Airway Memory CD4+ T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses
Identifieur interne : 002C75 ( Ncbi/Checkpoint ); précédent : 002C74; suivant : 002C76Airway Memory CD4+ T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses
Auteurs : Jincun Zhao [République populaire de Chine, États-Unis] ; Jingxian Zhao [États-Unis] ; Ashutosh K. Mangalam [États-Unis] ; Rudragouda Channappanavar [États-Unis] ; Craig Fett [États-Unis] ; David K. Meyerholz [États-Unis] ; Sudhakar Agnihothram [États-Unis] ; Ralph S. Baric [États-Unis] ; Chella S. David [États-Unis] ; Stanley Perlman [États-Unis]Source :
- Immunity [ 1074-7613 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Antigènes viraux (immunologie), Appareil respiratoire (immunologie), Cellules cultivées, Déterminants antigéniques des lymphocytes T (immunologie), Humains, Immunité, Infections à coronavirus (immunologie), Interféron gamma (métabolisme), Lignées consanguines de souris, Lymphocytes T CD4+ (immunologie), Lymphocytes T CD4+ (virologie), Lymphocytes T CD8+ (immunologie), Lymphocytes T CD8+ (virologie), Mémoire immunologique, Réactions croisées, Souris, Syndrome respiratoire aigu sévère (immunologie), Vaccination, Vaccins antiviraux (immunologie), Virion (immunologie), Virus du SRAS (immunologie).
- MESH :
- immunologie : Antigènes viraux, Appareil respiratoire, Déterminants antigéniques des lymphocytes T, Infections à coronavirus, Lymphocytes T CD4+, Lymphocytes T CD8+, Syndrome respiratoire aigu sévère, Vaccins antiviraux, Virion, Virus du SRAS.
- métabolisme : Interféron gamma.
- virologie : Lymphocytes T CD4+, Lymphocytes T CD8+.
- Animaux, Cellules cultivées, Humains, Immunité, Lignées consanguines de souris, Mémoire immunologique, Réactions croisées, Souris, Vaccination.
English descriptors
- KwdEn :
- Animals, Antigens, Viral (immunology), CD4-Positive T-Lymphocytes (immunology), CD4-Positive T-Lymphocytes (virology), CD8-Positive T-Lymphocytes (immunology), CD8-Positive T-Lymphocytes (virology), Cells, Cultured, Coronavirus Infections (immunology), Cross Reactions, Epitopes, T-Lymphocyte (immunology), Humans, Immunity, Immunologic Memory, Interferon-gamma (metabolism), Mice, Mice, Inbred Strains, Respiratory System (immunology), SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Vaccination, Viral Vaccines (immunology), Virion (immunology).
- MESH :
- chemical , immunology : Antigens, Viral, Epitopes, T-Lymphocyte, Viral Vaccines.
- immunology : CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Coronavirus Infections, Respiratory System, SARS Virus, Severe Acute Respiratory Syndrome, Virion.
- chemical , metabolism : Interferon-gamma.
- virology : CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes.
- Animals, Cells, Cultured, Cross Reactions, Humans, Immunity, Immunologic Memory, Mice, Mice, Inbred Strains, Vaccination.
Abstract
Two zoonotic coronaviruses (CoVs)—SARS-CoV and MERS-CoV—have crossed species to cause severe human respiratory disease. Here, we showed that induction of airway memory CD4+ T cells specific for a conserved epitope shared by SARS-CoV and MERS-CoV is a potential strategy for developing pan-coronavirus vaccines. Airway memory CD4+ T cells differed phenotypically and functionally from lung-derived cells and were crucial for protection against both CoVs in mice. Protection was dependent on interferon-γ and required early induction of robust innate and virus-specific CD8+ T cell responses. The conserved epitope was also recognized in SARS-CoV- and MERS-CoV-infected human leukocyte antigen DR2 and DR3 transgenic mice, indicating potential relevance in human populations. Additionally, this epitope was cross-protective between human and bat CoVs, the progenitors for many human CoVs. Vaccine strategies that induce airway memory CD4+ T cells targeting conserved epitopes might have broad applicability in the context of new CoVs and other respiratory virus outbreaks.
Url:
DOI: 10.1016/j.immuni.2016.05.006
PubMed: 27287409
PubMed Central: 4917442
Affiliations:
- République populaire de Chine, États-Unis
- Caroline du Nord, Guangdong, Iowa, Michigan
- Iowa City, Jiangmen
- Université de l'Iowa
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PMC:4917442Le document en format XML
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T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses</title>
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T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses</title>
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<author><name sortKey="Agnihothram, Sudhakar" sort="Agnihothram, Sudhakar" uniqKey="Agnihothram S" first="Sudhakar" last="Agnihothram">Sudhakar Agnihothram</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antigens, Viral (immunology)</term>
<term>CD4-Positive T-Lymphocytes (immunology)</term>
<term>CD4-Positive T-Lymphocytes (virology)</term>
<term>CD8-Positive T-Lymphocytes (immunology)</term>
<term>CD8-Positive T-Lymphocytes (virology)</term>
<term>Cells, Cultured</term>
<term>Coronavirus Infections (immunology)</term>
<term>Cross Reactions</term>
<term>Epitopes, T-Lymphocyte (immunology)</term>
<term>Humans</term>
<term>Immunity</term>
<term>Immunologic Memory</term>
<term>Interferon-gamma (metabolism)</term>
<term>Mice</term>
<term>Mice, Inbred Strains</term>
<term>Respiratory System (immunology)</term>
<term>SARS Virus (immunology)</term>
<term>Severe Acute Respiratory Syndrome (immunology)</term>
<term>Vaccination</term>
<term>Viral Vaccines (immunology)</term>
<term>Virion (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Antigènes viraux (immunologie)</term>
<term>Appareil respiratoire (immunologie)</term>
<term>Cellules cultivées</term>
<term>Déterminants antigéniques des lymphocytes T (immunologie)</term>
<term>Humains</term>
<term>Immunité</term>
<term>Infections à coronavirus (immunologie)</term>
<term>Interféron gamma (métabolisme)</term>
<term>Lignées consanguines de souris</term>
<term>Lymphocytes T CD4+ (immunologie)</term>
<term>Lymphocytes T CD4+ (virologie)</term>
<term>Lymphocytes T CD8+ (immunologie)</term>
<term>Lymphocytes T CD8+ (virologie)</term>
<term>Mémoire immunologique</term>
<term>Réactions croisées</term>
<term>Souris</term>
<term>Syndrome respiratoire aigu sévère (immunologie)</term>
<term>Vaccination</term>
<term>Vaccins antiviraux (immunologie)</term>
<term>Virion (immunologie)</term>
<term>Virus du SRAS (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Viral</term>
<term>Epitopes, T-Lymphocyte</term>
<term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes viraux</term>
<term>Appareil respiratoire</term>
<term>Déterminants antigéniques des lymphocytes T</term>
<term>Infections à coronavirus</term>
<term>Lymphocytes T CD4+</term>
<term>Lymphocytes T CD8+</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Vaccins antiviraux</term>
<term>Virion</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term>
<term>CD8-Positive T-Lymphocytes</term>
<term>Coronavirus Infections</term>
<term>Respiratory System</term>
<term>SARS Virus</term>
<term>Severe Acute Respiratory Syndrome</term>
<term>Virion</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Interferon-gamma</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Interféron gamma</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Lymphocytes T CD4+</term>
<term>Lymphocytes T CD8+</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term>
<term>CD8-Positive T-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cells, Cultured</term>
<term>Cross Reactions</term>
<term>Humans</term>
<term>Immunity</term>
<term>Immunologic Memory</term>
<term>Mice</term>
<term>Mice, Inbred Strains</term>
<term>Vaccination</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules cultivées</term>
<term>Humains</term>
<term>Immunité</term>
<term>Lignées consanguines de souris</term>
<term>Mémoire immunologique</term>
<term>Réactions croisées</term>
<term>Souris</term>
<term>Vaccination</term>
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<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p>Two zoonotic coronaviruses (CoVs)—SARS-CoV and MERS-CoV—have crossed species to cause severe human respiratory disease. Here, we showed that induction of airway memory CD4<sup>+</sup>
T cells specific for a conserved epitope shared by SARS-CoV and MERS-CoV is a potential strategy for developing pan-coronavirus vaccines. Airway memory CD4<sup>+</sup>
T cells differed phenotypically and functionally from lung-derived cells and were crucial for protection against both CoVs in mice. Protection was dependent on interferon-γ and required early induction of robust innate and virus-specific CD8<sup>+</sup>
T cell responses. The conserved epitope was also recognized in SARS-CoV- and MERS-CoV-infected human leukocyte antigen DR2 and DR3 transgenic mice, indicating potential relevance in human populations. Additionally, this epitope was cross-protective between human and bat CoVs, the progenitors for many human CoVs. Vaccine strategies that induce airway memory CD4<sup>+</sup>
T cells targeting conserved epitopes might have broad applicability in the context of new CoVs and other respiratory virus outbreaks.</p>
</div>
</front>
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</div1>
</back>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
<li>États-Unis</li>
</country>
<region><li>Caroline du Nord</li>
<li>Guangdong</li>
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<settlement><li>Iowa City</li>
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<orgName><li>Université de l'Iowa</li>
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</affiliations>
</record>
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