Severe acute respiratory syndrome coronavirus entry as a target of antiviral therapies.
Identifieur interne : 001A92 ( Ncbi/Checkpoint ); précédent : 001A91; suivant : 001A93Severe acute respiratory syndrome coronavirus entry as a target of antiviral therapies.
Auteurs : Jens H. Kuhn [États-Unis] ; Wenhui Li ; Sheli R. Radoshitzky ; Hyeryun Choe ; Michael FarzanSource :
- Antiviral therapy [ 1359-6535 ] ; 2007.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (pharmacologie), Antiviraux (usage thérapeutique), Bovins, Chats, Chiens, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (), Glycoprotéines membranaires (métabolisme), Humains, Lapins, Modèles moléculaires, Peptidyl-Dipeptidase A (), Peptidyl-Dipeptidase A (métabolisme), Protéines de l'enveloppe virale (), Protéines de l'enveloppe virale (métabolisme), Rats, Récepteurs viraux (), Récepteurs viraux (métabolisme), Syndrome respiratoire aigu sévère (traitement médicamenteux), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (), Virus du SRAS (pathogénicité).
- MESH :
- métabolisme : Glycoprotéines membranaires, Peptidyl-Dipeptidase A, Protéines de l'enveloppe virale, Récepteurs viraux.
- pathogénicité : Virus du SRAS.
- pharmacologie : Antiviraux.
- traitement médicamenteux : Syndrome respiratoire aigu sévère.
- usage thérapeutique : Antiviraux.
- virologie : Syndrome respiratoire aigu sévère.
- Animaux, Bovins, Chats, Chiens, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires, Humains, Lapins, Modèles moléculaires, Peptidyl-Dipeptidase A, Protéines de l'enveloppe virale, Rats, Récepteurs viraux, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), Cats, Cattle, Dogs, Humans, Membrane Glycoproteins (chemistry), Membrane Glycoproteins (drug effects), Membrane Glycoproteins (metabolism), Models, Molecular, Peptidyl-Dipeptidase A (drug effects), Peptidyl-Dipeptidase A (metabolism), Rabbits, Rats, Receptors, Virus (drug effects), Receptors, Virus (metabolism), SARS Virus (drug effects), SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (drug therapy), Severe Acute Respiratory Syndrome (virology), Spike Glycoprotein, Coronavirus, Viral Envelope Proteins (chemistry), Viral Envelope Proteins (drug effects), Viral Envelope Proteins (metabolism).
- MESH :
- chemical , chemistry : Membrane Glycoproteins, Viral Envelope Proteins.
- chemical , drug effects : Membrane Glycoproteins, Peptidyl-Dipeptidase A, Receptors, Virus, Viral Envelope Proteins.
- chemical , metabolism : Membrane Glycoproteins, Peptidyl-Dipeptidase A, Receptors, Virus, Viral Envelope Proteins.
- chemical , pharmacology : Antiviral Agents.
- chemical , therapeutic use : Antiviral Agents.
- drug effects : SARS Virus.
- drug therapy : Severe Acute Respiratory Syndrome.
- pathogenicity : SARS Virus.
- virology : Severe Acute Respiratory Syndrome.
- Animals, Cats, Cattle, Dogs, Humans, Models, Molecular, Rabbits, Rats, Spike Glycoprotein, Coronavirus.
Abstract
The identification in 2003 of a coronavirus as the aetiological agent of severe acute respiratory syndrome (SARS) intensified efforts to understand the biology of coronaviruses in general and SARS coronavirus (SARS-CoV) in particular. Rapid progress was made in describing the SARS-CoV genome, evolution and lifecycle. Identification of angiotensin-converting enzyme 2 (ACE2) as an obligate cellular receptor for SARS-CoV contributed to understanding of the SARS-CoV entry process, and helped to characterize two targets of antiviral therapeutics: the SARS-CoV spike protein and ACE2. Here we describe the role of these proteins in SARS-CoV replication and potential therapeutic strategies aimed at preventing entry of SARS-CoV into target cells.
PubMed: 17944271
Affiliations:
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pubmed:17944271Le document en format XML
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<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, MA, USA.</nlm:affiliation>
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<term>Antiviral Agents (pharmacology)</term>
<term>Antiviral Agents (therapeutic use)</term>
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<term>Cattle</term>
<term>Dogs</term>
<term>Humans</term>
<term>Membrane Glycoproteins (chemistry)</term>
<term>Membrane Glycoproteins (drug effects)</term>
<term>Membrane Glycoproteins (metabolism)</term>
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<term>Peptidyl-Dipeptidase A (drug effects)</term>
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<term>Receptors, Virus (metabolism)</term>
<term>SARS Virus (drug effects)</term>
<term>SARS Virus (pathogenicity)</term>
<term>Severe Acute Respiratory Syndrome (drug therapy)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Viral Envelope Proteins (chemistry)</term>
<term>Viral Envelope Proteins (drug effects)</term>
<term>Viral Envelope Proteins (metabolism)</term>
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<term>Antiviraux (pharmacologie)</term>
<term>Antiviraux (usage thérapeutique)</term>
<term>Bovins</term>
<term>Chats</term>
<term>Chiens</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Glycoprotéines membranaires ()</term>
<term>Glycoprotéines membranaires (métabolisme)</term>
<term>Humains</term>
<term>Lapins</term>
<term>Modèles moléculaires</term>
<term>Peptidyl-Dipeptidase A ()</term>
<term>Peptidyl-Dipeptidase A (métabolisme)</term>
<term>Protéines de l'enveloppe virale ()</term>
<term>Protéines de l'enveloppe virale (métabolisme)</term>
<term>Rats</term>
<term>Récepteurs viraux ()</term>
<term>Récepteurs viraux (métabolisme)</term>
<term>Syndrome respiratoire aigu sévère (traitement médicamenteux)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (pathogénicité)</term>
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<term>Viral Envelope Proteins</term>
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<term>Peptidyl-Dipeptidase A</term>
<term>Receptors, Virus</term>
<term>Viral Envelope Proteins</term>
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<term>Viral Envelope Proteins</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term>
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<term>Peptidyl-Dipeptidase A</term>
<term>Protéines de l'enveloppe virale</term>
<term>Récepteurs viraux</term>
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<term>Cattle</term>
<term>Dogs</term>
<term>Humans</term>
<term>Models, Molecular</term>
<term>Rabbits</term>
<term>Rats</term>
<term>Spike Glycoprotein, Coronavirus</term>
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<term>Chats</term>
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<front><div type="abstract" xml:lang="en">The identification in 2003 of a coronavirus as the aetiological agent of severe acute respiratory syndrome (SARS) intensified efforts to understand the biology of coronaviruses in general and SARS coronavirus (SARS-CoV) in particular. Rapid progress was made in describing the SARS-CoV genome, evolution and lifecycle. Identification of angiotensin-converting enzyme 2 (ACE2) as an obligate cellular receptor for SARS-CoV contributed to understanding of the SARS-CoV entry process, and helped to characterize two targets of antiviral therapeutics: the SARS-CoV spike protein and ACE2. Here we describe the role of these proteins in SARS-CoV replication and potential therapeutic strategies aimed at preventing entry of SARS-CoV into target cells.</div>
</front>
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<name sortKey="Farzan, Michael" sort="Farzan, Michael" uniqKey="Farzan M" first="Michael" last="Farzan">Michael Farzan</name>
<name sortKey="Li, Wenhui" sort="Li, Wenhui" uniqKey="Li W" first="Wenhui" last="Li">Wenhui Li</name>
<name sortKey="Radoshitzky, Sheli R" sort="Radoshitzky, Sheli R" uniqKey="Radoshitzky S" first="Sheli R" last="Radoshitzky">Sheli R. Radoshitzky</name>
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<country name="États-Unis"><region name="Massachusetts"><name sortKey="Kuhn, Jens H" sort="Kuhn, Jens H" uniqKey="Kuhn J" first="Jens H" last="Kuhn">Jens H. Kuhn</name>
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