SrasV1, Ncbi, Checkpoint, bibRecord, 002058

Ecoepidemiology and Complete Genome Comparison of Different Strains of Severe Acute Respiratory Syndrome-Related Rhinolophus Bat Coronavirus in China Reveal Bats as a Reservoir for Acute, Self-Limiting Infection That Allows Recombination Events▿ †

Identifieur interne : 002058 ( Ncbi/Checkpoint ); précédent : 002057; suivant : 002059

Ecoepidemiology and Complete Genome Comparison of Different Strains of Severe Acute Respiratory Syndrome-Related Rhinolophus Bat Coronavirus in China Reveal Bats as a Reservoir for Acute, Self-Limiting Infection That Allows Recombination Events▿ †

Auteurs : Susanna K. P. Lau ; Kenneth S. M. Li ; Yi Huang ; Chung-Tong Shek ; Herman Tse ; Ming Wang ; Garnet K. Y. Choi ; Huifang Xu ; Carol S. F. Lam ; Rongtong Guo ; Kwok-Hung Chan ; Bo-Jian Zheng ; Patrick C. Y. Woo ; Kwok-Yung Yuen

Source :

Journal of Virology [ 0022-538X ] ; 2010.

RBID : PMC:2826035

Descripteurs français

KwdFr :
- ARN viral (génétique), Animaux, Chine (épidémiologie), Chiroptera (virologie), Génome viral, Humains, Phylogénie, Recombinaison génétique, Réservoirs d'agents pathogènes (virologie), Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Virus du SRAS (), Virus du SRAS (génétique).
MESH :
- génétique : ARN viral, Virus du SRAS.
- virologie : Chiroptera, Réservoirs d'agents pathogènes, Syndrome respiratoire aigu sévère.
- épidémiologie : Chine, Syndrome respiratoire aigu sévère.
- Animaux, Génome viral, Humains, Phylogénie, Recombinaison génétique, Virus du SRAS.
Wicri :
- geographic : République populaire de Chine.

English descriptors

KwdEn :
- Animals, China (epidemiology), Chiroptera (virology), Disease Reservoirs (virology), Genome, Viral, Humans, Phylogeny, RNA, Viral (genetics), Recombination, Genetic, SARS Virus (classification), SARS Virus (genetics), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (virology).
MESH :
- chemical , genetics : RNA, Viral.
- geographic , epidemiology : China.
- classification : SARS Virus.
- epidemiology : Severe Acute Respiratory Syndrome.
- genetics : SARS Virus.
- virology : Chiroptera, Disease Reservoirs, Severe Acute Respiratory Syndrome.
- Animals, Genome, Viral, Humans, Phylogeny, Recombination, Genetic.

Abstract

Despite the identification of severe acute respiratory syndrome-related coronavirus (SARSr-CoV) in Rhinolophus Chinese horseshoe bats (SARSr-Rh-BatCoV) in China, the evolutionary and possible recombination origin of SARSr-CoV remains undetermined. We carried out the first study to investigate the migration pattern and SARSr-Rh-BatCoV genome epidemiology in Chinese horseshoe bats during a 4-year period. Of 1,401 Chinese horseshoe bats from Hong Kong and Guangdong, China, that were sampled, SARSr-Rh-BatCoV was detected in alimentary specimens from 130 (9.3%) bats, with peak activity during spring. A tagging exercise of 511 bats showed migration distances from 1.86 to 17 km. Bats carrying SARSr-Rh-BatCoV appeared healthy, with viral clearance occurring between 2 weeks and 4 months. However, lower body weights were observed in bats positive for SARSr-Rh-BatCoV, but not Rh-BatCoV HKU2. Complete genome sequencing of 10 SARSr-Rh-BatCoV strains showed frequent recombination between different strains. Moreover, recombination was detected between SARSr-Rh-BatCoV Rp3 from Guangxi, China, and Rf1 from Hubei, China, in the possible generation of civet SARSr-CoV SZ3, with a breakpoint at the nsp16/spike region. Molecular clock analysis showed that SARSr-CoVs were newly emerged viruses with the time of the most recent common ancestor (tMRCA) at 1972, which diverged between civet and bat strains in 1995. The present data suggest that SARSr-Rh-BatCoV causes acute, self-limiting infection in horseshoe bats, which serve as a reservoir for recombination between strains from different geographical locations within reachable foraging range. Civet SARSr-CoV is likely a recombinant virus arising from SARSr-CoV strains closely related to SARSr-Rh-BatCoV Rp3 and Rf1. Such frequent recombination, coupled with rapid evolution especially in ORF7b/ORF8 region, in these animals may have accounted for the cross-species transmission and emergence of SARS.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826035

DOI: 10.1128/JVI.02219-09
PubMed: 20071579
PubMed Central: 2826035

Affiliations:

Links to Exploration step

PMC:2826035

Le document en format XML

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 Bat Coronavirus in China Reveal Bats as a Reservoir for Acute, Self-Limiting Infection That Allows Recombination Events<xref ref-type="fn" rid="fn3">▿</xref>
 <xref ref-type="fn" rid="fn1">†</xref>
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<author><name sortKey="Guo, Rongtong" sort="Guo, Rongtong" uniqKey="Guo R" first="Rongtong" last="Guo">Rongtong Guo</name>
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<series><title level="j">Journal of Virology</title>
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<term>China (epidemiology)</term>
<term>Chiroptera (virology)</term>
<term>Disease Reservoirs (virology)</term>
<term>Genome, Viral</term>
<term>Humans</term>
<term>Phylogeny</term>
<term>RNA, Viral (genetics)</term>
<term>Recombination, Genetic</term>
<term>SARS Virus (classification)</term>
<term>SARS Virus (genetics)</term>
<term>Severe Acute Respiratory Syndrome (epidemiology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
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<term>Animaux</term>
<term>Chine (épidémiologie)</term>
<term>Chiroptera (virologie)</term>
<term>Génome viral</term>
<term>Humains</term>
<term>Phylogénie</term>
<term>Recombinaison génétique</term>
<term>Réservoirs d'agents pathogènes (virologie)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
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<term>Virus du SRAS ()</term>
<term>Virus du SRAS (génétique)</term>
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<term>Disease Reservoirs</term>
<term>Severe Acute Respiratory Syndrome</term>
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<term>Syndrome respiratoire aigu sévère</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Genome, Viral</term>
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<front><div type="abstract" xml:lang="en"><p>Despite the identification of severe acute respiratory syndrome-related coronavirus (SARSr-CoV) in <italic>Rhinolophus</italic>
 Chinese horseshoe bats (SARSr-Rh-BatCoV) in China, the evolutionary and possible recombination origin of SARSr-CoV remains undetermined. We carried out the first study to investigate the migration pattern and SARSr-Rh-BatCoV genome epidemiology in Chinese horseshoe bats during a 4-year period. Of 1,401 Chinese horseshoe bats from Hong Kong and Guangdong, China, that were sampled, SARSr-Rh-BatCoV was detected in alimentary specimens from 130 (9.3%) bats, with peak activity during spring. A tagging exercise of 511 bats showed migration distances from 1.86 to 17 km. Bats carrying SARSr-Rh-BatCoV appeared healthy, with viral clearance occurring between 2 weeks and 4 months. However, lower body weights were observed in bats positive for SARSr-Rh-BatCoV, but not Rh-BatCoV HKU2. Complete genome sequencing of 10 SARSr-Rh-BatCoV strains showed frequent recombination between different strains. Moreover, recombination was detected between SARSr-Rh-BatCoV Rp3 from Guangxi, China, and Rf1 from Hubei, China, in the possible generation of civet SARSr-CoV SZ3, with a breakpoint at the nsp16/spike region. Molecular clock analysis showed that SARSr-CoVs were newly emerged viruses with the time of the most recent common ancestor (tMRCA) at 1972, which diverged between civet and bat strains in 1995. The present data suggest that SARSr-Rh-BatCoV causes acute, self-limiting infection in horseshoe bats, which serve as a reservoir for recombination between strains from different geographical locations within reachable foraging range. Civet SARSr-CoV is likely a recombinant virus arising from SARSr-CoV strains closely related to SARSr-Rh-BatCoV Rp3 and Rf1. Such frequent recombination, coupled with rapid evolution especially in ORF7b/ORF8 region, in these animals may have accounted for the cross-species transmission and emergence of SARS.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Chan, Kwok Hung" sort="Chan, Kwok Hung" uniqKey="Chan K" first="Kwok-Hung" last="Chan">Kwok-Hung Chan</name>
<name sortKey="Choi, Garnet K Y" sort="Choi, Garnet K Y" uniqKey="Choi G" first="Garnet K. Y." last="Choi">Garnet K. Y. Choi</name>
<name sortKey="Guo, Rongtong" sort="Guo, Rongtong" uniqKey="Guo R" first="Rongtong" last="Guo">Rongtong Guo</name>
<name sortKey="Huang, Yi" sort="Huang, Yi" uniqKey="Huang Y" first="Yi" last="Huang">Yi Huang</name>
<name sortKey="Lam, Carol S F" sort="Lam, Carol S F" uniqKey="Lam C" first="Carol S. F." last="Lam">Carol S. F. Lam</name>
<name sortKey="Lau, Susanna K P" sort="Lau, Susanna K P" uniqKey="Lau S" first="Susanna K. P." last="Lau">Susanna K. P. Lau</name>
<name sortKey="Li, Kenneth S M" sort="Li, Kenneth S M" uniqKey="Li K" first="Kenneth S. M." last="Li">Kenneth S. M. Li</name>
<name sortKey="Shek, Chung Tong" sort="Shek, Chung Tong" uniqKey="Shek C" first="Chung-Tong" last="Shek">Chung-Tong Shek</name>
<name sortKey="Tse, Herman" sort="Tse, Herman" uniqKey="Tse H" first="Herman" last="Tse">Herman Tse</name>
<name sortKey="Wang, Ming" sort="Wang, Ming" uniqKey="Wang M" first="Ming" last="Wang">Ming Wang</name>
<name sortKey="Woo, Patrick C Y" sort="Woo, Patrick C Y" uniqKey="Woo P" first="Patrick C. Y." last="Woo">Patrick C. Y. Woo</name>
<name sortKey="Xu, Huifang" sort="Xu, Huifang" uniqKey="Xu H" first="Huifang" last="Xu">Huifang Xu</name>
<name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name>
<name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name>
</noCountry>
</tree>
</affiliations>
</record>

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   |texte=   Ecoepidemiology and Complete Genome Comparison of Different Strains of Severe Acute Respiratory Syndrome-Related Rhinolophus Bat Coronavirus in China Reveal Bats as a Reservoir for Acute, Self-Limiting Infection That Allows Recombination Events▿ † 
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Ecoepidemiology and Complete Genome Comparison of Different Strains of Severe Acute Respiratory Syndrome-Related Rhinolophus Bat Coronavirus in China Reveal Bats as a Reservoir for Acute, Self-Limiting Infection That Allows Recombination Events▿ †

Ecoepidemiology and Complete Genome Comparison of Different Strains of Severe Acute Respiratory Syndrome-Related Rhinolophus Bat Coronavirus in China Reveal Bats as a Reservoir for Acute, Self-Limiting Infection That Allows Recombination Events▿ †

Source :

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Abstract

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