Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors
Identifieur interne : 001D48 ( Ncbi/Checkpoint ); précédent : 001D47; suivant : 001D49Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors
Auteurs : Arun K. Ghosh [États-Unis] ; Gangli Gong [États-Unis] ; Valerie Grum-Tokars [États-Unis] ; Debbie C. Mulhearn [États-Unis] ; Susan C. Baker [États-Unis] ; Melissa Coughlin [États-Unis] ; Bellur S. Prabhakar [États-Unis] ; Katrina Sleeman [États-Unis] ; Michael E. Johnson [États-Unis] ; Andrew D. Mesecar [États-Unis]Source :
- Bioorganic & Medicinal Chemistry Letters [ 0960-894X ] ; 2008.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (), Antiviraux (pharmacologie), Antiviraux (synthèse chimique), Chimie pharmaceutique (), Concentration inhibitrice 50, Conception de médicament, Conformation moléculaire, Cysteine endopeptidases (), Domaine catalytique, Esters, Humains, Liaison aux protéines, Modèles chimiques, Modèles moléculaires, Protéines virales (antagonistes et inhibiteurs), Virus du SRAS (métabolisme).
- MESH :
- antagonistes et inhibiteurs : Protéines virales.
- métabolisme : Virus du SRAS.
- pharmacologie : Antiviraux.
- synthèse chimique : Antiviraux.
- Animaux, Antiviraux, Chimie pharmaceutique, Concentration inhibitrice 50, Conception de médicament, Conformation moléculaire, Cysteine endopeptidases, Domaine catalytique, Esters, Humains, Liaison aux protéines, Modèles chimiques, Modèles moléculaires.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (chemical synthesis), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Catalytic Domain, Chemistry, Pharmaceutical (methods), Cysteine Endopeptidases (chemistry), Drug Design, Esters, Humans, Inhibitory Concentration 50, Models, Chemical, Models, Molecular, Molecular Conformation, Protein Binding, SARS Virus (metabolism), Viral Proteins (antagonists & inhibitors).
- MESH :
- chemical , antagonists & inhibitors : Viral Proteins.
- chemical , chemical synthesis : Antiviral Agents.
- chemical , chemistry : Antiviral Agents, Cysteine Endopeptidases.
- chemical , pharmacology : Antiviral Agents.
- metabolism : SARS Virus.
- methods : Chemistry, Pharmaceutical.
- Animals, Catalytic Domain, Drug Design, Esters, Humans, Inhibitory Concentration 50, Models, Chemical, Models, Molecular, Molecular Conformation, Protein Binding.
Abstract
Design, synthesis and biological evaluation of a series of chloropyridyl ester-derived SARS-CoV 3CLpro Inhibitors are described Inhibitors
Url:
DOI: 10.1016/j.bmcl.2008.08.082
PubMed: 18796354
PubMed Central: 2745596
Affiliations:
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PMC:2745596Le document en format XML
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<term>Antiviral Agents (chemistry)</term>
<term>Antiviral Agents (pharmacology)</term>
<term>Catalytic Domain</term>
<term>Chemistry, Pharmaceutical (methods)</term>
<term>Cysteine Endopeptidases (chemistry)</term>
<term>Drug Design</term>
<term>Esters</term>
<term>Humans</term>
<term>Inhibitory Concentration 50</term>
<term>Models, Chemical</term>
<term>Models, Molecular</term>
<term>Molecular Conformation</term>
<term>Protein Binding</term>
<term>SARS Virus (metabolism)</term>
<term>Viral Proteins (antagonists & inhibitors)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Antiviraux ()</term>
<term>Antiviraux (pharmacologie)</term>
<term>Antiviraux (synthèse chimique)</term>
<term>Chimie pharmaceutique ()</term>
<term>Concentration inhibitrice 50</term>
<term>Conception de médicament</term>
<term>Conformation moléculaire</term>
<term>Cysteine endopeptidases ()</term>
<term>Domaine catalytique</term>
<term>Esters</term>
<term>Humains</term>
<term>Liaison aux protéines</term>
<term>Modèles chimiques</term>
<term>Modèles moléculaires</term>
<term>Protéines virales (antagonistes et inhibiteurs)</term>
<term>Virus du SRAS (métabolisme)</term>
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<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Viral Proteins</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Antiviral Agents</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term>
<term>Cysteine Endopeptidases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Protéines virales</term>
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<term>Protein Binding</term>
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<front><div type="abstract" xml:lang="en"><title>Graphical abstract</title>
<p>Design, synthesis and biological evaluation of a series of chloropyridyl ester-derived SARS-CoV 3CLpro Inhibitors are described Inhibitors <bold>10</bold>
has shown potent activity in both enzyme inhibitory and antiviral assays</p>
<fig id="d32e1103" position="anchor"><graphic xlink:href="fx1"></graphic>
</fig>
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<affiliations><list><country><li>États-Unis</li>
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