicity), Lung (cytology), Lung (immunology), Lung (virology), Macrophage Activation, Macrophages (immunology), Mice, Murine hepatitis virus (immunology), Nasal Mucosa (cytology), Nasal Mucosa (immunology), Nasal Mucosa (virology), Pneumonia, Viral (immunology), Pneumonia, Viral (mortality), Pneumonia, Viral (prevention & control), Pneumonia, Viral (virology), SARS Virus (immunology), SARS Virus (pathogenicity), Viral Hepatitis Vaccines (administration & dosage).
MESH :
- chemical , administration & dosage : Viral Hepatitis Vaccines.
- cytology : Lung, Nasal Mucosa.
- immunology : Influenza A virus, Lung, Macrophages, Murine hepatitis virus, Nasal Mucosa, Pneumonia, Viral, SARS Virus.
- mortality : Pneumonia, Viral.
- pathogenicity : Influenza A virus, SARS Virus.
- prevention & control : Pneumonia, Viral.
- virology : Lung, Nasal Mucosa, Pneumonia, Viral.
- Administration, Intranasal, Animals, Disease Models, Animal, Female, Humans, Immunity, Innate, Immunity, Mucosal, Macrophage Activation, Mice.

Abstract

The nasal mucosa is an important component of mucosal immunity. Immunogenic particles in inspired air are known to activate the local nasal mucosal immune system and can lead to sinonasal inflammation; however, little is known about the effect of this activation on the lung immune environment. Here, we showed that nasal inoculation of murine coronavirus (CoV) in the absence of direct lung infection primes the lung immune environment by recruiting activated monocytes (Ly6C⁺ inflammatory monocytes) and NK cells into the lungs. Unlike infiltration of these cells into directly infected lungs, a process that requires type I IFN signaling, nasally induced infiltration of Ly6C⁺ inflammatory monocytes into the lungs is IFN-I independent. These activated macrophages ingested antigen and migrated to pulmonary lymph nodes, and enhanced both innate and adaptive immunity after heterologous virus infection. Clinically, such nasal-only inoculation of MHV-1 failed to cause pneumonia but significantly reduced mortality and morbidity of lethal pneumonia caused by severe acute respiratory syndrome CoV (SARS-CoV) or influenza A virus. Together, the data indicate that the nose and upper airway remotely prime the lung immunity to protect the lungs from direct viral infections.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124400

DOI: 10.1172/jci.insight.99025
PubMed: 29875310
PubMed Central: 6124400

Affiliations:

Links to Exploration step

PMC:6124400

Le document en format XML

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<term>Animals</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Humans</term>
<term>Immunity, Innate</term>
<term>Immunity, Mucosal</term>
<term>Influenza A virus (immunology)</term>
<term>Influenza A virus (pathogenicity)</term>
<term>Lung (cytology)</term>
<term>Lung (immunology)</term>
<term>Lung (virology)</term>
<term>Macrophage Activation</term>
<term>Macrophages (immunology)</term>
<term>Mice</term>
<term>Murine hepatitis virus (immunology)</term>
<term>Nasal Mucosa (cytology)</term>
<term>Nasal Mucosa (immunology)</term>
<term>Nasal Mucosa (virology)</term>
<term>Pneumonia, Viral (immunology)</term>
<term>Pneumonia, Viral (mortality)</term>
<term>Pneumonia, Viral (prevention & control)</term>
<term>Pneumonia, Viral (virology)</term>
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<term>Administration par voie nasale</term>
<term>Animaux</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunité innée</term>
<term>Immunité muqueuse</term>
<term>Macrophages (immunologie)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Muqueuse nasale (cytologie)</term>
<term>Muqueuse nasale (immunologie)</term>
<term>Muqueuse nasale (virologie)</term>
<term>Pneumopathie virale ()</term>
<term>Pneumopathie virale (immunologie)</term>
<term>Pneumopathie virale (mortalité)</term>
<term>Pneumopathie virale (virologie)</term>
<term>Poumon (cytologie)</term>
<term>Poumon (immunologie)</term>
<term>Poumon (virologie)</term>
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<term>Vaccins contre les hépatites virales (administration et posologie)</term>
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<term>Virus de la grippe A (pathogénicité)</term>
<term>Virus du SRAS (immunologie)</term>
<term>Virus du SRAS (pathogénicité)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Viral Hepatitis Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins contre les hépatites virales</term>
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<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Muqueuse nasale</term>
<term>Poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Lung</term>
<term>Nasal Mucosa</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Macrophages</term>
<term>Muqueuse nasale</term>
<term>Pneumopathie virale</term>
<term>Poumon</term>
<term>Virus de l'hépatite murine</term>
<term>Virus de la grippe A</term>
<term>Virus du SRAS</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term>
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<term>Macrophages</term>
<term>Murine hepatitis virus</term>
<term>Nasal Mucosa</term>
<term>Pneumonia, Viral</term>
<term>SARS Virus</term>
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<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Pneumonia, Viral</term>
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<term>Pneumopathie virale</term>
<term>Poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Lung</term>
<term>Nasal Mucosa</term>
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</keywords>
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<term>Animals</term>
<term>Disease Models, Animal</term>
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<term>Humans</term>
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<term>Administration par voie nasale</term>
<term>Animaux</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunité innée</term>
<term>Immunité muqueuse</term>
<term>Modèles animaux de maladie humaine</term>
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<front><div type="abstract" xml:lang="en"><p>The nasal mucosa is an important component of mucosal immunity. Immunogenic particles in inspired air are known to activate the local nasal mucosal immune system and can lead to sinonasal inflammation; however, little is known about the effect of this activation on the lung immune environment. Here, we showed that nasal inoculation of murine coronavirus (CoV) in the absence of direct lung infection primes the lung immune environment by recruiting activated monocytes (Ly6C<sup>+</sup>
 inflammatory monocytes) and NK cells into the lungs. Unlike infiltration of these cells into directly infected lungs, a process that requires type I IFN signaling, nasally induced infiltration of Ly6C<sup>+</sup>
 inflammatory monocytes into the lungs is IFN-I independent. These activated macrophages ingested antigen and migrated to pulmonary lymph nodes, and enhanced both innate and adaptive immunity after heterologous virus infection. Clinically, such nasal-only inoculation of MHV-1 failed to cause pneumonia but significantly reduced mortality and morbidity of lethal pneumonia caused by severe acute respiratory syndrome CoV (SARS-CoV) or influenza A virus. Together, the data indicate that the nose and upper airway remotely prime the lung immunity to protect the lungs from direct viral infections.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
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<tree><noCountry><name sortKey="Athmer, Jeremiah" sort="Athmer, Jeremiah" uniqKey="Athmer J" first="Jeremiah" last="Athmer">Jeremiah Athmer</name>
<name sortKey="Channappanavar, Rudragouda" sort="Channappanavar, Rudragouda" uniqKey="Channappanavar R" first="Rudragouda" last="Channappanavar">Rudragouda Channappanavar</name>
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<name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name>
<name sortKey="Vijay, Rahul" sort="Vijay, Rahul" uniqKey="Vijay R" first="Rahul" last="Vijay">Rahul Vijay</name>
</noCountry>
<country name="États-Unis"><region name="Iowa"><name sortKey="Meyerholz, David K" sort="Meyerholz, David K" uniqKey="Meyerholz D" first="David K." last="Meyerholz">David K. Meyerholz</name>
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Nasal priming by a murine coronavirus provides protective immunity against lethal heterologous virus pneumonia

Nasal priming by a murine coronavirus provides protective immunity against lethal heterologous virus pneumonia

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Descripteurs français

English descriptors

Abstract

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Links to Exploration step

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