Concise SAR Exploration Based on the "Head-to-Tail" Approach: Discovery of PI4KIIIα Inhibitors Bearing Diverse Scaffolds.
Identifieur interne : 002D23 ( Ncbi/Checkpoint ); précédent : 002D22; suivant : 002D24Concise SAR Exploration Based on the "Head-to-Tail" Approach: Discovery of PI4KIIIα Inhibitors Bearing Diverse Scaffolds.
Auteurs : Satoru Noji [Japon] ; Noriyoshi Seki [Japon] ; Takaki Maeba [Japon] ; Takayuki Sakai [Japon] ; Eiichi Watanabe [Japon] ; Katsuya Maeda [Japon] ; Kyoko Fukushima [Japon] ; Toru Noguchi [Japon] ; Kazuya Ogawa [Japon] ; Yukiyo Toyonaga [Japon] ; Tamotsu Negoro [Japon] ; Hisashi Kawasaki [Japon] ; Makoto Shiozaki [Japon]Source :
- ACS medicinal chemistry letters [ 1948-5875 ] ; 2016.
Abstract
In typical kinase inhibitor programs, a hinge binder showing best potency with preferential specificity is initially selected, followed by fine-tuning of the accompanying substituents on its core module. A shortcoming of this approach is that the exclusive focus on a single chemotype can endanger all the analogues in the series if a critical shortcoming is revealed. Thus, an early evaluation of structure-activity relationships (SARs) can mitigate unforeseen outcomes within a series of multiple compounds, although there have been very few examples to follow such a policy. PI4KIIIα is one of four mammalian phosphatidylinositol-4 kinases and has recently drawn significant attention as an emerging target for hepatitis C virus (HCV) treatment. In this letter, a novel "head-to-tail" approach to discover a diverse set of PI4KIIIα inhibitors is reported. We believe this method will generate distinct core scaffolds, a rational strategy to circumvent potential risks in general kinase programs.
DOI: 10.1021/acsmedchemlett.6b00232
PubMed: 27774129
Affiliations:
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569-1125</wicri:noRegion></affiliation></author><author><name sortKey="Seki, Noriyoshi" sort="Seki, Noriyoshi" uniqKey="Seki N" first="Noriyoshi" last="Seki">Noriyoshi Seki</name><affiliation wicri:level="1"><nlm:affiliation>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125</wicri:regionArea><wicri:noRegion>Osaka 569-1125</wicri:noRegion></affiliation></author><author><name sortKey="Maeba, Takaki" sort="Maeba, Takaki" uniqKey="Maeba T" first="Takaki" last="Maeba">Takaki Maeba</name><affiliation wicri:level="1"><nlm:affiliation>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125</wicri:regionArea><wicri:noRegion>Osaka 569-1125</wicri:noRegion></affiliation></author><author><name sortKey="Sakai, Takayuki" sort="Sakai, Takayuki" uniqKey="Sakai T" first="Takayuki" last="Sakai">Takayuki Sakai</name><affiliation wicri:level="1"><nlm:affiliation>Chemical Research Laboratories, Biological Pharmacological Research 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Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125</wicri:regionArea><wicri:noRegion>Osaka 569-1125</wicri:noRegion></affiliation></author><author><name sortKey="Fukushima, Kyoko" sort="Fukushima, Kyoko" uniqKey="Fukushima K" first="Kyoko" last="Fukushima">Kyoko Fukushima</name><affiliation wicri:level="1"><nlm:affiliation>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125</wicri:regionArea><wicri:noRegion>Osaka 569-1125</wicri:noRegion></affiliation></author><author><name sortKey="Noguchi, Toru" sort="Noguchi, Toru" uniqKey="Noguchi T" first="Toru" last="Noguchi">Toru Noguchi</name><affiliation wicri:level="1"><nlm:affiliation>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125</wicri:regionArea><wicri:noRegion>Osaka 569-1125</wicri:noRegion></affiliation></author><author><name sortKey="Ogawa, Kazuya" sort="Ogawa, Kazuya" uniqKey="Ogawa K" first="Kazuya" last="Ogawa">Kazuya Ogawa</name><affiliation wicri:level="1"><nlm:affiliation>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125</wicri:regionArea><wicri:noRegion>Osaka 569-1125</wicri:noRegion></affiliation></author><author><name sortKey="Toyonaga, Yukiyo" sort="Toyonaga, Yukiyo" uniqKey="Toyonaga Y" first="Yukiyo" last="Toyonaga">Yukiyo Toyonaga</name><affiliation wicri:level="1"><nlm:affiliation>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125</wicri:regionArea><wicri:noRegion>Osaka 569-1125</wicri:noRegion></affiliation></author><author><name sortKey="Negoro, Tamotsu" sort="Negoro, Tamotsu" uniqKey="Negoro T" first="Tamotsu" last="Negoro">Tamotsu Negoro</name><affiliation wicri:level="1"><nlm:affiliation>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125</wicri:regionArea><wicri:noRegion>Osaka 569-1125</wicri:noRegion></affiliation></author><author><name sortKey="Kawasaki, Hisashi" sort="Kawasaki, Hisashi" uniqKey="Kawasaki H" first="Hisashi" last="Kawasaki">Hisashi Kawasaki</name><affiliation wicri:level="1"><nlm:affiliation>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125</wicri:regionArea><wicri:noRegion>Osaka 569-1125</wicri:noRegion></affiliation></author><author><name sortKey="Shiozaki, Makoto" sort="Shiozaki, Makoto" uniqKey="Shiozaki M" first="Makoto" last="Shiozaki">Makoto Shiozaki</name><affiliation wicri:level="1"><nlm:affiliation>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.</nlm:affiliation><country 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Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125</wicri:regionArea><wicri:noRegion>Osaka 569-1125</wicri:noRegion></affiliation></author><author><name sortKey="Seki, Noriyoshi" sort="Seki, Noriyoshi" uniqKey="Seki N" first="Noriyoshi" last="Seki">Noriyoshi Seki</name><affiliation wicri:level="1"><nlm:affiliation>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125</wicri:regionArea><wicri:noRegion>Osaka 569-1125</wicri:noRegion></affiliation></author><author><name sortKey="Maeba, Takaki" sort="Maeba, Takaki" uniqKey="Maeba T" first="Takaki" last="Maeba">Takaki Maeba</name><affiliation wicri:level="1"><nlm:affiliation>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125</wicri:regionArea><wicri:noRegion>Osaka 569-1125</wicri:noRegion></affiliation></author><author><name sortKey="Sakai, Takayuki" sort="Sakai, Takayuki" uniqKey="Sakai T" first="Takayuki" last="Sakai">Takayuki Sakai</name><affiliation wicri:level="1"><nlm:affiliation>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125</wicri:regionArea><wicri:noRegion>Osaka 569-1125</wicri:noRegion></affiliation></author><author><name sortKey="Watanabe, Eiichi" sort="Watanabe, Eiichi" uniqKey="Watanabe E" first="Eiichi" last="Watanabe">Eiichi Watanabe</name><affiliation wicri:level="1"><nlm:affiliation>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125</wicri:regionArea><wicri:noRegion>Osaka 569-1125</wicri:noRegion></affiliation></author><author><name sortKey="Maeda, Katsuya" sort="Maeda, Katsuya" uniqKey="Maeda K" first="Katsuya" last="Maeda">Katsuya Maeda</name><affiliation wicri:level="1"><nlm:affiliation>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125</wicri:regionArea><wicri:noRegion>Osaka 569-1125</wicri:noRegion></affiliation></author><author><name sortKey="Fukushima, Kyoko" sort="Fukushima, Kyoko" uniqKey="Fukushima K" first="Kyoko" last="Fukushima">Kyoko Fukushima</name><affiliation wicri:level="1"><nlm:affiliation>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125</wicri:regionArea><wicri:noRegion>Osaka 569-1125</wicri:noRegion></affiliation></author><author><name sortKey="Noguchi, Toru" sort="Noguchi, Toru" uniqKey="Noguchi T" first="Toru" last="Noguchi">Toru Noguchi</name><affiliation wicri:level="1"><nlm:affiliation>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125</wicri:regionArea><wicri:noRegion>Osaka 569-1125</wicri:noRegion></affiliation></author><author><name sortKey="Ogawa, Kazuya" sort="Ogawa, Kazuya" uniqKey="Ogawa K" first="Kazuya" last="Ogawa">Kazuya Ogawa</name><affiliation wicri:level="1"><nlm:affiliation>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125</wicri:regionArea><wicri:noRegion>Osaka 569-1125</wicri:noRegion></affiliation></author><author><name sortKey="Toyonaga, Yukiyo" sort="Toyonaga, Yukiyo" uniqKey="Toyonaga Y" first="Yukiyo" last="Toyonaga">Yukiyo Toyonaga</name><affiliation wicri:level="1"><nlm:affiliation>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125</wicri:regionArea><wicri:noRegion>Osaka 569-1125</wicri:noRegion></affiliation></author><author><name sortKey="Negoro, Tamotsu" sort="Negoro, Tamotsu" uniqKey="Negoro T" first="Tamotsu" last="Negoro">Tamotsu Negoro</name><affiliation wicri:level="1"><nlm:affiliation>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125</wicri:regionArea><wicri:noRegion>Osaka 569-1125</wicri:noRegion></affiliation></author><author><name sortKey="Kawasaki, Hisashi" sort="Kawasaki, Hisashi" uniqKey="Kawasaki H" first="Hisashi" last="Kawasaki">Hisashi Kawasaki</name><affiliation wicri:level="1"><nlm:affiliation>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125</wicri:regionArea><wicri:noRegion>Osaka 569-1125</wicri:noRegion></affiliation></author><author><name sortKey="Shiozaki, Makoto" sort="Shiozaki, Makoto" uniqKey="Shiozaki M" first="Makoto" last="Shiozaki">Makoto Shiozaki</name><affiliation wicri:level="1"><nlm:affiliation>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Chemical Research Laboratories, Biological Pharmacological Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. , 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125</wicri:regionArea><wicri:noRegion>Osaka 569-1125</wicri:noRegion></affiliation></author></analytic><series><title level="j">ACS medicinal chemistry letters</title><idno type="ISSN">1948-5875</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In typical kinase inhibitor programs, a hinge binder showing best potency with preferential specificity is initially selected, followed by fine-tuning of the accompanying substituents on its core module. A shortcoming of this approach is that the exclusive focus on a single chemotype can endanger all the analogues in the series if a critical shortcoming is revealed. Thus, an early evaluation of structure-activity relationships (SARs) can mitigate unforeseen outcomes within a series of multiple compounds, although there have been very few examples to follow such a policy. PI4KIIIα is one of four mammalian phosphatidylinositol-4 kinases and has recently drawn significant attention as an emerging target for hepatitis C virus (HCV) treatment. In this letter, a novel "head-to-tail" approach to discover a diverse set of PI4KIIIα inhibitors is reported. We believe this method will generate distinct core scaffolds, a rational strategy to circumvent potential risks in general kinase programs.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Noji, Satoru" sort="Noji, Satoru" uniqKey="Noji S" first="Satoru" last="Noji">Satoru Noji</name></noRegion><name sortKey="Fukushima, Kyoko" sort="Fukushima, Kyoko" uniqKey="Fukushima K" first="Kyoko" last="Fukushima">Kyoko Fukushima</name><name sortKey="Kawasaki, Hisashi" sort="Kawasaki, Hisashi" uniqKey="Kawasaki H" first="Hisashi" last="Kawasaki">Hisashi Kawasaki</name><name sortKey="Maeba, Takaki" sort="Maeba, Takaki" uniqKey="Maeba T" first="Takaki" last="Maeba">Takaki Maeba</name><name sortKey="Maeda, Katsuya" sort="Maeda, Katsuya" uniqKey="Maeda K" first="Katsuya" last="Maeda">Katsuya Maeda</name><name sortKey="Negoro, Tamotsu" sort="Negoro, Tamotsu" uniqKey="Negoro T" first="Tamotsu" last="Negoro">Tamotsu Negoro</name><name sortKey="Noguchi, Toru" sort="Noguchi, Toru" uniqKey="Noguchi T" first="Toru" last="Noguchi">Toru Noguchi</name><name sortKey="Ogawa, Kazuya" sort="Ogawa, Kazuya" uniqKey="Ogawa K" first="Kazuya" last="Ogawa">Kazuya Ogawa</name><name sortKey="Sakai, Takayuki" sort="Sakai, Takayuki" uniqKey="Sakai T" first="Takayuki" last="Sakai">Takayuki Sakai</name><name sortKey="Seki, Noriyoshi" sort="Seki, Noriyoshi" uniqKey="Seki N" first="Noriyoshi" last="Seki">Noriyoshi Seki</name><name sortKey="Shiozaki, Makoto" sort="Shiozaki, Makoto" uniqKey="Shiozaki M" first="Makoto" last="Shiozaki">Makoto Shiozaki</name><name sortKey="Toyonaga, Yukiyo" sort="Toyonaga, Yukiyo" uniqKey="Toyonaga Y" first="Yukiyo" last="Toyonaga">Yukiyo Toyonaga</name><name sortKey="Watanabe, Eiichi" sort="Watanabe, Eiichi" uniqKey="Watanabe E" first="Eiichi" last="Watanabe">Eiichi Watanabe</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|clé= pubmed:27774129
|texte= Concise SAR Exploration Based on the "Head-to-Tail" Approach: Discovery of PI4KIIIα Inhibitors Bearing Diverse Scaffolds.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:27774129" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |